dbPTM

KANK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KANK2_HUMAN
UniProt AC	Q63ZY3
Protein Name	KN motif and ankyrin repeat domain-containing protein 2
Gene Name	KANK2
Organism	Homo sapiens (Human).
Sequence Length	851
Subcellular Localization	Cytoplasm. Mitochondrion.
Protein Description	Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway. [PubMed: 24671081 May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus]
Protein Sequence	MAQVLHVPAPFPGTPGPASPPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPRLSSLPRGPGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGALETRGGFNPRVERTLLDARRRLEDQAATPTGLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVPPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPTAGRGRSELCLDLPDPPEDPVALETRSVGTWVRERDLGMPDGEAALAAKVAVLETQLKKALQELQAAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLEPYGTGLRALAMPGRPESPPVFRSQEVVETMCPVPAAATSNVHMVKKISITERSCDGAAGLPEVPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVRSIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLALEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDDESPTSSSAEE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	VPAPFPGTPGPASPP CCCCCCCCCCCCCCC	25.88	29255136
14 (in isoform 2)	Phosphorylation	-	25.88	27251275
19	Phosphorylation	PGTPGPASPPAFPAK CCCCCCCCCCCCCCC	34.25	29255136
19 (in isoform 2)	Phosphorylation	-	34.25	24719451
32	Phosphorylation	AKDPDPPYSVETPYG CCCCCCCCCCCCCCC	30.64	28857561
33	Phosphorylation	KDPDPPYSVETPYGY CCCCCCCCCCCCCCE	21.17	26074081
36	Phosphorylation	DPPYSVETPYGYRLD CCCCCCCCCCCEEEE	21.47	23607784
38	Phosphorylation	PYSVETPYGYRLDLD CCCCCCCCCEEEECH	33.92	23607784
40	Phosphorylation	SVETPYGYRLDLDFL CCCCCCCEEEECHHH	11.36	23607784
48	Ubiquitination	RLDLDFLKYVDDIEK EEECHHHHHHHHHHH	43.13	21906983
48 (in isoform 1)	Ubiquitination	-	43.13	21906983
48 (in isoform 2)	Ubiquitination	-	43.13	21906983
48 (in isoform 3)	Ubiquitination	-	43.13	21906983
58	Phosphorylation	DDIEKGHTLRRVAVQ HHHHHCCCCHHHHHH	30.54	18212344
71	Phosphorylation	VQRRPRLSSLPRGPG HHCCCCHHHCCCCCC	30.98	23927012
72	Phosphorylation	QRRPRLSSLPRGPGS HCCCCHHHCCCCCCC	47.16	28355574
72 (in isoform 2)	Phosphorylation	-	47.16	24719451
79	Phosphorylation	SLPRGPGSWWTSTES HCCCCCCCCCCCHHH	23.67	28857561
82	Phosphorylation	RGPGSWWTSTESLCS CCCCCCCCCHHHHHC	21.36	30576142
83	Phosphorylation	GPGSWWTSTESLCSN CCCCCCCCHHHHHCC	19.22	22617229
83 (in isoform 2)	Phosphorylation	-	19.22	24719451
84	Phosphorylation	PGSWWTSTESLCSNA CCCCCCCHHHHHCCC	23.40	26657352
84 (in isoform 2)	Phosphorylation	-	23.40	27251275
86	Phosphorylation	SWWTSTESLCSNASG CCCCCHHHHHCCCCC	34.46	26657352
86 (in isoform 2)	Phosphorylation	-	34.46	27251275
89	Phosphorylation	TSTESLCSNASGDSR CCHHHHHCCCCCCCC	40.50	27251275
92	Phosphorylation	ESLCSNASGDSRHSA HHHHCCCCCCCCCCC	47.59	22777824
92 (in isoform 2)	Phosphorylation	-	47.59	24719451
