PPGB_HUMAN - dbPTM
PPGB_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PPGB_HUMAN
UniProt AC P10619
Protein Name Lysosomal protective protein
Gene Name CTSA
Organism Homo sapiens (Human).
Sequence Length 480
Subcellular Localization Lysosome.
Protein Description Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins..
Protein Sequence MIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLVQPDGVTLEYNPYSWNLIANVLYLESPAGVGFSYSDDKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQDPSMNLQGLAVGNGLSSYEQNDNSLVYFAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYLKLLSSQKYQILLYNGDVDMACNFMGDEWFVDSLNQKMEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTMFSRFLNKQPY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
432-HydroxyisobutyrylationQRLPGLAKQPSFRQY
HCCCCCCCCCCHHHC		68.72-
55TrimethylationRQYSGYLKGSGSKHL
HHCCEEECCCCCCCE		42.41-
55MethylationRQYSGYLKGSGSKHL
HHCCEEECCCCCCCE		42.41-
145N-linked_GlycosylationDDKFYATNDTEVAQS
CCCEEECCCHHHHHH		46.1416263699
163N-linked_GlycosylationALQDFFRLFPEYKNN
HHHHHHHHCHHHCCC		7.6916263699
1682-HydroxyisobutyrylationFRLFPEYKNNKLFLT
HHHCHHHCCCEEEEC		53.00-
295PhosphorylationHFRYEKDTVVVQDLG
CCCCCCCEEEEEECH		26.69-
333N-linked_GlycosylationRMDPPCTNTTAASTY
ECCCCCCCCCCHHHH		41.9919159218
351N-linked_GlycosylationPYVRKALNIPEQLPQ
HHHHHHCCCCCCCCC		53.2619159218
374PhosphorylationNLQYRRLYRSMNSQY
HHHHHHHHHHHCHHH		9.9928331001
379PhosphorylationRLYRSMNSQYLKLLS
HHHHHHCHHHHHHHH		16.1528331001
381PhosphorylationYRSMNSQYLKLLSSQ
HHHHCHHHHHHHHCC		12.9628331001
429UbiquitinationQRRPWLVKYGDSGEQ
ECCCEEEEECCCHHH		41.152189047
4292-HydroxyisobutyrylationQRRPWLVKYGDSGEQ
ECCCEEEEECCCHHH		41.15-
430PhosphorylationRRPWLVKYGDSGEQI
CCCEEEEECCCHHHH		20.7728152594
447UbiquitinationFVKEFSHIAFLTIKG
HHHHHCCEEEEEECC		2.55-
469PhosphorylationDKPLAAFTMFSRFLN
CCHHHHHHHHHHHHC		16.75-
472PhosphorylationLAAFTMFSRFLNKQP
HHHHHHHHHHHCCCC		15.9924719451
490Phosphorylation-----------------
-----------------		24719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PPGB_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PPGB_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PPGB_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAB2A_HUMANRAB2Aphysical
22939629
UPAR_HUMANPLAURphysical
22939629
SUMO2_HUMANSUMO2physical
22939629
ABHEA_HUMANABHD14Aphysical
22863883
ASSY_HUMANASS1physical
22863883
BZW2_HUMANBZW2physical
22863883
CASP7_HUMANCASP7physical
22863883
FTO_HUMANFTOphysical
22863883
PSF2_HUMANGINS2physical
22863883
MVD1_HUMANMVDphysical
22863883
NAMPT_HUMANNAMPTphysical
22863883
PEPD_HUMANPEPDphysical
22863883
NNRE_HUMANAPOA1BPphysical
26344197
TIM9_HUMANTIMM9physical
26344197
TRNT1_HUMANTRNT1physical
26344197
YPEL5_HUMANYPEL5physical
27173435
BGAL_HUMANGLB1physical
27173435
VIME_HUMANVIMphysical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
256540Galactosialidosis (GSL)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PPGB_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145 AND ASN-333, AND MASSSPECTROMETRY.
"Elucidation of N-glycosylation sites on human platelet proteins: aglycoproteomic approach.";
Lewandrowski U., Moebius J., Walter U., Sickmann A.;
Mol. Cell. Proteomics 5:226-233(2006).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145, AND MASSSPECTROMETRY.

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