dbPTM

FIBA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FIBA_HUMAN
UniProt AC	P02671
Protein Name	Fibrinogen alpha chain
Gene Name	FGA
Organism	Homo sapiens (Human).
Sequence Length	866
Subcellular Localization	Secreted .
Protein Description	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways..
Protein Sequence	MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVVERHQSACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQDFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFSSANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQKNVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKDYEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPGNFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGSTSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSSGTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSPRPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESGSFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHTEKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTVIGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDGFRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESRGSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSSTSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAKSRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCDQETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEGEGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHFRVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHNNMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGIYYPGGSYDPRNNSPYEIENGVVWVSFRGADYSLRAVRMKIRPLVTQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MFSMRIVCLV -----CCCHHHHHHH	13.07	24505115
12	Phosphorylation	RIVCLVLSVVGTAWT HHHHHHHHHHCCCEE	13.79	24505115
16	Phosphorylation	LVLSVVGTAWTADSG HHHHHHCCCEECCCC	13.86	24505115
19	Phosphorylation	SVVGTAWTADSGEGD HHHCCCEECCCCCCC	20.37	24505115
22	Phosphorylation	GTAWTADSGEGDFLA CCCEECCCCCCCEEE	35.96	N.N.
45	Phosphorylation	RVVERHQSACKDSDW HHHHHCHHHHCCCCC	29.52	28857561
48	Acetylation	ERHQSACKDSDWPFC HHCHHHHCCCCCCCC	61.04	30585677
50	Phosphorylation	HQSACKDSDWPFCSD CHHHHCCCCCCCCCC	27.37	24275569
56	Phosphorylation	DSDWPFCSDEDWNYK CCCCCCCCCCCCCCC	44.40	26657352
63	Acetylation	SDEDWNYKCPSGCRM CCCCCCCCCCCCCCC	36.13	30585683
91	Phosphorylation	RINKLKNSLFEYQKN HHHHHHHHHHHHHHH	32.61	23911959
95	Nitration	LKNSLFEYQKNNKDS HHHHHHHHHHHCCCC	19.90	-
95	Phosphorylation	LKNSLFEYQKNNKDS HHHHHHHHHHHCCCC	19.90	23911959
100	Acetylation	FEYQKNNKDSHSLTT HHHHHHCCCCCCHHH	70.74	30585689
102	Phosphorylation	YQKNNKDSHSLTTNI HHHHCCCCCCHHHHH	19.31	26091039
106	O-linked_Glycosylation	NKDSHSLTTNIMEIL CCCCCCHHHHHHHHH	22.32	OGP
107	O-linked_Glycosylation	KDSHSLTTNIMEILR CCCCCHHHHHHHHHH	28.21	55834769
126	Phosphorylation	SANNRDNTYNRVSED CCCCCCCCHHHHCHH	26.85	-
127	Phosphorylation	ANNRDNTYNRVSEDL CCCCCCCHHHHCHHH	13.76	21253578