95	Phosphorylation	CSNASGDSRHSAYSY HCCCCCCCCCCCHHH	35.10	22617229
98	Phosphorylation	ASGDSRHSAYSYCGR CCCCCCCCCHHHCCC	28.00	26356563
100	Phosphorylation	GDSRHSAYSYCGRGF CCCCCCCHHHCCCCC	11.82	26356563
101	Phosphorylation	DSRHSAYSYCGRGFY CCCCCCHHHCCCCCC	17.42	26356563
101 (in isoform 2)	Phosphorylation	-	17.42	27251275
102	Phosphorylation	SRHSAYSYCGRGFYP CCCCCHHHCCCCCCC	6.05	26356563
105	Dimethylation	SAYSYCGRGFYPQYG CCHHHCCCCCCCCCC	28.61	-
105	Methylation	SAYSYCGRGFYPQYG CCHHHCCCCCCCCCC	28.61	24129315
111	Phosphorylation	GRGFYPQYGALETRG CCCCCCCCCCHHCCC	10.40	7474189
111 (in isoform 2)	Phosphorylation	-	10.40	27642862
117	Dimethylation	QYGALETRGGFNPRV CCCCHHCCCCCCHHH	33.58	-
117	Methylation	QYGALETRGGFNPRV CCCCHHCCCCCCHHH	33.58	-
123	Methylation	TRGGFNPRVERTLLD CCCCCCHHHHHHHHH	43.99	-
127	Phosphorylation	FNPRVERTLLDARRR CCHHHHHHHHHHHHH	20.40	28555341
141	Phosphorylation	RLEDQAATPTGLGSL HHHHCCCCCCCCCCC	25.13	30815301
143	Phosphorylation	EDQAATPTGLGSLTP HHCCCCCCCCCCCCC	40.46	22210691
147	Phosphorylation	ATPTGLGSLTPSAAG CCCCCCCCCCCCCCC	33.83	26657352
149	Phosphorylation	PTGLGSLTPSAAGST CCCCCCCCCCCCCCC	19.52	27251275
151	Phosphorylation	GLGSLTPSAAGSTAS CCCCCCCCCCCCCCE	26.05	26657352
155	Phosphorylation	LTPSAAGSTASLVGV CCCCCCCCCCEEEEC	18.97	26657352
155 (in isoform 2)	Phosphorylation	-	18.97	27251275
156	Phosphorylation	TPSAAGSTASLVGVG CCCCCCCCCEEEECC	21.24	26657352
158	Phosphorylation	SAAGSTASLVGVGLP CCCCCCCEEEECCCC	24.55	26657352
158 (in isoform 2)	Phosphorylation	-	24.55	24719451
168	Phosphorylation	GVGLPPPTPRSSGLS ECCCCCCCCCCCCCC	36.79	26657352
168 (in isoform 2)	Phosphorylation	-	36.79	27251275
171	Phosphorylation	LPPPTPRSSGLSTPV CCCCCCCCCCCCCCC	29.93	23927012
171 (in isoform 2)	Phosphorylation	-	29.93	24719451
172	Phosphorylation	PPPTPRSSGLSTPVP CCCCCCCCCCCCCCC	45.06	28355574
172 (in isoform 2)	Phosphorylation	-	45.06	24719451
175	Phosphorylation	TPRSSGLSTPVPPSA CCCCCCCCCCCCCCC	33.90	23927012
175 (in isoform 2)	Phosphorylation	-	33.90	24719451
176	Phosphorylation	PRSSGLSTPVPPSAG CCCCCCCCCCCCCCC	33.09	28355574
176 (in isoform 2)	Phosphorylation	-	33.09	24719451
181	Phosphorylation	LSTPVPPSAGHLAHV CCCCCCCCCCHHHHH	40.59	23927012
223	Malonylation	LSVLQEEKRQLTVQL HHHHHHHHHHHEEEE	44.70	26320211
223	Ubiquitination	LSVLQEEKRQLTVQL HHHHHHHHHHHEEEE	44.70	-
223 (in isoform 2)	Ubiquitination	-	44.70	-
231	Methylation	RQLTVQLKSQKFLGH HHHEEEECCHHHCCC	33.48	-
231	Ubiquitination	RQLTVQLKSQKFLGH HHHEEEECCHHHCCC	33.48	29967540
232	Phosphorylation	QLTVQLKSQKFLGHP HHEEEECCHHHCCCC	47.39	27251275
232 (in isoform 2)	Phosphorylation	-	47.39	27251275
234	Acetylation	TVQLKSQKFLGHPTA EEEECCHHHCCCCCC	50.04	26051181
234	Ubiquitination	TVQLKSQKFLGHPTA EEEECCHHHCCCCCC	50.04	29967540
240	Phosphorylation	QKFLGHPTAGRGRSE HHHCCCCCCCCCCCC	35.75	27251275
240 (in isoform 2)	Phosphorylation	-	35.75	27251275
