dbPTM

K0754_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	K0754_HUMAN
UniProt AC	O94854
Protein Name	Uncharacterized protein KIAA0754
Gene Name	KIAA0754
Organism	Homo sapiens (Human).
Sequence Length	1291
Subcellular Localization
Protein Description
Protein Sequence	MPPNFPEFAERIEASLSEVSEAGASNPSLQEKKESSSALTESSGHLDHREPQSESVTLEHVSKSIGIPEVQDFKNLSGDCQDFRFQQHSANPPHEFQPVESEAVATSGNTDVMQESRFSSATWPRATKSLAKGGFSEKQHPLGDTACTVEMPPLSPCLSEELLDPELHVLITPSLREKTESELKFEEDERWIMMEAEGEWEEEKLSDREKTFLMADEKNSLADIFEEREQANTAVVEDGSDCLAAVLRTFGHLSLGQICCPDDPQPAKDQLATVPKDIPLDCDCVLTGEDILGEVANRTAQGLEGLVSDSACTVGTIDAEQLSDTDSVQMFLELEKECLCEEGVTPLVELQNQISSEGLAASQDAENLLVISHFSGAALEKEQHLGLLHVRAKDYDTRLDCGYFNTLDSSQVPNAVELIAHVDIMRDTSTVSKEECEKVPFSPRTAEFKSRQPADLDSLEKLDPGGLLNSDHRVSHEEKLSGFIASELAKDNGSLSQGDCSQTEGNGEECIERVTFSFAFNHELTDVTSGPEVEVLYESNLLTDEIHLESGNVTVNQENNSLTSMGNVVTCELSVEKVCDEDGEAKELDYQATLLEDQAPAHFHRNFPEQVFQDLQRKSPESEILSLHLLVEELRLNPDGVETVNDTKPELNVASSEGGEMERRDSDSFLNIFPEKQVTKAGNTEPVLEEWIPVLQRPSRTAAVPTVKDALDAALPSPEEGTSIAAVPAPEGTAVVAALVPFPHEDILVASIVSLEEEDVTAAAVSAPERATVPAVTVSVPEGTAAVAAVSSPEETAPAVAAAITQEGMSAVAGFSPEWAALAITVPITEEDGTPEGPVTPATTVHAPEEPDTAAVRVSTPEEPASPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASFAAVVATLEEPTSPAASVPTPAAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEELSSPAASVPTPEEPASPAAAVSNLEEPASPAAAVPTPEVAAIPAASVPTPEVPAIPAAAVPPMEEVSPIGVPFLGVSAHTDSVPISEEGTPVLEEASSTGMWIKEDLDSLVFGIKEVTSTVLHGKVPLAATAGLNSDEVIVHFDSGKGLKSKVRFAGLTWW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	FAERIEASLSEVSEA HHHHHHHHHHHHHHH	21.46	29255136
16	Phosphorylation	AERIEASLSEVSEAG HHHHHHHHHHHHHHH	6.97	24719451
17	Phosphorylation	ERIEASLSEVSEAGA HHHHHHHHHHHHHHC	33.19	29255136
20	Phosphorylation	EASLSEVSEAGASNP HHHHHHHHHHHCCCH	20.06	30266825
25	Phosphorylation	EVSEAGASNPSLQEK HHHHHHCCCHHHHHH	48.64	30266825
28	Phosphorylation	EAGASNPSLQEKKES HHHCCCHHHHHHHHH	47.11	30266825
35	Phosphorylation	SLQEKKESSSALTES HHHHHHHHCCHHHHC	38.17	29255136
36	Phosphorylation	LQEKKESSSALTESS HHHHHHHCCHHHHCC	22.26	29255136
37	Phosphorylation	QEKKESSSALTESSG HHHHHHCCHHHHCCC	36.26	29255136
40	Phosphorylation	KESSSALTESSGHLD HHHCCHHHHCCCCCC	33.27	30266825
42	Phosphorylation	SSSALTESSGHLDHR HCCHHHHCCCCCCCC	36.06	25849741
43	Phosphorylation	SSALTESSGHLDHRE CCHHHHCCCCCCCCC	24.81	30266825
53 (in isoform 1)	Ubiquitination	-	42.42	21906983
53	Phosphorylation	LDHREPQSESVTLEH CCCCCCCCCCEEHHH	42.42	29255136
55	Phosphorylation	HREPQSESVTLEHVS CCCCCCCCEEHHHHH	26.16	29255136
57	Phosphorylation	EPQSESVTLEHVSKS CCCCCCEEHHHHHHH	35.39	29255136
62	Phosphorylation	SVTLEHVSKSIGIPE CEEHHHHHHHCCCCC	23.69	21406692
64	Phosphorylation	TLEHVSKSIGIPEVQ EHHHHHHHCCCCCHH	20.67	30266825
77	Phosphorylation	VQDFKNLSGDCQDFR HHCHHCCCCCCHHHC	41.81	25159151