142	Acetylation	RSRIEVLKRKVIEKV HHHHHHHHHHHHHHH	56.18	7666927
148	Acetylation	LKRKVIEKVQHIQLL HHHHHHHHHHHHHHH	35.75	27178108
148	Glycation	LKRKVIEKVQHIQLL HHHHHHHHHHHHHHH	35.75	-
167	Acetylation	RAQLVDMKRLEVDID HHHHCCCHHCEECEE	49.74	27178108
179	Phosphorylation	DIDIKIRSCRGSCSR CEEEEEECCCCHHHH	16.19	-
185	Phosphorylation	RSCRGSCSRALAREV ECCCCHHHHHHHHHC	23.45	-
195	Acetylation	LAREVDLKDYEDQQK HHHHCCCCCHHHHHH	54.52	27178108
197	Nitration	REVDLKDYEDQQKQL HHCCCCCHHHHHHHH	21.59	-
210	Acetylation	QLEQVIAKDLLPSRD HHHHHHHHHHCCCCC	37.47	22507986
215	Phosphorylation	IAKDLLPSRDRQHLP HHHHHCCCCCCCCCC	46.94	25278378
227	Acetylation	HLPLIKMKPVPDLVP CCCCCEEEECCCCCC	37.55	22507986
227	Glycation	HLPLIKMKPVPDLVP CCCCCEEEECCCCCC	37.55	-
238	Acetylation	DLVPGNFKSQLQKVP CCCCCCHHHHHCCCC	41.09	30585671
239	Phosphorylation	LVPGNFKSQLQKVPP CCCCCHHHHHCCCCH	31.80	28857561
243	Acetylation	NFKSQLQKVPPEWKA CHHHHHCCCCHHHHH	66.36	22507986
252	O-linked_Glycosylation	PPEWKALTDMPQMRM CHHHHHHCCCHHHHE	34.80	55827075
252	Phosphorylation	PPEWKALTDMPQMRM CHHHHHHCCCHHHHE	34.80	28857561
270	O-linked_Glycosylation	RPGGNEITRGGSTSY CCCCCCCCCCCCCCC	19.65	OGP
270	Phosphorylation	RPGGNEITRGGSTSY CCCCCCCCCCCCCCC	19.65	28111955
274	O-linked_Glycosylation	NEITRGGSTSYGTGS CCCCCCCCCCCCCCC	19.60	OGP
274	Phosphorylation	NEITRGGSTSYGTGS CCCCCCCCCCCCCCC	19.60	23911959
275	O-linked_Glycosylation	EITRGGSTSYGTGSE CCCCCCCCCCCCCCC	29.28	OGP
275	Phosphorylation	EITRGGSTSYGTGSE CCCCCCCCCCCCCCC	29.28	29691806
276	O-linked_Glycosylation	ITRGGSTSYGTGSET CCCCCCCCCCCCCCC	24.22	OGP
276	Phosphorylation	ITRGGSTSYGTGSET CCCCCCCCCCCCCCC	24.22	29691806
277	Nitration	TRGGSTSYGTGSETE CCCCCCCCCCCCCCC	20.85	-
277	Phosphorylation	TRGGSTSYGTGSETE CCCCCCCCCCCCCCC	20.85	21082442
279	O-linked_Glycosylation	GGSTSYGTGSETESP CCCCCCCCCCCCCCC	29.33	OGP
279	Phosphorylation	GGSTSYGTGSETESP CCCCCCCCCCCCCCC	29.33	29691806
281	O-linked_Glycosylation	STSYGTGSETESPRN CCCCCCCCCCCCCCC	40.98	OGP
281	Phosphorylation	STSYGTGSETESPRN CCCCCCCCCCCCCCC	40.98	29691806
283	O-linked_Glycosylation	SYGTGSETESPRNPS CCCCCCCCCCCCCCC	43.38	55833573
283	Phosphorylation	SYGTGSETESPRNPS CCCCCCCCCCCCCCC	43.38	29691806
285	O-linked_Glycosylation	GTGSETESPRNPSSA CCCCCCCCCCCCCCC	36.26	OGP
285	Phosphorylation	GTGSETESPRNPSSA CCCCCCCCCCCCCCC	36.26	29691806
290	O-linked_Glycosylation	TESPRNPSSAGSWNS CCCCCCCCCCCCCCC	36.05	OGP
290	Phosphorylation	TESPRNPSSAGSWNS CCCCCCCCCCCCCCC	36.05	29691806
291	O-linked_Glycosylation	ESPRNPSSAGSWNSG CCCCCCCCCCCCCCC	37.60	OGP
291	Phosphorylation	ESPRNPSSAGSWNSG CCCCCCCCCCCCCCC	37.60	26657352
294	O-linked_Glycosylation	RNPSSAGSWNSGSSG CCCCCCCCCCCCCCC	23.85	OGP
294	Phosphorylation	RNPSSAGSWNSGSSG CCCCCCCCCCCCCCC	23.85	29691806
297	O-linked_Glycosylation	SSAGSWNSGSSGPGS CCCCCCCCCCCCCCC	33.52	OGP
297	Phosphorylation	SSAGSWNSGSSGPGS CCCCCCCCCCCCCCC	33.52	28857561
