dbPTM

CDK2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDK2_HUMAN
UniProt AC	P24941
Protein Name	Cyclin-dependent kinase 2
Gene Name	CDK2
Organism	Homo sapiens (Human).
Sequence Length	298
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic traf
Protein Description	Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization. Phosphorylates FOXP3 and negatively regulates its transcriptional activity and protein stability (By similarity). Phosphorylates CDK2AP2. [PubMed: 12944431]
Protein Sequence	MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MENFQKVE -------CCCCCEEE	9.54	22814378
6	Acetylation	--MENFQKVEKIGEG --CCCCCEEEECCCC	48.50	19608861
6	Ubiquitination	--MENFQKVEKIGEG --CCCCCEEEECCCC	48.50	19608861
6	Sumoylation	--MENFQKVEKIGEG --CCCCCEEEECCCC	48.50	19608861
9	Ubiquitination	ENFQKVEKIGEGTYG CCCCEEEECCCCCCE	60.02	21890473
9	Acetylation	ENFQKVEKIGEGTYG CCCCEEEECCCCCCE	60.02	25953088
9	Ubiquitination	ENFQKVEKIGEGTYG CCCCEEEECCCCCCE	60.02	21890473
14	Phosphorylation	VEKIGEGTYGVVYKA EEECCCCCCEEEEEE	16.89	19664994
14	Dephosphorylation	VEKIGEGTYGVVYKA EEECCCCCCEEEEEE	16.89	12388094
15	Dephosphorylation	EKIGEGTYGVVYKAR EECCCCCCEEEEEEE	20.84	12388094
15	Phosphorylation	EKIGEGTYGVVYKAR EECCCCCCEEEEEEE	20.84	19664994
19	Phosphorylation	EGTYGVVYKARNKLT CCCCEEEEEEECCCC	9.12	22167270
20	Ubiquitination	GTYGVVYKARNKLTG CCCEEEEEEECCCCC	29.29	21890473
20	Acetylation	GTYGVVYKARNKLTG CCCEEEEEEECCCCC	29.29	25953088
24	Ubiquitination	VVYKARNKLTGEVVA EEEEEECCCCCEEEE	41.70	21890473
24	Acetylation	VVYKARNKLTGEVVA EEEEEECCCCCEEEE	41.70	25953088
33	Ubiquitination	TGEVVALKKIRLDTE CCEEEEEEEEECCCC	36.10	21890473
33	Sumoylation	TGEVVALKKIRLDTE CCEEEEEEEEECCCC	36.10	-
33	Sumoylation	TGEVVALKKIRLDTE CCEEEEEEEEECCCC	36.10	-
33	Acetylation	TGEVVALKKIRLDTE CCEEEEEEEEECCCC	36.10	25953088
39	Phosphorylation	LKKIRLDTETEGVPS EEEEECCCCCCCCCH	49.77	18354084
41	Phosphorylation	KIRLDTETEGVPSTA EEECCCCCCCCCHHH	39.88	23403867
46	Phosphorylation	TETEGVPSTAIREIS CCCCCCCHHHHHHHH	28.23	21082442
47	Phosphorylation	ETEGVPSTAIREISL CCCCCCHHHHHHHHH	21.75	23403867
53	Phosphorylation	STAIREISLLKELNH HHHHHHHHHHHHCCC	23.93	24719451
56	Ubiquitination	IREISLLKELNHPNI HHHHHHHHHCCCCCH	66.50	21890473
56	Ubiquitination	IREISLLKELNHPNI HHHHHHHHHCCCCCH	66.50	21890473
65	Ubiquitination	LNHPNIVKLLDVIHT CCCCCHHHHHHHHHC	39.26	-
129	Ubiquitination	RVLHRDLKPQNLLIN CHHCCCCCCCCEEEC	49.17	21890473
129	Ubiquitination	RVLHRDLKPQNLLIN CHHCCCCCCCCEEEC	49.17	21890473
137	Phosphorylation	PQNLLINTEGAIKLA CCCEEECCCCCHHHH	28.89	-
142	Ubiquitination	INTEGAIKLADFGLA ECCCCCHHHHHHHHH	36.77	21890473
158	Phosphorylation	AFGVPVRTYTHEVVT HHCCCEEEECCEEEE	32.76	22167270
159	Phosphorylation	FGVPVRTYTHEVVTL HCCCEEEECCEEEEH	8.78	27273156
160 (in isoform 2)	Phosphorylation	-	15.79	11532001
160	Dephosphorylation	GVPVRTYTHEVVTLW CCCEEEECCEEEEHH	15.79	10934208
160	Phosphorylation	GVPVRTYTHEVVTLW CCCEEEECCEEEEHH	15.79	22167270
165	Phosphorylation	TYTHEVVTLWYRAPE EECCEEEEHHHCCHH	19.42	18396144
168	Phosphorylation	HEVVTLWYRAPEILL CEEEEHHHCCHHHHH	10.46	18396144
179	Phosphorylation	EILLGCKYYSTAVDI HHHHCCCCCCHHHHH	13.51	22817900
207	Phosphorylation	RALFPGDSEIDQLFR HHCCCCCHHHHHHHH	42.22	21082442
221	Phosphorylation	RIFRTLGTPDEVVWP HHHHHHCCCCCCCCC	30.58	26853621
237	Ubiquitination	VTSMPDYKPSFPKWA CCCCCCCCCCCCHHH	41.38	21890473
250	Ubiquitination	WARQDFSKVVPPLDE HHCCCHHHCCCCCCC	47.44	21890473
257	Ubiquitination	KVVPPLDEDGRSLLS HCCCCCCCCHHHHHH	70.78	21890473
261	Phosphorylation	PLDEDGRSLLSQMLH CCCCCHHHHHHHHHC	38.91	20873877
264	Phosphorylation	EDGRSLLSQMLHYDP CCHHHHHHHHHCCCC	20.88	20873877
269	Phosphorylation	LLSQMLHYDPNKRIS HHHHHHCCCCCCCCC	29.18	20873877
273	Ubiquitination	MLHYDPNKRISAKAA HHCCCCCCCCCHHHH	57.40	21890473
278	Acetylation	PNKRISAKAALAHPF CCCCCCHHHHHHCHH	27.66	25953088
278	Ubiquitination	PNKRISAKAALAHPF CCCCCCHHHHHHCHH	27.66	21890473
291	Acetylation	PFFQDVTKPVPHLRL HHHCCCCCCCCCCCC	43.81	26051181
291	Ubiquitination	PFFQDVTKPVPHLRL HHHCCCCCCCCCCCC	43.81	21890473
297	Methylation	TKPVPHLRL------ CCCCCCCCC------	35.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
14	T	Phosphorylation	Kinase	WEE1	P30291	PSP
15	Y	Phosphorylation	Kinase	WEE1	P30291	Uniprot
39	T	Phosphorylation	Kinase	AKT1	P31749	PSP
39	T	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
46	S	Phosphorylation	Kinase	CDK7	P50613	PSP
160	T	Phosphorylation	Kinase	CDK2	P24941	PSP
160	T	Phosphorylation	Kinase	CDK20	Q8IZL9	PSP
160	T	Phosphorylation	Kinase	CDK7	P50613	PSP
160	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
160	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
165	T	Phosphorylation	Kinase	CDK7	P50613	PSP
168	Y	Phosphorylation	Kinase	CDK7	P50613	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	KLHL6	Q8WZ60	PMID:29720484

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
14	T	Phosphorylation	1396589
Phosphorylated on Thr-14 and Tyr-15 during S and G2 phases before being dephosphorylated by CDC25A.
160	T	Phosphorylation	1396589
Phosphorylated at Thr-160 by CDK7 in a CAK complex.
