CCNA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCNA1_HUMAN
• UniProt AC: P78396
• Protein Name: Cyclin-A1
• Gene Name: CCNA1
• Organism: Homo sapiens (Human).
• Sequence Length: 465
• Subcellular Localization: Nucleus.
• Protein Description: May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells..
• Protein Sequence: METGFPAIMYPGSFIGGWGEEYLSWEGPGLPDFVFQQQPVESEAMHCSNPKSGVVLATVARGPDACQILTRAPLGQDPPQRTVLGLLTANGQYRRTCGQGITRIRCYSGSENAFPPAGKKALPDCGVQEPPKQGFDIYMDELEQGDRDSCSVREGMAFEDVYEVDTGTLKSDLHFLLDFNTVSPMLVDSSLLSQSEDISSLGTDVINVTEYAEEIYQYLREAEIRHRPKAHYMKKQPDITEGMRTILVDWLVEVGEEYKLRAETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAMLLASKYEEIYPPEVDEFVYITDDTYTKRQLLKMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCVRTENLAKYVAELSLLEADPFLKYLPSLIAAAAFCLANYTVNKHFWPETLAAFTGYSLSEIVPCLSELHKAYLDIPHRPQQAIREKYKASKYLCVSLMEPPAVLLLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	KSGVVLATVARGPDA CCCEEEEEEECCCCH	15.55	22985185
168	Phosphorylation	VYEVDTGTLKSDLHF EEEECCCCCCCCEEH	32.86	-
280	Phosphorylation	DRFLSCMSVLRGKLQ HHHHHHHHHHCHHHH	23.48	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCNA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCNA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCNA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCAR2_HUMAN	CCAR2	physical	17353931
TGFI1_HUMAN	TGFB1I1	physical	17353931
VPS18_HUMAN	VPS18	physical	17353931
CRCM_HUMAN	MCC	physical	17353931
GPS2_HUMAN	GPS2	physical	15159402
XRCC6_HUMAN	XRCC6	physical	15159402
RACK1_HUMAN	GNB2L1	physical	15159402
RBM4_HUMAN	RBM4	physical	15159402
INCA1_HUMAN	INCA1	physical	15159402
KLDC9_HUMAN	KLHDC9	physical	15159402
PRCA1_HUMAN	PROCA1	physical	15159402
H11_HUMAN	HIST1H1A	physical	8565853
H2B1A_HUMAN	HIST1H2BA	physical	8565853
CDK2_HUMAN	CDK2	physical	8565853
CDK1_HUMAN	CDK1	physical	8565853
CDK2_HUMAN	CDK2	physical	9041194
CDK2_HUMAN	CDK2	physical	11264176
MYBB_HUMAN	MYBL2	physical	11264176
E2F1_HUMAN	E2F1	physical	10022926
RB_HUMAN	RB1	physical	10022926
MPIP1_HUMAN	CDC25A	physical	10926775
CDK2_HUMAN	CDK2	physical	10559988
SKP2_HUMAN	SKP2	physical	16774918
CDK2_HUMAN	CDK2	physical	16159883
SP1_HUMAN	SP1	physical	11598016
SKP2_HUMAN	SKP2	physical	10652300
CDK2_HUMAN	CDK2	physical	19423708
SKP2_MOUSE	Skp2	physical	10790373
UBP2_HUMAN	USP2	physical	22370483
MCM4_HUMAN	MCM4	physical	16519687
H15_HUMAN	HIST1H1B	physical	16191191
PRGR_HUMAN	PGR	physical	15601848
CDK2_HUMAN	CDK2	physical	15601848
CDK2_HUMAN	CDK2	physical	12970441
CDK2_HUMAN	CDK2	physical	12800980
FZR1_HUMAN	FZR1	physical	11340163
H11_HUMAN	HIST1H1A	physical	8397206
RFA1_HUMAN	RPA1	physical	8397206
H11_HUMAN	HIST1H1A	physical	9860976
SKP2_HUMAN	SKP2	physical	17308064
CDN1B_HUMAN	CDKN1B	physical	15583032
CDK2_HUMAN	CDK2	physical	15583032
MCM6_HUMAN	MCM6	physical	15232106
CDN1A_HUMAN	CDKN1A	physical	15232106
MCM4_HUMAN	MCM4	physical	15232106
CDK2_HUMAN	CDK2	physical	16009130
CDK1_HUMAN	CDK1	physical	16009130
CDN1A_HUMAN	CDKN1A	physical	16009130
CTNB1_HUMAN	CTNNB1	physical	14985333
RB_HUMAN	RB1	physical	9139732
MYBB_HUMAN	MYBL2	physical	10593981
H15_HUMAN	HIST1H1B	physical	11259605

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.