299	O-linked_Glycosylation	AGSWNSGSSGPGSTG CCCCCCCCCCCCCCC	31.76	OGP
299	Phosphorylation	AGSWNSGSSGPGSTG CCCCCCCCCCCCCCC	31.76	28857561
300	Phosphorylation	GSWNSGSSGPGSTGN CCCCCCCCCCCCCCC	53.16	28060719
304	Phosphorylation	SGSSGPGSTGNRNPG CCCCCCCCCCCCCCC	35.95	28060719
305	Phosphorylation	GSSGPGSTGNRNPGS CCCCCCCCCCCCCCC	44.37	28060719
312	Phosphorylation	TGNRNPGSSGTGGTA CCCCCCCCCCCCCCC	27.18	28270605
313	Phosphorylation	GNRNPGSSGTGGTAT CCCCCCCCCCCCCCE	46.41	28270605
315	O-linked_Glycosylation	RNPGSSGTGGTATWK CCCCCCCCCCCCEEC	34.09	OGP
315	Phosphorylation	RNPGSSGTGGTATWK CCCCCCCCCCCCEEC	34.09	28270605
318	O-linked_Glycosylation	GSSGTGGTATWKPGS CCCCCCCCCEECCCC	23.43	OGP
318	Phosphorylation	GSSGTGGTATWKPGS CCCCCCCCCEECCCC	23.43	28270605
320	O-linked_Glycosylation	SGTGGTATWKPGSSG CCCCCCCEECCCCCC	33.58	23050552
320	Phosphorylation	SGTGGTATWKPGSSG CCCCCCCEECCCCCC	33.58	28270605
325	O-linked_Glycosylation	TATWKPGSSGPGSTG CCEECCCCCCCCCCC	40.42	OGP
330	O-linked_Glycosylation	PGSSGPGSTGSWNSG CCCCCCCCCCCCCCC	32.50	OGP
331	O-linked_Glycosylation	GSSGPGSTGSWNSGS CCCCCCCCCCCCCCC	40.94	OGP
333	O-linked_Glycosylation	SGPGSTGSWNSGSSG CCCCCCCCCCCCCCC	24.15	OGP
336	O-linked_Glycosylation	GSTGSWNSGSSGTGS CCCCCCCCCCCCCCC	33.52	OGP
338	O-linked_Glycosylation	TGSWNSGSSGTGSTG CCCCCCCCCCCCCCC	25.97	OGP
339	O-linked_Glycosylation	GSWNSGSSGTGSTGN CCCCCCCCCCCCCCC	43.85	OGP
341	O-linked_Glycosylation	WNSGSSGTGSTGNQN CCCCCCCCCCCCCCC	29.88	OGP
344	O-linked_Glycosylation	GSSGTGSTGNQNPGS CCCCCCCCCCCCCCC	41.31	OGP
344	Phosphorylation	GSSGTGSTGNQNPGS CCCCCCCCCCCCCCC	41.31	28270605
351	O-linked_Glycosylation	TGNQNPGSPRPGSTG CCCCCCCCCCCCCCC	20.99	23050552
351	Phosphorylation	TGNQNPGSPRPGSTG CCCCCCCCCCCCCCC	20.99	28270605
356	Phosphorylation	PGSPRPGSTGTWNPG CCCCCCCCCCCCCCC	26.75	20058876
357	O-linked_Glycosylation	GSPRPGSTGTWNPGS CCCCCCCCCCCCCCC	44.54	OGP
357	Phosphorylation	GSPRPGSTGTWNPGS CCCCCCCCCCCCCCC	44.54	28270605
359	O-linked_Glycosylation	PRPGSTGTWNPGSSE CCCCCCCCCCCCCCC	23.35	OGP
359	Phosphorylation	PRPGSTGTWNPGSSE CCCCCCCCCCCCCCC	23.35	28270605
364	Phosphorylation	TGTWNPGSSERGSAG CCCCCCCCCCCCCCC	30.22	20058876
365	Phosphorylation	GTWNPGSSERGSAGH CCCCCCCCCCCCCCE	36.91	23025827
374	O-linked_Glycosylation	RGSAGHWTSESSVSG CCCCCEEECCCCCCC	19.55	OGP
374	Phosphorylation	RGSAGHWTSESSVSG CCCCCEEECCCCCCC	19.55	28270605
375	O-linked_Glycosylation	GSAGHWTSESSVSGS CCCCEEECCCCCCCC	30.23	OGP
375	Phosphorylation	GSAGHWTSESSVSGS CCCCEEECCCCCCCC	30.23	28270605
377	Phosphorylation	AGHWTSESSVSGSTG CCEEECCCCCCCCCC	35.49	28270605
378	O-linked_Glycosylation	GHWTSESSVSGSTGQ CEEECCCCCCCCCCC	19.09	OGP
378	Phosphorylation	GHWTSESSVSGSTGQ CEEECCCCCCCCCCC	19.09	28270605
380	Phosphorylation	WTSESSVSGSTGQWH EECCCCCCCCCCCEE	29.04	28270605
382	Phosphorylation	SESSVSGSTGQWHSE CCCCCCCCCCCEECC	23.12	28270605
383	Phosphorylation	ESSVSGSTGQWHSES CCCCCCCCCCEECCC	36.60	28270605