160	T	Phosphorylation	1396589
Phosphorylation at Thr-160 promotes kinase activity, whereas phosphorylation at Tyr-15 by WEE1 reduces slightly kinase activity.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDK2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDN1B_HUMAN	CDKN1B	physical	15619620
41_HUMAN	EPB41	physical	17353931
UBC12_HUMAN	UBE2M	physical	17353931
SORT_HUMAN	SORT1	physical	17353931
RADIL_HUMAN	RADIL	physical	17353931
NEDD8_HUMAN	NEDD8	physical	17353931
OGT1_HUMAN	OGT	physical	17353931
FBRL_HUMAN	FBL	physical	17353931
CDK15_HUMAN	CDK15	physical	17353931
NAA25_HUMAN	NAA25	physical	17353931
PED1A_HUMAN	PCED1A	physical	17353931
BRCA1_HUMAN	BRCA1	physical	10373534
INCA1_HUMAN	INCA1	physical	15159402
XRCC6_HUMAN	XRCC6	physical	15159402
RBM4_HUMAN	RBM4	physical	15159402
SPDYA_HUMAN	SPDYA	physical	12972555
CDN1B_HUMAN	CDKN1B	physical	12972555
FEN1_HUMAN	FEN1	physical	12853968
CDKA1_HUMAN	CDK2AP1	physical	10938106
RB_HUMAN	RB1	physical	10938106
DPOLA_HUMAN	POLA1	physical	10877824
RBL2_HUMAN	RBL2	physical	9891079
RBL1_HUMAN	RBL1	physical	9891079
CDK6_HUMAN	CDK6	physical	10934208
CDN1B_HUMAN	CDKN1B	physical	12417722
CDN1A_HUMAN	CDKN1A	physical	12417722
CDKN3_HUMAN	CDKN3	physical	8127873
CCNA1_HUMAN	CCNA1	physical	9041194
P53_HUMAN	TP53	physical	10884347
RRN3_HUMAN	RRN3	physical	15004009
CDKN3_HUMAN	CDKN3	physical	8242751
CDN1A_HUMAN	CDKN1A	physical	8242751
MYBB_HUMAN	MYBL2	physical	11264176
MYBB_MOUSE	Mybl2	physical	11264176
ORC1_HUMAN	ORC1	physical	11931757
ORC2_HUMAN	ORC2	physical	11931757
CKS1_HUMAN	CKS1B	physical	8601310
MCM4_HUMAN	MCM4	physical	10748114
MPIP2_HUMAN	CDC25B	physical	7644510
MS4A3_HUMAN	MS4A3	physical	11781350
PCNA_HUMAN	PCNA	physical	10930425
LYN_HUMAN	LYN	physical	10432313
RBL1_HUMAN	RBL1	physical	11884610
KPCL_HUMAN	PRKCH	physical	11175348
CDC5L_HUMAN	CDC5L	physical	10827081
CCNE1_HUMAN	CCNE1	physical	10827081
SKP2_HUMAN	SKP2	physical	9858587
CDN1A_HUMAN	CDKN1A	physical	9858587
UBE2A_HUMAN	UBE2A	physical	11953320
RB_HUMAN	RB1	physical	19225156
CAF1A_HUMAN	CHAF1A	physical	16826239
RAD53_YEAST	RAD53	genetic	21099355
CCNA2_HUMAN	CCNA2	physical	15647383
NOV_HUMAN	NOV	physical	15647383
CDN1A_HUMAN	CDKN1A	physical	15647383
CDN1B_HUMAN	CDKN1B	physical	15647383
SP1_HUMAN	SP1	physical	11598016
CDN1A_HUMAN	CDKN1A	physical	15557281
CDN1B_HUMAN	CDKN1B	physical	15557281
CCNE1_HUMAN	CCNE1	physical	15557281
CCNA2_HUMAN	CCNA2	physical	15557281
TSYL2_HUMAN	TSPYL2	physical	11395479
FOXM1_HUMAN	FOXM1	physical	15024056
RB_HUMAN	RB1	physical	15003538
H11_HUMAN	HIST1H1A	physical	17293600
CCNA1_HUMAN	CCNA1	physical	10652300
CDN1A_HUMAN	CDKN1A	physical	20587660
CCNE1_HUMAN	CCNE1	physical	20587660
EZH2_HUMAN	EZH2	physical	20935635
NPM_HUMAN	NPM1	physical	11278991
CDN1B_MOUSE	Cdkn1b	physical	15980415
PCNA_HUMAN	PCNA	physical	7903056
KAT2B_HUMAN	KAT2B	physical	19773423
CCNA2_HUMAN	CCNA2	physical	19773423
CCNB1_HUMAN	CCNB1	physical	10995390
H11_HUMAN	HIST1H1A	physical	21088490
CDN1A_HUMAN	CDKN1A	physical	18850315
CDN1B_HUMAN	CDKN1B	physical	18850315
H13_HUMAN	HIST1H1D	physical	18850315
CDC7_HUMAN	CDC7	physical	17927916
CDN1B_HUMAN	CDKN1B	physical	17671428
H15_HUMAN	HIST1H1B	physical	17671428
H11_HUMAN	HIST1H1A	physical	17431037
CDK2_HUMAN	CDK2	physical	17361108
H10_HUMAN	H1F0	physical	17361108
CCNA2_HUMAN	CCNA2	physical	17361108
H10_HUMAN	H1F0	physical	17224799
SPDYA_HUMAN	SPDYA	physical	16951407
H15_HUMAN	HIST1H1B	physical	16762841
MCM4_HUMAN	MCM4	physical	16519687
MCM2_HUMAN	MCM2	physical	16446360
H15_HUMAN	HIST1H1B	physical	16205633
H15_HUMAN	HIST1H1B	physical	16191191
MPIP1_HUMAN	CDC25A	physical	16191191
MPIP2_HUMAN	CDC25B	physical	16191191
MPIP3_HUMAN	CDC25C	physical	16191191
CDC45_HUMAN	CDC45	physical	15753125
H15_HUMAN	HIST1H1B	physical	15753125
H15_HUMAN	HIST1H1B	physical	15670215
TBG1_HUMAN	TUBG1	physical	15670215
CCNE1_HUMAN	CCNE1	physical	15670215
H15_HUMAN	HIST1H1B	physical	15607961
MITF_HUMAN	MITF	genetic	15607961
H15_HUMAN	HIST1H1B	physical	15514162
H15_HUMAN	HIST1H1B	physical	15169570
H15_HUMAN	HIST1H1B	physical	14701826
CCNA1_HUMAN	CCNA1	physical	14701826
CCNE1_HUMAN	CCNE1	physical	14701826
H15_HUMAN	HIST1H1B	physical	14681231
RB_HUMAN	RB1	physical	14681231
CCNA1_HUMAN	CCNA1	physical	14681231
H15_HUMAN	HIST1H1B	physical	14612406
H10_HUMAN	H1F0	physical	12970441
RB_HUMAN	RB1	physical	12970441
H10_HUMAN	H1F0	physical	12949733
CDN1A_HUMAN	CDKN1A	physical	12949733
CCNA1_HUMAN	CCNA1	physical	12800980
CCNE1_HUMAN	CCNE1	physical	12800980
CDN1A_HUMAN	CDKN1A	physical	12800980
CDN1B_HUMAN	CDKN1B	physical	12800980
RB_HUMAN	RB1	physical	12800980
H10_HUMAN	H1F0	physical	12800980
PSMD9_HUMAN	PSMD9	physical	12684681
FZR1_HUMAN	FZR1	physical	11340163
H11_HUMAN	HIST1H1A	physical	11132966
CCNE1_HUMAN	CCNE1	physical	11132966
CDN1A_HUMAN	CDKN1A	physical	11132966
CD5R1_HUMAN	CDK5R1	physical	22654103
CDN1A_HUMAN	CDKN1A	physical	10918595
CDN1A_HUMAN	CDKN1A	physical	10874474
CDN1B_HUMAN	CDKN1B	physical	10585280
RB_HUMAN	RB1	physical	10499802
CDN1B_MOUSE	Cdkn1b	physical	10393546
CDN1B_HUMAN	CDKN1B	physical	10393546
H11_HUMAN	HIST1H1A	physical	10393546
MARCS_HUMAN	MARCKS	physical	10359664
CCNE1_HUMAN	CCNE1	physical	10359664
CDN1B_HUMAN	CDKN1B	physical	18615582
H11_HUMAN	HIST1H1A	physical	10198259
CDN1B_HUMAN	CDKN1B	physical	10198259
H11_HUMAN	HIST1H1A	physical	9840927
CDN1A_HUMAN	CDKN1A	physical	9658399
CDN1B_HUMAN	CDKN1B	physical	9658399
CDN1A_HUMAN	CDKN1A	physical	9632134
CDN1B_HUMAN	CDKN1B	physical	9632134
H11_HUMAN	HIST1H1A	physical	9632134
H11_HUMAN	HIST1H1A	physical	9380407
CDN1A_HUMAN	CDKN1A	physical	9380407
