SNP29_HUMAN - dbPTM
SNP29_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SNP29_HUMAN
UniProt AC O95721
Protein Name Synaptosomal-associated protein 29 {ECO:0000312|HGNC:HGNC:11133}
Gene Name SNAP29 {ECO:0000312|HGNC:HGNC:11133}
Organism Homo sapiens (Human).
Sequence Length 258
Subcellular Localization Cytoplasm . Golgi apparatus membrane
Peripheral membrane protein . Cytoplasmic vesicle, autophagosome membrane
Peripheral membrane protein . Cell projection, cilium membrane
Peripheral membrane protein . Appears to be mostly membrane-bound, pro
Protein Description SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions..
Protein Sequence MSAYPKSYNPFDDDGEDEGARPAPWRDARDLPDGPDAPADRQQYLRQEVLRRAEATAASTSRSLALMYESEKVGVASSEELARQRGVLERTEKMVDKMDQDLKISQKHINSIKSVFGGLVNYFKSKPVETPPEQNGTLTSQPNNRLKEAISTSKEQEAKYQASHPNLRKLDDTDPVPRGAGSAMSTDAYPKNPHLRAYHQKIDSNLDELSMGLGRLKDIALGMQTEIEEQDDILDRLTTKVDKLDVNIKSTERKVRQL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2O-linked_Glycosylation------MSAYPKSYN
------CCCCCCCCC		36.1925419848
2Phosphorylation------MSAYPKSYN
------CCCCCCCCC		36.1930206219
4Phosphorylation----MSAYPKSYNPF
----CCCCCCCCCCC		12.1430206219
6Ubiquitination--MSAYPKSYNPFDD
--CCCCCCCCCCCCC		53.55-
7Phosphorylation-MSAYPKSYNPFDDD
-CCCCCCCCCCCCCC		26.1628796482
8PhosphorylationMSAYPKSYNPFDDDG
CCCCCCCCCCCCCCC		32.7425884760
29MethylationPAPWRDARDLPDGPD
CCCCCCCCCCCCCCC		50.73115917333
41MethylationGPDAPADRQQYLRQE
CCCCCHHHHHHHHHH		27.8482797397
44PhosphorylationAPADRQQYLRQEVLR
CCHHHHHHHHHHHHH		8.7725394399
56PhosphorylationVLRRAEATAASTSRS
HHHHHHHHHHHHHHH		17.79-
59PhosphorylationRAEATAASTSRSLAL
HHHHHHHHHHHHHHH		25.17-
60PhosphorylationAEATAASTSRSLALM
HHHHHHHHHHHHHHH		24.35-
61O-linked_GlycosylationEATAASTSRSLALMY
HHHHHHHHHHHHHHH		19.8525419848
61PhosphorylationEATAASTSRSLALMY
HHHHHHHHHHHHHHH		19.85-
63PhosphorylationTAASTSRSLALMYES
HHHHHHHHHHHHHHH		20.1220068231
68PhosphorylationSRSLALMYESEKVGV
HHHHHHHHHHHCCCC		19.7025159151
70PhosphorylationSLALMYESEKVGVAS
HHHHHHHHHCCCCCC		25.8126356563
77PhosphorylationSEKVGVASSEELARQ
HHCCCCCCHHHHHHH		35.5627794612
78PhosphorylationEKVGVASSEELARQR
HCCCCCCHHHHHHHH		25.9225159151
103UbiquitinationDKMDQDLKISQKHIN
HHHHHHCCCCHHHHH		48.9132015554
103AcetylationDKMDQDLKISQKHIN
HHHHHHCCCCHHHHH		48.9120167786
105PhosphorylationMDQDLKISQKHINSI
HHHHCCCCHHHHHHH		31.4328348404
107AcetylationQDLKISQKHINSIKS
HHCCCCHHHHHHHHH		39.3925953088
107UbiquitinationQDLKISQKHINSIKS
HHCCCCHHHHHHHHH		39.3923000965
111PhosphorylationISQKHINSIKSVFGG