388	Phosphorylation	GSTGQWHSESGSFRP CCCCCEECCCCCCCC	30.42	28270605
390	Phosphorylation	TGQWHSESGSFRPDS CCCEECCCCCCCCCC	42.63	28270605
392	Phosphorylation	QWHSESGSFRPDSPG CEECCCCCCCCCCCC	27.62	28270605
397	O-linked_Glycosylation	SGSFRPDSPGSGNAR CCCCCCCCCCCCCCC	33.57	OGP
397	Phosphorylation	SGSFRPDSPGSGNAR CCCCCCCCCCCCCCC	33.57	28270605
400	O-linked_Glycosylation	FRPDSPGSGNARPNN CCCCCCCCCCCCCCC	32.05	OGP
400	Phosphorylation	FRPDSPGSGNARPNN CCCCCCCCCCCCCCC	32.05	28270605
412	Phosphorylation	PNNPDWGTFEEVSGN CCCCCCCCCEECCCC	24.50	27499020
417	Phosphorylation	WGTFEEVSGNVSPGT CCCCEECCCCCCCCC	28.12	27251275
421	O-linked_Glycosylation	EEVSGNVSPGTRREY EECCCCCCCCCCCEE	22.93	OGP
421	Phosphorylation	EEVSGNVSPGTRREY EECCCCCCCCCCCEE	22.93	28270605
424	Phosphorylation	SGNVSPGTRREYHTE CCCCCCCCCCEEECE	29.91	28270605
430	O-linked_Glycosylation	GTRREYHTEKLVTSK CCCCEEECEEEECCC	33.63	OGP
430	Phosphorylation	GTRREYHTEKLVTSK CCCCEEECEEEECCC	33.63	28857561
435	O-linked_Glycosylation	YHTEKLVTSKGDKEL EECEEEECCCCCHHH	34.85	OGP
435	Phosphorylation	YHTEKLVTSKGDKEL EECEEEECCCCCHHH	34.85	26657352
436	Phosphorylation	HTEKLVTSKGDKELR ECEEEECCCCCHHHC	27.45	28857561
448	Acetylation	ELRTGKEKVTSGSTT HHCCCCEEECCCCCC	55.06	22507986
450	O-linked_Glycosylation	RTGKEKVTSGSTTTT CCCCEEECCCCCCCC	38.14	OGP
450	Phosphorylation	RTGKEKVTSGSTTTT CCCCEEECCCCCCCC	38.14	29691806
451	O-linked_Glycosylation	TGKEKVTSGSTTTTR CCCEEECCCCCCCCE	33.46	OGP
451	Phosphorylation	TGKEKVTSGSTTTTR CCCEEECCCCCCCCE	33.46	29691806
453	O-linked_Glycosylation	KEKVTSGSTTTTRRS CEEECCCCCCCCEEE	23.50	OGP
453	N-linked_Glycosylation	KEKVTSGSTTTTRRS CEEECCCCCCCCEEE	23.50	1675636
453	Phosphorylation	KEKVTSGSTTTTRRS CEEECCCCCCCCEEE	23.50	29691806
454	O-linked_Glycosylation	EKVTSGSTTTTRRSC EEECCCCCCCCEEEC	31.52	OGP
454	Phosphorylation	EKVTSGSTTTTRRSC EEECCCCCCCCEEEC	31.52	29691806
455	O-linked_Glycosylation	KVTSGSTTTTRRSCS EECCCCCCCCEEECC	28.06	OGP
455	Phosphorylation	KVTSGSTTTTRRSCS EECCCCCCCCEEECC	28.06	29691806
456	O-linked_Glycosylation	VTSGSTTTTRRSCSK ECCCCCCCCEEECCC	20.56	OGP
456	Phosphorylation	VTSGSTTTTRRSCSK ECCCCCCCCEEECCC	20.56	29691806
457	O-linked_Glycosylation	TSGSTTTTRRSCSKT CCCCCCCCEEECCCE	23.22	OGP
457	Phosphorylation	TSGSTTTTRRSCSKT CCCCCCCCEEECCCE	23.22	29691806
460	Phosphorylation	STTTTRRSCSKTVTK CCCCCEEECCCEEEE	21.32	29691806
462	Phosphorylation	TTTRRSCSKTVTKTV CCCEEECCCEEEEEE	32.38	29691806
464	Phosphorylation	TRRSCSKTVTKTVIG CEEECCCEEEEEEEC	19.67	29691806
466	O-linked_Glycosylation	RSCSKTVTKTVIGPD EECCCEEEEEEECCC	26.65	OGP
466	Phosphorylation	RSCSKTVTKTVIGPD EECCCEEEEEEECCC	26.65	23312004
468	O-linked_Glycosylation	CSKTVTKTVIGPDGH CCCEEEEEEECCCCC	14.16	OGP
468	Phosphorylation	CSKTVTKTVIGPDGH CCCEEEEEEECCCCC	14.16	23312004
476	Acetylation	VIGPDGHKEVTKEVV EECCCCCCEEEEEEE	60.45	22507986
479	Phosphorylation	PDGHKEVTKEVVTSE CCCCCEEEEEEEECC	23.68	26657352