CCNA2_HUMAN	CCNA2	physical	9380407
CDN1B_HUMAN	CDKN1B	physical	9380407
CDN1A_HUMAN	CDKN1A	physical	9218599
CDN1B_HUMAN	CDKN1B	physical	9218599
CDN1B_HUMAN	CDKN1B	physical	9192873
LMNB1_RAT	Lmnb1	physical	9053846
H11_HUMAN	HIST1H1A	physical	9053846
RB_HUMAN	RB1	physical	9053846
H11_HUMAN	HIST1H1A	physical	8647086
RB_HUMAN	RB1	physical	8647086
CCND1_HUMAN	CCND1	physical	8647086
CCNE1_HUMAN	CCNE1	physical	8647086
CDK7_HUMAN	CDK7	physical	8647086
CCNH_HUMAN	CCNH	physical	8647086
CCNE1_HUMAN	CCNE1	physical	8867812
H11_HUMAN	HIST1H1A	physical	8867812
H11_HUMAN	HIST1H1A	physical	8397207
CCNA1_HUMAN	CCNA1	physical	8397206
H11_HUMAN	HIST1H1A	physical	8397206
RFA1_HUMAN	RPA1	physical	8397206
H11_HUMAN	HIST1H1A	physical	8393783
CCNA2_BOVIN	CCNA2	physical	8393783
ACL6A_HUMAN	ACTL6A	physical	21699904
H11_HUMAN	HIST1H1A	physical	10447003
KI26B_HUMAN	KIF26B	physical	22768111
CDN1B_HUMAN	CDKN1B	physical	8978686
H11_HUMAN	HIST1H1A	physical	11063125
H11_HUMAN	HIST1H1A	physical	13678583
CDN1A_HUMAN	CDKN1A	physical	13678583
CKS1_HUMAN	CKS1B	physical	16979657
SKP2_HUMAN	SKP2	physical	16979657
SKP1_HUMAN	SKP1	physical	16979657
UHRF2_HUMAN	UHRF2	physical	15178429
RB_HUMAN	RB1	physical	20871633
H11_HUMAN	HIST1H1A	physical	19631451
CCNA2_HUMAN	CCNA2	physical	19631451
CCNE1_HUMAN	CCNE1	physical	19631451
CDN1B_HUMAN	CDKN1B	physical	19631451
H11_HUMAN	HIST1H1A	physical	15998794
DESP_HUMAN	DSP	physical	21319273
ACTB_HUMAN	ACTB	physical	21319273
HS90B_HUMAN	HSP90AB1	physical	21319273
FLNA_HUMAN	FLNA	physical	21319273
EF1A1_HUMAN	EEF1A1	physical	21319273
HSP7C_HUMAN	HSPA8	physical	21319273
HS90A_HUMAN	HSP90AA1	physical	21319273
ACTS_HUMAN	ACTA1	physical	21319273
HORN_HUMAN	HRNR	physical	21319273
G3P_HUMAN	GAPDH	physical	21319273
VINC_HUMAN	VCL	physical	21319273
TBB4B_HUMAN	TUBB4B	physical	21319273
S10A8_HUMAN	S100A8	physical	21319273
TBB2A_HUMAN	TUBB2A	physical	21319273
MYH9_HUMAN	MYH9	physical	21319273
PLAK_HUMAN	JUP	physical	21319273
DCD_HUMAN	DCD	physical	21319273
CH60_HUMAN	HSPD1	physical	21319273
DSG1_HUMAN	DSG1	physical	21319273
EF2_HUMAN	EEF2	physical	21319273
ENOA_HUMAN	ENO1	physical	21319273
TBA1C_HUMAN	TUBA1C	physical	21319273
DYHC1_HUMAN	DYNC1H1	physical	21319273
PRDX1_HUMAN	PRDX1	physical	21319273
ANXA2_HUMAN	ANXA2	physical	21319273
ENPL_HUMAN	HSP90B1	physical	21319273
PPIA_HUMAN	PPIA	physical	21319273
FAS_HUMAN	FASN	physical	21319273
CLH1_HUMAN	CLTC	physical	21319273
GRP78_HUMAN	HSPA5	physical	21319273
PDE4D_HUMAN	PDE4D	physical	21319273
FILA2_HUMAN	FLG2	physical	21319273
ATPB_HUMAN	ATP5B	physical	21319273
PRKDC_HUMAN	PRKDC	physical	21319273
IF4A1_HUMAN	EIF4A1	physical	21319273
H2B2E_HUMAN	HIST2H2BE	physical	21319273
H2A1H_HUMAN	HIST1H2AH	physical	21319273
SERPH_HUMAN	SERPINH1	physical	21319273
RS18_HUMAN	RPS18	physical	21319273
KPRP_HUMAN	KPRP	physical	21319273
LDHB_HUMAN	LDHB	physical	21319273
NASP_HUMAN	NASP	physical	21319273
RS3_HUMAN	RPS3	physical	21319273
RAB15_HUMAN	RAB15	physical	21319273
TLN1_HUMAN	TLN1	physical	21319273
KPYM_HUMAN	PKM	physical	21319273
DSC1_HUMAN	DSC1	physical	21319273
FLNC_HUMAN	FLNC	physical	21319273
DPYL3_HUMAN	DPYSL3	physical	21319273
LPPRC_HUMAN	LRPPRC	physical	21319273
RL35_HUMAN	RPL35	physical	21319273
GRN_HUMAN	GRN	physical	21319273
PDIA3_HUMAN	PDIA3	physical	21319273
AHNK_HUMAN	AHNAK	physical	21319273
ALDOA_HUMAN	ALDOA	physical	21319273
RL36_HUMAN	RPL36	physical	21319273
HNRPK_HUMAN	HNRNPK	physical	21319273
PDIA4_HUMAN	PDIA4	physical	21319273
1433E_HUMAN	YWHAE	physical	21319273
DHX9_HUMAN	DHX9	physical	21319273
TPIS_HUMAN	TPI1	physical	21319273
TCPQ_HUMAN	CCT8	physical	21319273
RL23A_HUMAN	RPL23A	physical	21319273
HMGB1_HUMAN	HMGB1	physical	21319273
TCPG_HUMAN	CCT3	physical	21319273
DPYL2_HUMAN	DPYSL2	physical	21319273
XRCC5_HUMAN	XRCC5	physical	21319273
TPM3_HUMAN	TPM3	physical	21319273
ZA2G_HUMAN	AZGP1	physical	21319273
RL7_HUMAN	RPL7	physical	21319273
PRDX2_HUMAN	PRDX2	physical	21319273
RL26_HUMAN	RPL26	physical	21319273
LYSC_HUMAN	LYZ	physical	21319273
UBA1_HUMAN	UBA1	physical	21319273
ATPA_HUMAN	ATP5A1	physical	21319273
GANAB_HUMAN	GANAB	physical	21319273
ROA1_HUMAN	HNRNPA1	physical	21319273
CDK2_HUMAN	CDK2	physical	21319273
EFTU_HUMAN	TUFM	physical	21319273
RL8_HUMAN	RPL8	physical	21319273
PCBP2_HUMAN	PCBP2	physical	21319273
COF1_HUMAN	CFL1	physical	21319273
SERA_HUMAN	PHGDH	physical	21319273
HYOU1_HUMAN	HYOU1	physical	21319273
HNRPU_HUMAN	HNRNPU	physical	21319273
PIMT_HUMAN	PCMT1	physical	21319273
MYH10_HUMAN	MYH10	physical	21319273
COPA_HUMAN	COPA	physical	21319273
RS16_HUMAN	RPS16	physical	21319273
LDHA_HUMAN	LDHA	physical	21319273
RS4X_HUMAN	RPS4X	physical	21319273
PROF1_HUMAN	PFN1	physical	21319273
TCPZ_HUMAN	CCT6A	physical	21319273
SEMG1_HUMAN	SEMG1	physical	21319273
PCBP1_HUMAN	PCBP1	physical	21319273
TPM4_HUMAN	TPM4	physical	21319273
GRP75_HUMAN	HSPA9	physical	21319273
EF1G_HUMAN	EEF1G	physical	21319273
RACK1_HUMAN	GNB2L1	physical	21319273
TALDO_HUMAN	TALDO1	physical	21319273
PARP1_HUMAN	PARP1	physical	21319273
RL32_HUMAN	RPL32	physical	21319273
SYTC_HUMAN	TARS	physical	21319273
TCPD_HUMAN	CCT4	physical	21319273
PODXL_HUMAN	PODXL	physical	21319273
PA2G4_HUMAN	PA2G4	physical	21319273
TCPA_HUMAN	TCP1	physical	21319273
FLNB_HUMAN	FLNB	physical	21319273
6PGD_HUMAN	PGD	physical	21319273
MOES_HUMAN	MSN	physical	21319273
ARF1_HUMAN	ARF1	physical	21319273
RS19_HUMAN	RPS19	physical	21319273
RS27A_HUMAN	RPS27A	physical	21319273
RS14_HUMAN	RPS14	physical	21319273
RL12_HUMAN	RPL12	physical	21319273
HNRPF_HUMAN	HNRNPF	physical	21319273
TKT_HUMAN	TKT	physical	21319273
