UB2G1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UB2G1_HUMAN
• UniProt AC: P62253
• Protein Name: Ubiquitin-conjugating enzyme E2 G1
• Gene Name: UBE2G1
• Organism: Homo sapiens (Human).
• Sequence Length: 170
• Protein Description: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4..
• Protein Sequence: MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKAHLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIHTVETIMISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCVRKSQETAFE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTELQSAL -------CCHHHHHH	6.24	22814378
2	Acetylation	------MTELQSALL ------CCHHHHHHH	45.46	22223895
2	Phosphorylation	------MTELQSALL ------CCHHHHHHH	45.46	20068231
6	Phosphorylation	--MTELQSALLLRRQ --CCHHHHHHHHHHH	33.24	20068231
19	Ubiquitination	RQLAELNKNPVEGFS HHHHHHCCCCCCCCC	75.22	-
56	Ubiquitination	LYEGGVFKAHLTFPK EEECCEEEEEEECCC	32.27	33845483
63	Ubiquitination	KAHLTFPKDYPLRPP EEEEECCCCCCCCCC	66.75	23000965
65	Phosphorylation	HLTFPKDYPLRPPKM EEECCCCCCCCCCCC	15.42	17384208
71	Ubiquitination	DYPLRPPKMKFITEI CCCCCCCCCCEEEEE	58.36	23000965
73	Ubiquitination	PLRPPKMKFITEIWH CCCCCCCCEEEEECC	39.48	23000965
76	Phosphorylation	PPKMKFITEIWHPNV CCCCCEEEEECCCCC	25.26	-
85	Ubiquitination	IWHPNVDKNGDVCIS ECCCCCCCCCCEEEE	59.55	21963094
101	Ubiquitination	LHEPGEDKYGYEKPE EECCCCCCCCCCCCH	35.95	21963094
102	Phosphorylation	HEPGEDKYGYEKPEE ECCCCCCCCCCCCHH	36.94	28796482
104	Phosphorylation	PGEDKYGYEKPEERW CCCCCCCCCCCHHHC	20.07	28796482
106	Ubiquitination	EDKYGYEKPEERWLP CCCCCCCCCHHHCCC	49.60	27667366
163	Ubiquitination	KVARCVRKSQETAFE HHHHHHHHHHHHHCC	35.77	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UB2G1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UB2G1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HOIL1_HUMAN	RBCK1	physical	19549727
AMFR_HUMAN	AMFR	physical	19560420
A4_HUMAN	APP	physical	21832049
UBP8_HUMAN	USP8	physical	22939629
WWP2_HUMAN	WWP2	physical	22939629
UB2G1_HUMAN	UBE2G1	physical	20061386

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Exploring proteomes and analyzing protein processing by massspectrometric identification of sorted N-terminal peptides.";
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A.,Thomas G.R., Vandekerckhove J.;
Nat. Biotechnol. 21:566-569(2003).
Cited for: PROTEIN SEQUENCE OF 2-11, AND ACETYLATION AT THR-2.
PubMed: 12665801