484	Phosphorylation	EVTKEVVTSEDGSDC EEEEEEEECCCCCCC	31.41	26657352
485	Phosphorylation	VTKEVVTSEDGSDCP EEEEEEECCCCCCCC	23.29	26657352
489	Phosphorylation	VVTSEDGSDCPEAMD EEECCCCCCCCCCCC	48.65	26657352
499	O-linked_Glycosylation	PEAMDLGTLSGIGTL CCCCCCCCCCCCCCC	25.66	OGP
499	Phosphorylation	PEAMDLGTLSGIGTL CCCCCCCCCCCCCCC	25.66	29691806
501	O-linked_Glycosylation	AMDLGTLSGIGTLDG CCCCCCCCCCCCCCC	28.36	OGP
501	Phosphorylation	AMDLGTLSGIGTLDG CCCCCCCCCCCCCCC	28.36	29691806
505	Phosphorylation	GTLSGIGTLDGFRHR CCCCCCCCCCCCCCC	21.54	29691806
522	O-linked_Glycosylation	DEAAFFDTASTGKTF CCCCEEECCCCCCCC	19.83	OGP
522	Phosphorylation	DEAAFFDTASTGKTF CCCCEEECCCCCCCC	19.83	26657352
524	O-linked_Glycosylation	AAFFDTASTGKTFPG CCEEECCCCCCCCCC	39.52	OGP
524	Phosphorylation	AAFFDTASTGKTFPG CCEEECCCCCCCCCC	39.52	23911959
525	O-linked_Glycosylation	AFFDTASTGKTFPGF CEEECCCCCCCCCCC	39.99	55832707
525	Phosphorylation	AFFDTASTGKTFPGF CEEECCCCCCCCCCC	39.99	29691806
528	O-linked_Glycosylation	DTASTGKTFPGFFSP ECCCCCCCCCCCHHH	36.09	OGP
528	Phosphorylation	DTASTGKTFPGFFSP ECCCCCCCCCCCHHH	36.09	28060719
534	O-linked_Glycosylation	KTFPGFFSPMLGEFV CCCCCCHHHHHHHHH	13.72	OGP
534	Phosphorylation	KTFPGFFSPMLGEFV CCCCCCHHHHHHHHH	13.72	29691806
542	Phosphorylation	PMLGEFVSETESRGS HHHHHHHCCCCCCCC	44.09	29691806
544	Phosphorylation	LGEFVSETESRGSES HHHHHCCCCCCCCCC	31.58	29691806
546	O-linked_Glycosylation	EFVSETESRGSESGI HHHCCCCCCCCCCCC	49.73	OGP
546	Phosphorylation	EFVSETESRGSESGI HHHCCCCCCCCCCCC	49.73	19824718
549	O-linked_Glycosylation	SETESRGSESGIFTN CCCCCCCCCCCCEEC	27.72	OGP
549	Phosphorylation	SETESRGSESGIFTN CCCCCCCCCCCCEEC	27.72	21082442
551	O-linked_Glycosylation	TESRGSESGIFTNTK CCCCCCCCCCEECCC	38.60	OGP
551	Phosphorylation	TESRGSESGIFTNTK CCCCCCCCCCEECCC	38.60	29691806
555	O-linked_Glycosylation	GSESGIFTNTKESSS CCCCCCEECCCCCCC	39.80	OGP
555	Phosphorylation	GSESGIFTNTKESSS CCCCCCEECCCCCCC	39.80	29691806
557	O-linked_Glycosylation	ESGIFTNTKESSSHH CCCCEECCCCCCCCC	32.88	OGP
557	Phosphorylation	ESGIFTNTKESSSHH CCCCEECCCCCCCCC	32.88	28857561
558	Acetylation	SGIFTNTKESSSHHP CCCEECCCCCCCCCC	58.63	22507986
560	O-linked_Glycosylation	IFTNTKESSSHHPGI CEECCCCCCCCCCCC	38.40	OGP
560	Phosphorylation	IFTNTKESSSHHPGI CEECCCCCCCCCCCC	38.40	26657352
561	O-linked_Glycosylation	FTNTKESSSHHPGIA EECCCCCCCCCCCCC	34.48	OGP
561	Phosphorylation	FTNTKESSSHHPGIA EECCCCCCCCCCCCC	34.48	28857561
562	O-linked_Glycosylation	TNTKESSSHHPGIAE ECCCCCCCCCCCCCC	34.78	55830579
562	Phosphorylation	TNTKESSSHHPGIAE ECCCCCCCCCCCCCC	34.78	28857561
565	Hydroxylation	KESSSHHPGIAEFPS CCCCCCCCCCCCCCC	30.38	19696023
572	O-linked_Glycosylation	PGIAEFPSRGKSSSY CCCCCCCCCCCCCCC	60.01	OGP
572	Phosphorylation	PGIAEFPSRGKSSSY CCCCCCCCCCCCCCC	60.01	29691806
576	Phosphorylation	EFPSRGKSSSYSKQF CCCCCCCCCCCCCCC	27.60	29691806
577	Phosphorylation	FPSRGKSSSYSKQFT CCCCCCCCCCCCCCC	36.46	29691806
