| UniProt ID | SETX_HUMAN | |
|---|---|---|
| UniProt AC | Q7Z333 | |
| Protein Name | Probable helicase senataxin {ECO:0000305} | |
| Gene Name | SETX {ECO:0000303|PubMed:14770181, ECO:0000312|HGNC:HGNC:445} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 2677 | |
| Subcellular Localization | Nucleus . Nucleus, nucleoplasm . Nucleus, nucleolus . Cytoplasm . Chromosome . Chromosome, telomere . Cell projection, axon . Cell projection, growth cone . May be detected in the nucleolus only in cycling cells. At pachytene stage, colocalizes predo | |
| Protein Description | Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription. [PubMed: 19515850] | |
| Protein Sequence | MSTCCWCTPGGASTIDFLKRYASNTPSGEFQTADEDLCYCLECVAEYHKARDELPFLHEVLWELETLRLINHFEKSMKAEIGDDDELYIVDNNGEMPLFDITGQDFENKLRVPLLEILKYPYLLLHERVNELCVEALCRMEQANCSFQVFDKHPGIYLFLVHPNEMVRRWAILTARNLGKVDRDDYYDLQEVLLCLFKVIELGLLESPDIYTSSVLEKGKLILLPSHMYDTTNYKSYWLGICMLLTILEEQAMDSLLLGSDKQNDFMQSILHTMEREADDDSVDPFWPALHCFMVILDRLGSKVWGQLMDPIVAFQTIINNASYNREIRHIRNSSVRTKLEPESYLDDMVTCSQIVYNYNPEKTKKDSGWRTAICPDYCPNMYEEMETLASVLQSDIGQDMRVHNSTFLWFIPFVQSLMDLKDLGVAYIAQVVNHLYSEVKEVLNQTDAVCDKVTEFFLLILVSVIELHRNKKCLHLLWVSSQQWVEAVVKCAKLPTTAFTRSSEKSSGNCSKGTAMISSLSLHSMPSNSVQLAYVQLIRSLLKEGYQLGQQSLCKRFWDKLNLFLRGNLSLGWQLTSQETHELQSCLKQIIRNIKFKAPPCNTFVDLTSACKISPASYNKEESEQMGKTSRKDMHCLEASSPTFSKEPMKVQDSVLIKADNTIEGDNNEQNYIKDVKLEDHLLAGSCLKQSSKNIFTERAEDQIKISTRKQKSVKEISSYTPKDCTSRNGPERGCDRGIIVSTRLLTDSSTDALEKVSTSNEDFSLKDDALAKTSKRKTKVQKDEICAKLSHVIKKQHRKSTLVDNTINLDENLTVSNIESFYSRKDTGVQKGDGFIHNLSLDPSGVLDDKNGEQKSQNNVLPKEKQLKNEELVIFSFHENNCKIQEFHVDGKELIPFTEMTNASEKKSSPFKDLMTVPESRDEEMSNSTSVIYSNLTREQAPDISPKSDTLTDSQIDRDLHKLSLLAQASVITFPSDSPQNSSQLQRKVKEDKRCFTANQNNVGDTSRGQVIIISDSDDDDDERILSLEKLTKQDKICLEREHPEQHVSTVNSKEEKNPVKEEKTETLFQFEESDSQCFEFESSSEVFSVWQDHPDDNNSVQDGEKKCLAPIANTTNGQGCTDYVSEVVKKGAEGIEEHTRPRSISVEEFCEIEVKKPKRKRSEKPMAEDPVRPSSSVRNEGQSDTNKRDLVGNDFKSIDRRTSTPNSRIQRATTVSQKKSSKLCTCTEPIRKVPVSKTPKKTHSDAKKGQNRSSNYLSCRTTPAIVPPKKFRQCPEPTSTAEKLGLKKGPRKAYELSQRSLDYVAQLRDHGKTVGVVDTRKKTKLISPQNLSVRNNKKLLTSQELQMQRQIRPKSQKNRRRLSDCESTDVKRAGSHTAQNSDIFVPESDRSDYNCTGGTEVLANSNRKQLIKCMPSEPETIKAKHGSPATDDACPLNQCDSVVLNGTVPTNEVIVSTSEDPLGGGDPTARHIEMAALKEGEPDSSSDAEEDNLFLTQNDPEDMDLCSQMENDNYKLIELIHGKDTVEVEEDSVSRPQLESLSGTKCKYKDCLETTKNQGEYCPKHSEVKAADEDVFRKPGLPPPASKPLRPTTKIFSSKSTSRIAGLSKSLETSSALSPSLKNKSKGIQSILKVPQPVPLIAQKPVGEMKNSCNVLHPQSPNNSNRQGCKVPFGESKYFPSSSPVNILLSSQSVSDTFVKEVLKWKYEMFLNFGQCGPPASLCQSISRPVPVRFHNYGDYFNVFFPLMVLNTFETVAQEWLNSPNRENFYQLQVRKFPADYIKYWEFAVYLEECELAKQLYPKENDLVFLAPERINEEKKDTERNDIQDLHEYHSGYVHKFRRTSVMRNGKTECYLSIQTQENFPANLNELVNCIVISSLVTTQRKLKAMSLLGSRNQLARAVLNPNPMDFCTKDLLTTTSERIIAYLRDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENSNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINSEVLKFSLDSQVNHRMKKELPSHVQAMHKRKEFLDYQLDELSRQRALCRGGREIQRQELDENISKVSKERQELASKIKEVQGRPQKTQSIIILESHIICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCEIETLTPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCRLLEENVEHNMISRLPILQLTVQYRMHPDICLFPSNYVYNRNLKTNRQTEAIRCSSDWPFQPYLVFDVGDGSERRDNDSYINVQEIKLVMEIIKLIKDKRKDVSFRNIGIITHYKAQKTMIQKDLDKEFDRKGPAEVDTVDAFQGRQKDCVIVTCVRANSIQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWNQLIQDAQKRGAIIKTCDKNYRHDAVKILKLKPVLQRSLTHPPTIAPEGSRPQGGLPSSKLDSGFAKTSVAASLYHTPSDSKEITLTVTSKDPERPPVHDQLQDPRLLKRMGIEVKGGIFLWDPQPSSPQHPGATPPTGEPGFPVVHQDLSHIQQPAAVVAALSSHKPPVRGEPPAASPEASTCQSKCDDPEEELCHRREARAFSEGEQEKCGSETHHTRRNSRWDKRTLEQEDSSSKKRKLL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Ubiquitination | ASTIDFLKRYASNTP HHHHHHHHHHHCCCC | 43.27 | 22505724 | |
| 19 (in isoform 3) | Ubiquitination | - | 43.27 | - | |
| 49 | Ubiquitination | ECVAEYHKARDELPF HHHHHHHHHHHHCHH | 44.19 | 21963094 | |
| 68 | Ubiquitination | LWELETLRLINHFEK HHHHHHHHHHHHHHH | 40.73 | 21963094 | |
| 75 | Ubiquitination | RLINHFEKSMKAEIG HHHHHHHHHHCCCCC | 55.71 | 22817900 | |
| 75 (in isoform 1) | Ubiquitination | - | 55.71 | 21906983 | |
| 75 (in isoform 3) | Ubiquitination | - | 55.71 | 21906983 | |
| 75 (in isoform 4) | Ubiquitination | - | 55.71 | 21906983 | |
| 78 | Sumoylation | NHFEKSMKAEIGDDD HHHHHHHCCCCCCCC | 50.38 | - | |
| 78 | Ubiquitination | NHFEKSMKAEIGDDD HHHHHHHCCCCCCCC | 50.38 | 22817900 | |
| 109 | Sumoylation | TGQDFENKLRVPLLE CCCCCCCCCCCHHHH | 30.39 | - | |
| 119 | Ubiquitination | VPLLEILKYPYLLLH CHHHHHHHCHHHHHH | 50.25 | 21906983 | |
| 119 (in isoform 1) | Ubiquitination | - | 50.25 | 21906983 | |
| 119 (in isoform 3) | Ubiquitination | - | 50.25 | 21906983 | |
| 119 (in isoform 4) | Ubiquitination | - | 50.25 | 21906983 | |
| 180 | Ubiquitination | LTARNLGKVDRDDYY HHHHHCCCCCHHHCC | 44.09 | 21987572 | |
| 201 | Ubiquitination | LCLFKVIELGLLESP HHHHHHHHHHCCCCC | 39.51 | 22817900 | |
| 207 | Phosphorylation | IELGLLESPDIYTSS HHHHCCCCCCCCCHH | 28.04 | 27732954 | |
| 211 | Phosphorylation | LLESPDIYTSSVLEK CCCCCCCCCHHHHHC | 14.14 | 28102081 | |
| 212 | Phosphorylation | LESPDIYTSSVLEKG CCCCCCCCHHHHHCC | 18.17 | 28102081 | |
