FMC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FMC1_HUMAN
• UniProt AC: Q96HJ9
• Protein Name: Protein FMC1 homolog
• Gene Name: FMC1 {ECO:0000312|HGNC:HGNC:26946}
• Organism: Homo sapiens (Human).
• Sequence Length: 113
• Subcellular Localization: Mitochondrion .
• Protein Description: Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V). [PubMed: 28719601]
• Protein Sequence: MAALGSPSHTFRGLLRELRYLSAATGRPYRDTAAYRYLVKAFRAHRVTSEKLCRAQHELHFQAATYLCLLRSIRKHVALHQEFHGKGERSVEESAGLVGLKLPHQPGGKGWEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	LRYLSAATGRPYRDT HHHHHHHHCCCCCHH		24719451
29	Phosphorylation	SAATGRPYRDTAAYR HHHHCCCCCHHHHHH		24719451
40	Acetylation	AAYRYLVKAFRAHRV HHHHHHHHHHHHCCC		19608861
40	Ubiquitination	AAYRYLVKAFRAHRV HHHHHHHHHHHHCCC		19608861
40	Ubiquitination	AAYRYLVKAFRAHRV HHHHHHHHHHHHCCC		21890473
51	Ubiquitination	AHRVTSEKLCRAQHE HCCCCHHHHHHHHHH		24816145
75	Acetylation	CLLRSIRKHVALHQE HHHHHHHHHHHHHHH		25825284
90	Phosphorylation	FHGKGERSVEESAGL HCCCCCCCHHHHHCC		20071362
109	Ubiquitination	LPHQPGGKGWEP--- CCCCCCCCCCCC---		33845483
205 (in isoform 2)	Ubiquitination	-		-
227 (in isoform 2)	Acetylation	-		-
227 (in isoform 2)	Ubiquitination	-		-
413	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		27251275
449	Phosphorylation	------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FMC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FMC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FMC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATPF2_HUMAN	ATPAF2	physical	27499296
RT63_HUMAN	MRPL57	physical	27499296
NT5D2_HUMAN	NT5DC2	physical	27499296
CYC_HUMAN	CYCS	physical	27499296
CLPX_HUMAN	CLPX	physical	27499296
PDIP2_HUMAN	POLDIP2	physical	27499296
S2551_HUMAN	SLC25A51	physical	27499296
RM46_HUMAN	MRPL46	physical	27499296
ATPO_HUMAN	ATP5O	physical	27499296
STML2_HUMAN	STOML2	physical	27499296
ATP5E_HUMAN	ATP5E	physical	27499296
CHCH2_HUMAN	CHCHD2	physical	27499296
SCOT1_HUMAN	OXCT1	physical	27499296
ACPM_HUMAN	NDUFAB1	physical	27499296
ATP5H_HUMAN	ATP5H	physical	27499296
C1QBP_HUMAN	C1QBP	physical	27499296
NDUV1_HUMAN	NDUFV1	physical	27499296
MPPA_HUMAN	PMPCA	physical	27499296
MPPB_HUMAN	PMPCB	physical	27499296
NDUA8_HUMAN	NDUFA8	physical	27499296
ATPG_HUMAN	ATP5C1	physical	27499296
AT5F1_HUMAN	ATP5F1	physical	27499296
SNP29_HUMAN	SNAP29	physical	27499296

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.