dbPTM

APOA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	APOA1_HUMAN
UniProt AC	P02647
Protein Name	Apolipoprotein A-I
Gene Name	APOA1
Organism	Homo sapiens (Human).
Sequence Length	267
Subcellular Localization	Secreted.
Protein Description	Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility..
Protein Sequence	MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Glycation	QSPWDRVKDLATVYV CCCCHHHHHHHHHHH	48.17	-
40	O-linked_Glycosylation	DRVKDLATVYVDVLK HHHHHHHHHHHHHHH	21.48	OGP
42	Nitration	VKDLATVYVDVLKDS HHHHHHHHHHHHHHC	6.13	-
47	Glycation	TVYVDVLKDSGRDYV HHHHHHHHHCCCCHH	50.09	-
53	Phosphorylation	LKDSGRDYVSQFEGS HHHCCCCHHHHHCCC	10.71	23911959
53	Nitration	LKDSGRDYVSQFEGS HHHCCCCHHHHHCCC	10.71	-
55	Phosphorylation	DSGRDYVSQFEGSAL HCCCCHHHHHCCCHH	23.95	27130503
60	Phosphorylation	YVSQFEGSALGKQLN HHHHHCCCHHHHHHC	17.08	23911959
76	O-linked_Glycosylation	KLLDNWDSVTSTFSK HHHCCCHHHHHHHHH	20.93	OGP
78	O-linked_Glycosylation	LDNWDSVTSTFSKLR HCCCHHHHHHHHHHH	26.46	OGP
78	Phosphorylation	LDNWDSVTSTFSKLR HCCCHHHHHHHHHHH	26.46	27251275
79	Phosphorylation	DNWDSVTSTFSKLRE CCCHHHHHHHHHHHH	25.87	27251275
80	Phosphorylation	NWDSVTSTFSKLREQ CCHHHHHHHHHHHHH	23.67	27251275
82	Phosphorylation	DSVTSTFSKLREQLG HHHHHHHHHHHHHHC	30.76	27251275
110	Oxidation	TEGLRQEMSKDLEEV HHHHHHHHHHCHHHH	4.58	12576517
110	Methionine sulfoxide	TEGLRQEMSKDLEEV HHHHHHHHHHCHHHH	4.58	-
112	Sulfoxidation	GLRQEMSKDLEEVKA HHHHHHHHCHHHHHH	66.09	20133843
118	Acetylation	SKDLEEVKAKVQPYL HHCHHHHHHHHHHHH	45.85	27178108
120	Glycation	DLEEVKAKVQPYLDD CHHHHHHHHHHHHHH	35.37	-
124	Nitration	VKAKVQPYLDDFQKK HHHHHHHHHHHHHHH	12.98	-
130	Glycation	PYLDDFQKKWQEEME HHHHHHHHHHHHHHH	56.84	-
130	Acetylation	PYLDDFQKKWQEEME HHHHHHHHHHHHHHH	56.84	27178108
131	Glycation	YLDDFQKKWQEEMEL HHHHHHHHHHHHHHH	43.24	-
131	Acetylation	YLDDFQKKWQEEMEL HHHHHHHHHHHHHHH	43.24	27178108
136	Oxidation	QKKWQEEMELYRQKV HHHHHHHHHHHHHHH	4.18	12576517
136	Methionine sulfoxide	QKKWQEEMELYRQKV HHHHHHHHHHHHHHH	4.18	-
139	Nitration	WQEEMELYRQKVEPL HHHHHHHHHHHHHHH	9.55	-
142	Ubiquitination	EMELYRQKVEPLRAE HHHHHHHHHHHHHHH	39.30	-
148	Sulfoxidation	QKVEPLRAELQEGAR HHHHHHHHHHHHHHH	29.54	20133843
157	Glycation	LQEGARQKLHELQEK HHHHHHHHHHHHHHH	46.38	-
164	Glycation	KLHELQEKLSPLGEE HHHHHHHHHCHHCHH	41.10	-
164	Acetylation	KLHELQEKLSPLGEE HHHHHHHHHCHHCHH	41.10	27178108
166	Phosphorylation	HELQEKLSPLGEEMR HHHHHHHCHHCHHHH	29.19	19945452
185	Phosphorylation	AHVDALRTHLAPYSD HHHHHHHHHCCCCCH	23.30	19945452
190	Phosphorylation	LRTHLAPYSDELRQR HHHHCCCCCHHHHHH	24.13	23911959
