NNRE_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NNRE_HUMAN
• UniProt AC: Q8NCW5
• Protein Name: NAD(P)H-hydrate epimerase {ECO:0000255|HAMAP-Rule:MF_03159}
• Gene Name: NAXE {ECO:0000312|HGNC:HGNC:18453}
• Organism: Homo sapiens (Human).
• Sequence Length: 288
• Subcellular Localization: Mitochondrion . Secreted . In sperm, secretion gradually increases during capacitation.
• Protein Description: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX..
• Protein Sequence: MSRLRALLGLGLLVAGSRVPRIKSQTIACRSGPTWWGPQRLNSGGRWDSEVMASTVVKYLSQEEAQAVDQELFNEYQFSVDQLMELAGLSCATAIAKAYPPTSMSRSPPTVLVICGPGNNGGDGLVCARHLKLFGYEPTIYYPKRPNKPLFTALVTQCQKMDIPFLGEMPAEPMTIDELYELVVDAIFGFSFKGDVREPFHSILSVLKGLTVPIASIDIPSGWDVEKGNAGGIQPDLLISLTAPKKSATQFTGRYHYLGGRFVPPALEKKYQLNLPPYPDTECVYRLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	SRVPRIKSQTIACRS CCCCCCCCCEEEECC	30.13	-
29 (in isoform 2)	Ubiquitination	-	2.92	21890473
34	O-linked_Glycosylation	IACRSGPTWWGPQRL EEECCCCCCCCCCCC	37.06	55834729
49	Phosphorylation	NSGGRWDSEVMASTV CCCCCCCHHHHHHHH	25.73	26356563
54	Phosphorylation	WDSEVMASTVVKYLS CCHHHHHHHHHHHCC	12.02	26356563
55	Phosphorylation	DSEVMASTVVKYLSQ CHHHHHHHHHHHCCH	21.56	26356563
132	Ubiquitination	LVCARHLKLFGYEPT EEECHHHHHCCCCCE	35.33	32015554
132 (in isoform 1)	Ubiquitination	-	35.33	21890473
132	Acetylation	LVCARHLKLFGYEPT EEECHHHHHCCCCCE	35.33	25953088
136	Phosphorylation	RHLKLFGYEPTIYYP HHHHHCCCCCEEECC	16.05	24719451
139	Phosphorylation	KLFGYEPTIYYPKRP HHCCCCCEEECCCCC	15.07	28152594
141	Phosphorylation	FGYEPTIYYPKRPNK CCCCCEEECCCCCCC	19.05	28152594
142	Phosphorylation	GYEPTIYYPKRPNKP CCCCEEECCCCCCCC	9.83	28152594
144	Acetylation	EPTIYYPKRPNKPLF CCEEECCCCCCCCCH	65.45	7625399
144	Succinylation	EPTIYYPKRPNKPLF CCEEECCCCCCCCCH	65.45	-
144	Succinylation	EPTIYYPKRPNKPLF CCEEECCCCCCCCCH	65.45	-
148	Acetylation	YYPKRPNKPLFTALV ECCCCCCCCCHHHHH	45.86	25953088
148	Malonylation	YYPKRPNKPLFTALV ECCCCCCCCCHHHHH	45.86	26320211
191	Phosphorylation	VDAIFGFSFKGDVRE HHHHHCCCCCCCCCC	26.82	24719451
240	Phosphorylation	IQPDLLISLTAPKKS CCCCEEEEEECCCCC	21.45	-
245	Ubiquitination	LISLTAPKKSATQFT EEEEECCCCCCCCCC	57.82	29967540
245	2-Hydroxyisobutyrylation	LISLTAPKKSATQFT EEEEECCCCCCCCCC	57.82	-
246	Ubiquitination	ISLTAPKKSATQFTG EEEECCCCCCCCCCC	44.24	27667366
247	Phosphorylation	SLTAPKKSATQFTGR EEECCCCCCCCCCCC	42.55	26437602
249	Phosphorylation	TAPKKSATQFTGRYH ECCCCCCCCCCCCEE	31.16	26437602
252	Phosphorylation	KKSATQFTGRYHYLG CCCCCCCCCCEEEEC	15.78	-
255	Phosphorylation	ATQFTGRYHYLGGRF CCCCCCCEEEECCEE	9.00	24927040
257	Phosphorylation	QFTGRYHYLGGRFVP CCCCCEEEECCEECC	9.71	28152594
261	Methylation	RYHYLGGRFVPPALE CEEEECCEECCHHHH	27.82	-
269	2-Hydroxyisobutyrylation	FVPPALEKKYQLNLP ECCHHHHHHCCCCCC	58.60	-
269	Succinylation	FVPPALEKKYQLNLP ECCHHHHHHCCCCCC	58.60	23954790
269	Ubiquitination	FVPPALEKKYQLNLP ECCHHHHHHCCCCCC	58.60	32015554
270	Ubiquitination	VPPALEKKYQLNLPP CCHHHHHHCCCCCCC	28.93	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NNRE_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NNRE_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NNRE_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APOA1_HUMAN	APOA1	physical	11991719
ARMT1_HUMAN	C6orf211	physical	26344197
DPYD_HUMAN	DPYD	physical	26344197
ES8L2_HUMAN	EPS8L2	physical	26344197
FADD_HUMAN	FADD	physical	26344197
MEMO1_HUMAN	MEMO1	physical	26344197
UB2G1_HUMAN	UBE2G1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.