dbPTM

SKP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SKP2_HUMAN
UniProt AC	Q13309
Protein Name	S-phase kinase-associated protein 2
Gene Name	SKP2
Organism	Homo sapiens (Human).
Sequence Length	424
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration..
Protein Sequence	MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLGHPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQKPSCL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	WGWDSSKTSELLSGM CCCCCHHHHHHHCCC	29.40	24144214
30	Phosphorylation	GWDSSKTSELLSGMG CCCCHHHHHHHCCCC	29.95	24144214
34	Phosphorylation	SKTSELLSGMGVSAL HHHHHHHCCCCCCHH	39.08	24144214
39	Phosphorylation	LLSGMGVSALEKEEP HHCCCCCCHHCCCCC	22.77	24144214
43	Sumoylation	MGVSALEKEEPDSEN CCCCHHCCCCCCCCC	69.13	-
48 (in isoform 2)	Phosphorylation	-	43.17	-
48	Phosphorylation	LEKEEPDSENIPQEL HCCCCCCCCCCCHHH	43.17	25159151
57 (in isoform 2)	Phosphorylation	-	42.50	-
57	Phosphorylation	NIPQELLSNLGHPES CCCHHHHHHCCCCCC	42.50	22167270
64	Phosphorylation	SNLGHPESPPRKRLK HHCCCCCCCCCHHCC	44.66	22167270
64 (in isoform 2)	Phosphorylation	-	44.66	-
68	Acetylation	HPESPPRKRLKSKGS CCCCCCCHHCCCCCC	68.78	22770219
71	Acetylation	SPPRKRLKSKGSDKD CCCCHHCCCCCCCCC	54.90	22770219
72	Phosphorylation	PPRKRLKSKGSDKDF CCCHHCCCCCCCCCE	47.01	23927012
73	Ubiquitination	PRKRLKSKGSDKDFV CCHHCCCCCCCCCEE	61.93	-
75	Phosphorylation	KRLKSKGSDKDFVIV HHCCCCCCCCCEEEE	45.27	23927012
77	Ubiquitination	LKSKGSDKDFVIVRR CCCCCCCCCEEEEEC	55.55	-
77	Acetylation	LKSKGSDKDFVIVRR CCCCCCCCCEEEEEC	55.55	25953088
125	Ubiquitination	LKVSGVCKRWYRLAS HHHHCCCHHHHHHCC	43.49	-
145	Ubiquitination	QTLDLTGKNLHPDVT HHHCCCCCCCCCCHH	51.61	21890473
145 (in isoform 1)	Ubiquitination	-	51.61	21890473
145 (in isoform 2)	Ubiquitination	-	51.61	21890473
145	Ubiquitination	QTLDLTGKNLHPDVT HHHCCCCCCCCCCHH	51.61	21890473
179	Phosphorylation	QPLAEHFSPFRVQHM CHHHHHCCCCEEEEC	25.66	30266825
206	Phosphorylation	HGILSQCSKLQNLSL HHHHHHHHHHCCCCC	28.85	24719451
207	Ubiquitination	GILSQCSKLQNLSLE HHHHHHHHHCCCCCC	62.81	-
212	Phosphorylation	CSKLQNLSLEGLRLS HHHHCCCCCCCCCCC	31.74	21406692
219	Phosphorylation	SLEGLRLSDPIVNTL CCCCCCCCCHHHHHH	34.60	27461979
225	Phosphorylation	LSDPIVNTLAKNSNL CCCHHHHHHHHCCCE	19.73	27461979
228 (in isoform 2)	Ubiquitination	-	65.11	21890473
228 (in isoform 1)	Ubiquitination	-	65.11	21890473
228	Ubiquitination	PIVNTLAKNSNLVRL HHHHHHHHCCCEEEE	65.11	2190698
256	Phosphorylation	QTLLSSCSRLDELNL HHHHHHCCCCHHCCC	37.51	-
299	Ubiquitination	GYRKNLQKSDLSTLV HHHHHCCHHCHHHHH	49.45	-
303	Phosphorylation	NLQKSDLSTLVRRCP HCCHHCHHHHHHHCC	25.37	-
341	Phosphorylation	LNYLQHLSLSRCYDI HHHHHHHCHHHHHHC	23.36	24719451
