| UniProt ID | APOB_MOUSE | |
|---|---|---|
| UniProt AC | E9Q414 | |
| Protein Name | Apolipoprotein B-100 | |
| Gene Name | Apob | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 4505 | |
| Subcellular Localization | Cytoplasm . Secreted . | |
| Protein Description | Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.. | |
| Protein Sequence | MGPRKPALRTPLLLLFLLLFLDTSVWAQDEVLENLSFSCPKDATRFKHLRKYVYNYEAESSSGVQGTADSRSATKINCKVELEVPQICGFIMRTNQCTLKEVYGFNPEGKALMKKTKNSEEFAAAMSRYELKLAIPEGKQIVLYPDKDEPKYILNIKRGIISALLVPPETEEDQQELFLDTVYGNCSTQVTVNSRKGTVPTEMSTERNLQQCDGFQPISTSVSPLALIKGLVHPLSTLISSSQTCQYTLDPKRKHVSEAVCDEQHLFLPFSYKNKYGIMTRVTQKLSLEDTPKINSRFFSEGTNRMGLAFESTKSTSSPKQADAVLKTLQELKKLSISEQNAQRANLFNKLVTELRGLTGEAITSLLPQLIEVSSPITLQALVQCGQPQCYTHILQWLKTEKAHPLLVDIVTYLMALIPNPSTQRLQEIFNTAKEQQSRATLYALSHAVNSYFDVDHSRSPVLQDIAGYLLKQIDNECTGNEDHTFLILRVIGNMGRTMEQVMPALKSSVLSCVRSTKPSLLIQKAALQALRKMELEDEVRTILFDTFVNGVAPVEKRLAAYLLLMKNPSSSDINKIAQLLQWEQSEQVKNFVASHIANILNSEELYVQDLKVLIKNALENSQFPTIMDFRKFSRNYQISKSASLPMFDPVSVKIEGNLIFDPSSYLPRESLLKTTLTVFGLASLDLFEIGLEGKGFEPTLEALFGKQGFFPDSVNKALYWVNGRVPDGVSKVLVDHFGYTTDGKHEQDMVNGIMPIVDKLIKDLKSKEIPEARAYLRILGKELSFVRLQDLQVLGKLLLSGAQTLQGIPQMVVQAIREGSKNDLFLHYIFMDNAFELPTGAGLQLQVSSSGVFTPGIKAGVRLELANIQAELVAKPSVSLEFVTNMGIIIPDFAKSSVQMNTNFFHESGLEARVALKAGQLKVIIPSPKRPVKLFSGSNTLHLVSTTKTEVIPPLVENRQSWSTCKPLFTGMNYCTTGAYSNASSTESASYYPLTGDTRYELELRPTGEVEQYSATATYELLKEDKSLVDTLKFLVQAEGVQQSEATVLFKYNRRSRTLSSEVLIPGFDVNFGTILRVNDESAKDKNTYKLILDIQNKKITEVSLVGHLSYDKKGDGKIKGVVSIPRLQAEARSEVHTHWSSTKLLFQMDSSATAYGSTISKRVTWRYDNEIIEFDWNTGTNVDTKKVASNFPVDLSHYPRMLHEYANGLLDHRVPQTDVTFRDMGSKLIVATNTWLQMATRGLPYPQTLQDHLNSLSELNLLKMGLSDFHIPDNLFLKTDGRVKYTMNRNKINIDIPLPLGGKSSKDLKMPESVRTPALNFKSVGFHLPSREVQVPTFTIPKTHQLQVPLLGVLDLSTNVYSNLYNWSASYTGGNTSRDHFSLQAQYRMKTDSVVDLFSYSVQGSGETTYDSKNTFTLSCDGSLHHKFLDSKFKVSHVEKFGNSPVSKGLLTFETSSALGPQMSATVHLDSKKKQHLYVKDIKVDGQFRASSFYAQGKYGLSCERDVTTGQLSGESNMRFNSTYFQGTNQIVGMYQDGALSITSTSDLQDGIFKNTASLKYENYELTLKSDSSGQYENFAASNKLDVTFSTQSALLRSEHQANYKSLRLVTLLSGSLTSQGVELNADILGTDKINTGAHKATLKIARDGLSTSATTNLKYSPLLLENELNAELGLSGASMKLSTNGRFKEHHAKFSLDGRAALTEVSLGSIYQAMILGADSKNIFNFKLSREGLRLSNDLMGSYAEMKLDHTHSLNIAGLSLDFFSKMDNIYSGDKFYKQNFNLQLQPYSFITTLSNDLRYGALDLTNNGRFRLEPLKLNVGGNFKGTYQNNELKHIYTISYTDLVVASYRADTVAKVQGVEFSHRLNADIEGLTSSVDVTTSYNSDPLHFNNVFHFSLAPFTLGIDTHTSGDGKLSFWGEHTGQLYSKFLLKAEPLALIVSHDYKGSTSHSLPYESSISTALEHTVSALLTPAEQTSTWKFKTKLNDKVYSQDFEAYNTKDKIGVELSGRADLSGLYSPIKLPFFYSEPVNVLNGLEVNDAVDKPQEFTIIAVVKYDKNQDVHTINLPFFKSLPDYLERNRRGMISLLEAMRGELQRLSVDQFVRKYRAALSRLPQQIHHYLNASDWERQVAGAKEKITSFMENYRITDNDVLIAIDSAKINFNEKLSQLETYAIQFDQYIKDNYDPHDLKRTIAEIIDRIIEKLKILDEQYHIRVNLAKSIHNLYLFVENVDLNQVSSSNTSWIQNVDSNYQVRIQIQEKLQQLRTQIQNIDIQQLAAEVKRQMDAIDVTMHLDQLRTAILFQRISDIIDRVKYFVMNLIEDFKVTEKINTFRVIVRELIEKYEVDQHIQVLMDKSVELAHRYSLSEPLQKLSNVLQRIEIKDYYEKLVGFIDDTVEWLKALSFKNTIEELNRLTDMLVKKLKAFDYHQFVDKTNSKIREMTQRINAEIQALKLPQKMEALKLLVEDFKTTVSNSLERLKDTKVTVVIDWLQDILTQMKDHFQDTLEDVRDRIYQMDIQRELEHFLSLVNQVYSTLVTYMSDWWTLTAKNITDFAEQYSIQNWAESIKVLVEQGFIVPEMQTFLWTMPAFEVSLRALQEGNFQTPVFIVPLTDLRIPSIRINFKMLKNIKIPLRFSTPEFTLLNTFHVHSFTIDLLEIKAKIIRTIDQILSSELQWPLPEMYLRDLDVVNIPLARLTLPDFHVPEITIPEFTIPNVNLKDLHVPDLHIPEFQLPHLSHTIEIPAFGKLHSILKIQSPLFILDANANIQNVTTSGNKAEIVASVTAKGESQFEALNFDFQAQAQFLELNPHPPVLKESMNFSSKHVRMEHEGEIVFDGKAIEGKSDTVASLHTEKNEVEFNNGMTVKVNNQLTLDSHTKYFHKLSVPRLDFSSKASLNNEIKTLLEAGHVALTSSGTGSWNWACPNFSDEGIHSSQISFTVDGPIAFVGLSNNINGKHLRVIQKLTYESGFLNYSKFEVESKVESQHVGSSILTANGRALLKDAKAEMTGEHNANLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVGFPLKLTGKIDFLNNYALFLSPRAQQASWQASTRFNQYKYNQNFSAINNEHNIEASIGMNGDANLDFLNIPLTIPEINLPYTEFKTPLLKDFSIWEETGLKEFLKTTKQSFDLSVKAQYKKNSDKHSIVVPLGMFYEFILNNVNSWDRKFEKVRNNALHFLTTSYNEAKIKVDKYKTENSLNQPSGTFQNHGYTIPVVNIEVSPFAVETLASSHVIPTAISTPSVTIPGPNIMVPSYKLVLPPLELPVFHGPGNLFKFFLPDFKGFNTIDNIYIPAMGNFTYDFSFKSSVITLNTNAGLYNQSDIVAHFLSSSSFVTDALQYKLEGTSRLMRKRGLKLATAVSLTNKFVKGSHDSTISLTKKNMEASVRTTANLHAPIFSMNFKQELNGNTKSKPTVSSSIELNYDFNSSKLHSTATGGIDHKFSLESLTSYFSIESFTKGNIKSSFLSQEYSGSVANEANVYLNSKGTRSSVRLQGASKVDGIWNVEVGENFAGEATLQRIYTTWEHNMKNHLQVYSYFFTKGKQTCRATLELSPWTMSTLLQVHVSQLSSLLDLHHFDQEVILKANTKNQKISWKGGVQVESRVLQHNAQFSNDQEEIRLDLAGSLDGQLWDLEAIFLPVYGKSLQELLQMDGKRQYLQASTSLLYTKNPNGYLLSLPVQELADRFIIPGIKLNDFSGVKIYKKLSTSPFALNLTMLPKVKFPGIDLLTQYSTPEGSSVPIFEATIPEIHLTVSQFTLPKSLPVGNTVFDLNKLANMIADVDLPSVTLPEQTIVIPPLEFSVPAGIFIPFFGELTARAGMASPLYNVTWSAGWKTKADHVETFLDSMCTSTLQFLEYALKVVETHKIEEDLLTYNIKGTLQHCDFNVEYNEDGLFKGLWDWQGEAHLDITSPALTDFHLYYKEDKTSLSASAASSTIGTVGLDSSTDDQSVELNVYFHPQSPPEKKLSIFKTEWRYKESDGERYIKINWEEEAASRLLGSLKSNVPKASKAIYDYANKYHLEYVSSELRKSLQVNAEHARRMVDEMNMSFQRVARDTYQNLYEEMLAQKSLSIPENLKKRVLDSIVHVTQKYHMAVMWLMDSFIHFLKFNRVQFPGYAGTYTVDELYTIVMKETKKSLSQLFNGLGNLLSYVQNQVEKSRLINDITFKCPFFSKPCKLKDLILIFREELNILSNIGQQDIKFTTILSSLQGFLERVLDIIEEQIKCLKDNESTCVADHINMVFKIQVPYAFKSLREDIYFVLGEFNDFLQSILQEGSYKLQQVHQYMKALREEYFDPSMVGWTVKYYEIEENMVELIKTLLVSFRDVYSEYSVTAADFASKMSTQVEQFVSRDIREYLSMLTDINGKWMEKIAELSIVAKETMKSWVTAVAKIMSDYPQQFHSNLQDFSDQLSSYYEKFVGESTRLIDLSIQNYHVFLRYITELLRKLQVATANNVSPYIKLAQGELMITF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 34 | N-linked_Glycosylation | AQDEVLENLSFSCPK CCHHHHHHCCCCCCC | - | ||