| 213 | Phosphorylation | ESPDIYTSSVLEKGK CCCCCCCHHHHHCCC | 11.07 | 28102081 | |
| 214 | Phosphorylation | SPDIYTSSVLEKGKL CCCCCCHHHHHCCCE | 23.95 | 28102081 | |
| 218 | Ubiquitination | YTSSVLEKGKLILLP CCHHHHHCCCEEEEC | 58.13 | 21906983 | |
| 218 (in isoform 1) | Ubiquitination | - | 58.13 | 21906983 | |
| 218 (in isoform 3) | Ubiquitination | - | 58.13 | 21906983 | |
| 218 (in isoform 4) | Ubiquitination | - | 58.13 | 21906983 | |
| 220 | Ubiquitination | SSVLEKGKLILLPSH HHHHHCCCEEEECCC | 43.34 | 22817900 | |
| 269 | Ubiquitination | KQNDFMQSILHTMER HHCHHHHHHHHHHHH | 18.48 | 22817900 | |
| 272 | Ubiquitination | DFMQSILHTMEREAD HHHHHHHHHHHHHCC | 22.84 | 22817900 | |
| 332 | Methylation | NREIRHIRNSSVRTK CCHHCHHCCCCCCCC | 30.74 | 24411293 | |
| 337 | Methylation | HIRNSSVRTKLEPES HHCCCCCCCCCCCHH | 28.26 | 24411303 | |
| 339 | Sumoylation | RNSSVRTKLEPESYL CCCCCCCCCCCHHHH | 40.04 | 25114211 | |
| 339 | Ubiquitination | RNSSVRTKLEPESYL CCCCCCCCCCCHHHH | 40.04 | 21963094 | |
| 363 | Ubiquitination | VYNYNPEKTKKDSGW HHHCCHHHCCCCCCC | 67.89 | 29967540 | |
| 372 | Phosphorylation | KKDSGWRTAICPDYC CCCCCCEEEECCCCC | 17.54 | - | |
| 378 | Phosphorylation | RTAICPDYCPNMYEE EEEECCCCCCCHHHH | 8.57 | - | |
| 383 | Phosphorylation | PDYCPNMYEEMETLA CCCCCCHHHHHHHHH | 18.51 | - | |
| 506 | Ubiquitination | AFTRSSEKSSGNCSK CEECCCCCCCCCCCC | 52.44 | 27667366 | |
| 512 | Ubiquitination | EKSSGNCSKGTAMIS CCCCCCCCCCEEEEE | 37.81 | 22817900 | |
| 515 | Phosphorylation | SGNCSKGTAMISSLS CCCCCCCEEEEEEEE | 19.45 | 24043423 | |
| 517 | Ubiquitination | NCSKGTAMISSLSLH CCCCCEEEEEEEECC | 2.83 | 22817900 | |
| 519 | Phosphorylation | SKGTAMISSLSLHSM CCCEEEEEEEECCCC | 16.49 | 24043423 | |
| 520 | Phosphorylation | KGTAMISSLSLHSMP CCEEEEEEEECCCCC | 15.85 | 24043423 | |
| 522 | Phosphorylation | TAMISSLSLHSMPSN EEEEEEEECCCCCCC | 26.45 | 24043423 | |
| 525 | Phosphorylation | ISSLSLHSMPSNSVQ EEEEECCCCCCCHHH | 37.37 | 24043423 | |
| 528 | Phosphorylation | LSLHSMPSNSVQLAY EECCCCCCCHHHHHH | 32.85 | 24043423 | |
| 530 | Phosphorylation | LHSMPSNSVQLAYVQ CCCCCCCHHHHHHHH | 18.64 | 24043423 | |
| 535 | Phosphorylation | SNSVQLAYVQLIRSL CCHHHHHHHHHHHHH | 9.42 | 24043423 | |
| 541 | Phosphorylation | AYVQLIRSLLKEGYQ HHHHHHHHHHHHCHH | 30.93 | 24719451 | |
| 544 | Ubiquitination | QLIRSLLKEGYQLGQ HHHHHHHHHCHHHHC | 55.15 | 21963094 | |
| 556 | Ubiquitination | LGQQSLCKRFWDKLN HHCHHHHHHHHHHHC | 56.79 | 29967540 | |
| 561 | Ubiquitination | LCKRFWDKLNLFLRG HHHHHHHHHCHHHHC | 29.85 | - | |
| 596 | Ubiquitination | KQIIRNIKFKAPPCN HHHHHHCCCCCCCCC | 44.34 | 22817900 | |
| 598 | Ubiquitination | IIRNIKFKAPPCNTF HHHHCCCCCCCCCCE | 55.79 | 21963094 | |
| 613 | Ubiquitination | VDLTSACKISPASYN EEHHHHCCCCCCCCC | 46.03 | 32015554 | |
| 615 | Phosphorylation | LTSACKISPASYNKE HHHHCCCCCCCCCHH | 10.42 | 25159151 | |
| 618 | O-linked_Glycosylation | ACKISPASYNKEESE HCCCCCCCCCHHHHH | 32.40 | 30379171 | |
| 619 | Phosphorylation | CKISPASYNKEESEQ CCCCCCCCCHHHHHH | 32.15 | - | |
| 621 | Sumoylation | ISPASYNKEESEQMG CCCCCCCHHHHHHHC | 55.41 | - | |
| 621 | Sumoylation | ISPASYNKEESEQMG CCCCCCCHHHHHHHC | 55.41 | - | |
| 621 | Ubiquitination | ISPASYNKEESEQMG CCCCCCCHHHHHHHC | 55.41 | 21906983 | |
| 621 (in isoform 1) | Ubiquitination | - | 55.41 | 21906983 | |
| 621 (in isoform 3) | Ubiquitination | - | 55.41 | 21906983 | |
| 621 (in isoform 4) | Ubiquitination | - | 55.41 | 21906983 | |
| 629 | Acetylation | EESEQMGKTSRKDMH HHHHHHCCCCHHHHH | 37.68 | 26051181 | |
| 629 | Ubiquitination | EESEQMGKTSRKDMH HHHHHHCCCCHHHHH | 37.68 | 21906983 | |
| 629 (in isoform 1) | Ubiquitination | - | 37.68 | 21906983 | |
| 629 (in isoform 3) | Ubiquitination | - | 37.68 | 21906983 | |
| 629 (in isoform 4) | Ubiquitination | - | 37.68 | 21906983 | |
| 633 | Ubiquitination | QMGKTSRKDMHCLEA HHCCCCHHHHHHHHC | 60.20 | 22817900 | |
| 641 | Phosphorylation | DMHCLEASSPTFSKE HHHHHHCCCCCCCCC | 27.72 | 23401153 | |
| 642 | Phosphorylation | MHCLEASSPTFSKEP HHHHHCCCCCCCCCC | 34.70 | 25159151 | |
| 644 | Phosphorylation | CLEASSPTFSKEPMK HHHCCCCCCCCCCCC | 42.35 | 28450419 | |
| 645 | Ubiquitination | LEASSPTFSKEPMKV HHCCCCCCCCCCCCC | 12.78 | 22817900 | |
| 646 | Phosphorylation | EASSPTFSKEPMKVQ HCCCCCCCCCCCCCC | 38.29 | 28450419 | |
| 647 | Ubiquitination | ASSPTFSKEPMKVQD CCCCCCCCCCCCCCC | 62.74 | 22817900 | |
| 651 | Sumoylation | TFSKEPMKVQDSVLI CCCCCCCCCCCEEEE | 47.67 | - | |
| 651 | Sumoylation | TFSKEPMKVQDSVLI CCCCCCCCCCCEEEE | 47.67 | - | |
| 651 | Ubiquitination | TFSKEPMKVQDSVLI CCCCCCCCCCCEEEE | 47.67 | 22817900 | |
| 651 (in isoform 1) | Ubiquitination | - | 47.67 | 21906983 | |
| 651 (in isoform 3) | Ubiquitination | - | 47.67 | 21906983 | |
| 651 (in isoform 4) | Ubiquitination | - | 47.67 | 21906983 | |
| 652 | Ubiquitination | FSKEPMKVQDSVLIK CCCCCCCCCCEEEEE | 6.59 | 22817900 | |
| 659 | Ubiquitination | VQDSVLIKADNTIEG CCCEEEEECCCCCCC | 45.59 | 21906983 | |