RL11_HUMAN	RPL11	physical	21319273
TCPB_HUMAN	CCT2	physical	21319273
1433G_HUMAN	YWHAG	physical	21319273
RL27_HUMAN	RPL27	physical	21319273
C1TC_HUMAN	MTHFD1	physical	21319273
ARF4_HUMAN	ARF4	physical	21319273
CAND1_HUMAN	CAND1	physical	21319273
GTF2I_HUMAN	GTF2I	physical	21319273
CYTA_HUMAN	CSTA	physical	21319273
G6PI_HUMAN	GPI	physical	21319273
RS11_HUMAN	RPS11	physical	21319273
ADT1_HUMAN	SLC25A4	physical	21319273
TERA_HUMAN	VCP	physical	21319273
XPO2_HUMAN	CSE1L	physical	21319273
1433Z_HUMAN	YWHAZ	physical	21319273
RS2_HUMAN	RPS2	physical	21319273
SYEP_HUMAN	EPRS	physical	21319273
RS20_HUMAN	RPS20	physical	21319273
SFPQ_HUMAN	SFPQ	physical	21319273
HSP74_HUMAN	HSPA4	physical	21319273
GARS_HUMAN	GARS	physical	21319273
HBB_HUMAN	HBB	physical	21319273
RAN_HUMAN	RAN	physical	21319273
RS3A_HUMAN	RPS3A	physical	21319273
RL10A_HUMAN	RPL10A	physical	21319273
SMCA5_HUMAN	SMARCA5	physical	21319273
RS15A_HUMAN	RPS15A	physical	21319273
RS13_HUMAN	RPS13	physical	21319273
RABP1_HUMAN	CRABP1	physical	21319273
GSTP1_HUMAN	GSTP1	physical	21319273
ILF3_HUMAN	ILF3	physical	21319273
LEG7_HUMAN	LGALS7	physical	21319273
RL22_HUMAN	RPL22	physical	21319273
FSCN1_HUMAN	FSCN1	physical	21319273
PHB2_HUMAN	PHB2	physical	21319273
RL19_HUMAN	RPL19	physical	21319273
TITIN_HUMAN	TTN	physical	21319273
DEK_HUMAN	DEK	physical	21319273
TCPH_HUMAN	CCT7	physical	21319273
PSMD2_HUMAN	PSMD2	physical	21319273
SAHH_HUMAN	AHCY	physical	21319273
PDIA1_HUMAN	P4HB	physical	21319273
IF4A3_HUMAN	EIF4A3	physical	21319273
IF2B3_HUMAN	IGF2BP3	physical	21319273
TAGL2_HUMAN	TAGLN2	physical	21319273
ARGL1_HUMAN	ARGLU1	physical	21319273
CYC_HUMAN	CYCS	physical	21319273
TIF1B_HUMAN	TRIM28	physical	21319273
DHX15_HUMAN	DHX15	physical	21319273
MYL6_HUMAN	MYL6	physical	21319273
MCM7_HUMAN	MCM7	physical	21319273
RS17_HUMAN	RPS17	physical	21319273
SYSC_HUMAN	SARS	physical	21319273
RL30_HUMAN	RPL30	physical	21319273
FKBP4_HUMAN	FKBP4	physical	21319273
ENOG_HUMAN	ENO2	physical	21319273
MCM2_HUMAN	MCM2	physical	21319273
SYLC_HUMAN	LARS	physical	21319273
PUF60_HUMAN	PUF60	physical	21319273
HNRPD_HUMAN	HNRNPD	physical	21319273
SP16H_HUMAN	SUPT16H	physical	21319273
MFAP1_HUMAN	MFAP1	physical	21319273
MPCP_HUMAN	SLC25A3	physical	21319273
PCNA_HUMAN	PCNA	physical	21319273
AATM_HUMAN	GOT2	physical	21319273
PHB_HUMAN	PHB	physical	21319273
PLEC_HUMAN	PLEC	physical	21319273
PSMD3_HUMAN	PSMD3	physical	21319273
TCPE_HUMAN	CCT5	physical	21319273
RL23_HUMAN	RPL23	physical	21319273
RLA0_HUMAN	RPLP0	physical	21319273
APOD_HUMAN	APOD	physical	21319273
SPTB2_HUMAN	SPTBN1	physical	21319273
SERC_HUMAN	PSAT1	physical	21319273
IMB1_HUMAN	KPNB1	physical	21319273
PSB6_HUMAN	PSMB6	physical	21319273
DDX17_HUMAN	DDX17	physical	21319273
SYIC_HUMAN	IARS	physical	21319273
STMN1_HUMAN	STMN1	physical	21319273
RL13_HUMAN	RPL13	physical	21319273
ANXA5_HUMAN	ANXA5	physical	21319273
UGPA_HUMAN	UGP2	physical	21319273
PYR1_HUMAN	CAD	physical	21319273
SF3B3_HUMAN	SF3B3	physical	21319273
PDIA6_HUMAN	PDIA6	physical	21319273
TCP4_HUMAN	SUB1	physical	21319273
HMGB2_HUMAN	HMGB2	physical	21319273
PTBP1_HUMAN	PTBP1	physical	21319273
HMGA1_HUMAN	HMGA1	physical	21319273
PGK1_HUMAN	PGK1	physical	21319273
SND1_HUMAN	SND1	physical	21319273
RL14_HUMAN	RPL14	physical	21319273
F10A1_HUMAN	ST13	physical	21319273
MCM6_HUMAN	MCM6	physical	21319273
EIF3A_HUMAN	EIF3A	physical	21319273
SYQ_HUMAN	QARS	physical	21319273
RL31_HUMAN	RPL31	physical	21319273
ESYT1_HUMAN	ESYT1	physical	21319273
LMNA_HUMAN	LMNA	physical	21319273
MYOF_HUMAN	MYOF	physical	21319273
CALR_HUMAN	CALR	physical	21319273
RO52_HUMAN	TRIM21	physical	21319273
ANM1_HUMAN	PRMT1	physical	21319273
HXK1_HUMAN	HK1	physical	21319273
ACTN1_HUMAN	ACTN1	physical	21319273
GDIA_HUMAN	GDI1	physical	21319273
IQGA1_HUMAN	IQGAP1	physical	21319273
RS5_HUMAN	RPS5	physical	21319273
ATPO_HUMAN	ATP5O	physical	21319273
SYYC_HUMAN	YARS	physical	21319273
SART3_HUMAN	SART3	physical	21319273
SRSF7_HUMAN	SRSF7	physical	21319273
SYVC_HUMAN	VARS	physical	21319273
PININ_HUMAN	PNN	physical	21319273
RS28_HUMAN	RPS28	physical	21319273
PPIB_HUMAN	PPIB	physical	21319273
RL3_HUMAN	RPL3	physical	21319273
RL27A_HUMAN	RPL27A	physical	21319273
GSLG1_HUMAN	GLG1	physical	21319273
CDK1_HUMAN	CDK1	physical	21319273
NOMO1_HUMAN	NOMO1	physical	21319273
SMC4_HUMAN	SMC4	physical	21319273
IF2G_HUMAN	EIF2S3	physical	21319273
CASP3_HUMAN	CASP3	physical	21319273
PSA5_HUMAN	PSMA5	physical	21319273
IMDH2_HUMAN	IMPDH2	physical	21319273
PYRG1_HUMAN	CTPS1	physical	21319273
PUR9_HUMAN	ATIC	physical	21319273
FUS_HUMAN	FUS	physical	21319273
RS9_HUMAN	RPS9	physical	21319273
PRDX6_HUMAN	PRDX6	physical	21319273
CBS_HUMAN	CBS	physical	21319273
RL34_HUMAN	RPL34	physical	21319273
RS23_HUMAN	RPS23	physical	21319273
PUR6_HUMAN	PAICS	physical	21319273
RS8_HUMAN	RPS8	physical	21319273
1433F_HUMAN	YWHAH	physical	21319273
VDAC1_HUMAN	VDAC1	physical	21319273
DDX3X_HUMAN	DDX3X	physical	21319273
SPF45_HUMAN	RBM17	physical	21319273
HNRPM_HUMAN	HNRNPM	physical	21319273
CP2S1_HUMAN	CYP2S1	physical	21319273
PSD11_HUMAN	PSMD11	physical	21319273
SET_HUMAN	SET	physical	21319273
RL10L_HUMAN	RPL10L	physical	21319273
ML12B_HUMAN	MYL12B	physical	21319273
ECHA_HUMAN	HADHA	physical	21319273
RS24_HUMAN	RPS24	physical	21319273
AT5F1_HUMAN	ATP5F1	physical	21319273
RHOC_HUMAN	RHOC	physical	21319273
IDHC_HUMAN	IDH1	physical	21319273
PA1B2_HUMAN	PAFAH1B2	physical	21319273
PSA_HUMAN	NPEPPS	physical	21319273
PRDX3_HUMAN	PRDX3	physical	21319273
VDAC2_HUMAN	VDAC2	physical	21319273
NP1L1_HUMAN	NAP1L1	physical	21319273
KCRB_HUMAN	CKB	physical	21319273