CCHHHHHHHHHHHHH		30.6930576142
113UbiquitinationQKHINSIKSVFGGLV
HHHHHHHHHHHHHHH		40.1523000965
114PhosphorylationKHINSIKSVFGGLVN
HHHHHHHHHHHHHHH		22.4726356563
122PhosphorylationVFGGLVNYFKSKPVE
HHHHHHHHHHCCCCC		12.6125106551
124UbiquitinationGGLVNYFKSKPVETP
HHHHHHHHCCCCCCC		47.4022817900
124AcetylationGGLVNYFKSKPVETP
HHHHHHHHCCCCCCC		47.4019608861
126UbiquitinationLVNYFKSKPVETPPE
HHHHHHCCCCCCCCC		54.3922817900
130O-linked_GlycosylationFKSKPVETPPEQNGT
HHCCCCCCCCCCCCC		44.3625419848
130PhosphorylationFKSKPVETPPEQNGT
HHCCCCCCCCCCCCC		44.3628985074
137PhosphorylationTPPEQNGTLTSQPNN
CCCCCCCCCCCCCCH		34.1223186163
147UbiquitinationSQPNNRLKEAISTSK
CCCCHHHHHHHHCCH		41.6927667366
153PhosphorylationLKEAISTSKEQEAKY
HHHHHHCCHHHHHHH		27.66-
153O-linked_GlycosylationLKEAISTSKEQEAKY
HHHHHHCCHHHHHHH		27.6625419848
154UbiquitinationKEAISTSKEQEAKYQ
HHHHHCCHHHHHHHH		64.6024816145
154AcetylationKEAISTSKEQEAKYQ
HHHHHCCHHHHHHHH		64.607677579
159UbiquitinationTSKEQEAKYQASHPN
CCHHHHHHHHHCCCC		36.8229967540
160PhosphorylationSKEQEAKYQASHPNL
CHHHHHHHHHCCCCH		19.1623898821
163PhosphorylationQEAKYQASHPNLRKL
HHHHHHHCCCCHHHC		24.7723911959
169UbiquitinationASHPNLRKLDDTDPV
HCCCCHHHCCCCCCC		60.4829967540
173PhosphorylationNLRKLDDTDPVPRGA
CHHHCCCCCCCCCCC		41.7029514088
182PhosphorylationPVPRGAGSAMSTDAY
CCCCCCCCCCCCCCC		21.9223917254
184SulfoxidationPRGAGSAMSTDAYPK
CCCCCCCCCCCCCCC		4.7930846556
185PhosphorylationRGAGSAMSTDAYPKN
CCCCCCCCCCCCCCC		23.8930242111
186O-linked_GlycosylationGAGSAMSTDAYPKNP
CCCCCCCCCCCCCCH		16.15OGP
186PhosphorylationGAGSAMSTDAYPKNP
CCCCCCCCCCCCCCH		16.1526356563
189PhosphorylationSAMSTDAYPKNPHLR
CCCCCCCCCCCHHHH		19.9726356563
191UbiquitinationMSTDAYPKNPHLRAY
CCCCCCCCCHHHHHH		71.1329967540
204PhosphorylationAYHQKIDSNLDELSM
HHHHHHCCCHHHHHH		42.6423917254
210PhosphorylationDSNLDELSMGLGRLK
CCCHHHHHHHHHHHH		14.5728857561
211SulfoxidationSNLDELSMGLGRLKD
CCHHHHHHHHHHHHH		8.8621406390
240UbiquitinationILDRLTTKVDKLDVN
HHHHHHHHHHHHCCC		43.1129967540
243AcetylationRLTTKVDKLDVNIKS
HHHHHHHHHCCCCHH		49.9625953088
249UbiquitinationDKLDVNIKSTERKVR
HHHCCCCHHHHHHHH		46.2332015554
250PhosphorylationKLDVNIKSTERKVRQ
HHCCCCHHHHHHHHC		31.5329214152
251PhosphorylationLDVNIKSTERKVRQL
HCCCCHHHHHHHHCC		34.5030108239
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
105SPhosphorylationKinaseNEK3P51956
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SNP29_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SNP29_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LURA1_HUMANLURAP1physical