| 659 (in isoform 1) | Ubiquitination | - | 45.59 | 21906983 | |
| 659 (in isoform 3) | Ubiquitination | - | 45.59 | 21906983 | |
| 659 (in isoform 4) | Ubiquitination | - | 45.59 | 21906983 | |
| 674 | Ubiquitination | DNNEQNYIKDVKLED CCCCCCEEECCCHHH | 3.94 | 22817900 | |
| 675 | Sumoylation | NNEQNYIKDVKLEDH CCCCCEEECCCHHHH | 46.22 | - | |
| 675 | Ubiquitination | NNEQNYIKDVKLEDH CCCCCEEECCCHHHH | 46.22 | 21906983 | |
| 675 (in isoform 1) | Ubiquitination | - | 46.22 | 21906983 | |
| 675 (in isoform 3) | Ubiquitination | - | 46.22 | 21906983 | |
| 675 (in isoform 4) | Ubiquitination | - | 46.22 | 21906983 | |
| 678 | Sumoylation | QNYIKDVKLEDHLLA CCEEECCCHHHHHHH | 57.18 | - | |
| 678 | Sumoylation | QNYIKDVKLEDHLLA CCEEECCCHHHHHHH | 57.18 | - | |
| 678 | Ubiquitination | QNYIKDVKLEDHLLA CCEEECCCHHHHHHH | 57.18 | 22817900 | |
| 681 | Ubiquitination | IKDVKLEDHLLAGSC EECCCHHHHHHHHHH | 48.44 | 22817900 | |
| 687 | Phosphorylation | EDHLLAGSCLKQSSK HHHHHHHHHHHHHCC | 15.63 | 28555341 | |
| 690 | Ubiquitination | LLAGSCLKQSSKNIF HHHHHHHHHHCCCCC | 53.08 | 32015554 | |
| 694 | Acetylation | SCLKQSSKNIFTERA HHHHHHCCCCCCHHH | 60.35 | 25953088 | |
| 694 | Ubiquitination | SCLKQSSKNIFTERA HHHHHHCCCCCCHHH | 60.35 | 32015554 | |
| 706 | Ubiquitination | ERAEDQIKISTRKQK HHHHHHHHHCCCCCC | 25.60 | 21906983 | |
| 706 (in isoform 1) | Ubiquitination | - | 25.60 | 21906983 | |
| 706 (in isoform 3) | Ubiquitination | - | 25.60 | 21906983 | |
| 706 (in isoform 4) | Ubiquitination | - | 25.60 | 21906983 | |
| 711 | Ubiquitination | QIKISTRKQKSVKEI HHHHCCCCCCCHHHH | 63.27 | 22817900 | |
| 716 | Ubiquitination | TRKQKSVKEISSYTP CCCCCCHHHHHHCCC | 57.32 | 29967540 | |
| 719 | Phosphorylation | QKSVKEISSYTPKDC CCCHHHHHHCCCCCC | 20.55 | 29759185 | |
| 720 | Phosphorylation | KSVKEISSYTPKDCT CCHHHHHHCCCCCCC | 38.39 | 29759185 | |
| 722 | Phosphorylation | VKEISSYTPKDCTSR HHHHHHCCCCCCCCC | 26.30 | 29759185 | |
| 724 | Ubiquitination | EISSYTPKDCTSRNG HHHHCCCCCCCCCCC | 58.60 | - | |
| 757 | Ubiquitination | SSTDALEKVSTSNED CCCHHHHHHCCCCCC | 42.19 | 21906983 | |
| 757 (in isoform 1) | Ubiquitination | - | 42.19 | 21906983 | |
| 757 (in isoform 3) | Ubiquitination | - | 42.19 | 21906983 | |
| 757 (in isoform 4) | Ubiquitination | - | 42.19 | 21906983 | |
| 759 | Phosphorylation | TDALEKVSTSNEDFS CHHHHHHCCCCCCCC | 36.87 | 28555341 | |
| 766 | Phosphorylation | STSNEDFSLKDDALA CCCCCCCCCCHHHHH | 47.00 | 28555341 | |
| 768 | Ubiquitination | SNEDFSLKDDALAKT CCCCCCCCHHHHHHH | 52.98 | 21906983 | |
| 768 (in isoform 1) | Ubiquitination | - | 52.98 | 21906983 | |
| 768 (in isoform 3) | Ubiquitination | - | 52.98 | 21906983 | |
| 768 (in isoform 4) | Ubiquitination | - | 52.98 | 21906983 | |
| 774 | Ubiquitination | LKDDALAKTSKRKTK CCHHHHHHHCCCCCC | 54.93 | 21906983 | |
| 774 (in isoform 1) | Ubiquitination | - | 54.93 | 21906983 | |
| 774 (in isoform 3) | Ubiquitination | - | 54.93 | 21906983 | |
| 774 (in isoform 4) | Ubiquitination | - | 54.93 | 21906983 | |
| 777 | Ubiquitination | DALAKTSKRKTKVQK HHHHHHCCCCCCCCH | 64.25 | 22817900 | |
| 779 | Ubiquitination | LAKTSKRKTKVQKDE HHHHCCCCCCCCHHH | 57.33 | 22817900 | |
| 790 | Ubiquitination | QKDEICAKLSHVIKK CHHHHHHHHHHHHHH | 46.22 | 29967540 | |
| 792 | Phosphorylation | DEICAKLSHVIKKQH HHHHHHHHHHHHHHH | 18.27 | 28674151 | |
| 827 | Ubiquitination | IESFYSRKDTGVQKG HHHHHHCCCCCCCCC | 54.42 | 22817900 | |
| 827 (in isoform 1) | Ubiquitination | - | 54.42 | 21906983 | |
| 827 (in isoform 3) | Ubiquitination | - | 54.42 | 21906983 | |
| 827 (in isoform 4) | Ubiquitination | - | 54.42 | 21906983 | |
| 833 | Ubiquitination | RKDTGVQKGDGFIHN CCCCCCCCCCCEEEE | 57.47 | 21906983 | |
| 833 (in isoform 1) | Ubiquitination | - | 57.47 | 21906983 | |
| 833 (in isoform 3) | Ubiquitination | - | 57.47 | 21906983 | |
| 833 (in isoform 4) | Ubiquitination | - | 57.47 | 21906983 | |
| 842 | Phosphorylation | DGFIHNLSLDPSGVL CCEEEECEECCCCCC | 35.72 | 30576142 | |
| 852 | Ubiquitination | PSGVLDDKNGEQKSQ CCCCCCCCCCCCCCC | 67.53 | 21906983 | |
| 852 (in isoform 1) | Ubiquitination | - | 67.53 | 21906983 | |
| 852 (in isoform 3) | Ubiquitination | - | 67.53 | 21906983 | |
| 852 (in isoform 4) | Ubiquitination | - | 67.53 | 21906983 | |
| 857 | Ubiquitination | DDKNGEQKSQNNVLP CCCCCCCCCCCCCCC | 50.10 | 22817900 | |
| 857 (in isoform 1) | Ubiquitination | - | 50.10 | 21906983 | |
| 857 (in isoform 3) | Ubiquitination | - | 50.10 | 21906983 | |
| 857 (in isoform 4) | Ubiquitination | - | 50.10 | 21906983 | |
| 858 | Phosphorylation | DKNGEQKSQNNVLPK CCCCCCCCCCCCCCH | 37.52 | 24719451 | |
| 878 | Phosphorylation | NEELVIFSFHENNCK CCCEEEEEEECCCCE | 17.99 | - | |
| 894 | Sumoylation | QEFHVDGKELIPFTE EEEEECCEEEECCCC | 44.90 | - | |
| 894 | Sumoylation | QEFHVDGKELIPFTE EEEEECCEEEECCCC | 44.90 | 28112733 | |
| 894 | Ubiquitination | QEFHVDGKELIPFTE EEEEECCEEEECCCC | 44.90 | 21906983 | |