ECHB_HUMAN	HADHB	physical	21319273
OAT_HUMAN	OAT	physical	21319273
VIGLN_HUMAN	HDLBP	physical	21319273
PRS10_HUMAN	PSMC6	physical	21319273
1433T_HUMAN	YWHAQ	physical	21319273
SMD2_HUMAN	SNRPD2	physical	21319273
PNPH_HUMAN	PNP	physical	21319273
RS21_HUMAN	RPS21	physical	21319273
EIF3C_HUMAN	EIF3C	physical	21319273
DDX21_HUMAN	DDX21	physical	21319273
SARNP_HUMAN	SARNP	physical	21319273
RS12_HUMAN	RPS12	physical	21319273
RS7_HUMAN	RPS7	physical	21319273
EIF3I_HUMAN	EIF3I	physical	21319273
IDHP_HUMAN	IDH2	physical	21319273
CLIC1_HUMAN	CLIC1	physical	21319273
TCTP_HUMAN	TPT1	physical	21319273
AT1A1_HUMAN	ATP1A1	physical	21319273
ILF2_HUMAN	ILF2	physical	21319273
UBE2N_HUMAN	UBE2N	physical	21319273
CLIC4_HUMAN	CLIC4	physical	21319273
SPTN1_HUMAN	SPTAN1	physical	21319273
WDR1_HUMAN	WDR1	physical	21319273
EIF3H_HUMAN	EIF3H	physical	21319273
DX39B_HUMAN	DDX39B	physical	21319273
MRP_HUMAN	MARCKSL1	physical	21319273
ASNS_HUMAN	ASNS	physical	21319273
FUBP2_HUMAN	KHSRP	physical	21319273
RCC2_HUMAN	RCC2	physical	21319273
VIME_HUMAN	VIM	physical	21319273
TOP1_HUMAN	TOP1	physical	21319273
FUBP1_HUMAN	FUBP1	physical	21319273
RL6_HUMAN	RPL6	physical	21319273
NB5R3_HUMAN	CYB5R3	physical	21319273
AP1B1_HUMAN	AP1B1	physical	21319273
FUMH_HUMAN	FH	physical	21319273
COPB_HUMAN	COPB1	physical	21319273
DDX1_HUMAN	DDX1	physical	21319273
MIF_HUMAN	MIF	physical	21319273
SMC1A_HUMAN	SMC1A	physical	21319273
SMC3_HUMAN	SMC3	physical	21319273
ANXA1_HUMAN	ANXA1	physical	21319273
LIS1_HUMAN	PAFAH1B1	physical	21319273
HNRPC_HUMAN	HNRNPC	physical	21319273
RABP2_HUMAN	CRABP2	physical	21319273
RL18_HUMAN	RPL18	physical	21319273
RL28_HUMAN	RPL28	physical	21319273
BZW1_HUMAN	BZW1	physical	21319273
CUL4B_HUMAN	CUL4B	physical	21319273
COG7_HUMAN	COG7	physical	21319273
VAT1_HUMAN	VAT1	physical	21319273
DHRS1_HUMAN	DHRS1	physical	21319273
MGN2_HUMAN	MAGOHB	physical	21319273
RENT1_HUMAN	UPF1	physical	21319273
COQ6_HUMAN	COQ6	physical	21319273
SPB9_HUMAN	SERPINB9	physical	21319273
SSBP_HUMAN	SSBP1	physical	21319273
ERH_HUMAN	ERH	physical	21319273
PSA6_HUMAN	PSMA6	physical	21319273
TMEDA_HUMAN	TMED10	physical	21319273
S10A6_HUMAN	S100A6	physical	21319273
ATP5L_HUMAN	ATP5L	physical	21319273
SYAC_HUMAN	AARS	physical	21319273
CAPZB_HUMAN	CAPZB	physical	21319273
PRS8_HUMAN	PSMC5	physical	21319273
EF1D_HUMAN	EEF1D	physical	21319273
RB11B_HUMAN	RAB11B	physical	21319273
TPP2_HUMAN	TPP2	physical	21319273
HCFC1_HUMAN	HCFC1	physical	21319273
VPS35_HUMAN	VPS35	physical	21319273
UCHL1_HUMAN	UCHL1	physical	21319273
MARE1_HUMAN	MAPRE1	physical	21319273
COX2_HUMAN	COX2	physical	21319273
SC23A_HUMAN	SEC23A	physical	21319273
MSH2_HUMAN	MSH2	physical	21319273
MATR3_HUMAN	MATR3	physical	21319273
RAB5C_HUMAN	RAB5C	physical	21319273
RIR1_HUMAN	RRM1	physical	21319273
EIF3E_HUMAN	EIF3E	physical	21319273
RRAS2_HUMAN	RRAS2	physical	21319273
SAP18_HUMAN	SAP18	physical	21319273
BACH_HUMAN	ACOT7	physical	21319273
RAC1_HUMAN	RAC1	physical	21319273
PSMD8_HUMAN	PSMD8	physical	21319273
DAD1_HUMAN	DAD1	physical	21319273
G3BP2_HUMAN	G3BP2	physical	21319273
LA_HUMAN	SSB	physical	21319273
P5CS_HUMAN	ALDH18A1	physical	21319273
RLA2_HUMAN	RPLP2	physical	21319273
RS10_HUMAN	RPS10	physical	21319273
NACA2_HUMAN	NACA2	physical	21319273
IPO7_HUMAN	IPO7	physical	21319273
NUMA1_HUMAN	NUMA1	physical	21319273
ARPC2_HUMAN	ARPC2	physical	21319273
UBP7_HUMAN	USP7	physical	21319273
GDIR1_HUMAN	ARHGDIA	physical	21319273
GBB2_HUMAN	GNB2	physical	21319273
IMA1_HUMAN	KPNA2	physical	21319273
GCN1_HUMAN	GCN1L1	physical	21319273
DEST_HUMAN	DSTN	physical	21319273
RS27_HUMAN	RPS27	physical	21319273
AKIP_HUMAN	AURKAIP1	physical	21319273
VPS39_HUMAN	VPS39	physical	21319273
MDHM_HUMAN	MDH2	physical	21319273
RUXF_HUMAN	SNRPF	physical	21319273
CH10_HUMAN	HSPE1	physical	21319273
PPAC_HUMAN	ACP1	physical	21319273
HMGN2_HUMAN	HMGN2	physical	21319273
THIO_HUMAN	TXN	physical	21319273
MIC26_HUMAN	APOO	physical	21319273
UBC9_HUMAN	UBE2I	physical	21319273
ELAV2_HUMAN	ELAVL2	physical	21319273
RUXE_HUMAN	SNRPE	physical	21319273
NH2L1_HUMAN	NHP2L1	physical	21319273
ATPD_HUMAN	ATP5D	physical	21319273
RBM3_HUMAN	RBM3	physical	21319273
ACO13_HUMAN	ACOT13	physical	21319273
SSRD_HUMAN	SSR4	physical	21319273
SNRPA_HUMAN	SNRPA	physical	21319273
IFM2_HUMAN	IFITM2	physical	21319273
IF5A2_HUMAN	EIF5A2	physical	21319273
AT2A3_HUMAN	ATP2A3	physical	21319273
H10_HUMAN	H1F0	physical	12383116
CCNA1_HUMAN	CCNA1	physical	12190313
RB_HUMAN	RB1	physical	12190313
H10_HUMAN	H1F0	physical	16985050
P53_HUMAN	TP53	physical	19556892
RB_HUMAN	RB1	physical	15173007
SKP1_HUMAN	SKP1	physical	9636170
SKP2_HUMAN	SKP2	physical	9636170
CUL1_HUMAN	CUL1	physical	9636170
CCNA1_HUMAN	CCNA1	physical	9636170
TMM54_HUMAN	TMEM54	physical	19829063
H10_HUMAN	H1F0	physical	19829063
PRGR_HUMAN	PGR	physical	21447625
CCNA2_HUMAN	CCNA2	physical	21447625
SKP2_HUMAN	SKP2	physical	7553852
SKP1_HUMAN	SKP1	physical	7553852
CCNA2_HUMAN	CCNA2	physical	7553852
CDT1_HUMAN	CDT1	physical	15855168
BRCA1_HUMAN	BRCA1	physical	8764100
H11_HUMAN	HIST1H1A	physical	7629134
H11_HUMAN	HIST1H1A	physical	17371838
RB_HUMAN	RB1	physical	21697511
CCNB1_HUMAN	CCNB1	physical	7799941
CCNA1_HUMAN	CCNA1	physical	7799941
CCNE1_HUMAN	CCNE1	physical	7799941
H10_HUMAN	H1F0	physical	15147269
LATS2_HUMAN	LATS2	physical	15147269
RB_HUMAN	RB1	physical	15811853
H11_HUMAN	HIST1H1A	physical	14597612
CCNA2_HUMAN	CCNA2	physical	12941338
ID2_HUMAN	ID2	physical	9372912
ID3_HUMAN	ID3	physical	9372912
RB_HUMAN	RB1	physical	9199321
TFDP1_HUMAN	TFDP1	physical	9199321
E2F1_HUMAN	E2F1	physical	9199321
H11_HUMAN	HIST1H1A	physical	9199321