89	Phosphorylation	DFRFQQHSANPPHEF HHCCCCCCCCCCCCC	25.96	22210691
106	Phosphorylation	VESEAVATSGNTDVM CCCEEEECCCCCCHH	30.48	22210691
107	Phosphorylation	ESEAVATSGNTDVMQ CCEEEECCCCCCHHH	21.95	22210691
119	Phosphorylation	VMQESRFSSATWPRA HHHHHHCCCCCCCHH	20.25	23403867
120	Phosphorylation	MQESRFSSATWPRAT HHHHHCCCCCCCHHH	27.32	30266825
122	Phosphorylation	ESRFSSATWPRATKS HHHCCCCCCCHHHHH	37.64	19664994
129	Phosphorylation	TWPRATKSLAKGGFS CCCHHHHHHHCCCCC	29.25	24719451
148	Phosphorylation	PLGDTACTVEMPPLS CCCCCCEEEECCCCC	19.62	28122231
155	Phosphorylation	TVEMPPLSPCLSEEL EEECCCCCCCCCHHH	21.24	25159151
156	Phosphorylation	VEMPPLSPCLSEELL EECCCCCCCCCHHHC	30.65	24719451
159	Phosphorylation	PPLSPCLSEELLDPE CCCCCCCCHHHCCHH	35.42	23898821
161	Phosphorylation	LSPCLSEELLDPELH CCCCCCHHHCCHHHE	51.78	27251275
164	Phosphorylation	CLSEELLDPELHVLI CCCHHHCCHHHEEEE	47.45	27251275
171	Phosphorylation	DPELHVLITPSLREK CHHHEEEECHHHHHH	5.32	-
172	Phosphorylation	PELHVLITPSLREKT HHHEEEECHHHHHHC	11.58	25627689
174	Phosphorylation	LHVLITPSLREKTES HEEEECHHHHHHCHH	31.26	24719451
176	Phosphorylation	VLITPSLREKTESEL EEECHHHHHHCHHHC	47.94	24719451
179	Phosphorylation	TPSLREKTESELKFE CHHHHHHCHHHCCCC	39.74	30266825
181	Phosphorylation	SLREKTESELKFEED HHHHHCHHHCCCCCC	54.16	23401153
189	Phosphorylation	ELKFEEDERWIMMEA HCCCCCCCCEEEEEE	53.87	-
193	Phosphorylation	EEDERWIMMEAEGEW CCCCCEEEEEECCCC	1.25	-
200	Phosphorylation	MMEAEGEWEEEKLSD EEEECCCCCHHHCCH	29.20	-
206	Phosphorylation	EWEEEKLSDREKTFL CCCHHHCCHHHCEEE	45.77	26471730
211	Phosphorylation	KLSDREKTFLMADEK HCCHHHCEEEHHHCC	19.76	-
213	Phosphorylation	SDREKTFLMADEKNS CHHHCEEEHHHCCCC	3.15	24719451
220	Phosphorylation	LMADEKNSLADIFEE EHHHCCCCHHHHHHH	35.68	21815630
249	Phosphorylation	CLAAVLRTFGHLSLG HHHHHHHHHCCCCCC	29.79	30576142
254	Phosphorylation	LRTFGHLSLGQICCP HHHHCCCCCCCCCCC	25.44	30576142
258	Phosphorylation	GHLSLGQICCPDDPQ CCCCCCCCCCCCCCC	2.18	19664994
265	Phosphorylation	ICCPDDPQPAKDQLA CCCCCCCCCCCHHHC	58.54	24719451
273	Phosphorylation	PAKDQLATVPKDIPL CCCHHHCCCCCCCCC	46.03	23312004
291	Phosphorylation	CVLTGEDILGEVANR EEEECHHHHHHHHHH	4.66	-
310	Phosphorylation	LEGLVSDSACTVGTI CCHHHCCCCCEECCC	20.10	-
315	Phosphorylation	SDSACTVGTIDAEQL CCCCCEECCCCHHHC	9.98	-
317	Phosphorylation	SACTVGTIDAEQLSD CCCEECCCCHHHCCC	3.77	24719451
346	Ubiquitination	LCEEGVTPLVELQNQ HHCCCCCHHHHHHHH	31.81	29967540
356	Phosphorylation	ELQNQISSEGLAASQ HHHHHHCCCCCCCCC	36.99	19651622
385	Phosphorylation	ALEKEQHLGLLHVRA HHHHHHHCCEEEEEC	5.30	27251275
390	Phosphorylation	QHLGLLHVRAKDYDT HHCCEEEEECCCCCC	6.85	27251275
403	Phosphorylation	DTRLDCGYFNTLDSS CCCCCCCCCCCCCHH	10.45	-
428	Phosphorylation	HVDIMRDTSTVSKEE EEEEECCCCCCCHHH	18.88	24732914