| 894 (in isoform 1) | Ubiquitination | - | 44.90 | 21906983 | |
| 894 (in isoform 3) | Ubiquitination | - | 44.90 | 21906983 | |
| 894 (in isoform 4) | Ubiquitination | - | 44.90 | 21906983 | |
| 900 | Phosphorylation | GKELIPFTEMTNASE CEEEECCCCCCCCCC | 21.35 | - | |
| 903 | Phosphorylation | LIPFTEMTNASEKKS EECCCCCCCCCCCCC | 22.77 | 26074081 | |
| 906 | Phosphorylation | FTEMTNASEKKSSPF CCCCCCCCCCCCCCC | 52.60 | 26074081 | |
| 908 | Ubiquitination | EMTNASEKKSSPFKD CCCCCCCCCCCCCHH | 56.30 | 21906983 | |
| 908 (in isoform 1) | Ubiquitination | - | 56.30 | 21906983 | |
| 908 (in isoform 3) | Ubiquitination | - | 56.30 | 21906983 | |
| 908 (in isoform 4) | Ubiquitination | - | 56.30 | 21906983 | |
| 909 | Ubiquitination | MTNASEKKSSPFKDL CCCCCCCCCCCCHHC | 52.71 | 22817900 | |
| 910 | Phosphorylation | TNASEKKSSPFKDLM CCCCCCCCCCCHHCC | 55.07 | 30266825 | |
| 911 | Phosphorylation | NASEKKSSPFKDLMT CCCCCCCCCCHHCCC | 43.14 | 23401153 | |
| 914 | Ubiquitination | EKKSSPFKDLMTVPE CCCCCCCHHCCCCCC | 54.02 | 21906983 | |
| 914 (in isoform 1) | Ubiquitination | - | 54.02 | 21906983 | |
| 914 (in isoform 3) | Ubiquitination | - | 54.02 | 21906983 | |
| 914 (in isoform 4) | Ubiquitination | - | 54.02 | 21906983 | |
| 918 | Phosphorylation | SPFKDLMTVPESRDE CCCHHCCCCCCCCCH | 39.96 | 23927012 | |
| 922 | Phosphorylation | DLMTVPESRDEEMSN HCCCCCCCCCHHHHC | 38.67 | 23927012 | |
| 928 | Phosphorylation | ESRDEEMSNSTSVIY CCCCHHHHCCHHHHH | 30.79 | 29978859 | |
| 930 | Phosphorylation | RDEEMSNSTSVIYSN CCHHHHCCHHHHHCC | 18.11 | 29978859 | |
| 931 | Phosphorylation | DEEMSNSTSVIYSNL CHHHHCCHHHHHCCC | 31.12 | 29978859 | |
| 932 | Phosphorylation | EEMSNSTSVIYSNLT HHHHCCHHHHHCCCC | 13.31 | 29978859 | |
| 935 | Phosphorylation | SNSTSVIYSNLTREQ HCCHHHHHCCCCHHH | 6.86 | 29978859 | |
| 935 (in isoform 4) | Phosphorylation | - | 6.86 | 27642862 | |
| 936 | Phosphorylation | NSTSVIYSNLTREQA CCHHHHHCCCCHHHC | 17.78 | 29978859 | |
| 947 | Phosphorylation | REQAPDISPKSDTLT HHHCCCCCCCCCCCC | 33.39 | 23401153 | |
| 947 (in isoform 4) | Phosphorylation | - | 33.39 | 21406692 | |
| 949 | Ubiquitination | QAPDISPKSDTLTDS HCCCCCCCCCCCCHH | 54.92 | 21906983 | |
| 949 (in isoform 1) | Ubiquitination | - | 54.92 | 21906983 | |
| 949 (in isoform 3) | Ubiquitination | - | 54.92 | 21906983 | |
| 949 (in isoform 4) | Ubiquitination | - | 54.92 | 21906983 | |
| 950 | Phosphorylation | APDISPKSDTLTDSQ CCCCCCCCCCCCHHH | 38.93 | 27362937 | |
| 952 | Phosphorylation | DISPKSDTLTDSQID CCCCCCCCCCHHHHH | 38.35 | 25159151 | |
| 954 | Phosphorylation | SPKSDTLTDSQIDRD CCCCCCCCHHHHHHH | 35.38 | 29255136 | |
| 956 | Phosphorylation | KSDTLTDSQIDRDLH CCCCCCHHHHHHHHH | 24.65 | 23401153 | |
| 964 | Ubiquitination | QIDRDLHKLSLLAQA HHHHHHHHHHHHHEE | 47.25 | 29967540 | |
| 978 | Phosphorylation | ASVITFPSDSPQNSS EEEEECCCCCCCCHH | 46.67 | 21712546 | |
| 980 | Phosphorylation | VITFPSDSPQNSSQL EEECCCCCCCCHHHH | 32.49 | 27251275 | |
| 984 | Phosphorylation | PSDSPQNSSQLQRKV CCCCCCCHHHHHHHH | 17.76 | 21712546 | |
| 985 | Phosphorylation | SDSPQNSSQLQRKVK CCCCCCHHHHHHHHH | 42.32 | 27251275 | |
| 1008 | Phosphorylation | NQNNVGDTSRGQVII CCCCCCCCCCCCEEE | 17.88 | 28985074 | |
| 1009 | Phosphorylation | QNNVGDTSRGQVIII CCCCCCCCCCCEEEE | 38.87 | 21815630 | |
| 1017 | Phosphorylation | RGQVIIISDSDDDDD CCCEEEEECCCCCCH | 22.21 | 29255136 | |
| 1017 (in isoform 4) | Phosphorylation | - | 22.21 | 21406692 | |
| 1019 | Phosphorylation | QVIIISDSDDDDDER CEEEEECCCCCCHHH | 35.83 | 29255136 | |
| 1019 (in isoform 4) | Phosphorylation | - | 35.83 | 21406692 | |
| 1029 | Phosphorylation | DDDERILSLEKLTKQ CCHHHCCCHHHHHHH | 31.92 | 21406692 | |
| 1029 (in isoform 4) | Phosphorylation | - | 31.92 | 21406692 | |
| 1032 | Ubiquitination | ERILSLEKLTKQDKI HHCCCHHHHHHHCCC | 67.74 | 21906983 | |
| 1032 (in isoform 1) | Ubiquitination | - | 67.74 | 21906983 | |
| 1032 (in isoform 3) | Ubiquitination | - | 67.74 | 21906983 | |
| 1032 (in isoform 4) | Ubiquitination | - | 67.74 | 21906983 | |
| 1035 | Ubiquitination | LSLEKLTKQDKICLE CCHHHHHHHCCCHHC | 67.92 | 22817900 | |
| 1035 (in isoform 1) | Ubiquitination | - | 67.92 | 21906983 | |
| 1035 (in isoform 3) | Ubiquitination | - | 67.92 | 21906983 | |
| 1035 (in isoform 4) | Ubiquitination | - | 67.92 | 21906983 | |
| 1038 | Ubiquitination | EKLTKQDKICLEREH HHHHHHCCCHHCCCC | 32.59 | 22817900 | |
| 1055 | O-linked_Glycosylation | QHVSTVNSKEEKNPV HCCCCCCCCCCCCCC | 36.79 | 30379171 | |
| 1056 | Sumoylation | HVSTVNSKEEKNPVK CCCCCCCCCCCCCCC | 65.77 | 28112733 | |
| 1056 | Ubiquitination | HVSTVNSKEEKNPVK CCCCCCCCCCCCCCC | 65.77 | 22817900 | |
| 1056 (in isoform 1) | Ubiquitination | - | 65.77 | 21906983 | |
| 1056 (in isoform 3) | Ubiquitination | - | 65.77 | 21906983 | |
| 1056 (in isoform 4) | Ubiquitination | - | 65.77 | 21906983 | |
| 1059 | Ubiquitination | TVNSKEEKNPVKEEK CCCCCCCCCCCCCHH | 68.58 | 22817900 | |
| 1063 | Sumoylation | KEEKNPVKEEKTETL CCCCCCCCCHHHEEE | 62.50 | - | |
