TXND2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TXND2_HUMAN
• UniProt AC: Q86VQ3
• Protein Name: Thioredoxin domain-containing protein 2
• Gene Name: TXNDC2
• Organism: Homo sapiens (Human).
• Sequence Length: 553
• Subcellular Localization: Cytoplasm . In ejaculated spermatozoa, it localizes in the caudal region of the head to the end of the principal piece.
• Protein Description: Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase..
• Protein Sequence: MDVDKELGMESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQAKEKAFLPMVSHTFHMRTEESDASQEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFEASLKEAGERLVAVDFSATWCGPCRTIRPFFHALSVKHEDVVFLEVDADNCEEVVRECAIMCVPTFQFYKKEEKVDELCGALKEKLEAVIAELK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
104	Phosphorylation	SHPKQDDSPKSSEET CCCCCCCCCCCCCCC	42.38	26074081
107	Phosphorylation	KQDDSPKSSEETIQP CCCCCCCCCCCCCCC	46.49	26074081
108	Phosphorylation	QDDSPKSSEETIQPK CCCCCCCCCCCCCCC	45.65	26074081
111	Phosphorylation	SPKSSEETIQPKEGD CCCCCCCCCCCCCCC	22.36	26074081
137	Phosphorylation	KKEDLPKSSEKAIQP CHHHCCCCCCCCCCC	41.61	25599653
172	Phosphorylation	PKASVKPSQPKEGDI CCCCCCCCCCCCCCC	54.09	25599653
232	Phosphorylation	AKTSVKPSQPKESDI CCCCCCCCCCCCCCC	54.09	28122231
237	Phosphorylation	KPSQPKESDIPKSPE CCCCCCCCCCCCCHH	47.14	28122231
277	Phosphorylation	PKASVKPSQPKEGDI CCCCCCCCCCCCCCC	54.09	-
302	Phosphorylation	KEGDLPKSLEEAIQP CCCCCCHHHHHHHCC	38.79	25693802
347	Phosphorylation	KEGDIPKSPEETIQP CCCCCCCCHHHCCCC	31.99	27251275
351	Phosphorylation	IPKSPEETIQPKKGD CCCCHHHCCCCCCCC	24.21	27251275
362	Phosphorylation	KKGDIPKSPEEAIQP CCCCCCCCHHHHCCC	31.99	-
377	Phosphorylation	KEGDIPKSPKQAIQP CCCCCCCCHHHCCCC	31.79	25262027
392	Phosphorylation	KEGDIPKSLEEAIPP CCCCCCCHHHHHCCH	35.34	-
407	Phosphorylation	KEIDIPKSPEETIQP HHCCCCCCHHHCCCC	31.99	23312004
411	Phosphorylation	IPKSPEETIQPKEDD CCCCHHHCCCCCCCC	24.21	23312004
542	Acetylation	DELCGALKEKLEAVI HHHHHHHHHHHHHHH	52.87	18529145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TXND2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TXND2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TXND2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TXND2_HUMAN	TXNDC2	physical	12387870

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.