429	Phosphorylation	VDIMRDTSTVSKEEC EEEECCCCCCCHHHH	30.97	24732914
430	Phosphorylation	DIMRDTSTVSKEECE EEECCCCCCCHHHHC	30.78	24732914
432	Phosphorylation	MRDTSTVSKEECEKV ECCCCCCCHHHHCCC	34.14	24732914
442	Phosphorylation	ECEKVPFSPRTAEFK HHCCCCCCCCCHHHH	13.85	28355574
445	Phosphorylation	KVPFSPRTAEFKSRQ CCCCCCCCHHHHCCC	33.64	29514088
450	Phosphorylation	PRTAEFKSRQPADLD CCCHHHHCCCCCCHH	41.28	28111955
458	Phosphorylation	RQPADLDSLEKLDPG CCCCCHHHHHHCCCC	45.80	29507054
470	Phosphorylation	DPGGLLNSDHRVSHE CCCCCCCCCCCCCHH	34.46	28348404
475	Phosphorylation	LNSDHRVSHEEKLSG CCCCCCCCHHHHHHH	25.74	24961811
481	Phosphorylation	VSHEEKLSGFIASEL CCHHHHHHHHHHHHH	42.60	28555341
496	Phosphorylation	AKDNGSLSQGDCSQT HHCCCCCCCCCCCCC	33.54	28985074
501	Phosphorylation	SLSQGDCSQTEGNGE CCCCCCCCCCCCCHH	44.89	21712546
578	Phosphorylation	CELSVEKVCDEDGEA EEEEEEEEECCCCCE	2.92	24719451
590	Phosphorylation	GEAKELDYQATLLED CCEEEEHHHHEECCC	16.81	25159151
594	Phosphorylation	ELDYQATLLEDQAPA EEHHHHEECCCCCCH	5.74	-
597	Ubiquitination	YQATLLEDQAPAHFH HHHEECCCCCCHHHH	50.33	29967540
615	Ubiquitination	PEQVFQDLQRKSPES HHHHHHHHHHHCHHH	3.54	29967540
619	Phosphorylation	FQDLQRKSPESEILS HHHHHHHCHHHHHHH	35.77	25159151
622	Phosphorylation	LQRKSPESEILSLHL HHHHCHHHHHHHHHH	33.06	23607784
626	Phosphorylation	SPESEILSLHLLVEE CHHHHHHHHHHHHHH	21.29	23607784
637	Phosphorylation	LVEELRLNPDGVETV HHHHHCCCCCCCCCC	26.61	-
655	Phosphorylation	KPELNVASSEGGEME CCCCEEECCCCCCCC	25.33	26471730
656	Phosphorylation	PELNVASSEGGEMER CCCEEECCCCCCCCC	30.44	26471730
666	Phosphorylation	GEMERRDSDSFLNIF CCCCCCCCCCHHHCC	33.09	30266825
668	Phosphorylation	MERRDSDSFLNIFPE CCCCCCCCHHHCCCH	35.27	30266825
706	Phosphorylation	SRTAAVPTVKDALDA CCCCCCCCHHHHHHH	33.32	20068231
717	Phosphorylation	ALDAALPSPEEGTSI HHHHCCCCCCCCCCE	45.88	24275569
726	Phosphorylation	EEGTSIAAVPAPEGT CCCCCEEEEECCCCE	13.22	-
755	Phosphorylation	LVASIVSLEEEDVTA EEEEEEECCHHCCCC	7.13	17081983
802	Phosphorylation	ETAPAVAAAITQEGM HHHHHHHHHHHHHCH	7.87	32142685
804	Phosphorylation	APAVAAAITQEGMSA HHHHHHHHHHHCHHH	3.33	-
853	Phosphorylation	HAPEEPDTAAVRVST CCCCCCCCCEEEECC	27.51	-
1281	Phosphorylation	DSGKGLKSKVRFAGL CCCCCHHCCEEEECC	41.23	21955146

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of K0754_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of K0754_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of K0754_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of K0754_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of K0754_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; SER-28 AND SER-666,AND MASS SPECTROMETRY.	19690332 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-619, AND MASSSPECTROMETRY.	17081983 [Abstract]