190	Nitration	LRTHLAPYSDELRQR HHHHCCCCCHHHHHH	24.13	-
191	Phosphorylation	RTHLAPYSDELRQRL HHHCCCCCHHHHHHH	24.45	27130503
206	Glycation	AARLEALKENGGARL HHHHHHHHHCCCHHH	57.06	-
216	Phosphorylation	GGARLAEYHAKATEH CCHHHHHHHHHHHHH	11.06	-
216	Nitration	GGARLAEYHAKATEH CCHHHHHHHHHHHHH	11.06	-
219	Acetylation	RLAEYHAKATEHLST HHHHHHHHHHHHHHH	42.39	7683359
219	Glycation	RLAEYHAKATEHLST HHHHHHHHHHHHHHH	42.39	-
221	Phosphorylation	AEYHAKATEHLSTLS HHHHHHHHHHHHHHH	24.19	19945452
221	O-linked_Glycosylation	AEYHAKATEHLSTLS HHHHHHHHHHHHHHH	24.19	23109999
225	O-linked_Glycosylation	AKATEHLSTLSEKAK HHHHHHHHHHHHHHH	29.25	OGP
225	Phosphorylation	AKATEHLSTLSEKAK HHHHHHHHHHHHHHH	29.25	27130503
226	O-linked_Glycosylation	KATEHLSTLSEKAKP HHHHHHHHHHHHHHH	40.43	OGP
226	Phosphorylation	KATEHLSTLSEKAKP HHHHHHHHHHHHHHH	40.43	27130503
228	Phosphorylation	TEHLSTLSEKAKPAL HHHHHHHHHHHHHHH	36.82	28857561
228	O-linked_Glycosylation	TEHLSTLSEKAKPAL HHHHHHHHHHHHHHH	36.82	55828079
232	Acetylation	STLSEKAKPALEDLR HHHHHHHHHHHHHHH	41.72	27452117
252	Phosphorylation	VLESFKVSFLSALEE HHHHHHHHHHHHHHH	22.51	19945452
255	Phosphorylation	SFKVSFLSALEEYTK HHHHHHHHHHHHHHH	28.88	30087585
260	Nitration	FLSALEEYTKKLNTQ HHHHHHHHHHHHCCC	17.93	-
261	O-linked_Glycosylation	LSALEEYTKKLNTQ- HHHHHHHHHHHCCC-	25.61	OGP
262	Acetylation	SALEEYTKKLNTQ-- HHHHHHHHHHCCC--	55.12	30586961
263	N-linked_Glycosylation	ALEEYTKKLNTQ--- HHHHHHHHHCCC---	38.89	8261628
263	Glycation	ALEEYTKKLNTQ--- HHHHHHHHHCCC---	38.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of APOA1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of APOA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of APOA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDE1A_HUMAN	PDE1A	physical	11991719
PLTP_HUMAN	PLTP	physical	9469594
ABCA1_HUMAN	ABCA1	physical	12084722
APOA1_HUMAN	APOA1	physical	9356442
LCAT_HUMAN	LCAT	physical	1644835
APOC1_HUMAN	APOC1	physical	11991719
SAA2_HUMAN	SAA2	physical	11991719
LCAT_HUMAN	LCAT	physical	1587806
APOB_HUMAN	APOB	physical	19164805
TERA_HUMAN	VCP	physical	19164805
A4_HUMAN	APP	physical	21832049
ABCA6_HUMAN	ABCA6	physical	15174051
ASM3A_HUMAN	SMPDL3A	physical	15174051
APOA1_HUMAN	APOA1	physical	15174051
APOC1_HUMAN	APOC1	physical	15174051
APOC3_HUMAN	APOC3	physical	15174051
SETX_HUMAN	SETX	physical	15174051
PDE4B_HUMAN	PDE4B	physical	15174051
CATL1_HUMAN	CTSL	physical	15174051
CERU_HUMAN	CP	physical	15174051
CNMD_HUMAN	LECT1	physical	15174051
CLUS_HUMAN	CLU	physical	15174051
