CDN1C_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDN1C_HUMAN
• UniProt AC: P49918
• Protein Name: Cyclin-dependent kinase inhibitor 1C
• Gene Name: CDKN1C
• Organism: Homo sapiens (Human).
• Sequence Length: 316
• Subcellular Localization: Nucleus.
• Protein Description: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life..
• Protein Sequence: MSDASLRSTSTMERLVARGTFPVLVRTSACRSLFGPVDHEELSRELQARLAELNAEDQNRWDYDFQQDMPLRGPGRLQWTEVDSDSVPAFYRETVQVGRCRLLLAPRPVAVAVAVSPPLEPAAESLDGLEEAPEQLPSVPVPAPASTPPPVPVLAPAPAPAPAPVAAPVAAPVAVAVLAPAPAPAPAPAPAPAPVAAPAPAPAPAPAPAPAPAPAPDAAPQESAEQGANQGQRGQEPLADQLHSGISGRPAAGTAAASANGAAIKKLSGPLISDFFAKRKRSAPEKSSGDVPAPCPSPSAAPGVGSVEQTPRKRLR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	TFPVLVRTSACRSLF CCCEEEECHHHHHHH	17.13	24719451
43	Phosphorylation	PVDHEELSRELQARL CCCHHHHHHHHHHHH	27.30	24719451
107	Methylation	CRLLLAPRPVAVAVA EEEEECCCCEEEEEE	32.49	-
266	Acetylation	ANGAAIKKLSGPLIS CCCHHHHHHHCCHHH	41.60	30591107
268	Phosphorylation	GAAIKKLSGPLISDF CHHHHHHHCCHHHHH	47.44	18669648
275	Ubiquitination	SGPLISDFFAKRKRS HCCHHHHHHHHCCCC	5.25	21963094
278	Acetylation	LISDFFAKRKRSAPE HHHHHHHHCCCCCCC	53.98	24468109
282	Phosphorylation	FFAKRKRSAPEKSSG HHHHCCCCCCCCCCC	51.73	-
286	Ubiquitination	RKRSAPEKSSGDVPA CCCCCCCCCCCCCCC	49.19	21963094
286	Phosphorylation	RKRSAPEKSSGDVPA CCCCCCCCCCCCCCC	49.19	33259812
287	Phosphorylation	KRSAPEKSSGDVPAP CCCCCCCCCCCCCCC	37.58	27251275
288	Phosphorylation	RSAPEKSSGDVPAPC CCCCCCCCCCCCCCC	50.51	26552605
297	Phosphorylation	DVPAPCPSPSAAPGV CCCCCCCCCCCCCCC	37.90	25159151
299	Phosphorylation	PAPCPSPSAAPGVGS CCCCCCCCCCCCCCC	41.21	27050516
306	Phosphorylation	SAAPGVGSVEQTPRK CCCCCCCCCCCCCCH	21.78	26552605
310	Phosphorylation	GVGSVEQTPRKRLR- CCCCCCCCCCHHCC-	16.14	12925736

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
282	S	Phosphorylation	Kinase	AKT1	P31749	PSP
310	T	Phosphorylation	Kinase	AKT1	P31749	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:12925736
-	K	Ubiquitination	E3 ubiquitin ligase	FBXL12	Q9NXK8	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDN1C_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDN1C_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LIMK1_HUMAN	LIMK1	physical	14530263
SKP2_HUMAN	SKP2	physical	12925736
PCNA_HUMAN	PCNA	physical	9465025
MYOD1_HUMAN	MYOD1	physical	10764802
CCND1_HUMAN	CCND1	physical	10764802
CCNE2_HUMAN	CCNE2	physical	9840943
AKT1_HUMAN	AKT1	physical	23421998
CSN5_HUMAN	COPS5	physical	26606000
CCND1_HUMAN	CCND1	physical	10713702
CDN1C_HUMAN	CDKN1C	physical	10713702
CDK4_HUMAN	CDK4	physical	10713702

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 130650: Beckwith-Wiedemann syndrome (BWS)
• 614732: Intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies (IMAGE)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, AND MASSSPECTROMETRY.
PubMed: 18669648