343	Phosphorylation	YLQHLSLSRCYDIIP HHHHHCHHHHHHCCH	19.54	17081983
367 (in isoform 2)	Phosphorylation	-	5.51	30631047
405	Ubiquitination	RPTIGNKKNQEIWGI CCCCCCCCCCEEEEE	68.79	-
413	Ubiquitination	NQEIWGIKCRLTLQK CCEEEEEEEEEEECC	14.90	-
417	Phosphorylation	WGIKCRLTLQKPSCL EEEEEEEEECCCCCC	14.06	20663873
420	Ubiquitination	KCRLTLQKPSCL--- EEEEEECCCCCC---	41.85	-
420	Acetylation	KCRLTLQKPSCL--- EEEEEECCCCCC---	41.85	25953088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
64	S	Phosphorylation	Kinase	CDK2	P24941	PSP
64	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
64	S	Phosphorylation	Kinase	PIM1	P11309	PSP
64	S	Phosphorylation	Kinase	PIM1	P26794	PSP
72	S	Phosphorylation	Kinase	PIM1	P11309	PSP
72	S	Phosphorylation	Kinase	PIM1	P26794	PSP
256	S	Phosphorylation	Kinase	AMPKB1	Q9Y478	PSP
256	S	Phosphorylation	Kinase	AMPKG2	Q9UGJ0	PSP
256	S	Phosphorylation	Kinase	AMPKA1	Q13131	PSP
417	T	Phosphorylation	Kinase	PIM1	P11309	PSP
417	T	Phosphorylation	Kinase	PIM1	P26794	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	FZR1	Q9UM11	PMID:15014502
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:12813041
-	K	Ubiquitination	E3 ubiquitin ligase	VHL	P40337	PMID:21358672

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
68	K	Acetylation	22770219
Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention.
71	K	Acetylation	22770219
Acetylation at Lys-68 and Lys-71 increases stability through impairment of APC/C-mediated proteolysis and promotes cytoplasmic retention.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SKP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TFE2_HUMAN	TCF3	physical	14592976
CUL1_HUMAN	CUL1	physical	12840033
CDT1_HUMAN	CDT1	physical	12840033
CKS1_HUMAN	CKS1B	physical	12813041
CDN1B_HUMAN	CDKN1B	physical	12813041
CUL1_HUMAN	CUL1	physical	12609982
SKP1_HUMAN	SKP1	physical	12609982
CKS1_HUMAN	CKS1B	physical	12140288
CDN1B_HUMAN	CDKN1B	physical	12140288
CKS1_HUMAN	CKS1B	physical	11231585
CUL1_HUMAN	CUL1	physical	9430629
SKP1_HUMAN	SKP1	physical	10918611
ORC1_HUMAN	ORC1	physical	11931757
CUL1_HUMAN	CUL1	physical	10559858
CCNA2_HUMAN	CCNA2	physical	10559858
CDK2_HUMAN	CDK2	physical	10559858
SKP1_HUMAN	SKP1	physical	10559858
E2F1_HUMAN	E2F1	physical	10559858
MYBB_HUMAN	MYBL2	physical	10871850
CKS1_HUMAN	CKS1B	physical	18519678
TAL1_HUMAN	TAL1	physical	17962192
CDN1A_HUMAN	CDKN1A	physical	17679094
CUL1_HUMAN	CUL1	physical	17439941
CKS1_HUMAN	CKS1B	physical	17409098
CCNA1_HUMAN	CCNA1	physical	16774918
CUL1_HUMAN	CUL1	physical	16774918
CDN1B_HUMAN	CDKN1B	physical	16774918
TOB1_HUMAN	TOB1	physical	16951159
CUL1_HUMAN	CUL1	physical	16880511
RO52_HUMAN	TRIM21	physical	16880511
