DGAT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DGAT1_HUMAN
• UniProt AC: O75907
• Protein Name: Diacylglycerol O-acyltransferase 1
• Gene Name: DGAT1
• Organism: Homo sapiens (Human).
• Sequence Length: 488
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders..
• Protein Sequence: MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREFYRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVSVPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLNYEAPAAEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	GSSRRRRTGSRPSSH CCCCCCCCCCCCCCC	37.38	23401153
14	Phosphorylation	SRRRRTGSRPSSHGG CCCCCCCCCCCCCCC	40.17	30278072
17	Phosphorylation	RRTGSRPSSHGGGGP CCCCCCCCCCCCCCC	33.58	30278072
18	Phosphorylation	RTGSRPSSHGGGGPA CCCCCCCCCCCCCCC	28.91	30278072
61	Phosphorylation	DGDAGVGSGHWELRC CCCCCCCCCCEEEEE	25.69	23898821
80	Phosphorylation	DSLFSSDSGFSNYRG HHHCCCCCCCCCHHH	43.62	-
233	Phosphorylation	ASAGKKASSAAAPHT HHCCCHHHCCCCCCC	29.41	23312004
234	Phosphorylation	SAGKKASSAAAPHTV HCCCHHHCCCCCCCC	27.13	23312004
240	Phosphorylation	SSAAAPHTVSYPDNL HCCCCCCCCCCCCCC	15.30	23312004
242	Phosphorylation	AAAPHTVSYPDNLTY CCCCCCCCCCCCCCH	31.91	23312004
243	Phosphorylation	AAPHTVSYPDNLTYR CCCCCCCCCCCCCHH	15.40	23312004
248	Phosphorylation	VSYPDNLTYRDLYYF CCCCCCCCHHHHHHH	23.82	23312004
249	Phosphorylation	SYPDNLTYRDLYYFL CCCCCCCHHHHHHHH	12.80	23312004
316	Phosphorylation	KPFKDMDYSRIIERL CCCCCCCHHHHHHHH	8.00	22817900
367	Phosphorylation	FYRDWWNSESVTYFW HHHHHCCCCCEEEEH	19.95	23684312
369	Phosphorylation	RDWWNSESVTYFWQN HHHCCCCCEEEEHHC	21.41	23684312
371	Phosphorylation	WWNSESVTYFWQNWN HCCCCCEEEEHHCCC	23.45	23684312
391	Malonylation	WCIRHFYKPMLRRGS HHHHHHHHHHHHCCC	24.02	26320211
398	Phosphorylation	KPMLRRGSSKWMART HHHHHCCCCHHHHHH	27.25	24260401

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DGAT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DGAT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DGAT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DGAT1_HUMAN	DGAT1	physical	11672446
GBRA4_HUMAN	GABRA4	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615863: Diarrhea 7 (DIAR7)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.