| 157 | Ubiquitination | PKYILNIKRGIISAL CCEEEEECCCCEEEE | 22790023 | ||
| 185 | N-linked_Glycosylation | FLDTVYGNCSTQVTV HHHHHHCCCEEEEEE | - | ||
| 320 | Ubiquitination | TKSTSSPKQADAVLK CCCCCCHHHHHHHHH | 22790023 | ||
| 434 | Ubiquitination | QEIFNTAKEQQSRAT HHHHHHHHHHHHHHH | 22790023 | ||
| 458 | Phosphorylation | SYFDVDHSRSPVLQD HHCCCCCCCCHHHHH | - | ||
| 460 | Phosphorylation | FDVDHSRSPVLQDIA CCCCCCCCHHHHHHH | - | ||
| 498 | Phosphorylation | VIGNMGRTMEQVMPA ECCCCCCCHHHHHHH | - | ||
| 525 | Ubiquitination | KPSLLIQKAALQALR CHHHHHHHHHHHHHH | 22790023 | ||
| 607 | Phosphorylation | ILNSEELYVQDLKVL HCCCHHHHHHHHHHH | - | ||
| 622 | Phosphorylation | IKNALENSQFPTIMD HHHHHHCCCCCCHHC | - | ||
| 626 | Phosphorylation | LENSQFPTIMDFRKF HHCCCCCCHHCHHHH | - | ||
| 731 | Phosphorylation | GRVPDGVSKVLVDHF CCCCCCCCEEEEEEC | 23737553 | ||
| 782 | Ubiquitination | AYLRILGKELSFVRL HHHHHHCCCCCCEEH | 22790023 | ||
| 947 | Phosphorylation | NTLHLVSTTKTEVIP CEEEEEEECCCCCCC | - | ||
| 983 | N-linked_Glycosylation | CTTGAYSNASSTESA CCCCCCCCCCCCCEE | - | ||
| 1163 | Acetylation | AYGSTISKRVTWRYD CCCCCCCCCEEEECC | 51082261 | ||
| 1305 | Ubiquitination | IPLPLGGKSSKDLKM ECCCCCCCCCCCCCC | 22790023 | ||
| 1368 | N-linked_Glycosylation | NVYSNLYNWSASYTG CHHHHCCCCCCCCCC | - | ||
| 1377 | N-linked_Glycosylation | SASYTGGNTSRDHFS CCCCCCCCCCCCCEE | - | ||
| 1523 | N-linked_Glycosylation | GESNMRFNSTYFQGT CCCCCEEECEEECCC | - | ||
| 1655 | Phosphorylation | ARDGLSTSATTNLKY ECCCCCCCCCCCCCC | 25777480 | ||
| 1657 | Phosphorylation | DGLSTSATTNLKYSP CCCCCCCCCCCCCCC | 25777480 | ||
| 1658 | Phosphorylation | GLSTSATTNLKYSPL CCCCCCCCCCCCCCC | 25777480 | ||
| 1662 | Phosphorylation | SATTNLKYSPLLLEN CCCCCCCCCCCEECC | 25777480 | ||
| 1663 | Phosphorylation | ATTNLKYSPLLLENE CCCCCCCCCCEECCH | 25777480 | ||
| 1678 | Phosphorylation | LNAELGLSGASMKLS HHHHCCCCCCCCEEC | 25777480 | ||
| 1698 | Phosphorylation | KEHHAKFSLDGRAAL CCEEEEECCCCHHHH | 24719451 | ||
| 1828 | Ubiquitination | LNVGGNFKGTYQNNE ECCCCCCCCEECCCC | 22790023 | ||
| 1991 | Ubiquitination | FKTKLNDKVYSQDFE EEECCCCCEECCCCC | 22790023 | ||
| 2005 | Acetylation | EAYNTKDKIGVELSG CCCCCCCCCCEEECC | - | ||
| 2142 | Phosphorylation | AGAKEKITSFMENYR HHHHHHHHHHHHHCC | 30635358 | ||