| 1063 | Sumoylation | KEEKNPVKEEKTETL CCCCCCCCCHHHEEE | 62.50 | 25755297 | |
| 1109 | Sumoylation | SVQDGEKKCLAPIAN CCCCCCCEEECCCCC | 30.13 | - | |
| 1109 | Sumoylation | SVQDGEKKCLAPIAN CCCCCCCEEECCCCC | 30.13 | - | |
| 1109 | Ubiquitination | SVQDGEKKCLAPIAN CCCCCCCEEECCCCC | 30.13 | - | |
| 1132 | Ubiquitination | DYVSEVVKKGAEGIE HHHHHHHHHCCCCCH | 51.14 | - | |
| 1133 | Ubiquitination | YVSEVVKKGAEGIEE HHHHHHHHCCCCCHH | 52.31 | 21987572 | |
| 1146 | Phosphorylation | EEHTRPRSISVEEFC HHCCCCCCCCHHHHH | 23.15 | 30301811 | |
| 1148 | Phosphorylation | HTRPRSISVEEFCEI CCCCCCCCHHHHHEE | 25.40 | 30624053 | |
| 1163 | Ubiquitination | EVKKPKRKRSEKPMA EECCCCCCCCCCCCC | 67.42 | 22817900 | |
| 1165 | Phosphorylation | KKPKRKRSEKPMAED CCCCCCCCCCCCCCC | 53.67 | 28555341 | |
| 1167 | Acetylation | PKRKRSEKPMAEDPV CCCCCCCCCCCCCCC | 41.14 | 25953088 | |
| 1167 | Ubiquitination | PKRKRSEKPMAEDPV CCCCCCCCCCCCCCC | 41.14 | 22817900 | |
| 1167 (in isoform 1) | Ubiquitination | - | 41.14 | 21906983 | |
| 1167 (in isoform 3) | Ubiquitination | - | 41.14 | 21906983 | |
| 1167 (in isoform 4) | Ubiquitination | - | 41.14 | 21906983 | |
| 1190 | Ubiquitination | EGQSDTNKRDLVGND CCCCCCCCHHHCCCC | 49.75 | 21906983 | |
| 1190 (in isoform 1) | Ubiquitination | - | 49.75 | 21906983 | |
| 1190 (in isoform 3) | Ubiquitination | - | 49.75 | 21906983 | |
| 1190 (in isoform 4) | Ubiquitination | - | 49.75 | 21906983 | |
| 1223 | Phosphorylation | TTVSQKKSSKLCTCT EECCCCCCCCCCCCC | 39.48 | 24719451 | |
| 1224 | Phosphorylation | TVSQKKSSKLCTCTE ECCCCCCCCCCCCCC | 38.23 | 24719451 | |
| 1225 | Acetylation | VSQKKSSKLCTCTEP CCCCCCCCCCCCCCC | 55.46 | 25953088 | |
| 1228 | Phosphorylation | KKSSKLCTCTEPIRK CCCCCCCCCCCCCCC | 32.66 | 26074081 | |
| 1230 | Phosphorylation | SSKLCTCTEPIRKVP CCCCCCCCCCCCCCC | 27.00 | 24719451 | |
| 1239 | Phosphorylation | PIRKVPVSKTPKKTH CCCCCCCCCCCCCCC | 25.41 | 26657352 | |
| 1241 | Phosphorylation | RKVPVSKTPKKTHSD CCCCCCCCCCCCCCC | 32.60 | 26074081 | |
| 1256 | Phosphorylation | AKKGQNRSSNYLSCR CCCCCCCCCCCCCCC | 30.41 | 26657352 | |
| 1265 | Phosphorylation | NYLSCRTTPAIVPPK CCCCCCCCCCCCCCH | 7.44 | 26657352 | |
| 1297 | Phosphorylation | KKGPRKAYELSQRSL CCCCCHHHHHHHHCH | 22.04 | 23312004 | |
| 1300 | Phosphorylation | PRKAYELSQRSLDYV CCHHHHHHHHCHHHH | 16.17 | 24719451 | |
| 1303 | Phosphorylation | AYELSQRSLDYVAQL HHHHHHHCHHHHHHH | 20.25 | 28857561 | |
| 1306 | Phosphorylation | LSQRSLDYVAQLRDH HHHHCHHHHHHHHHC | 11.72 | - | |
| 1315 | Ubiquitination | AQLRDHGKTVGVVDT HHHHHCCCEEEEEEC | 36.30 | 21906983 | |
| 1315 (in isoform 1) | Ubiquitination | - | 36.30 | 21906983 | |
| 1315 (in isoform 3) | Ubiquitination | - | 36.30 | 21906983 | |
| 1315 (in isoform 4) | Ubiquitination | - | 36.30 | 21906983 | |
| 1324 | Ubiquitination | VGVVDTRKKTKLISP EEEEECCCCCCCCCC | 67.87 | - | |
| 1325 | Ubiquitination | GVVDTRKKTKLISPQ EEEECCCCCCCCCCC | 47.83 | - | |
| 1330 | Phosphorylation | RKKTKLISPQNLSVR CCCCCCCCCCCCCCC | 30.76 | 25159151 | |
| 1335 | Phosphorylation | LISPQNLSVRNNKKL CCCCCCCCCCCCHHH | 26.95 | 24732914 | |
| 1340 | Sumoylation | NLSVRNNKKLLTSQE CCCCCCCHHHCCHHH | 48.63 | 28112733 | |
| 1341 | Sumoylation | LSVRNNKKLLTSQEL CCCCCCHHHCCHHHH | 51.34 | - | |
| 1341 | Sumoylation | LSVRNNKKLLTSQEL CCCCCCHHHCCHHHH | 51.34 | 28112733 | |
| 1344 | Phosphorylation | RNNKKLLTSQELQMQ CCCHHHCCHHHHHHH | 38.51 | 30001349 | |
| 1345 | Phosphorylation | NNKKLLTSQELQMQR CCHHHCCHHHHHHHH | 22.94 | 25159151 | |
| 1366 | Phosphorylation | QKNRRRLSDCESTDV HHHHHCHHHHCCCCH | 38.10 | 29255136 | |
| 1366 (in isoform 4) | Phosphorylation | - | 38.10 | 21406692 | |
| 1370 | Phosphorylation | RRLSDCESTDVKRAG HCHHHHCCCCHHHCC | 35.92 | 29255136 | |
| 1371 | Phosphorylation | RLSDCESTDVKRAGS CHHHHCCCCHHHCCC | 23.63 | 29255136 | |
| 1415 | Sumoylation | SNRKQLIKCMPSEPE CCCCHHHCCCCCCCC | 32.83 | 28112733 | |
| 1430 | Phosphorylation | TIKAKHGSPATDDAC CHHHCCCCCCCCCCC | 15.87 | 28348404 | |
| 1433 | Phosphorylation | AKHGSPATDDACPLN HCCCCCCCCCCCCHH | 37.48 | 28348404 | |
| 1444 | Phosphorylation | CPLNQCDSVVLNGTV CCHHHCCEEEEECCC | 23.04 | 28348404 | |
| 1487 | Phosphorylation | LKEGEPDSSSDAEED HHCCCCCCCCCHHHC | 42.32 | 22210691 | |
| 1488 | Phosphorylation | KEGEPDSSSDAEEDN HCCCCCCCCCHHHCC | 39.35 | 25137130 | |
| 1489 | Phosphorylation | EGEPDSSSDAEEDNL CCCCCCCCCHHHCCC | 44.80 | 30576142 | |
| 1499 | Phosphorylation | EEDNLFLTQNDPEDM HHCCCEECCCCHHHC | 20.28 | 24144214 | |
| 1517 | Phosphorylation | SQMENDNYKLIELIH HHHCCCCEEEEEHHH | 15.27 | 30576142 | |
| 1550 | Acetylation | SLSGTKCKYKDCLET HCCCCCCCHHHHHHH | 57.82 | 11793403 | |
| 1552 | Acetylation | SGTKCKYKDCLETTK CCCCCCHHHHHHHCC | 27.71 | 11793415 | |
| 1552 | Ubiquitination | SGTKCKYKDCLETTK CCCCCCHHHHHHHCC | 27.71 | - | |
| 1557 | Phosphorylation | KYKDCLETTKNQGEY CHHHHHHHCCCCCCC | 30.07 | - | |
| 1558 | Phosphorylation | YKDCLETTKNQGEYC HHHHHHHCCCCCCCC | 20.72 | - | |