SKP1_HUMAN	SKP1	physical	16880511
ELF4_HUMAN	ELF4	physical	16581786
RAG2_HUMAN	RAG2	physical	15949444
FOXO1_HUMAN	FOXO1	physical	15668399
RB_HUMAN	RB1	physical	15469821
SKP1_HUMAN	SKP1	physical	15469821
SKP1_HUMAN	SKP1	physical	15342634
UBP18_HUMAN	USP18	physical	15342634
SMAD4_HUMAN	SMAD4	physical	15314162
WEE1_HUMAN	WEE1	physical	15070733
SKP1_HUMAN	SKP1	physical	15070733
CDT1_HUMAN	CDT1	physical	15004027
E2F1_HUMAN	E2F1	physical	12097298
MYC_HUMAN	MYC	physical	12769844
RASF1_HUMAN	RASSF1	physical	18071316
UBP13_HUMAN	USP13	physical	21571647
UFD1_HUMAN	UFD1L	physical	21571647
KMT2A_HUMAN	KMT2A	physical	20818375
PIM1_HUMAN	PIM1	physical	20663873
UB2R1_HUMAN	CDC34	physical	20663873
CDC20_HUMAN	CDC20	physical	20663873
ING3_HUMAN	ING3	physical	19935701
CDN1A_HUMAN	CDKN1A	physical	19686743
CDN1B_HUMAN	CDKN1B	physical	19686743
CDN1C_HUMAN	CDKN1C	physical	19686743
RASF1_HUMAN	RASSF1	physical	19686743
FOXO1_HUMAN	FOXO1	physical	19686743
FZR1_HUMAN	FZR1	physical	19686743
CDK2_HUMAN	CDK2	physical	19686743
CC14B_HUMAN	CDC14B	physical	19686743
BTG2_HUMAN	BTG2	physical	19615363
AKT1_HUMAN	AKT1	physical	19270694
SKP1_HUMAN	SKP1	physical	19270694
CUL1_HUMAN	CUL1	physical	19270694
1433B_HUMAN	YWHAB	physical	19270694
JAK3_MOUSE	Jak3	physical	21969365
SKP1_HUMAN	SKP1	physical	20041211
FOXO3_HUMAN	FOXO3	physical	21841822
JAK2_HUMAN	JAK2	physical	21119685
ASB2_HUMAN	ASB2	physical	21119685
CUL1_HUMAN	CUL1	physical	21119685
CUL5_HUMAN	CUL5	physical	21119685
PHB_HUMAN	PHB	physical	20134482
VHL_HUMAN	VHL	physical	21358672
AKT1_HUMAN	AKT1	physical	21358672
FZR1_HUMAN	FZR1	physical	20663873
CUL1_HUMAN	CUL1	physical	15456869
SKP1_HUMAN	SKP1	physical	15456869
TFE2_HUMAN	TCF3	physical	15456869
CHIP_HUMAN	STUB1	physical	15456869
DNJB5_HUMAN	DNAJB5	physical	15456869
CKS1_HUMAN	CKS1B	physical	11463388
CDN1B_HUMAN	CDKN1B	physical	11463388
ATM_HUMAN	ATM	physical	22464731
RAD50_HUMAN	RAD50	physical	22464731
MRE11_HUMAN	MRE11A	physical	22464731
CUL1_HUMAN	CUL1	physical	22464731
SKP1_HUMAN	SKP1	physical	22464731
NBN_HUMAN	NBN	physical	22464731
TYY1_HUMAN	YY1	physical	22440256
CUL1_HUMAN	CUL1	physical	17704768
ELOC_HUMAN	TCEB1	physical	17786314
MYC_HUMAN	MYC	physical	12963825
CCNG2_HUMAN	CCNG2	physical	18784254
CDN1A_HUMAN	CDKN1A	physical	13678583
AKT1_HUMAN	AKT1	physical	19270695
CDK2_HUMAN	CDK2	physical	19270695
CCNA1_HUMAN	CCNA1	physical	19270695
IMA5_HUMAN	KPNA1	physical	19270695
IMA7_HUMAN	KPNA6	physical	19270695
SPDYA_HUMAN	SPDYA	physical	19622356
CUL1_HUMAN	CUL1	physical	20160477
SKP1_HUMAN	SKP1	physical	20160477
CDN1B_HUMAN	CDKN1B	physical	20160477
CCNB1_HUMAN	CCNB1	physical	20160477
CDK2_HUMAN	CDK2	physical	20160477
CCNA2_HUMAN	CCNA2	physical	20160477