| 2143 | Phosphorylation | GAKEKITSFMENYRI HHHHHHHHHHHHCCC | 30635358 | ||
| 2148 | Phosphorylation | ITSFMENYRITDNDV HHHHHHHCCCCCCCE | 30635358 | ||
| 2196 | Phosphorylation | DPHDLKRTIAEIIDR CHHHHHHHHHHHHHH | 25159016 | ||
| 2554 | N-linked_Glycosylation | WWTLTAKNITDFAEQ CEEEEECCHHHHHHH | - | ||
| 2608 | Phosphorylation | LQEGNFQTPVFIVPL HHHCCCCCCEEEEEC | - | ||
| 2622 | Phosphorylation | LTDLRIPSIRINFKM CCCCCCCCEEEEEEE | 24719451 | ||
| 2754 | Phosphorylation | PAFGKLHSILKIQSP CCCCHHHHHHHCCCC | 26370283 | ||
| 2773 | N-linked_Glycosylation | DANANIQNVTTSGNK ECCCCEEEECCCCCC | 16944957 | ||
| 2888 | Phosphorylation | TKYFHKLSVPRLDFS CCEEEECCCCCCCCC | 24719451 | ||
| 2976 | N-linked_Glycosylation | TYESGFLNYSKFEVE EECCCCCCCCEEEEE | 16944957 | ||
| 3095 | N-linked_Glycosylation | NQYKYNQNFSAINNE HCCCCCCCCCCCCCC | - | ||
| 3270 | Phosphorylation | ASSHVIPTAISTPSV HHCCCCCCCCCCCCC | 25777480 | ||
| 3273 | Phosphorylation | HVIPTAISTPSVTIP CCCCCCCCCCCCEEC | 25777480 | ||
| 3274 | Phosphorylation | VIPTAISTPSVTIPG CCCCCCCCCCCEECC | 25777480 | ||
| 3276 | Phosphorylation | PTAISTPSVTIPGPN CCCCCCCCCEECCCC | 25777480 | ||
| 3278 | Phosphorylation | AISTPSVTIPGPNIM CCCCCCCEECCCCEE | 25777480 | ||
| 3288 | Phosphorylation | GPNIMVPSYKLVLPP CCCEECCCEEEEECC | 25777480 | ||
| 3289 | Phosphorylation | PNIMVPSYKLVLPPL CCEECCCEEEEECCC | 25777480 | ||
| 3331 | N-linked_Glycosylation | IYIPAMGNFTYDFSF EEECCCCCEEEEEEE | - | ||
| 3353 | N-linked_Glycosylation | NTNAGLYNQSDIVAH ECCCCCCCHHHHHHH | - | ||
| 3460 | N-linked_Glycosylation | IELNYDFNSSKLHST EEEEECCCCCCCEEE | - | ||
| 3860 | N-linked_Glycosylation | GMASPLYNVTWSAGW CCCCCCEEECCCCCC | - | ||
| 4013 | Phosphorylation | TEWRYKESDGERYIK EEEEEECCCCCEEEE | - | ||
| 4018 | Phosphorylation | KESDGERYIKINWEE ECCCCCEEEEEECHH | - | ||
| 4057 | Phosphorylation | ANKYHLEYVSSELRK HHHHHHHHHCHHHHH | - | ||
| 4311 | Phosphorylation | QSILQEGSYKLQQVH HHHHHHCCHHHHHHH | 23140645 | ||
| 4312 | Phosphorylation | SILQEGSYKLQQVHQ HHHHHCCHHHHHHHH | 23140645 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of APOB_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of APOB_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of APOB_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| APOA1_HUMAN | APOA1 | physical | 16204232 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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