| 1559 | Ubiquitination | KDCLETTKNQGEYCP HHHHHHCCCCCCCCC | 55.48 | 33845483 | |
| 1567 | Ubiquitination | NQGEYCPKHSEVKAA CCCCCCCCCCCCCCC | 57.09 | 22817900 | |
| 1572 | Ubiquitination | CPKHSEVKAADEDVF CCCCCCCCCCCCHHH | 33.53 | 21906983 | |
| 1572 (in isoform 1) | Ubiquitination | - | 33.53 | 21906983 | |
| 1572 (in isoform 3) | Ubiquitination | - | 33.53 | 21906983 | |
| 1572 (in isoform 4) | Ubiquitination | - | 33.53 | 21906983 | |
| 1581 | Acetylation | ADEDVFRKPGLPPPA CCCHHHCCCCCCCCC | 31.79 | 26051181 | |
| 1581 | Ubiquitination | ADEDVFRKPGLPPPA CCCHHHCCCCCCCCC | 31.79 | 27667366 | |
| 1589 | Phosphorylation | PGLPPPASKPLRPTT CCCCCCCCCCCCCCC | 40.35 | 24719451 | |
| 1590 | Acetylation | GLPPPASKPLRPTTK CCCCCCCCCCCCCCE | 50.61 | 26051181 | |
| 1600 | Phosphorylation | RPTTKIFSSKSTSRI CCCCEECCCCCHHHH | 40.09 | 20860994 | |
| 1601 | Phosphorylation | PTTKIFSSKSTSRIA CCCEECCCCCHHHHC | 21.63 | 20860994 | |
| 1602 | Ubiquitination | TTKIFSSKSTSRIAG CCEECCCCCHHHHCC | 57.46 | 27667366 | |
| 1603 | Phosphorylation | TKIFSSKSTSRIAGL CEECCCCCHHHHCCC | 33.30 | 20860994 | |
| 1604 | Phosphorylation | KIFSSKSTSRIAGLS EECCCCCHHHHCCCC | 26.26 | 20860994 | |
| 1605 | Phosphorylation | IFSSKSTSRIAGLSK ECCCCCHHHHCCCCH | 28.87 | 20860994 | |
| 1611 | Phosphorylation | TSRIAGLSKSLETSS HHHHCCCCHHHHCCC | 21.20 | 28634298 | |
| 1612 | Ubiquitination | SRIAGLSKSLETSSA HHHCCCCHHHHCCCC | 65.19 | 23000965 | |
| 1612 (in isoform 1) | Ubiquitination | - | 65.19 | 21906983 | |
| 1612 (in isoform 3) | Ubiquitination | - | 65.19 | 21906983 | |
| 1612 (in isoform 4) | Ubiquitination | - | 65.19 | 21906983 | |
| 1613 | Phosphorylation | RIAGLSKSLETSSAL HHCCCCHHHHCCCCC | 28.23 | 19845377 | |
| 1616 | Phosphorylation | GLSKSLETSSALSPS CCCHHHHCCCCCCHH | 33.02 | 28634298 | |
| 1617 | Phosphorylation | LSKSLETSSALSPSL CCHHHHCCCCCCHHH | 12.30 | 29255136 | |
| 1618 | Phosphorylation | SKSLETSSALSPSLK CHHHHCCCCCCHHHC | 40.42 | 29255136 | |
| 1621 | Phosphorylation | LETSSALSPSLKNKS HHCCCCCCHHHCCCC | 16.50 | 29255136 | |
| 1623 | Phosphorylation | TSSALSPSLKNKSKG CCCCCCHHHCCCCCC | 48.91 | 29255136 | |
| 1625 | Methylation | SALSPSLKNKSKGIQ CCCCHHHCCCCCCHH | 67.67 | 42368729 | |
| 1625 | Ubiquitination | SALSPSLKNKSKGIQ CCCCHHHCCCCCCHH | 67.67 | 21906983 | |
| 1625 (in isoform 1) | Ubiquitination | - | 67.67 | 21906983 | |
| 1625 (in isoform 3) | Ubiquitination | - | 67.67 | 21906983 | |
| 1625 (in isoform 4) | Ubiquitination | - | 67.67 | 21906983 | |
| 1627 | Methylation | LSPSLKNKSKGIQSI CCHHHCCCCCCHHHH | 52.54 | 115981595 | |
| 1627 | Ubiquitination | LSPSLKNKSKGIQSI CCHHHCCCCCCHHHH | 52.54 | 22817900 | |
| 1628 | Phosphorylation | SPSLKNKSKGIQSIL CHHHCCCCCCHHHHH | 45.57 | 19845377 | |
| 1629 | Ubiquitination | PSLKNKSKGIQSILK HHHCCCCCCHHHHHC | 62.74 | 22817900 | |
| 1633 | Phosphorylation | NKSKGIQSILKVPQP CCCCCHHHHHCCCCC | 28.15 | 24719451 | |
| 1636 | Ubiquitination | KGIQSILKVPQPVPL CCHHHHHCCCCCCCE | 50.64 | - | |
| 1647 | Acetylation | PVPLIAQKPVGEMKN CCCEEECCCCCCCCC | 32.42 | 23954790 | |
| 1647 | Ubiquitination | PVPLIAQKPVGEMKN CCCEEECCCCCCCCC | 32.42 | 21906983 | |
| 1647 (in isoform 1) | Ubiquitination | - | 32.42 | 21906983 | |
| 1647 (in isoform 3) | Ubiquitination | - | 32.42 | 21906983 | |
| 1647 (in isoform 4) | Ubiquitination | - | 32.42 | 21906983 | |
| 1653 | Ubiquitination | QKPVGEMKNSCNVLH CCCCCCCCCCCEECC | 41.21 | 23503661 | |
| 1655 | Phosphorylation | PVGEMKNSCNVLHPQ CCCCCCCCCEECCCC | 11.10 | 30266825 | |
| 1663 | Phosphorylation | CNVLHPQSPNNSNRQ CEECCCCCCCCCCCC | 33.76 | 30266825 | |
| 1667 | Phosphorylation | HPQSPNNSNRQGCKV CCCCCCCCCCCCCCC | 39.78 | 30266825 | |
| 1673 | Ubiquitination | NSNRQGCKVPFGESK CCCCCCCCCCCCCCC | 60.82 | 29967540 | |
| 1680 | Ubiquitination | KVPFGESKYFPSSSP CCCCCCCCCCCCCCC | 46.76 | 21906983 | |
| 1680 (in isoform 1) | Ubiquitination | - | 46.76 | 21906983 | |
| 1680 (in isoform 3) | Ubiquitination | - | 46.76 | 21906983 | |
| 1680 (in isoform 4) | Ubiquitination | - | 46.76 | 21906983 | |
| 1681 | Phosphorylation | VPFGESKYFPSSSPV CCCCCCCCCCCCCCC | 29.96 | 27080861 | |
| 1684 | Phosphorylation | GESKYFPSSSPVNIL CCCCCCCCCCCCEEE | 33.28 | 22199227 | |
| 1685 | Phosphorylation | ESKYFPSSSPVNILL CCCCCCCCCCCEEEE | 38.61 | 22199227 | |
| 1686 | Phosphorylation | SKYFPSSSPVNILLS CCCCCCCCCCEEEEC | 36.89 | 22199227 | |
| 1693 | Phosphorylation | SPVNILLSSQSVSDT CCCEEEECCCCCCHH | 23.92 | 22199227 | |
| 1694 | Phosphorylation | PVNILLSSQSVSDTF CCEEEECCCCCCHHH | 26.83 | 22199227 | |
| 1696 | Phosphorylation | NILLSSQSVSDTFVK EEEECCCCCCHHHHH | 26.07 | 27080861 | |
| 1698 | Phosphorylation | LLSSQSVSDTFVKEV EECCCCCCHHHHHHH | 35.86 | 24719451 | |
| 1710 | Phosphorylation | KEVLKWKYEMFLNFG HHHHHHHHHHHCCCC | 16.12 | 24043423 | |
| 1724 | Phosphorylation | GQCGPPASLCQSISR CCCCCCHHHHHHCCC | 35.14 | 24043423 | |
| 1728 | Phosphorylation | PPASLCQSISRPVPV CCHHHHHHCCCCCCC | 22.87 | 24043423 | |