CDN1B_HUMAN	CDKN1B	physical	15075339
SKP1_HUMAN	SKP1	physical	19398581
RBX1_HUMAN	RBX1	physical	19398581
CUL1_HUMAN	CUL1	physical	19398581
CCNA2_HUMAN	CCNA2	physical	18604603
CDK2_HUMAN	CDK2	physical	18604603
CUL1_HUMAN	CUL1	physical	22013077
CUL1_HUMAN	CUL1	physical	17438373
RBL2_HUMAN	RBL2	physical	12435635
CDN1B_HUMAN	CDKN1B	physical	15355997
CCNA2_HUMAN	CCNA2	physical	15355997
SKP1_HUMAN	SKP1	physical	16275325
RBX2_HUMAN	RNF7	physical	11255262
CDN1B_HUMAN	CDKN1B	physical	10559916
CUL1_HUMAN	CUL1	physical	10559916
SKP1_HUMAN	SKP1	physical	10559916
CKS1_HUMAN	CKS1B	physical	16338391
CUL1_HUMAN	CUL1	physical	9636170
CDN1B_HUMAN	CDKN1B	physical	22310285
SKP1_HUMAN	SKP1	physical	22310285
CUL1_HUMAN	CUL1	physical	22310285
FOXO3_HUMAN	FOXO3	physical	22310285
E2F1_HUMAN	E2F1	physical	17471231
RIR2_HUMAN	RRM2	physical	18820369
BTG1_HUMAN	BTG1	physical	22975506
BTG2_HUMAN	BTG2	physical	22975506
SIR3_HUMAN	SIRT3	physical	23045395
CDN1B_HUMAN	CDKN1B	physical	11565034
UB2R1_HUMAN	CDC34	physical	16774918
BRCA1_HUMAN	BRCA1	physical	23086937
BARD1_HUMAN	BARD1	physical	23086937
FBW1A_HUMAN	BTRC	physical	23071779
SKP1_HUMAN	SKP1	physical	23261596
CDN1A_HUMAN	CDKN1A	physical	23261596
CUL1_HUMAN	CUL1	physical	18239684
SKP1_HUMAN	SKP1	physical	18239684
RBX1_HUMAN	RBX1	physical	18239684
CKS1_HUMAN	CKS1B	physical	18239684
CDN1B_HUMAN	CDKN1B	physical	18239684
SIR3_HUMAN	SIRT3	physical	22770219
SIR4_HUMAN	SIRT4	physical	22770219
SIR6_HUMAN	SIRT6	physical	22770219
CDK2_HUMAN	CDK2	physical	22770219
IMA5_HUMAN	KPNA1	physical	22770219
IMA7_HUMAN	KPNA6	physical	22770219
EP300_HUMAN	EP300	physical	22770219
CDN1B_MOUSE	Cdkn1b	physical	23589337
E2F1_HUMAN	E2F1	physical	23868976
SKP1_HUMAN	SKP1	physical	23868976
CUL1_HUMAN	CUL1	physical	23868976
KMT2A_HUMAN	KMT2A	physical	23868976
CDN1B_HUMAN	CDKN1B	physical	23910095
FZR1_HUMAN	FZR1	physical	23972993
CUL1_HUMAN	CUL1	physical	24085301
SKP1_HUMAN	SKP1	physical	24085301
CDN1B_HUMAN	CDKN1B	physical	24085301
RND3_HUMAN	RND3	physical	24045951
ANDR_HUMAN	AR	physical	24347472
CUL1_HUMAN	CUL1	physical	25143387
CDN1A_HUMAN	CDKN1A	physical	18794347
ESR1_HUMAN	ESR1	physical	23770852
SKP1_HUMAN	SKP1	physical	23770852
CUL1_HUMAN	CUL1	physical	23770852
RBX1_HUMAN	RBX1	physical	23770852
CDN1C_HUMAN	CDKN1C	physical	12925736
CDN1B_HUMAN	CDKN1B	physical	20663873
FZR1_HUMAN	FZR1	physical	19270695
FZR1_HUMAN	FZR1	physical	22770219
CDN1B_HUMAN	CDKN1B	physical	22959436
CCNE1_HUMAN	CCNE1	physical	22959436
CADH1_HUMAN	CDH1	physical	20717963
CDN1B_MOUSE	Cdkn1b	physical	15980415
CDN1A_HUMAN	CDKN1A	physical	15980415
MEF2D_HUMAN	MEF2D	physical	25733682
MEF2C_HUMAN	MEF2C	physical	25733682