H11_HUMAN	HIST1H1A	physical	9464540
CDN1A_HUMAN	CDKN1A	physical	9464540
H11_HUMAN	HIST1H1A	physical	12963725
H11_HUMAN	HIST1H1A	physical	8606778
RB_HUMAN	RB1	physical	8626527
PRC1_HUMAN	PRC1	physical	9885575
RB_HUMAN	RB1	physical	9885575
H11_HUMAN	HIST1H1A	physical	9885575
CCNA2_HUMAN	CCNA2	physical	11377199
UBF1_HUMAN	UBTF	physical	10202152
CDN1A_HUMAN	CDKN1A	physical	11302688
DPOD1_HUMAN	POLD1	physical	9545286
RB_HUMAN	RB1	physical	9258347
CDN1A_HUMAN	CDKN1A	physical	12361598
PCNA_HUMAN	PCNA	physical	12361598
CP110_HUMAN	CCP110	physical	12361598
RB_HUMAN	RB1	physical	12361598
SPDYA_HUMAN	SPDYA	physical	11980914
H15_HUMAN	HIST1H1B	physical	11980914
CCNA2_HUMAN	CCNA2	physical	12044161
H11_HUMAN	HIST1H1A	physical	9380698
CDC7_HUMAN	CDC7	physical	10846177
DBF4A_HUMAN	DBF4	physical	10846177
H11_HUMAN	HIST1H1A	physical	15583032
FBXW7_HUMAN	FBXW7	physical	23082202
STML1_HUMAN	STOML1	physical	23082202
ID2_HUMAN	ID2	physical	9029153
RB_HUMAN	RB1	physical	9029153
CCNE1_HUMAN	CCNE1	physical	21092281
CCNE1_HUMAN	CCNE1	physical	17254967
CDN1B_HUMAN	CDKN1B	physical	17254967
RB_HUMAN	RB1	physical	9190208
CDK7_HUMAN	CDK7	physical	16327805
CCNA2_HUMAN	CCNA2	physical	16290148
SMAD3_HUMAN	SMAD3	physical	15241418
SMAD2_HUMAN	SMAD2	physical	15241418
RB_HUMAN	RB1	physical	15241418
CDN1A_HUMAN	CDKN1A	physical	8756624
RB_HUMAN	RB1	physical	8756624
CCNA1_HUMAN	CCNA1	physical	12191604
MYBB_HUMAN	MYBL2	physical	10095772
BRCA2_HUMAN	BRCA2	physical	15800615
H15_HUMAN	HIST1H1B	physical	15800615
CDN1A_HUMAN	CDKN1A	physical	9660939
CDN1B_HUMAN	CDKN1B	physical	9660939
H11_HUMAN	HIST1H1A	physical	21241890
PML_HUMAN	PML	physical	21840486
CCNE2_HUMAN	CCNE2	physical	9840943
ORC2_HUMAN	ORC2	physical	15232106
MCM3_HUMAN	MCM3	physical	15232106
CDN1A_HUMAN	CDKN1A	physical	15232106
P73_HUMAN	TP73	physical	12676926
RB_HUMAN	RB1	physical	12676926
CDC6_HUMAN	CDC6	physical	10339564
KAP0_HUMAN	PRKAR1A	physical	16582606
H11_HUMAN	HIST1H1A	physical	9886493
MYBB_MOUSE	Mybl2	physical	9840932
RB_MOUSE	Rb1	physical	9840932
H11_HUMAN	HIST1H1A	physical	8641969
CDN1A_HUMAN	CDKN1A	physical	8641969
CDN1B_HUMAN	CDKN1B	physical	9472014
RBL1_HUMAN	RBL1	physical	9472014
RBL2_HUMAN	RBL2	physical	9472014
NPAT_HUMAN	NPAT	physical	9472014
CCNE1_HUMAN	CCNE1	physical	9472014
CCNA2_HUMAN	CCNA2	physical	12244298
NFYA_HUMAN	NFYA	physical	12857729
NFYB_HUMAN	NFYB	physical	12857729
NFYC_HUMAN	NFYC	physical	12857729
CDK7_HUMAN	CDK7	physical	11113184
FOXM1_HUMAN	FOXM1	physical	16504183
RB_HUMAN	RB1	physical	16326706
SPDYA_HUMAN	SPDYA	physical	12839962
CCNA2_HUMAN	CCNA2	physical	14656438
CTNB1_HUMAN	CTNNB1	physical	14985333
H11_HUMAN	HIST1H1A	physical	16962592
CCNA2_HUMAN	CCNA2	physical	15455144
RB_HUMAN	RB1	physical	9139732
CCNA2_HUMAN	CCNA2	physical	15189033
MYBB_HUMAN	MYBL2	physical	10593981
CDN1A_HUMAN	CDKN1A	physical	9546435
RB_HUMAN	RB1	physical	17254966
CDN1B_HUMAN	CDKN1B	physical	17254966
H11_HUMAN	HIST1H1A	physical	17254966
RB_HUMAN	RB1	physical	10486249
CCNA2_HUMAN	CCNA2	physical	15828833
RB_HUMAN	RB1	physical	15828833
DPOLA_HUMAN	POLA1	physical	11259605
H15_HUMAN	HIST1H1B	physical	11259605
H11_HUMAN	HIST1H1A	physical	23776205
I15RA_HUMAN	IL15RA	physical	21988832
MARE2_HUMAN	MAPRE2	physical	21988832
PHLA3_HUMAN	PHLDA3	physical	21988832
FZR1_HUMAN	FZR1	physical	23972993
IMDH2_HUMAN	IMPDH2	physical	23602568
CDN1A_HUMAN	CDKN1A	physical	23602568
CCNA2_HUMAN	CCNA2	physical	23602568
CDN1B_HUMAN	CDKN1B	physical	23602568
CCNE1_HUMAN	CCNE1	physical	23602568
SKP2_HUMAN	SKP2	physical	23602568
CKS1_HUMAN	CKS1B	physical	23602568
CCNB1_HUMAN	CCNB1	physical	23602568
CDK2_HUMAN	CDK2	physical	23602568
RBL2_HUMAN	RBL2	physical	23602568
RBL1_HUMAN	RBL1	physical	23602568
GOGA2_HUMAN	GOLGA2	physical	23602568
CBP_HUMAN	CREBBP	physical	23602568
SKP1_HUMAN	SKP1	physical	23602568
CCNE2_HUMAN	CCNE2	physical	23602568
CDK13_HUMAN	CDK13	physical	23602568
CDN1C_HUMAN	CDKN1C	physical	23602568
FZR1_HUMAN	FZR1	physical	23670162
GEMI_HUMAN	GMNN	physical	23455922
CCNB2_HUMAN	CCNB2	physical	23455922
CCNE2_HUMAN	CCNE2	physical	23455922
HS90A_HUMAN	HSP90AA1	physical	23455922
HS90B_HUMAN	HSP90AB1	physical	23455922
CCNB1_HUMAN	CCNB1	physical	23455922
CCNA2_HUMAN	CCNA2	physical	23455922
CCND1_HUMAN	CCND1	physical	23455922
CCNE1_HUMAN	CCNE1	physical	23455922
RBL1_HUMAN	RBL1	physical	23455922
CKS2_HUMAN	CKS2	physical	23455922
CDN1A_HUMAN	CDKN1A	physical	23455922
CDN1B_HUMAN	CDKN1B	physical	23455922
CDN1C_HUMAN	CDKN1C	physical	23455922
CDK7_HUMAN	CDK7	physical	23455922
MAT1_HUMAN	MNAT1	physical	23455922
CKS1_HUMAN	CKS1B	physical	23455922
CDK3_HUMAN	CDK3	physical	23455922
GOGA2_HUMAN	GOLGA2	physical	23455922
RBL2_HUMAN	RBL2	physical	23455922
EP300_HUMAN	EP300	physical	23455922
CDC20_HUMAN	CDC20	physical	23455922
SKP2_HUMAN	SKP2	physical	23455922
TCOF_HUMAN	TCOF1	physical	23455922
CCNJ_HUMAN	CCNJ	physical	23455922
MK15_HUMAN	MAPK15	physical	23455922
CBP_HUMAN	CREBBP	physical	23455922
CDT1_HUMAN	CDT1	physical	23455922
CCNA2_HUMAN	CCNA2	physical	24302728
TAU_HUMAN	MAPT	physical	19014373
ESR1_HUMAN	ESR1	physical	23770852
RB_HUMAN	RB1	physical	16878158
H11_HUMAN	HIST1H1A	physical	16878158
RB_HUMAN	RB1	physical	11433299
CCNE1_HUMAN	CCNE1	physical	11433299
E2F5_MOUSE	E2f5	physical	10783242
H11_HUMAN	HIST1H1A	physical	10783242
E2F1_HUMAN	E2F1	physical	11245432
SCN5A_HUMAN	SCN5A	physical	23421998
H2B1B_HUMAN	HIST1H2BB	physical	22539978
H11_HUMAN	HIST1H1A	physical	22539978
CDN1B_HUMAN	CDKN1B	physical	10323868
BARD1_HUMAN	BARD1	physical	15665273
H11_HUMAN	HIST1H1A	physical	15695403
CAPR1_HUMAN	CAPRIN1	physical	25852190
