HEMH_HUMAN - dbPTM
HEMH_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HEMH_HUMAN
UniProt AC P22830
Protein Name Ferrochelatase, mitochondrial
Gene Name FECH
Organism Homo sapiens (Human).
Sequence Length 423
Subcellular Localization Mitochondrion inner membrane
Peripheral membrane protein
Matrix side.
Protein Description Catalyzes the ferrous insertion into protoporphyrin IX..
Protein Sequence MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQVQPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQEQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERDGLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADHILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLVWQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKECGVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTSQQL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26PhosphorylationLRDPLASSSWRVCQP
HCCCCCCCCCEECCC		28.4529449344
27PhosphorylationRDPLASSSWRVCQPW
CCCCCCCCCEECCCC		19.1929449344
37AcetylationVCQPWRWKSGAAAAA
ECCCCCCCCCCCEEE		30.3620167786
49PhosphorylationAAAVTTETAQHAQGA
EEEHHHHHHHHHCCC		29.53-
57AcetylationAQHAQGAKPQVQPQK
HHHHCCCCCCCCCCC		42.69-
57UbiquitinationAQHAQGAKPQVQPQK
HHHHCCCCCCCCCCC		42.69-
57MalonylationAQHAQGAKPQVQPQK
HHHHCCCCCCCCCCC		42.6926320211
106UbiquitinationMTLPIQNKLAPFIAK
CCCCCCCCCHHHHHC		29.6521906983
112UbiquitinationNKLAPFIAKRRTPKI
CCCHHHHHCCCCHHH		10.3221890473
112 (in isoform 2)Ubiquitination-10.32-
130PhosphorylationYRRIGGGSPIKIWTS
HHHHCCCCCCEEEEC		27.0823898821
133AcetylationIGGGSPIKIWTSKQG
HCCCCCCEEEECCCC		35.2625953088
138SuccinylationPIKIWTSKQGEGMVK
CCEEEECCCCCCHHH		55.75-
138AcetylationPIKIWTSKQGEGMVK
CCEEEECCCCCCHHH		55.7525953088
138SuccinylationPIKIWTSKQGEGMVK
CCEEEECCCCCCHHH		55.75-
151PhosphorylationVKLLDELSPNTAPHK
HHHHHHCCCCCCCCC		17.66-
158AcetylationSPNTAPHKYYIGFRY
CCCCCCCCEEEEEEE		38.3925953088
189PhosphorylationLERAIAFTQYPQYSC
HHHHHHHHCCCCCCC		20.4024043423
191PhosphorylationRAIAFTQYPQYSCST
HHHHHHCCCCCCCCC		6.8324043423
194PhosphorylationAFTQYPQYSCSTTGS
HHHCCCCCCCCCCCH		13.7224043423
195PhosphorylationFTQYPQYSCSTTGSS
HHCCCCCCCCCCCHH		9.0624043423
197PhosphorylationQYPQYSCSTTGSSLN
CCCCCCCCCCCHHHH		24.0624043423
198PhosphorylationYPQYSCSTTGSSLNA
CCCCCCCCCCHHHHH		39.2324043423
199PhosphorylationPQYSCSTTGSSLNAI
CCCCCCCCCHHHHHH		20.8324043423
201PhosphorylationYSCSTTGSSLNAIYR
CCCCCCCHHHHHHHH		29.5624043423
202PhosphorylationSCSTTGSSLNAIYRY
CCCCCCHHHHHHHHH		27.3024043423
207PhosphorylationGSSLNAIYRYYNQVG
CHHHHHHHHHHHHCC		7.0824043423
210PhosphorylationLNAIYRYYNQVGRKP
HHHHHHHHHHCCCCC		7.07-
2522-HydroxyisobutyrylationLDHFPLEKRSEVVIL
HCCCCCCCCCEEEEE		69.75-
252UbiquitinationLDHFPLEKRSEVVIL
HCCCCCCCCCEEEEE		69.75-
276PhosphorylationVVNRGDPYPQEVSAT
HCCCCCCCCHHHHHH		23.4522210691
297PhosphorylationRLEYCNPYRLVWQSK
HHHHCCHHHEEEEEC		11.5525839225
304UbiquitinationYRLVWQSKVGPMPWL
HHEEEEECCCCCCCC		35.792190698
310 (in isoform 2)Ubiquitination-14.01-
315PhosphorylationMPWLGPQTDESIKGL
CCCCCCCCHHHHHHH		44.88-
318PhosphorylationLGPQTDESIKGLCER
CCCCCHHHHHHHHHH		32.2020071362
320UbiquitinationPQTDESIKGLCERGR
CCCHHHHHHHHHHCC		55.92-
378PhosphorylationLNGNPLFSKALADLV
HCCCHHHHHHHHHHH		25.3824719451
415UbiquitinationNPVCRETKSFFTSQQ
CHHHHHCHHHHHCCC		40.28-
415SuccinylationNPVCRETKSFFTSQQ
CHHHHHCHHHHHCCC		40.28-
415SuccinylationNPVCRETKSFFTSQQ
CHHHHHCHHHHHCCC		40.28-
415AcetylationNPVCRETKSFFTSQQ
CHHHHHCHHHHHCCC		40.2890281
420PhosphorylationETKSFFTSQQL----
HCHHHHHCCCC----		15.69-
421 (in isoform 2)Ubiquitination-45.60-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HEMH_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HEMH_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HEMH_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HEMH_HUMANFECHphysical
11175906
ATPF2_HUMANATPAF2physical
28514442
NELFB_HUMANNELFBphysical
28514442
NELFD_HUMANNELFCDphysical
28514442
FMC1_HUMANC7orf55physical
28514442
NELFE_HUMANNELFEphysical
28514442
CLU_HUMANCLUHphysical
28514442
PDK2_HUMANPDK2physical
28514442
UQCC1_HUMANUQCC1physical
28514442
PGRC1_HUMANPGRMC1physical
28514442
SIR3_HUMANSIRT3physical
28514442
MCCA_HUMANMCCC1physical
28514442
Drug and Disease Associations
Kegg Disease
H00201 Erythropoietic porphyria (EP), including: Erythropoietic protoporphyria (EPP); Congenital erythropoi
OMIM Disease
177000Erythropoietic protoporphyria (EPP)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB02659Cholic Acid
Regulatory Network of HEMH_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory