SMTL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMTL2_HUMAN
• UniProt AC: Q2TAL5
• Protein Name: Smoothelin-like protein 2
• Gene Name: SMTNL2
• Organism: Homo sapiens (Human).
• Sequence Length: 461
• Protein Sequence: MEPAPDAQEARTVREALGRYEAALEGAVRALHEDMRGLQRGVERRVAEAMRLAGPLARTVADLQRDNQRLQAQLERLTRQVEALGLASGMSPVPGTPGTPSPPPAPGVPDRAPRLGSARFASHATFSLSGRGQSLDHDEASESEMRKTSNSCIMENGHQPGAGPGDGPPEIAQNFSAPDPPRPRPVSLSLRLPHQPVTAITRVSDRFSGETSAAALSPMSAATLGGLNPSPSEVITPWTPSPSEKNSSFTWSVPSSGYGAVTASKHSNSPPLVTPPQSPVSPQPPAITQVHRQGERRRELVRSQTLPRTSEAQARKALFEKWEQETAAGKGKGEARARLKRSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDYNSLSPTQRQKNFELAFTMAENLANCERLIEVEDMMVMGRKPDPMCVFTYVQSLYNHLRRFE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
96	Phosphorylation	GMSPVPGTPGTPSPP CCCCCCCCCCCCCCC	16.69	22673903
99	Phosphorylation	PVPGTPGTPSPPPAP CCCCCCCCCCCCCCC	23.07	28857561
101	Phosphorylation	PGTPGTPSPPPAPGV CCCCCCCCCCCCCCC	50.29	26437602
122	Phosphorylation	LGSARFASHATFSLS CCCCCCCCCCEEECC	15.79	24905233
125	Phosphorylation	ARFASHATFSLSGRG CCCCCCCEEECCCCC	14.34	22673903
127	Phosphorylation	FASHATFSLSGRGQS CCCCCEEECCCCCCC	19.78	26437602
129	Phosphorylation	SHATFSLSGRGQSLD CCCEEECCCCCCCCC	25.83	28857561
134	Phosphorylation	SLSGRGQSLDHDEAS ECCCCCCCCCCCCCC	38.29	19764811
141	Phosphorylation	SLDHDEASESEMRKT CCCCCCCCHHHHHHH	39.34	24905233
143	Phosphorylation	DHDEASESEMRKTSN CCCCCCHHHHHHHHC	33.91	22673903
186	Ubiquitination	DPPRPRPVSLSLRLP CCCCCCCCEEEEECC	10.70	32015554
187	Phosphorylation	PPRPRPVSLSLRLPH CCCCCCCEEEEECCC	18.22	17081983
189	Phosphorylation	RPRPVSLSLRLPHQP CCCCCEEEEECCCCC	12.16	17081983
198	Phosphorylation	RLPHQPVTAITRVSD ECCCCCEEEEEEEHH	21.01	26437602
200	Phosphorylation	PHQPVTAITRVSDRF CCCCEEEEEEEHHCC	1.52	32645325
247	Phosphorylation	PSPSEKNSSFTWSVP CCCCCCCCCCEEECC	37.59	28857561
248	Phosphorylation	SPSEKNSSFTWSVPS CCCCCCCCCEEECCC	35.77	28857561
249	Ubiquitination	PSEKNSSFTWSVPSS CCCCCCCCEEECCCC	9.00	32015554
256	Phosphorylation	FTWSVPSSGYGAVTA CEEECCCCCCCEEEC	29.93	-
263	Phosphorylation	SGYGAVTASKHSNSP CCCCEEECCCCCCCC	15.24	32645325
267	Phosphorylation	AVTASKHSNSPPLVT EEECCCCCCCCCCCC	42.62	19764811
269	Phosphorylation	TASKHSNSPPLVTPP ECCCCCCCCCCCCCC	30.80	19764811
274	Phosphorylation	SNSPPLVTPPQSPVS CCCCCCCCCCCCCCC	36.61	19764811
278	Phosphorylation	PLVTPPQSPVSPQPP CCCCCCCCCCCCCCC	32.80	19764811
281	Phosphorylation	TPPQSPVSPQPPAIT CCCCCCCCCCCCCCH	22.62	19764811
303	Phosphorylation	RRRELVRSQTLPRTS HHHHHHHHCCCCCCC	21.75	22210691
305	Phosphorylation	RELVRSQTLPRTSEA HHHHHHCCCCCCCHH	39.72	22210691
330	Ubiquitination	EQETAAGKGKGEARA HHHHHCCCCHHHHHH	53.36	32015554
342	Phosphorylation	ARARLKRSQSFGVAS HHHHHHHHHHCCCCC	28.70	29978859
344	Phosphorylation	ARLKRSQSFGVASAS HHHHHHHHCCCCCHH	25.80	22617229
349	Phosphorylation	SQSFGVASASSIKQI HHHCCCCCHHHHHHH	26.69	27251275
351	Phosphorylation	SFGVASASSIKQILL HCCCCCHHHHHHHHH	30.05	27251275
352	Phosphorylation	FGVASASSIKQILLE CCCCCHHHHHHHHHH	33.26	27251275
354	Methylation	VASASSIKQILLEWC CCCHHHHHHHHHHHH	32.98	23644510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMTL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMTL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMTL2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
CCNA2_HUMAN	CCNA2	physical	28514442
SKP2_HUMAN	SKP2	physical	28514442
1433Z_HUMAN	YWHAZ	physical	28514442
1433G_HUMAN	YWHAG	physical	28514442
1433E_HUMAN	YWHAE	physical	28514442
1433F_HUMAN	YWHAH	physical	28514442
CDK2_HUMAN	CDK2	physical	28514442
1433B_HUMAN	YWHAB	physical	28514442
1433S_HUMAN	SFN	physical	28514442
1433T_HUMAN	YWHAQ	physical	28514442
NEUL_HUMAN	NLN	physical	28514442
CUL1_HUMAN	CUL1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.