CCNA2_HUMAN	CCNA2	physical	25852190
CCNB1_HUMAN	CCNB1	physical	25852190
CCNE1_HUMAN	CCNE1	physical	25852190
CCNE2_HUMAN	CCNE2	physical	25852190
CDC20_HUMAN	CDC20	physical	25852190
CDK7_HUMAN	CDK7	physical	25852190
CDN1B_HUMAN	CDKN1B	physical	25852190
CDN1C_HUMAN	CDKN1C	physical	25852190
CDKN3_HUMAN	CDKN3	physical	25852190
CKS1_HUMAN	CKS1B	physical	25852190
CKS2_HUMAN	CKS2	physical	25852190
CNBP_HUMAN	CNBP	physical	25852190
YBOX3_HUMAN	YBX3	physical	25852190
DDX5_HUMAN	DDX5	physical	25852190
DYST_HUMAN	DST	physical	25852190
E2F4_HUMAN	E2F4	physical	25852190
F133B_HUMAN	FAM133B	physical	25852190
GOGA2_HUMAN	GOLGA2	physical	25852190
LIN37_HUMAN	LIN37	physical	25852190
MK15_HUMAN	MAPK15	physical	25852190
MT1E_HUMAN	MT1E	physical	25852190
PHB2_HUMAN	PHB2	physical	25852190
RBL1_HUMAN	RBL1	physical	25852190
RBL2_HUMAN	RBL2	physical	25852190
RL37_HUMAN	RPL37	physical	25852190
SHRM3_HUMAN	SHROOM3	physical	25852190
SKP1_HUMAN	SKP1	physical	25852190
SKP2_HUMAN	SKP2	physical	25852190
SRRM2_HUMAN	SRRM2	physical	25852190
TCP4_HUMAN	SUB1	physical	25852190
TFDP1_HUMAN	TFDP1	physical	25852190
THOC4_HUMAN	ALYREF	physical	25852190
TITIN_HUMAN	TTN	physical	25852190
MEP50_HUMAN	WDR77	physical	25852190
XRCC6_HUMAN	XRCC6	physical	25852190
MDM2_MOUSE	Mdm2	physical	11983168
UBP37_HUMAN	USP37	physical	21596315
CCNA2_HUMAN	CCNA2	physical	26186194
CCNE1_HUMAN	CCNE1	physical	26186194
CDK3_HUMAN	CDK3	physical	26186194
CCNB2_HUMAN	CCNB2	physical	26186194
GEMI_HUMAN	GMNN	physical	26186194
RBL1_HUMAN	RBL1	physical	26186194
RBL2_HUMAN	RBL2	physical	26186194
CUL1_HUMAN	CUL1	physical	26186194
CCNB1_HUMAN	CCNB1	physical	26186194
PPGB_HUMAN	CTSA	physical	26186194
CCNE2_HUMAN	CCNE2	physical	26186194
CBP_HUMAN	CREBBP	physical	26186194
EP300_HUMAN	EP300	physical	26186194
GOGA2_HUMAN	GOLGA2	physical	26186194
SKP2_HUMAN	SKP2	physical	26186194
CDN1B_HUMAN	CDKN1B	physical	26186194
CCNH_HUMAN	CCNH	physical	26186194
RPC8_HUMAN	POLR3H	physical	26186194
GORS1_HUMAN	GORASP1	physical	26186194
CDN1A_HUMAN	CDKN1A	physical	26186194
C2CD5_HUMAN	C2CD5	physical	26186194
CKS1_HUMAN	CKS1B	physical	26186194
CKS2_HUMAN	CKS2	physical	26186194
CDKN3_HUMAN	CDKN3	physical	26186194
CDN1C_HUMAN	CDKN1C	physical	26186194
MK15_HUMAN	MAPK15	physical	26186194
FZR1_HUMAN	FZR1	physical	26083744
GATA3_HUMAN	GATA3	physical	24820417
LATS1_HUMAN	LATS1	physical	25218637
ALDOA_HUMAN	ALDOA	physical	26344197
ARF6_HUMAN	ARF6	physical	26344197
CKS1_HUMAN	CKS1B	physical	26344197
NOP2_HUMAN	NOP2	physical	26344197
RPE_HUMAN	RPE	physical	26344197
CCNA2_HUMAN	CCNA2	physical	8397207
ACTG_HUMAN	ACTG1	physical	26496610
CCND1_HUMAN	CCND1	physical	26496610
BUB1_HUMAN	BUB1	physical	26496610
CCNA2_HUMAN	CCNA2	physical	26496610
CCNB1_HUMAN	CCNB1	physical	26496610
CCND3_HUMAN	CCND3	physical	26496610
CCNE1_HUMAN	CCNE1	physical	26496610
CCNH_HUMAN	CCNH	physical	26496610
CDN1A_HUMAN	CDKN1A	physical	26496610
CDN1B_HUMAN	CDKN1B	physical	26496610
CDN1C_HUMAN	CDKN1C	physical	26496610
CKS1_HUMAN	CKS1B	physical	26496610
CKS2_HUMAN	CKS2	physical	26496610
CLCA_HUMAN	CLTA	physical	26496610
CLH1_HUMAN	CLTC	physical	26496610
DAPK3_HUMAN	DAPK3	physical	26496610
DREB_HUMAN	DBN1	physical	26496610
DNMT1_HUMAN	DNMT1	physical	26496610
FLII_HUMAN	FLII	physical	26496610
GELS_HUMAN	GSN	physical	26496610
HMGB2_HUMAN	HMGB2	physical	26496610
CH60_HUMAN	HSPD1	physical	26496610
ABLM1_HUMAN	ABLIM1	physical	26496610
LMO7_HUMAN	LMO7	physical	26496610
MYO1B_HUMAN	MYO1B	physical	26496610
MYH9_HUMAN	MYH9	physical	26496610
MYO1C_HUMAN	MYO1C	physical	26496610
MYO5A_HUMAN	MYO5A	physical	26496610
MYO6_HUMAN	MYO6	physical	26496610
MYPT1_HUMAN	PPP1R12A	physical	26496610
PCNA_HUMAN	PCNA	physical	26496610
CDK16_HUMAN	CDK16	physical	26496610
PP1B_HUMAN	PPP1CB	physical	26496610
GDS1_HUMAN	RAP1GDS1	physical	26496610
ROBO1_HUMAN	ROBO1	physical	26496610
S10A4_HUMAN	S100A4	physical	26496610
SKP1_HUMAN	SKP1	physical	26496610
SKP2_HUMAN	SKP2	physical	26496610
SPTN1_HUMAN	SPTAN1	physical	26496610
SPTB2_HUMAN	SPTBN1	physical	26496610
SVIL_HUMAN	SVIL	physical	26496610
TAF7_HUMAN	TAF7	physical	26496610
TMOD1_HUMAN	TMOD1	physical	26496610
TPM1_HUMAN	TPM1	physical	26496610
TPM2_HUMAN	TPM2	physical	26496610
TPM3_HUMAN	TPM3	physical	26496610
TPM4_HUMAN	TPM4	physical	26496610
LUZP1_HUMAN	LUZP1	physical	26496610
ARK72_HUMAN	AKR7A2	physical	26496610
CDK13_HUMAN	CDK13	physical	26496610
CCNE2_HUMAN	CCNE2	physical	26496610
LRRF2_HUMAN	LRRFIP2	physical	26496610
BCLF1_HUMAN	BCLAF1	physical	26496610
SC16A_HUMAN	SEC16A	physical	26496610
ARC1B_HUMAN	ARPC1B	physical	26496610
RBM7_HUMAN	RBM7	physical	26496610
HNRPQ_HUMAN	SYNCRIP	physical	26496610
ZMY11_HUMAN	ZMYND11	physical	26496610
SYNPO_HUMAN	SYNPO	physical	26496610
LIMC1_HUMAN	LIMCH1	physical	26496610
UH1BL_HUMAN	UHRF1BP1L	physical	26496610
MPRIP_HUMAN	MPRIP	physical	26496610
CYTSA_HUMAN	SPECC1L	physical	26496610
COR1C_HUMAN	CORO1C	physical	26496610
RAI14_HUMAN	RAI14	physical	26496610
TES_HUMAN	TES	physical	26496610
ASTE1_HUMAN	ASTE1	physical	26496610
TMOD3_HUMAN	TMOD3	physical	26496610
TRA2A_HUMAN	TRA2A	physical	26496610
RMD1_HUMAN	RMDN1	physical	26496610
RM27_HUMAN	MRPL27	physical	26496610
LIMA1_HUMAN	LIMA1	physical	26496610
BMP2K_HUMAN	BMP2K	physical	26496610
YETS2_HUMAN	YEATS2	physical	26496610
NNRD_HUMAN	CARKD	physical	26496610
THA11_HUMAN	THAP11	physical	26496610
AFAP1_HUMAN	AFAP1	physical	26496610
ARP5L_HUMAN	ARPC5L	physical	26496610
PAR10_HUMAN	PARP10	physical	26496610
DOCK7_HUMAN	DOCK7	physical	26496610
EMSA1_HUMAN	ELMSAN1	physical	26496610
TOP1M_HUMAN	TOP1MT	physical	26496610
PGAM5_HUMAN	PGAM5	physical	26496610
