K1C9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K1C9_HUMAN
• UniProt AC: P35527
• Protein Name: Keratin, type I cytoskeletal 9
• Gene Name: KRT9
• Organism: Homo sapiens (Human).
• Sequence Length: 623
• Protein Description: May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly..
• Protein Sequence: MSCRQFSSSYLSRSGGGGGGGLGSGGSIRSSYSRFSSSGGGGGGGRFSSSSGYGGGSSRVCGRGGGGSFGYSYGGGSGGGFSASSLGGGFGGGSRGFGGASGGGYSSSGGFGGGFGGGSGGGFGGGYGSGFGGFGGFGGGAGGGDGGILTANEKSTMQELNSRLASYLDKVQALEEANNDLENKIQDWYDKKGPAAIQKNYSPYYNTIDDLKDQIVDLTVGNNKTLLDIDNTRMTLDDFRIKFEMEQNLRQGVDADINGLRQVLDNLTMEKSDLEMQYETLQEELMALKKNHKEEMSQLTGQNSGDVNVEINVAPGKDLTKTLNDMRQEYEQLIAKNRKDIENQYETQITQIEHEVSSSGQEVQSSAKEVTQLRHGVQELEIELQSQLSKKAALEKSLEDTKNRYCGQLQMIQEQISNLEAQITDVRQEIECQNQEYSLLLSIKMRLEKEIETYHNLLEGGQEDFESSGAGKIGLGGRGGSGGSYGRGSRGGSGGSYGGGGSGGGYGGGSGSRGGSGGSYGGGSGSGGGSGGGYGGGSGGGHSGGSGGGHSGGSGGNYGGGSGSGGGSGGGYGGGSGSRGGSGGSHGGGSGFGGESGGSYGGGEEASGSGGGYGGGSGKSSHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MSCRQFSSSYLSRS -CCHHHCCHHHCCCC	15.27	27251275
14	Phosphorylation	SSSYLSRSGGGGGGG CHHHCCCCCCCCCCC	38.11	24905233
24	Phosphorylation	GGGGGLGSGGSIRSS CCCCCCCCCCCCCCC	45.05	23532336
27	Phosphorylation	GGLGSGGSIRSSYSR CCCCCCCCCCCCCCC	20.53	24905233
30	Phosphorylation	GSGGSIRSSYSRFSS CCCCCCCCCCCCCCC	31.77	24905233
31	Phosphorylation	SGGSIRSSYSRFSSS CCCCCCCCCCCCCCC	19.78	24905233
32	Phosphorylation	GGSIRSSYSRFSSSG CCCCCCCCCCCCCCC	12.71	24905233
33	Phosphorylation	GSIRSSYSRFSSSGG CCCCCCCCCCCCCCC	28.88	24905233
36	Phosphorylation	RSSYSRFSSSGGGGG CCCCCCCCCCCCCCC	23.60	24905233
37	Phosphorylation	SSYSRFSSSGGGGGG CCCCCCCCCCCCCCC	30.23	24905233
38	Phosphorylation	SYSRFSSSGGGGGGG CCCCCCCCCCCCCCC	40.01	24905233
48	Phosphorylation	GGGGGRFSSSSGYGG CCCCCCCCCCCCCCC	28.13	23401153
49	Phosphorylation	GGGGRFSSSSGYGGG CCCCCCCCCCCCCCC	26.30	23401153
50	Phosphorylation	GGGRFSSSSGYGGGS CCCCCCCCCCCCCCC	26.95	23401153
51	Phosphorylation	GGRFSSSSGYGGGSS CCCCCCCCCCCCCCC	37.67	23401153
53	Phosphorylation	RFSSSSGYGGGSSRV CCCCCCCCCCCCCCC	17.97	23401153
57	Phosphorylation	SSGYGGGSSRVCGRG CCCCCCCCCCCCCCC	20.46	23401153
58	Phosphorylation	SGYGGGSSRVCGRGG CCCCCCCCCCCCCCC	31.82	23401153
71	Phosphorylation	GGGGSFGYSYGGGSG CCCCCCCCCCCCCCC	9.19	-
77	Phosphorylation	GYSYGGGSGGGFSAS CCCCCCCCCCCCCHH	37.22	28348404
