PDE4B_HUMAN - dbPTM
PDE4B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDE4B_HUMAN
UniProt AC Q07343
Protein Name cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Gene Name PDE4B
Organism Homo sapiens (Human).
Sequence Length 736
Subcellular Localization
Protein Description Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents..
Protein Sequence MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MKKSRSVMTVM
----CCCCCCCEEEE		25.0325072903
6Phosphorylation--MKKSRSVMTVMAD
--CCCCCCCEEEEEC		24.2725072903
9PhosphorylationKKSRSVMTVMADDNV
CCCCCCEEEEECCCH		12.6525072903
41 (in isoform 3)Phosphorylation-35.7224117733
42 (in isoform 3)Phosphorylation-15.1424117733
46 (in isoform 3)Phosphorylation-5.7524117733
49 (in isoform 3)Phosphorylation-14.3422617229
50 (in isoform 3)Phosphorylation-6.7128842319
54 (in isoform 3)Phosphorylation-53.9222617229
65 (in isoform 3)Malonylation-25.3826320211
66 (in isoform 3)Phosphorylation-37.7124117733
78 (in isoform 2)Ubiquitination-26.1021906983
106PhosphorylationNGPSPGRSPLDPQAS
CCCCCCCCCCCCCCC		35.4129978859
113PhosphorylationSPLDPQASSSAGLVL
CCCCCCCCCCCCEEE		21.4129978859
114PhosphorylationPLDPQASSSAGLVLH
CCCCCCCCCCCEEEE		27.5029978859
115PhosphorylationLDPQASSSAGLVLHA
CCCCCCCCCCEEEEE		24.7029978859
123PhosphorylationAGLVLHATFPGHSQR
CCEEEEEECCCCCCC		21.4429978859
128PhosphorylationHATFPGHSQRRESFL
EEECCCCCCCCHHEE		31.1529978859
133PhosphorylationGHSQRRESFLYRSDS
CCCCCCHHEEECCCC		20.8123927012
136PhosphorylationQRRESFLYRSDSDYD
CCCHHEEECCCCCCC		13.1723403867
138PhosphorylationRESFLYRSDSDYDLS
CHHEEECCCCCCCCC		28.1022167270
140PhosphorylationSFLYRSDSDYDLSPK
HEEECCCCCCCCCHH		39.0425463755
142PhosphorylationLYRSDSDYDLSPKAM
EECCCCCCCCCHHHH		23.8023927012
145PhosphorylationSDSDYDLSPKAMSRN
CCCCCCCCHHHHHCC		22.8125463755
153PhosphorylationPKAMSRNSSLPSEQH
HHHHHCCCCCCHHHC		31.9427080861
154PhosphorylationKAMSRNSSLPSEQHG
HHHHCCCCCCHHHCC		48.0927080861
157PhosphorylationSRNSSLPSEQHGDDL
HCCCCCCHHHCCCCE		56.0027080861
167PhosphorylationHGDDLIVTPFAQVLA
CCCCEEECHHHHHHH		13.0017081983
175PhosphorylationPFAQVLASLRSVRNN
HHHHHHHHHHHHHHC		21.8324719451
197PhosphorylationHGTSNKRSPAASQPP
CCCCCCCCCCHHCCC		22.0929255136
201PhosphorylationNKRSPAASQPPVSRV
CCCCCCHHCCCCCCC		45.3822817900
214PhosphorylationRVNPQEESYQKLAME
CCCCCHHHHHHHHHH		31.92-
215PhosphorylationVNPQEESYQKLAMET
CCCCHHHHHHHHHHH		16.97-
234 (in isoform 3)Ubiquitination-37.9321906983
249 (in isoform 1)Ubiquitination-50.1721906983
249UbiquitinationVSEMASNKFKRMLNR
HHHHHHHHHHHHHHH		50.17-
251MethylationEMASNKFKRMLNREL
HHHHHHHHHHHHHHH		38.21-
259PhosphorylationRMLNRELTHLSEMSR
HHHHHHHHHHHHHHC		18.9323186163
262PhosphorylationNRELTHLSEMSRSGN
HHHHHHHHHHHCCCC		24.5324719451
265PhosphorylationLTHLSEMSRSGNQVS
HHHHHHHHCCCCHHH		21.1728555341
290PhosphorylationQNDVEIPSPTQKDRE
CCCCCCCCCCHHHHH		46.3629255136
