GNA15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNA15_HUMAN
• UniProt AC: P30679
• Protein Name: Guanine nucleotide-binding protein subunit alpha-15
• Gene Name: GNA15
• Organism: Homo sapiens (Human).
• Sequence Length: 374
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems..
• Protein Sequence: MARSLTWRCCPWCLTEDEKAAARVDQEINRILLEQKKQDRGELKLLLLGPGESGKSTFIKQMRIIHGAGYSEEERKGFRPLVYQNIFVSMRAMIEAMERLQIPFSRPESKHHASLVMSQDPYKVTTFEKRYAAAMQWLWRDAGIRAYYERRREFHLLDSAVYYLSHLERITEEGYVPTAQDVLRSRMPTTGINEYCFSVQKTNLRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQCLEENNQENRMKESLALFGTILELPWFKSTSVILFLNKTDILEEKIPTSHLATYFPSFQGPKQDAEAAKRFILDMYTRMYTGCVDGPEGSKKGARSRRLFSHYTCATDTQNIRKVFKDVRDSVLARYLDEINLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	S-palmitoylation	ARSLTWRCCPWCLTE CCCCCCCCCCCCCCC	2.17	17620339
10	S-palmitoylation	RSLTWRCCPWCLTED CCCCCCCCCCCCCCC	1.89	17620339
19	Ubiquitination	WCLTEDEKAAARVDQ CCCCCCHHHHHHHHH	56.50	29967540
36	Ubiquitination	NRILLEQKKQDRGEL HHHHHHHHHCCCCCE	42.92	29967540
37	Ubiquitination	RILLEQKKQDRGELK HHHHHHHHCCCCCEE	58.06	-
44	Ubiquitination	KQDRGELKLLLLGPG HCCCCCEEEEEECCC	32.55	29967540
55	Ubiquitination	LGPGESGKSTFIKQM ECCCCCCCHHHHHHE	56.45	29967540
71	Phosphorylation	IIHGAGYSEEERKGF EHHCCCCCHHHHCCC	37.30	-
114	Phosphorylation	PESKHHASLVMSQDP CCHHCCCEEEECCCC	19.69	29083192
118	Phosphorylation	HHASLVMSQDPYKVT CCCEEEECCCCCCCC	24.77	29083192
122	Phosphorylation	LVMSQDPYKVTTFEK EEECCCCCCCCCHHH	26.78	29083192
123	Ubiquitination	VMSQDPYKVTTFEKR EECCCCCCCCCHHHH	38.19	29967540
148	Phosphorylation	DAGIRAYYERRREFH HHHHHHHHHHHHHHH	11.28	30576142
186	ADP-ribosylation	AQDVLRSRMPTTGIN HHHHHHHCCCCCCHH	28.76	-
186	ADP-ribosylation	AQDVLRSRMPTTGIN HHHHHHHCCCCCCHH	28.76	-
201	Ubiquitination	EYCFSVQKTNLRIVD HHEEEEECCCEEEEE	36.91	22505724
205	Dimethylation	SVQKTNLRIVDVGGQ EEECCCEEEEECCCC	29.02	-
213	Ubiquitination	IVDVGGQKSERKKWI EEECCCCCCHHHHHH	58.52	29967540
214	Phosphorylation	VDVGGQKSERKKWIH EECCCCCCHHHHHHH	34.44	-
285	Ubiquitination	KTDILEEKIPTSHLA CCHHHHHHCCHHHHH	44.61	29967540
294	Phosphorylation	PTSHLATYFPSFQGP CHHHHHHCCCCCCCC	14.11	27642862
302	Ubiquitination	FPSFQGPKQDAEAAK CCCCCCCHHCHHHHH	68.58	29967540
316	Phosphorylation	KRFILDMYTRMYTGC HHHHHHHHHHHHCCC	7.29	-
320	Phosphorylation	LDMYTRMYTGCVDGP HHHHHHHHCCCCCCC	9.18	26552605
321	Phosphorylation	DMYTRMYTGCVDGPE HHHHHHHCCCCCCCC	18.11	26552605
330	Phosphorylation	CVDGPEGSKKGARSR CCCCCCCCCCCHHHH	29.54	23684312
331	Ubiquitination	VDGPEGSKKGARSRR CCCCCCCCCCHHHHH	67.11	22505724
332	Ubiquitination	DGPEGSKKGARSRRL CCCCCCCCCHHHHHH	60.54	-
336	Phosphorylation	GSKKGARSRRLFSHY CCCCCHHHHHHHCCC	22.63	22817900
341	Phosphorylation	ARSRRLFSHYTCATD HHHHHHHCCCCCCCC	21.85	22210691
347	Phosphorylation	FSHYTCATDTQNIRK HCCCCCCCCCHHHHH	41.55	22210691
349	Phosphorylation	HYTCATDTQNIRKVF CCCCCCCCHHHHHHH	21.11	22210691
354	Ubiquitination	TDTQNIRKVFKDVRD CCCHHHHHHHHHHHH	48.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
336	S	Phosphorylation	Kinase	PRKCA	P05696	GPS
336	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
336	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNA15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNA15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TTC1_HUMAN	TTC1	physical	12748287
A4_HUMAN	APP	physical	21832049
WDCP_HUMAN	C2orf44	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
APBP2_HUMAN	APPBP2	physical	28514442
HEMH_HUMAN	FECH	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.