RCBT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RCBT2_HUMAN
• UniProt AC: O95199
• Protein Name: RCC1 and BTB domain-containing protein 2
• Gene Name: RCBTB2
• Organism: Homo sapiens (Human).
• Sequence Length: 551
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, acrosome . Mainly found in the acrosomal cap region.
• Protein Sequence: MEEELPLFSGDSGKPVQATLSSLKMLDVGKWPIFSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAAKTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	SGKPVQATLSSLKML CCCCEEEEHHHCCCC	15.30	29978859
21	Phosphorylation	KPVQATLSSLKMLDV CCEEEEHHHCCCCCC	29.30	26699800
22	Phosphorylation	PVQATLSSLKMLDVG CEEEEHHHCCCCCCC	34.81	26699800
307	Ubiquitination	PTPVTVEKDRIIEIA CCCCEEECCCEEEEE	48.23	-
397	Ubiquitination	NPDTADLKFLVDGKY CCCCCCEEEEECCEE	36.88	-
497	Phosphorylation	ENAIALLSAAVKYDA HHHHHHHHHHHCCCH	18.29	26074081
541	Phosphorylation	DLLKNFISKASRVGA HHHHHHHHHHHHHCC	20.31	21712546
544	Phosphorylation	KNFISKASRVGAFKN HHHHHHHHHHCCCCC	31.10	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RCBT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RCBT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RCBT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSN4_HUMAN	COPS4	physical	16189514
RCBT2_HUMAN	RCBTB2	physical	16189514
RCBT2_HUMAN	RCBTB2	physical	25416956
UBC9_HUMAN	UBE2I	physical	25416956
SYFM_HUMAN	FARS2	physical	25416956
RCBT1_HUMAN	RCBTB1	physical	28514442
HEMH_HUMAN	FECH	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.