578	Phosphorylation	PSRGKSSSYSKQFTS CCCCCCCCCCCCCCC	40.28	29691806
579	Nitration	SRGKSSSYSKQFTSS CCCCCCCCCCCCCCC	23.10	-
580	Phosphorylation	RGKSSSYSKQFTSST CCCCCCCCCCCCCCC	23.17	28857561
581	Acetylation	GKSSSYSKQFTSSTS CCCCCCCCCCCCCCC	40.99	22507986
584	O-linked_Glycosylation	SSYSKQFTSSTSYNR CCCCCCCCCCCCCCC	21.19	OGP
584	Phosphorylation	SSYSKQFTSSTSYNR CCCCCCCCCCCCCCC	21.19	29691806
585	O-linked_Glycosylation	SYSKQFTSSTSYNRG CCCCCCCCCCCCCCC	32.67	OGP
585	Phosphorylation	SYSKQFTSSTSYNRG CCCCCCCCCCCCCCC	32.67	29691806
586	O-linked_Glycosylation	YSKQFTSSTSYNRGD CCCCCCCCCCCCCCC	20.51	55832141
586	Phosphorylation	YSKQFTSSTSYNRGD CCCCCCCCCCCCCCC	20.51	29691806
587	O-linked_Glycosylation	SKQFTSSTSYNRGDS CCCCCCCCCCCCCCC	34.69	OGP
587	Phosphorylation	SKQFTSSTSYNRGDS CCCCCCCCCCCCCCC	34.69	29691806
588	O-linked_Glycosylation	KQFTSSTSYNRGDST CCCCCCCCCCCCCCC	23.51	OGP
588	Phosphorylation	KQFTSSTSYNRGDST CCCCCCCCCCCCCCC	23.51	29691806
589	Nitration	QFTSSTSYNRGDSTF CCCCCCCCCCCCCCC	14.68	-
589	Phosphorylation	QFTSSTSYNRGDSTF CCCCCCCCCCCCCCC	14.68	28060719
594	O-linked_Glycosylation	TSYNRGDSTFESKSY CCCCCCCCCCCCCEE	37.51	OGP
594	Phosphorylation	TSYNRGDSTFESKSY CCCCCCCCCCCCCEE	37.51	29691806
595	O-linked_Glycosylation	SYNRGDSTFESKSYK CCCCCCCCCCCCEEE	35.84	OGP
595	Phosphorylation	SYNRGDSTFESKSYK CCCCCCCCCCCCEEE	35.84	29691806
598	O-linked_Glycosylation	RGDSTFESKSYKMAD CCCCCCCCCEEEECC	23.78	OGP
598	Phosphorylation	RGDSTFESKSYKMAD CCCCCCCCCEEEECC	23.78	28857561
599	Acetylation	GDSTFESKSYKMADE CCCCCCCCEEEECCC	51.08	7822951
609	O-linked_Glycosylation	KMADEAGSEADHEGT EECCCCCCCCCCCCC	36.34	OGP
609	Phosphorylation	KMADEAGSEADHEGT EECCCCCCCCCCCCC	36.34	8461606
616	O-linked_Glycosylation	SEADHEGTHSTKRGH CCCCCCCCCCCCCCC	15.07	55827653
616	Phosphorylation	SEADHEGTHSTKRGH CCCCCCCCCCCCCCC	15.07	29691806
618	O-linked_Glycosylation	ADHEGTHSTKRGHAK CCCCCCCCCCCCCCC	35.15	OGP
618	Phosphorylation	ADHEGTHSTKRGHAK CCCCCCCCCCCCCCC	35.15	29691806
619	O-linked_Glycosylation	DHEGTHSTKRGHAKS CCCCCCCCCCCCCCC	19.70	OGP
619	Phosphorylation	DHEGTHSTKRGHAKS CCCCCCCCCCCCCCC	19.70	29691806
620	Acetylation	HEGTHSTKRGHAKSR CCCCCCCCCCCCCCC	60.44	7675133
625	Acetylation	STKRGHAKSRPVRDC CCCCCCCCCCCCCCC	41.12	14978003
626	Phosphorylation	TKRGHAKSRPVRDCD CCCCCCCCCCCCCCC	42.47	-
635 (in isoform 2)	O-linked_Glycosylation	-	2.45	OGP
641 (in isoform 2)	O-linked_Glycosylation	-	47.04	OGP
686	N-linked_Glycosylation	MDGSLNFNRTWQDYK CCCCCCCCCCCCHHH	39.12	17623646
686	N-linked_Glycosylation	MDGSLNFNRTWQDYK CCCCCCCCCCCCHHH	39.12	16335952
713	Nitration	EFWLGNDYLHLLTQR EEECCCHHHHHHHCC	10.46	-
835	Nitration	DPRNNSPYEIENGVV CCCCCCCCEEECCEE	29.38	-
852	Phosphorylation	SFRGADYSLRAVRMK EECCCCCCHHHHHHH	16.36	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
45	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
56	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
