APOC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APOC1_HUMAN
• UniProt AC: P02654
• Protein Name: Apolipoprotein C-I
• Gene Name: APOC1
• Organism: Homo sapiens (Human).
• Sequence Length: 83
• Subcellular Localization: Secreted .
• Protein Description: Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein..
• Protein Sequence: MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSALDKLKEFGNTLEDKARELISRIKQSELSAKMREWFSETFQKVKEKLKIDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	PVLVVVLSIVLEGPA HHHHHHHHHHHCCCC	10.07	22210691
27	Phosphorylation	GPAPAQGTPDVSSAL CCCCCCCCCCHHHHH	12.30	22210691
31	Phosphorylation	AQGTPDVSSALDKLK CCCCCCHHHHHHHHH	19.78	22210691
32	Phosphorylation	QGTPDVSSALDKLKE CCCCCHHHHHHHHHH	32.47	22210691
53	Phosphorylation	DKARELISRIKQSEL HHHHHHHHHHHHHHH	40.35	24719451
53	O-linked_Glycosylation	DKARELISRIKQSEL HHHHHHHHHHHHHHH	40.35	OGP
63	Ubiquitination	KQSELSAKMREWFSE HHHHHHHHHHHHHHH	34.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APOC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APOC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APOC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NSG2_HUMAN	HMP19	physical	21900206

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.