292PhosphorylationDVEIPSPTQKDREKK
CCCCCCCCHHHHHHH		53.2229255136
309PhosphorylationQQLMTQISGVKKLMH
HHHHHHHHHHHHHHC		27.9328348404
317PhosphorylationGVKKLMHSSSLNNTS
HHHHHHCCCCCCCCC		13.9924117733
318PhosphorylationVKKLMHSSSLNNTSI
HHHHHCCCCCCCCCC		24.9429507054
319PhosphorylationKKLMHSSSLNNTSIS
HHHHCCCCCCCCCCH		37.8225159151
323PhosphorylationHSSSLNNTSISRFGV
CCCCCCCCCCHHCCC		26.7728857561
324PhosphorylationSSSLNNTSISRFGVN
CCCCCCCCCHHCCCC		22.2327080861
326PhosphorylationSLNNTSISRFGVNTE
CCCCCCCHHCCCCCC		22.7127080861
520PhosphorylationMVLATDMSKHMSLLA
HHHHCCHHHHHHHHH		23.40-
521AcetylationVLATDMSKHMSLLAD
HHHCCHHHHHHHHHH		36.3712433547
536AcetylationLKTMVETKKVTSSGV
HHHHHHCCCCCCCCE		31.576570343
537AcetylationKTMVETKKVTSSGVL
HHHHHCCCCCCCCEE		59.1619809671
540PhosphorylationVETKKVTSSGVLLLD
HHCCCCCCCCEEEEC		28.2520068231
541PhosphorylationETKKVTSSGVLLLDN
HCCCCCCCCEEEECC		24.45-
549PhosphorylationGVLLLDNYTDRIQVL
CEEEECCCHHHHHHH		15.08-
601PhosphorylationRERGMEISPMCDKHT
HHCCCCCCCCCCCCC		8.0221815630
610PhosphorylationMCDKHTASVEKSQVG
CCCCCCCCCCHHHCC		31.7824719451
652PhosphorylationLEDNRNWYQSMIPQS
HHHHHHHHHHHCCCC		8.3427080861
654PhosphorylationDNRNWYQSMIPQSPS
HHHHHHHHHCCCCCC		11.7227080861
659PhosphorylationYQSMIPQSPSPPLDE
HHHHCCCCCCCCCCC		23.2227732954
661PhosphorylationSMIPQSPSPPLDEQN
HHCCCCCCCCCCCCC		44.3827080861
689PhosphorylationLTLDEEDSEGPEKEG
EECCCCCCCCCCCCC		47.9728348404
703PhosphorylationGEGHSYFSSTKTLCV
CCCCCCCCCCCEEEE		28.9427251275
704PhosphorylationEGHSYFSSTKTLCVI
CCCCCCCCCCEEEEE		24.8327251275
718PhosphorylationIDPENRDSLGETDID
ECCCCCCCCCCCCCE		34.7322617229
722PhosphorylationNRDSLGETDIDIATE
CCCCCCCCCCEECCC		36.1328348404
728PhosphorylationETDIDIATEDKSPVD
CCCCEECCCCCCCCC		45.0828348404
732PhosphorylationDIATEDKSPVDT---
EECCCCCCCCCC---		42.3415345747
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
133SPhosphorylationKinasePRKACAP17612
GPS
133SPhosphorylationKinasePKA-FAMILY-GPS
133SPhosphorylationKinasePKA_GROUP-PhosphoELM
487SPhosphorylationKinaseMAPK1P28482
GPS
659SPhosphorylationKinaseMAPK1P28482
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDE4B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDE4B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LIS1_HUMANPAFAH1B1physical
21652625
MAGAB_HUMANMAGEA11physical
24722188
RCBT2_HUMANRCBTB2physical
24722188
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00131Adenosine monophosphate
DB01427Amrinone
DB00201Caffeine
DB00651Dyphylline
DB00824Enprofylline
DB05266Ibudilast
DB01088Iloprost
DB00920Ketotifen
DB01113Papaverine
DB00806Pentoxifylline
DB01656Roflumilast
DB01412Theobromine
DB00277Theophylline
Regulatory Network of PDE4B_HUMAN

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Related Literatures of Post-Translational Modification

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