MY18A_HUMAN	MYO18A	physical	26496610
CDN1B_HUMAN	CDKN1B	physical	25241761
CCNA1_HUMAN	CCNA1	physical	25241761
CDN1A_HUMAN	CDKN1A	physical	25241761
CDK6_HUMAN	CDK6	physical	25241761
SMAD3_HUMAN	SMAD3	physical	25241761
P53_HUMAN	TP53	physical	25241761
CCNE1_HUMAN	CCNE1	physical	25728284
KLF10_HUMAN	KLF10	physical	25728284
DPOLL_HUMAN	POLL	physical	22370481
H11_HUMAN	HIST1H1A	physical	11160398
UBE2T_HUMAN	UBE2T	physical	28162934
UBE2H_HUMAN	UBE2H	physical	28162934
SIR2_HUMAN	SIRT2	physical	26303530
CCNA2_HUMAN	CCNA2	physical	28514442
CCNE2_HUMAN	CCNE2	physical	28514442
CDK3_HUMAN	CDK3	physical	28514442
CCNE1_HUMAN	CCNE1	physical	28514442
RBL2_HUMAN	RBL2	physical	28514442
RBL1_HUMAN	RBL1	physical	28514442
CCNB1_HUMAN	CCNB1	physical	28514442
SKP2_HUMAN	SKP2	physical	28514442
EP300_HUMAN	EP300	physical	28514442
CBP_HUMAN	CREBBP	physical	28514442
CDN1C_HUMAN	CDKN1C	physical	28514442
CDN1B_HUMAN	CDKN1B	physical	28514442
CDN1A_HUMAN	CDKN1A	physical	28514442
CCNB2_HUMAN	CCNB2	physical	28514442
CCNH_HUMAN	CCNH	physical	28514442
MK15_HUMAN	MAPK15	physical	28514442
C2CD5_HUMAN	C2CD5	physical	28514442
RPC8_HUMAN	POLR3H	physical	28514442
CDKN3_HUMAN	CDKN3	physical	28514442
CUL1_HUMAN	CUL1	physical	28514442
CDK1_HUMAN	CDK1	physical	28514442
BGAL_HUMAN	GLB1	physical	28514442
CDN1B_HUMAN	CDKN1B	physical	27998760
RN157_HUMAN	RNF157	physical	28655764
RB_HUMAN	RB1	physical	11306463
H10_HUMAN	H1F0	physical	16365885

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB06616	Bosutinib

Regulatory Network of CDK2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND LYS-6, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14; TYR-15; TYR-19;SER-46; THR-158 AND TYR-159, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-15 AND SER-46, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Briefly bound to activate: transient binding of a second catalyticmagnesium activates the structure and dynamics of CDK2 kinase forcatalysis."; Bao Z.Q., Jacobsen D.M., Young M.A.; Structure 19:675-690(2011). Cited for: X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) OF 1-296 IN COMPLEX WITH ATPAND MAGNESIUM, AND PHOSPHORYLATION AT THR-160.	21565702 [Abstract]
"How tyrosine 15 phosphorylation inhibits the activity of cyclin-dependent kinase 2-cyclin A."; Welburn J.P.I., Tucker J.A., Johnson T., Lindert L., Morgan M.,Willis A., Noble M.E.M., Endicott J.A.; J. Biol. Chem. 282:3173-3181(2007). Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH ATP, ANDPHOSPHORYLATION AT THR-14; TYR-15 AND THR-160.	17095507 [Abstract]
"Discovery of a potent CDK2 inhibitor with a novel binding mode, usingvirtual screening and initial, structure-guided lead scoping."; Richardson C.M., Nunns C.L., Williamson D.S., Parratt M.J.,Dokurno P., Howes R., Borgognoni J., Drysdale M.J., Finch H.,Hubbard R.E., Jackson P.S., Kierstan P., Lentzen G., Moore J.D.,Murray J.B., Simmonite H., Surgenor A.E., Torrance C.J.; Bioorg. Med. Chem. Lett. 17:3880-3885(2007). Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) IN COMPLEX WITH INHIBITORS, ANDPHOSPHORYLATION AT THR-160.	17570665 [Abstract]
"Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: proteinstructure-guided design and SAR."; Richardson C.M., Williamson D.S., Parratt M.J., Borgognoni J.,Cansfield A.D., Dokurno P., Francis G.L., Howes R., Moore J.D.,Murray J.B., Robertson A., Surgenor A.E., Torrance C.J.; Bioorg. Med. Chem. Lett. 16:1353-1357(2006). Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH INHIBITORS, ANDPHOSPHORYLATION AT THR-160.	16325401 [Abstract]
"Cdc25 phosphatases are required for timely assembly of CDK1-cyclin Bat the G2/M transition."; Timofeev O., Cizmecioglu O., Settele F., Kempf T., Hoffmann I.; J. Biol. Chem. 285:16978-16990(2010). Cited for: PHOSPHORYLATION AT THR-160 BY CAK, AND DEPHOSPHORYLATION BY CDC25A.	20360007 [Abstract]
"Nuclear targeting of cyclin-dependent kinase 2 reveals essentialroles of cyclin-dependent kinase 2 localization and cyclin E invitamin D-mediated growth inhibition."; Flores O., Wang Z., Knudsen K.E., Burnstein K.L.; Endocrinology 151:896-908(2010). Cited for: FUNCTION IN VITAMIN D-MEDIATED GROWTH INHIBITION, SUBCELLULARLOCATION, ENZYME REGULATION, AND PHOSPHORYLATION AT THR-160.	20147522 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-15 AND THR-160, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Proteomics analysis of protein kinases by target class-selectiveprefractionation and tandem mass spectrometry."; Wissing J., Jaensch L., Nimtz M., Dieterich G., Hornberger R.,Keri G., Wehland J., Daub H.; Mol. Cell. Proteomics 6:537-547(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14; TYR-15; TYR-19 ANDTHR-160, AND MASS SPECTROMETRY.	17192257 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-14, AND MASSSPECTROMETRY.	15302935 [Abstract]
"p42, a novel cyclin-dependent kinase-activating kinase in mammaliancells."; Liu Y., Wu C., Galaktionov K.; J. Biol. Chem. 279:4507-4514(2004). Cited for: PHOSPHORYLATION AT THR-160.	14597612 [Abstract]
"Cell cycle regulation of CDK2 activity by phosphorylation of Thr160and Tyr15."; Gu Y., Rosenblatt J., O'Morgan D.O.; EMBO J. 11:3995-4005(1992). Cited for: PHOSPHORYLATION AT THR-14; TYR-15 AND THR-160, AND MUTAGENESIS OFTHR-14; TYR-15 AND THR-160.	1396589 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-15, AND MASSSPECTROMETRY.	19534553 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-15 AND TYR-19, AND MASSSPECTROMETRY.	18083107 [Abstract]

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