82	Phosphorylation	GGSGGGFSASSLGGG CCCCCCCCHHHCCCC	30.43	28348404
84	Phosphorylation	SGGGFSASSLGGGFG CCCCCCHHHCCCCCC	25.54	28348404
85	Phosphorylation	GGGFSASSLGGGFGG CCCCCHHHCCCCCCC	30.65	28348404
166	Phosphorylation	ELNSRLASYLDKVQA HHHHHHHHHHHHHHH	30.71	25106551
167	Phosphorylation	LNSRLASYLDKVQAL HHHHHHHHHHHHHHH	17.20	27251275
170	Ubiquitination	RLASYLDKVQALEEA HHHHHHHHHHHHHHH	33.38	-
205	Phosphorylation	QKNYSPYYNTIDDLK HHCCCCCCCCHHHHH	14.82	-
297	Phosphorylation	KNHKEEMSQLTGQNS HHHHHHHHHHCCCCC	25.89	-
304	Phosphorylation	SQLTGQNSGDVNVEI HHHCCCCCCCCEEEE	28.60	-
320	Phosphorylation	VAPGKDLTKTLNDMR ECCCCCHHHHHHHHH	31.92	-
396	Acetylation	SKKAALEKSLEDTKN HHHHHHHHHHHHHCH	62.28	26051181
442	Phosphorylation	QEYSLLLSIKMRLEK CHHHHHHHHHHHHHH	21.82	24719451
481	Phosphorylation	GLGGRGGSGGSYGRG CCCCCCCCCCCCCCC	42.69	-
484	Phosphorylation	GRGGSGGSYGRGSRG CCCCCCCCCCCCCCC	28.12	-
485	Phosphorylation	RGGSGGSYGRGSRGG CCCCCCCCCCCCCCC	17.70	18669648
489	Phosphorylation	GGSYGRGSRGGSGGS CCCCCCCCCCCCCCC	26.79	22210691
493	Phosphorylation	GRGSRGGSGGSYGGG CCCCCCCCCCCCCCC	42.69	24114839
496	Phosphorylation	SRGGSGGSYGGGGSG CCCCCCCCCCCCCCC	24.91	20044836
497	Phosphorylation	RGGSGGSYGGGGSGG CCCCCCCCCCCCCCC	24.06	20044836
502	Phosphorylation	GSYGGGGSGGGYGGG CCCCCCCCCCCCCCC	37.22	20044836
510	Phosphorylation	GGGYGGGSGSRGGSG CCCCCCCCCCCCCCC	36.55	20044836
512	Phosphorylation	GYGGGSGSRGGSGGS CCCCCCCCCCCCCCC	29.46	20044836
516	Phosphorylation	GSGSRGGSGGSYGGG CCCCCCCCCCCCCCC	42.69	-
519	Phosphorylation	SRGGSGGSYGGGSGS CCCCCCCCCCCCCCC	24.91	-
520	Phosphorylation	RGGSGGSYGGGSGSG CCCCCCCCCCCCCCC	24.06	-
576	Phosphorylation	GGGYGGGSGSRGGSG CCCCCCCCCCCCCCC	36.55	-
578	Phosphorylation	GYGGGSGSRGGSGGS CCCCCCCCCCCCCCC	29.46	-
596	Phosphorylation	GSGFGGESGGSYGGG CCCCCCCCCCCCCCC	52.29	-
607	Phosphorylation	YGGGEEASGSGGGYG CCCCCCCCCCCCCCC	36.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K1C9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K1C9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K1C9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K2C1_HUMAN	KRT1	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 144200: Keratoderma, palmoplantar, epidermolytic (EPPK)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.