| 1730 | Phosphorylation | ASLCQSISRPVPVRF HHHHHHCCCCCCCCC | 35.46 | 24043423 | |
| 1801 | Ubiquitination | LEECELAKQLYPKEN HHHHHHHHHHCCCCC | 54.16 | 22817900 | |
| 1806 | Ubiquitination | LAKQLYPKENDLVFL HHHHHCCCCCCEEEE | 56.44 | 21906983 | |
| 1806 (in isoform 1) | Ubiquitination | - | 56.44 | 21906983 | |
| 1806 (in isoform 3) | Ubiquitination | - | 56.44 | 21906983 | |
| 1806 (in isoform 4) | Ubiquitination | - | 56.44 | 21906983 | |
| 1823 | Ubiquitination | ERINEEKKDTERNDI HHCCHHHCCCCCCCC | 73.49 | 29967540 | |
| 1843 | Ubiquitination | YHSGYVHKFRRTSVM HHCCCCCEEECEECH | 30.44 | 29967540 | |
| 1847 | Phosphorylation | YVHKFRRTSVMRNGK CCCEEECEECHHCCE | 22.78 | - | |
| 1860 | Phosphorylation | GKTECYLSIQTQENF CEEEEEEEEECCCCC | 6.03 | - | |
| 1898 | Phosphorylation | KAMSLLGSRNQLARA HHHHHHCCHHHHHHH | 28.20 | 28634120 | |
| 1917 | Ubiquitination | NPMDFCTKDLLTTTS CCCCCCCHHHCCCCH | 47.78 | 21963094 | |
| 1930 | Phosphorylation | TSERIIAYLRDFNED CHHHHHHHHHCCCHH | 7.58 | 22817900 | |
| 1940 | Ubiquitination | DFNEDQKKAIETAYA CCCHHHHHHHHHHHH | 49.30 | 29967540 | |
| 1944 | Phosphorylation | DQKKAIETAYAMVKH HHHHHHHHHHHHHHC | 20.89 | 29396449 | |
| 1946 | Phosphorylation | KKAIETAYAMVKHSP HHHHHHHHHHHHCCC | 11.58 | 29396449 | |
| 1950 | Ubiquitination | ETAYAMVKHSPSVAK HHHHHHHHCCCCCEE | 25.86 | 29967540 | |
| 1957 | Ubiquitination | KHSPSVAKICLIHGP HCCCCCEEEEEEECC | 31.62 | 29967540 | |
| 1969 | Ubiquitination | HGPPGTGKSKTIVGL ECCCCCCHHHHHHHH | 48.92 | 29967540 | |
| 1970 | Phosphorylation | GPPGTGKSKTIVGLL CCCCCCHHHHHHHHH | 36.05 | - | |
| 1971 | Ubiquitination | PPGTGKSKTIVGLLY CCCCCHHHHHHHHHH | 45.84 | - | |
| 1978 | Phosphorylation | KTIVGLLYRLLTENQ HHHHHHHHHHHHHCH | 12.31 | - | |
| 1997 | Ubiquitination | SDENSNAKIKQNRVL CCCCCCCCCCCCCEE | 55.47 | 29967540 | |
| 2019 | Ubiquitination | AVDELMKKIILEFKE HHHHHHHHHHHHHHH | 22.48 | - | |
| 2025 | Ubiquitination | KKIILEFKEKCKDKK HHHHHHHHHHHCCCC | 47.06 | - | |
| 2027 | Trimethylation | IILEFKEKCKDKKNP HHHHHHHHHCCCCCC | 47.37 | - | |
| 2027 | Methylation | IILEFKEKCKDKKNP HHHHHHHHHCCCCCC | 47.37 | 23644510 | |
| 2032 | Ubiquitination | KEKCKDKKNPLGNCG HHHHCCCCCCCCCCC | 74.14 | 29967540 | |
| 2050 | Ubiquitination | LVRLGPEKSINSEVL EEECCCCCCCCCHHH | 60.82 | 21906983 | |
| 2050 (in isoform 1) | Ubiquitination | - | 60.82 | 21906983 | |
| 2050 (in isoform 3) | Ubiquitination | - | 60.82 | 21906983 | |
| 2050 (in isoform 4) | Ubiquitination | - | 60.82 | 21906983 | |
| 2054 | Phosphorylation | GPEKSINSEVLKFSL CCCCCCCCHHHHHHH | 27.67 | 25137130 | |
| 2058 | Ubiquitination | SINSEVLKFSLDSQV CCCCHHHHHHHHHHH | 37.77 | - | |
| 2071 | Ubiquitination | QVNHRMKKELPSHVQ HHHHHHHHHCHHHHH | 55.96 | 29967540 | |
| 2075 | Phosphorylation | RMKKELPSHVQAMHK HHHHHCHHHHHHHHH | 49.25 | - | |
| 2084 | Ubiquitination | VQAMHKRKEFLDYQL HHHHHHHHHHHHHHH | 58.59 | 29967540 | |
| 2117 | Phosphorylation | QELDENISKVSKERQ HHHHHHHHHHHHHHH | 38.29 | 21406692 | |
| 2118 | Ubiquitination | ELDENISKVSKERQE HHHHHHHHHHHHHHH | 46.89 | 21906983 | |
| 2118 (in isoform 1) | Ubiquitination | - | 46.89 | 21906983 | |
| 2118 (in isoform 3) | Ubiquitination | - | 46.89 | 21906983 | |
| 2118 (in isoform 4) | Ubiquitination | - | 46.89 | 21906983 | |
| 2120 | Phosphorylation | DENISKVSKERQELA HHHHHHHHHHHHHHH | 32.32 | 21406692 | |
| 2121 | Ubiquitination | ENISKVSKERQELAS HHHHHHHHHHHHHHH | 60.96 | 22817900 | |
| 2129 | Ubiquitination | ERQELASKIKEVQGR HHHHHHHHHHHHHCC | 52.79 | 29967540 | |
| 2131 | Ubiquitination | QELASKIKEVQGRPQ HHHHHHHHHHHCCCC | 56.41 | 29967540 | |
| 2201 | Ubiquitination | PLIHRCNKLILVGDP HHHHHCCEEEEECCH | 40.30 | - | |
| 2255 | Phosphorylation | RLPILQLTVQYRMHP CCCEEHHEEEEECCC | 7.81 | 27251275 | |
| 2258 | Phosphorylation | ILQLTVQYRMHPDIC EEHHEEEEECCCCEE | 12.93 | 27251275 | |
| 2313 | Phosphorylation | SERRDNDSYINVQEI CCCCCCCCCCCHHHH | 33.88 | 28509920 | |
| 2314 | Phosphorylation | ERRDNDSYINVQEIK CCCCCCCCCCHHHHH | 10.20 | 28509920 | |
| 2349 | Ubiquitination | IGIITHYKAQKTMIQ CEEEEEHHHHHHHHH | 36.42 | - | |
| 2352 | Ubiquitination | ITHYKAQKTMIQKDL EEEHHHHHHHHHHHH | 44.94 | - | |
| 2357 | Ubiquitination | AQKTMIQKDLDKEFD HHHHHHHHHHHHHHH | 49.70 | 29967540 | |
| 2361 | Ubiquitination | MIQKDLDKEFDRKGP HHHHHHHHHHHCCCC | 68.52 | 22817900 | |
| 2366 | Sumoylation | LDKEFDRKGPAEVDT HHHHHHCCCCCCCCC | 71.71 | - | |
| 2366 | Sumoylation | LDKEFDRKGPAEVDT HHHHHHCCCCCCCCC | 71.71 | - | |
| 2366 | Ubiquitination | LDKEFDRKGPAEVDT HHHHHHCCCCCCCCC | 71.71 | 21906983 | |
| 2366 (in isoform 1) | Ubiquitination | - | 71.71 | 21906983 | |
| 2366 (in isoform 4) | Ubiquitination | - | 71.71 | 21906983 | |
| 2443 | Ubiquitination | QLIQDAQKRGAIIKT HHHHHHHHCCCEEEE | 55.29 | - | |
| 2449 | Ubiquitination | QKRGAIIKTCDKNYR HHCCCEEEECCCCCC | 36.67 | 29967540 | |
| 2461 | Ubiquitination | NYRHDAVKILKLKPV CCCCCHHHHHHHHHH | 44.00 | 33845483 | |
| 2461 (in isoform 3) | Ubiquitination | - | 44.00 | 21906983 | |