243	Methylation	LGHPTAGRGRSELCL CCCCCCCCCCCCEEC	34.58	-
246	Phosphorylation	PTAGRGRSELCLDLP CCCCCCCCCEECCCC	37.43	26657352
246 (in isoform 2)	Phosphorylation	-	37.43	27251275
278	Sulfoxidation	VRERDLGMPDGEAAL EHHHHCCCCCHHHHH	3.39	30846556
288	Ubiquitination	GEAALAAKVAVLETQ HHHHHHHHHHHHHHH	25.72	29967540
297	Malonylation	AVLETQLKKALQELQ HHHHHHHHHHHHHHH	26.61	26320211
297	Ubiquitination	AVLETQLKKALQELQ HHHHHHHHHHHHHHH	26.61	29967540
298	Malonylation	VLETQLKKALQELQA HHHHHHHHHHHHHHH	64.02	26320211
323	Phosphorylation	QAWPPPDSPVRVDTV CCCCCCCCCCEEEEE	30.94	22167270
323 (in isoform 2)	Phosphorylation	-	30.94	24719451
329	Phosphorylation	DSPVRVDTVRVVEGP CCCCEEEEEEEEECC	13.83	22167270
344	O-linked_Glycosylation	REVEVVASTAAGAPA CEEEEEEECCCCCCH	13.63	28657654
344	Phosphorylation	REVEVVASTAAGAPA CEEEEEEECCCCCCH	13.63	26074081
345	Phosphorylation	EVEVVASTAAGAPAQ EEEEEEECCCCCCHH	15.70	26074081
356	Phosphorylation	APAQRAQSLEPYGTG CCHHHHHCCCCCCCC	33.44	21082442
356 (in isoform 2)	Phosphorylation	-	33.44	24719451
360	Phosphorylation	RAQSLEPYGTGLRAL HHHCCCCCCCCCHHH	20.25	7594775
360 (in isoform 2)	Phosphorylation	-	20.25	27642862
362	Phosphorylation	QSLEPYGTGLRALAM HCCCCCCCCCHHHCC	27.48	26074081
375	Phosphorylation	AMPGRPESPPVFRSQ CCCCCCCCCCCCCCH	36.87	29255136
375 (in isoform 2)	Phosphorylation	-	36.87	24719451
381	Phosphorylation	ESPPVFRSQEVVETM CCCCCCCCHHHHHHH	21.16	29514088
387	Phosphorylation	RSQEVVETMCPVPAA CCHHHHHHHCCCCCH	16.68	29514088
406	Phosphorylation	VHMVKKISITERSCD EEEEEEEEECCCCCC	32.13	23911959
406 (in isoform 2)	Phosphorylation	-	32.13	24719451
408	Phosphorylation	MVKKISITERSCDGA EEEEEEECCCCCCCC	20.68	24972180
411	Phosphorylation	KISITERSCDGAAGL EEEECCCCCCCCCCC	15.44	27251275
425	Phosphorylation	LPEVPAESSSSPPGS CCCCCCCCCCCCCCC	37.31	27251789
425 (in isoform 2)	Phosphorylation	-	37.31	24719451
426	Phosphorylation	PEVPAESSSSPPGSE CCCCCCCCCCCCCCH	26.75	26657352
427	Phosphorylation	EVPAESSSSPPGSEV CCCCCCCCCCCCCHH	57.02	26657352
428	Phosphorylation	VPAESSSSPPGSEVA CCCCCCCCCCCCHHH	36.74	25159151
428 (in isoform 2)	Phosphorylation	-	36.74	27251275
432	Phosphorylation	SSSSPPGSEVASLTQ CCCCCCCCHHHCCCC	34.37	27251275
438	Phosphorylation	GSEVASLTQPEKSTG CCHHHCCCCCCCCCC	39.31	30576142
443	Phosphorylation	SLTQPEKSTGRVPTQ CCCCCCCCCCCCCCC	34.14	24275569
444	Phosphorylation	LTQPEKSTGRVPTQE CCCCCCCCCCCCCCC	39.82	28555341
463	Phosphorylation	EPTRQAASQESEEAG CCCHHHHHHHHHHHC	37.18	26657352
472	Phosphorylation	ESEEAGGTGGPPAGV HHHHHCCCCCCCHHH	37.74	18669648
472 (in isoform 2)	Phosphorylation	-	37.74	28985074
477 (in isoform 2)	Phosphorylation	-	32.04	25850435
478 (in isoform 2)	Phosphorylation	-	22.57	26657352
493	Phosphorylation	KEEVADPTAHRRSLQ HHHHCCCCCCCCCEE	35.33	20393185
540	Phosphorylation	EPRERVPSVAEAPQL CCHHHCCCHHHCCCC	30.97	29255136