364	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
460	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
460	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
524	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
542	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
560	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
576	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
576	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
577	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
577	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
578	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
578	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM
609	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
609	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
618	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
618	S	Phosphorylation	Kinase	PKC_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
686	N	Glycosylation	16335952
Besides, glycosylation at Asn-686 is supported by large-scale glycoproteomics studies.
686	N	Glycosylation	16335952
Most likely, Asn-686 is not glycosylated in the healthy human body, or only with low efficiency.
686	N	Glycosylation	16335952
The alpha chain is normally not N-glycosylated.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FIBA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FIBB_HUMAN	FGB	physical	12356313
TPA_HUMAN	PLAT	physical	11170397
FIBA_HUMAN	FGA	physical	9689040
THRB_HUMAN	F2	physical	25241761
ITA2B_HUMAN	ITGA2B	physical	9058485
ITB3_HUMAN	ITGB3	physical	9058485

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
202400	Congenital afibrinogenemia (CAFBN)
105200	Amyloidosis 8 (AMYL8)
616004	Dysfibrinogenemia, congenital (DYSFIBRIN)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FIBA_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-686, AND MASSSPECTROMETRY.	19159218 [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-686, AND MASSSPECTROMETRY.	16335952 [Abstract]
Phosphorylation
Reference	PubMed
"An initial characterization of the serum phosphoproteome."; Zhou W., Ross M.M., Tessitore A., Ornstein D., Vanmeter A.,Liotta L.A., Petricoin E.F. III; J. Proteome Res. 8:5523-5531(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364 AND SER-546, TISSUESPECIFICITY, AND MASS SPECTROMETRY.	19824718 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-364; THR-412; SER-524;SER-549 AND SER-609, AND MASS SPECTROMETRY.	18088087 [Abstract]
"Phosphoproteomic analysis of the human pituitary."; Beranova-Giorgianni S., Zhao Y., Desiderio D.M., Giorgianni F.; Pituitary 9:109-120(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND MASSSPECTROMETRY.	16807684 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-277, AND MASSSPECTROMETRY.	18083107 [Abstract]

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