| 2464 | Ubiquitination | HDAVKILKLKPVLQR CCHHHHHHHHHHHHH | 58.92 | 29967540 | |
| 2466 | Ubiquitination | AVKILKLKPVLQRSL HHHHHHHHHHHHHHC | 31.34 | 29967540 | |
| 2468 (in isoform 3) | Ubiquitination | - | 7.32 | 21906983 | |
| 2472 | Phosphorylation | LKPVLQRSLTHPPTI HHHHHHHHCCCCCCC | 25.34 | 30266825 | |
| 2474 | Phosphorylation | PVLQRSLTHPPTIAP HHHHHHCCCCCCCCC | 33.32 | 23401153 | |
| 2478 | Phosphorylation | RSLTHPPTIAPEGSR HHCCCCCCCCCCCCC | 33.93 | 30266825 | |
| 2484 | Phosphorylation | PTIAPEGSRPQGGLP CCCCCCCCCCCCCCC | 38.84 | 23090842 | |
| 2490 | Ubiquitination | GSRPQGGLPSSKLDS CCCCCCCCCHHHCCC | 4.80 | 33845483 | |
| 2492 | Phosphorylation | RPQGGLPSSKLDSGF CCCCCCCHHHCCCCC | 45.18 | 23090842 | |
| 2493 | Phosphorylation | PQGGLPSSKLDSGFA CCCCCCHHHCCCCCC | 34.99 | 23090842 | |
| 2494 | Ubiquitination | QGGLPSSKLDSGFAK CCCCCHHHCCCCCCC | 61.73 | 21906983 | |
| 2494 (in isoform 1) | Ubiquitination | - | 61.73 | 21906983 | |
| 2497 | Phosphorylation | LPSSKLDSGFAKTSV CCHHHCCCCCCCCHH | 46.37 | 23312004 | |
| 2501 | Methylation | KLDSGFAKTSVAASL HCCCCCCCCHHHHHC | 38.79 | 42368685 | |
| 2501 | Ubiquitination | KLDSGFAKTSVAASL HCCCCCCCCHHHHHC | 38.79 | 22817900 | |
| 2501 (in isoform 1) | Ubiquitination | - | 38.79 | 21906983 | |
| 2502 | Phosphorylation | LDSGFAKTSVAASLY CCCCCCCCHHHHHCC | 25.63 | 23312004 | |
| 2503 | Phosphorylation | DSGFAKTSVAASLYH CCCCCCCHHHHHCCC | 14.73 | 23312004 | |
| 2507 | Phosphorylation | AKTSVAASLYHTPSD CCCHHHHHCCCCCCC | 21.52 | 23312004 | |
| 2509 | Phosphorylation | TSVAASLYHTPSDSK CHHHHHCCCCCCCCC | 10.93 | 23312004 | |
| 2511 | Phosphorylation | VAASLYHTPSDSKEI HHHHCCCCCCCCCEE | 15.78 | 23312004 | |
| 2513 | Phosphorylation | ASLYHTPSDSKEITL HHCCCCCCCCCEEEE | 56.52 | 23312004 | |
| 2515 | Phosphorylation | LYHTPSDSKEITLTV CCCCCCCCCEEEEEE | 36.20 | 23312004 | |
| 2519 | Phosphorylation | PSDSKEITLTVTSKD CCCCCEEEEEEEECC | 19.91 | 21406692 | |
| 2521 | Phosphorylation | DSKEITLTVTSKDPE CCCEEEEEEEECCCC | 17.06 | 24719451 | |
| 2523 | Phosphorylation | KEITLTVTSKDPERP CEEEEEEEECCCCCC | 25.48 | 21406692 | |
| 2523 | Ubiquitination | KEITLTVTSKDPERP CEEEEEEEECCCCCC | 25.48 | 22817900 | |
| 2523 (in isoform 4) | Ubiquitination | - | 25.48 | 21906983 | |
| 2524 | Phosphorylation | EITLTVTSKDPERPP EEEEEEEECCCCCCC | 30.63 | 24719451 | |
| 2530 | Ubiquitination | TSKDPERPPVHDQLQ EECCCCCCCCCHHHC | 33.34 | 22817900 | |
| 2530 (in isoform 4) | Ubiquitination | - | 33.34 | 21906983 | |
| 2538 (in isoform 4) | Phosphorylation | - | 38.59 | 27642862 | |
| 2550 (in isoform 4) | Phosphorylation | - | 38.33 | 21406692 | |
| 2561 | Phosphorylation | FLWDPQPSSPQHPGA EEECCCCCCCCCCCC | 49.78 | 26074081 | |
| 2562 | Phosphorylation | LWDPQPSSPQHPGAT EECCCCCCCCCCCCC | 34.95 | 26074081 | |
| 2569 | Phosphorylation | SPQHPGATPPTGEPG CCCCCCCCCCCCCCC | 35.40 | 26074081 | |
| 2572 | Phosphorylation | HPGATPPTGEPGFPV CCCCCCCCCCCCCCC | 56.21 | 26074081 | |
| 2612 | Phosphorylation | RGEPPAASPEASTCQ CCCCCCCCCCHHHHH | 25.94 | 29255136 | |
| 2616 | Phosphorylation | PAASPEASTCQSKCD CCCCCCHHHHHHHCC | 28.23 | 29255136 | |
| 2617 | Phosphorylation | AASPEASTCQSKCDD CCCCCHHHHHHHCCC | 22.93 | 29255136 | |
| 2620 | Phosphorylation | PEASTCQSKCDDPEE CCHHHHHHHCCCHHH | 37.08 | 29255136 | |
| 2639 | Phosphorylation | RREARAFSEGEQEKC HHHHHHCCCCCHHHC | 43.64 | 25159151 | |
| 2663 | Phosphorylation | NSRWDKRTLEQEDSS CCHHCHHHHCCCCCH | 40.15 | 29449344 | |
| 2669 | Phosphorylation | RTLEQEDSSSKKRKL HHHCCCCCHHHCHHC | 35.44 | 29449344 | |
| 2670 | Phosphorylation | TLEQEDSSSKKRKLL HHCCCCCHHHCHHCC | 59.50 | 29449344 | |
| 2671 | Phosphorylation | LEQEDSSSKKRKLL- HCCCCCHHHCHHCC- | 46.26 | 29449344 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SETX_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SETX_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SETX_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| BRCA1_HUMAN | BRCA1 | physical | 25184681 | |
| BRCA1_HUMAN | BRCA1 | physical | 25699710 | |
| SMN_HUMAN | SMN1 | physical | 26700805 | |
| VPS28_HUMAN | VPS28 | physical | 28514442 | |
| RHG01_HUMAN | ARHGAP1 | physical | 28514442 | |
| CD2AP_HUMAN | CD2AP | physical | 28514442 | |
| PAK1_HUMAN | PAK1 | physical | 28514442 |
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| Acetylation | |
| Reference | PubMed |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1647, AND MASS SPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-615; SER-1017 ANDSER-1019, AND MASS SPECTROMETRY. | |
| "Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1330, AND MASSSPECTROMETRY. | |
| "Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-956; SER-1330 ANDSER-1621, AND MASS SPECTROMETRY. | |
| "A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1621, AND MASSSPECTROMETRY. | |
| "Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1017 AND SER-1019, ANDMASS SPECTROMETRY. | |
