PDE1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDE1A_HUMAN
• UniProt AC: P54750
• Protein Name: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
• Gene Name: PDE1A
• Organism: Homo sapiens (Human).
• Sequence Length: 535
• Protein Description: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP..
• Protein Sequence: MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGSSATEIEE -----CCCCCHHHHH	18.59	22468782
4	Phosphorylation	----MGSSATEIEEL ----CCCCCHHHHHH	33.22	22468782
14	Phosphorylation	EIEELENTTFKYLTG HHHHHHHCCCHHHCH	25.00	22468782
40	Acetylation	GILRCLVKQLERGDV HHHHHHHHHHHCCCC	35.90	26051181
53	Ubiquitination	DVNVVDLKKNIEYAA CCCEEECHHHHHHHH	39.03	-
58	Phosphorylation	DLKKNIEYAASVLEA ECHHHHHHHHHHHHH	12.04	24719451
71	Phosphorylation	EAVYIDETRRLLDTE HHHHHHHHHHHCCCH	19.83	24719451
82	Phosphorylation	LDTEDELSDIQTDSV CCCHHHHHHCCCCCC	30.53	-
86	Phosphorylation	DELSDIQTDSVPSEV HHHHHCCCCCCCHHH	30.49	-
99	Phosphorylation	EVRDWLASTFTRKMG HHHHHHHHHHHHHCC	23.14	29083192
100	Phosphorylation	VRDWLASTFTRKMGM HHHHHHHHHHHHCCC	24.34	29083192
102	Phosphorylation	DWLASTFTRKMGMTK HHHHHHHHHHCCCCC	29.48	29083192
108	Phosphorylation	FTRKMGMTKKKPEEK HHHHCCCCCCCCCCC	33.70	29083192
185	Phosphorylation	FMIYELFTRYDLINR HHHHHHHHHHHHHHH	40.73	-
198	Phosphorylation	NRFKIPVSCLITFAE HHCCCCHHHHHHHHH	9.61	-
202	Phosphorylation	IPVSCLITFAEALEV CCHHHHHHHHHHHHH	12.12	-
212	Phosphorylation	EALEVGYSKYKNPYH HHHHHCCCCCCCCCC	24.47	-
214	Phosphorylation	LEVGYSKYKNPYHNL HHHCCCCCCCCCCCH	15.28	-
282	Phosphorylation	RSDVAILYNDRSVLE CCCEEEEECCCHHHH	14.65	19664995
403	Phosphorylation	AELGLPFSPLCDRKS CCCCCCCCCCCCCCC	18.28	25159151
416	Phosphorylation	KSTMVAQSQIGFIDF CCCHHHHHHHCCCEE	17.64	-
480	Phosphorylation	RRSNTKGSMSDGSYS HHCCCCCCCCCCCCC	19.37	28555341
482	Phosphorylation	SNTKGSMSDGSYSPD CCCCCCCCCCCCCCC	40.28	28555341
486	Phosphorylation	GSMSDGSYSPDYSLA CCCCCCCCCCCCCEE	29.74	24076635
487	Phosphorylation	SMSDGSYSPDYSLAA CCCCCCCCCCCCEEE	17.00	25159151
499	Phosphorylation	LAAVDLKSFKNNLVD EEEEEHHHHHHCHHH	49.07	24719451
527	Phosphorylation	AQEARTSSQKCEFIH HHHHHHHHHHCCCCC	32.80	29214152

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDE1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDE1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDE1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01244: Bepridil
• DB00201: Caffeine
• DB01023: Felodipine
• DB00622: Nicardipine