16189514
SNP29_HUMANSNAP29physical
11423532
EHD1_HUMANEHD1physical
11423532
VAMP5_HUMANVAMP5physical
25416956
STX12_HUMANSTX12physical
25416956
FAM9B_HUMANFAM9Bphysical
25416956
TRPM7_HUMANTRPM7physical
26186194
VPS53_HUMANVPS53physical
26186194
BRE1A_HUMANRNF20physical
26186194
CA122_HUMANC1orf122physical
26186194
MACF1_HUMANMACF1physical
26186194
TRAF3_HUMANTRAF3physical
26186194
EXOC4_HUMANEXOC4physical
26186194
STX18_HUMANSTX18physical
26186194
STRN4_HUMANSTRN4physical
26186194
TRI62_HUMANTRIM62physical
26186194
TACC3_HUMANTACC3physical
26186194
VPS51_HUMANVPS51physical
26186194
CAVN1_HUMANPTRFphysical
26186194
BRE1B_HUMANRNF40physical
26186194
STX5_HUMANSTX5physical
26186194
STXB5_HUMANSTXBP5physical
26186194
VPS50_HUMANCCDC132physical
26186194
NDE1_HUMANNDE1physical
26186194
NDEL1_HUMANNDEL1physical
26186194
FP100_HUMANC17orf70physical
26186194
SKA1_HUMANSKA1physical
26186194
SGF29_HUMANCCDC101physical
26186194
EXOC1_HUMANEXOC1physical
26186194
TRAF6_HUMANTRAF6physical
26186194
EIPR1_HUMANTSSC1physical
26186194
ITPR3_HUMANITPR3physical
26186194
VAMP7_HUMANVAMP7physical
26186194
CCHCR_HUMANCCHCR1physical
26186194
FKB15_HUMANFKBP15physical
26186194
SNAA_HUMANNAPAphysical
26344197
STX7_HUMANSTX7physical
26344197
STXB5_HUMANSTXBP5physical
28514442
TRAF3_HUMANTRAF3physical
28514442
SKA1_HUMANSKA1physical
28514442
TRI62_HUMANTRIM62physical
28514442
TRPM7_HUMANTRPM7physical
28514442
TACC3_HUMANTACC3physical
28514442
EIPR1_HUMANTSSC1physical
28514442
VPS51_HUMANVPS51physical
28514442
TRAF6_HUMANTRAF6physical
28514442
VPS50_HUMANCCDC132physical
28514442
CCHCR_HUMANCCHCR1physical
28514442
FP100_HUMANC17orf70physical
28514442
CA122_HUMANC1orf122physical
28514442
NDE1_HUMANNDE1physical
28514442
STRN4_HUMANSTRN4physical
28514442
CAVN1_HUMANPTRFphysical
28514442
SGF29_HUMANCCDC101physical
28514442
SMTL2_HUMANSMTNL2physical
28514442
BRE1A_HUMANRNF20physical
28514442
VAMP7_HUMANVAMP7physical
28514442
STX5_HUMANSTX5physical
28514442
BRE1B_HUMANRNF40physical
28514442
MACF1_HUMANMACF1physical
28514442
NDEL1_HUMANNDEL1physical
28514442
EXOC4_HUMANEXOC4physical
28514442
ITPR3_HUMANITPR3physical
28514442
STX18_HUMANSTX18physical
28514442
Drug and Disease Associations
Kegg Disease
H00799 Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome; CEDNIK syndrome
OMIM Disease
609528Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome (CEDNIK)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SNP29_HUMAN

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