C1QA_HUMAN	C1QA	physical	15174051
C1QC_HUMAN	C1QC	physical	15174051
DHPR_HUMAN	QDPR	physical	15174051
FA83C_HUMAN	FAM83C	physical	15174051
TDT_HUMAN	DNTT	physical	15174051
FIBA_HUMAN	FGA	physical	15174051
FINC_HUMAN	FN1	physical	15174051
HBA_HUMAN	HBA1	physical	15174051
SRTD3_HUMAN	SERTAD3	physical	15174051
SPEF2_HUMAN	SPEF2	physical	15174051
ROBO3_HUMAN	ROBO3	physical	15174051
TENS3_HUMAN	TNS3	physical	15174051
SAFB2_HUMAN	SAFB2	physical	15174051
RRP1B_HUMAN	RRP1B	physical	15174051
F169A_HUMAN	FAM169A	physical	15174051
K1C16_HUMAN	KRT16	physical	15174051
K1C9_HUMAN	KRT9	physical	15174051
K2C1_HUMAN	KRT1	physical	15174051
K0754_HUMAN	KIAA0754	physical	15174051
NLRP1_HUMAN	NLRP1	physical	15174051
PTN5_HUMAN	PTPN5	physical	15174051
MOCOS_HUMAN	MOCOS	physical	15174051
TXND2_HUMAN	TXNDC2	physical	15174051
TTHY_HUMAN	TTR	physical	15174051
APOA1_HUMAN	APOA1	physical	11744719
APOA2_HUMAN	APOA2	physical	10722751
LCAT_HUMAN	LCAT	physical	3104518
DGAT1_HUMAN	DGAT1	physical	3104518
APOA2_HUMAN	APOA2	physical	3104518
APOD_HUMAN	APOD	physical	3104518
APOB_MOUSE	Apob	physical	16204232
OSTP_HUMAN	SPP1	physical	21988832
RPA12_HUMAN	ZNRD1	physical	21988832
FBLN1_HUMAN	FBLN1	physical	21988832
JAK3_HUMAN	JAK3	physical	21988832
CKLF5_HUMAN	CMTM5	physical	25416956
FIBA_HUMAN	FGA	physical	25241761
APOA1_HUMAN	APOA1	physical	8810909
TMM43_HUMAN	TMEM43	physical	28514442
ABCA1_HUMAN	ABCA1	physical	27017521
APOB_HUMAN	APOB	physical	28183703

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
604091	High density lipoprotein deficiency 2 (HDLD2)
205400	High density lipoprotein deficiency 1 (HDLD1)
3142462 and PubMed	Note=APOA1 mutations may be involved in the pathogenesis of amyloid polyneuropathy-nephropathy Iowa type, also known as amyloidosis van Allen type or familial amyloid polyneuropathy type III (PubMed
105200
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of APOA1_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"The preferential site of non-enzymatic glycation of humanapolipoprotein A-I in vivo."; Calvo C., Ulloa N., Campos M., Verdugo C., Ayrault-Jarrier M.; Clin. Chim. Acta 217:193-198(1993). Cited for: GLYCATION AT LYS-263.	8261628 [Abstract]
Phosphorylation
Reference	PubMed
"An initial characterization of the serum phosphoproteome."; Zhou W., Ross M.M., Tessitore A., Ornstein D., Vanmeter A.,Liotta L.A., Petricoin E.F. III; J. Proteome Res. 8:5523-5531(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191, TISSUE SPECIFICITY,AND MASS SPECTROMETRY.	19824718 [Abstract]