548	Phosphorylation	VAEAPQLRPAGTAAA HHHCCCCCCCCCHHH	17.49	32645325
548 (in isoform 2)	Phosphorylation	-	17.49	24719451
552	Phosphorylation	PQLRPAGTAAAKTSR CCCCCCCCHHHHHHH	18.41	23927012
565	Phosphorylation	SRQECQLSRESQHIP HHHHHHHCHHHCCCC	14.23	27251275
568	Phosphorylation	ECQLSRESQHIPTAE HHHHCHHHCCCCCCC	26.42	26657352
573	Phosphorylation	RESQHIPTAEGASGS HHHCCCCCCCCCCCC	36.42	29255136
576 (in isoform 2)	Phosphorylation	-	23.68	27251275
578	Phosphorylation	IPTAEGASGSNTEEE CCCCCCCCCCCCHHH	54.32	26657352
580	Phosphorylation	TAEGASGSNTEEEIR CCCCCCCCCCHHHHH	37.78	26657352
582	Phosphorylation	EGASGSNTEEEIRME CCCCCCCCHHHHHHH	46.61	29255136
603	Ubiquitination	SACLALEKYLDNPNA HHHHHHHHHCCCCCC	52.54	29967540
611	Ubiquitination	YLDNPNALTERELKV HCCCCCCCCHHHHHH	6.94	29967540
621	Phosphorylation	RELKVAYTTVLQEWL HHHHHHHHHHHHHHH	10.74	20068231
647	Phosphorylation	LVRRHLVTFRAMSAR HHHHHHHHHHHHHHH	17.48	23403867
652	Phosphorylation	LVTFRAMSARLLDYV HHHHHHHHHHHHHHH	14.84	24114839
702	Phosphorylation	DKQNRAGYSPIMLTA CCCCCCCCCHHHHHH	15.41	22817900
708	Phosphorylation	GYSPIMLTALATLKT CCCHHHHHHHHHCCC	11.40	29759185
712	Phosphorylation	IMLTALATLKTQDDI HHHHHHHHCCCCCHH	29.63	29759185
734	Acetylation	RLGNINAKASQAGQT HHCCCCCCHHHHHHH	44.04	7290057
741	Phosphorylation	KASQAGQTALMLAVS CHHHHHHHHHHHHHH	22.35	46164097
827	Phosphorylation	EIASMLYSRMNIKCS HHHHHHHHHCCCEEE	22.53	24719451
843	Phosphorylation	APMSDDESPTSSSAE CCCCCCCCCCCCCCC	40.24	27251275
845	Phosphorylation	MSDDESPTSSSAEE- CCCCCCCCCCCCCC-	50.98	27251275
846	Phosphorylation	SDDESPTSSSAEE-- CCCCCCCCCCCCC--	26.19	27251275
847	Phosphorylation	DDESPTSSSAEE--- CCCCCCCCCCCC---	35.73	27251275
851 (in isoform 2)	Phosphorylation	-	66.69	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KANK2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KANK2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KANK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCOA1_HUMAN	NCOA1	physical	17476305
NCOA3_HUMAN	NCOA3	physical	17476305
NCOA2_HUMAN	NCOA2	physical	17476305
KANK2_HUMAN	KANK2	physical	25416956
GPSM1_HUMAN	GPSM1	physical	25416956
ABI3_HUMAN	ABI3	physical	25416956
MOB1A_HUMAN	MOB1A	physical	25416956
CCD33_HUMAN	CCDC33	physical	25416956
CEP70_HUMAN	CEP70	physical	25416956
TXLNA_HUMAN	TXLNA	physical	25416956
IHO1_HUMAN	CCDC36	physical	25416956
GOGA2_HUMAN	GOLGA2	physical	21516116

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616099	Palmoplantar keratoderma and woolly hair (PPKWH)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KANK2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-375, AND MASSSPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72; SER-356; SER-375;SER-463 AND THR-472, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-568, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-375 AND SER-540,AND MASS SPECTROMETRY.	17081983 [Abstract]