CDN1B_HUMAN	CDKN1B	physical	22524983
SKP1_HUMAN	SKP1	physical	22524983
CUL1_HUMAN	CUL1	physical	22524983
NHRF1_HUMAN	SLC9A3R1	physical	25492869
SK2L2_HUMAN	SKIV2L2	physical	26344197
TP4AP_HUMAN	TRPC4AP	physical	26038816
MYC_HUMAN	MYC	physical	26038816
EP300_HUMAN	EP300	physical	26593157
SKP1_HUMAN	SKP1	physical	26087183
AURKB_HUMAN	AURKB	physical	26697838
SKP1_HUMAN	SKP1	physical	26474281
CADH1_HUMAN	CDH1	physical	26474281
BRCA1_HUMAN	BRCA1	physical	25659039
SKP2_HUMAN	SKP2	physical	17254749
CUL1_HUMAN	CUL1	physical	27542266
DCNL3_HUMAN	DCUN1D3	physical	27542266
FBXW2_HUMAN	FBXW2	physical	28090088
IFI27_HUMAN	IFI27	physical	27194766
RICTR_HUMAN	RICTOR	physical	28514442
CDK1_HUMAN	CDK1	physical	28514442
LRCH2_HUMAN	LRCH2	physical	28514442
LRC58_HUMAN	LRRC58	physical	28514442
AP5B1_HUMAN	AP5B1	physical	28514442
TTC9C_HUMAN	TTC9C	physical	28514442
LRC40_HUMAN	LRRC40	physical	28514442
DDX11_HUMAN	DDX11	physical	28514442
OFD1_HUMAN	OFD1	physical	28514442
FA83H_HUMAN	FAM83H	physical	28514442
ATG2B_HUMAN	ATG2B	physical	28514442
IMDH2_HUMAN	IMPDH2	physical	28514442
CDC20_HUMAN	CDC20	physical	28514442
DISC1_HUMAN	DISC1	physical	28514442
GFAP_HUMAN	GFAP	physical	28514442
SGT1_HUMAN	SUGT1	physical	28514442
GRDN_HUMAN	CCDC88A	physical	28514442
KDM5C_HUMAN	KDM5C	physical	28514442
KPCD2_HUMAN	PRKD2	physical	28514442
MFR1L_HUMAN	MTFR1L	physical	28514442
UBB_HUMAN	UBB	physical	28514442
APC1_HUMAN	ANAPC1	physical	28514442
IQEC1_HUMAN	IQSEC1	physical	28514442
ALMS1_HUMAN	ALMS1	physical	28514442
CUL1_HUMAN	CUL1	physical	28514442
KIRR1_HUMAN	KIRREL	physical	28514442
FXL18_HUMAN	FBXL18	physical	28514442
STIL_HUMAN	STIL	physical	28514442
STK3_HUMAN	STK3	physical	28514442
SAMD1_HUMAN	SAMD1	physical	28514442
PHLP1_HUMAN	PHLPP1	physical	28514442
WDR59_HUMAN	WDR59	physical	28514442
MCM8_HUMAN	MCM8	physical	28514442
UBP19_HUMAN	USP19	physical	28514442
CSN2_HUMAN	COPS2	physical	28514442
KAP1_HUMAN	PRKAR1B	physical	28514442
TBB3_HUMAN	TUBB3	physical	28514442
K1671_HUMAN	KIAA1671	physical	28514442
CSN7A_HUMAN	COPS7A	physical	28514442
DPYL4_HUMAN	DPYSL4	physical	28514442
RUVB1_HUMAN	RUVBL1	physical	28514442
KANK2_HUMAN	KANK2	physical	28514442
ZN507_HUMAN	ZNF507	physical	28514442
SENP1_HUMAN	SENP1	physical	28514442
CSN6_HUMAN	COPS6	physical	28514442
P73_HUMAN	TP73	physical	28514442
CDN1B_HUMAN	CDKN1B	physical	19112177
SKP1_HUMAN	SKP1	physical	28614300
CUL1_HUMAN	CUL1	physical	28614300
MTOR_HUMAN	MTOR	physical	28446188

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SKP2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, AND MASSSPECTROMETRY.	17081983 [Abstract]

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