RM46_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RM46_HUMAN
• UniProt AC: Q9H2W6
• Protein Name: 39S ribosomal protein L46, mitochondrial
• Gene Name: MRPL46
• Organism: Homo sapiens (Human).
• Sequence Length: 279
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MAAPVRRTLLGVAGGWRRFERLWAGSLSSRSLALAAAPSSNGSPWRLLGALCLQRPPVVSKPLTPLQEEMASLLQQIEIERSLYSDHELRALDENQRLAKKKADLHDEEDEQDILLAQDLEDMWEQKFLQFKLGARITEADEKNDRTSLNRKLDRNLVLLVREKFGDQDVWILPQAEWQPGETLRGTAERTLATLSENNMEAKFLGNAPCGHYTFKFPQAMRTESNLGAKVFFFKALLLTGDFSQAGNKGHHVWVTKDELGDYLKPKYLAQVRRFVSDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAAPVRRTLLGVAGG CCCCHHHHHHHHHCC	18.77	-
26	Phosphorylation	FERLWAGSLSSRSLA HHHHHCCCCCCCHHH	19.82	23025827
60	Phosphorylation	LQRPPVVSKPLTPLQ CCCCCCCCCCCCHHH	28.87	24719451
82	Phosphorylation	QQIEIERSLYSDHEL HHHHHHHHCCCHHHH	20.90	23186163
84	Phosphorylation	IEIERSLYSDHELRA HHHHHHCCCHHHHHH	17.19	25884760
85	Phosphorylation	EIERSLYSDHELRAL HHHHHCCCHHHHHHH	37.47	25003641
127	Ubiquitination	LEDMWEQKFLQFKLG HHHHHHHHHHHHHHC	36.21	22817900
132	Ubiquitination	EQKFLQFKLGARITE HHHHHHHHHCCCCCC	32.81	22817900
194	Phosphorylation	TAERTLATLSENNME HHHHHHHHHCCCCCE	33.65	22210691
200	Sulfoxidation	ATLSENNMEAKFLGN HHHCCCCCEEEECCC	8.81	21406390
203	Ubiquitination	SENNMEAKFLGNAPC CCCCCEEEECCCCCC	28.02	21890473
216	Acetylation	PCGHYTFKFPQAMRT CCCCEEEECCCHHCC	48.62	25953088
230	Ubiquitination	TESNLGAKVFFFKAL CCCHHHCHHHHHHHH	37.46	22817900
230	Acetylation	TESNLGAKVFFFKAL CCCHHHCHHHHHHHH	37.46	19608861
235	Ubiquitination	GAKVFFFKALLLTGD HCHHHHHHHHHHHCC	32.73	22817900
249	Malonylation	DFSQAGNKGHHVWVT CHHHCCCCCCEEEEE	59.72	26320211
263	Phosphorylation	TKDELGDYLKPKYLA EHHHHHHHCCHHHHH	18.15	20068231
265	Ubiquitination	DELGDYLKPKYLAQV HHHHHHCCHHHHHHH	32.98	19608861
265	Acetylation	DELGDYLKPKYLAQV HHHHHHCCHHHHHHH	32.98	23236377
267	Acetylation	LGDYLKPKYLAQVRR HHHHCCHHHHHHHHH	51.84	23236377
267	Malonylation	LGDYLKPKYLAQVRR HHHHCCHHHHHHHHH	51.84	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RM46_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RM46_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RM46_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VPP1_HUMAN	ATP6V0A1	physical	22939629
RM48_HUMAN	MRPL48	physical	26186194
RM40_HUMAN	MRPL40	physical	26186194
ETFR1_HUMAN	LYRM5	physical	26186194
RM55_HUMAN	MRPL55	physical	26186194
MGME1_HUMAN	MGME1	physical	26186194
ACPM_HUMAN	NDUFAB1	physical	26186194
RM40_HUMAN	MRPL40	physical	26344197
RM55_HUMAN	MRPL55	physical	26344197
RM40_HUMAN	MRPL40	physical	28514442
RM55_HUMAN	MRPL55	physical	28514442
RM48_HUMAN	MRPL48	physical	28514442
MGME1_HUMAN	MGME1	physical	28514442
CGL_HUMAN	CTH	physical	28514442
ACPM_HUMAN	NDUFAB1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-230 AND LYS-265, AND MASSSPECTROMETRY.
PubMed: 19608861