CNMD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNMD_HUMAN
• UniProt AC: O75829
• Protein Name: Leukocyte cell-derived chemotaxin 1 {ECO:0000305}
• Gene Name: CNMD {ECO:0000312|HGNC:HGNC:17005}
• Organism: Homo sapiens (Human).
• Sequence Length: 334
• Subcellular Localization: Chondromodulin-1: Secreted, extracellular space, extracellular matrix. Accumulated in the inter-territorial matrix of cartilage.; Chondrosurfactant protein: Endomembrane system ; Single-pass membrane protein .
• Protein Description: Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization..
• Protein Sequence: MTENSDKVPIALVGPDDVEFCSPPAYATLTVKPSSPARLLKVGAVVLISGAVLLLFGAIGAFYFWKGSDSHIYNVHYTMSINGKLQDGSMEIDAGNNLETFKMGSGAEEAIAVNDFQNGITGIRFAGGEKCYIKAQVKARIPEVGAVTKQSISSKLEGKIMPVKYEENSLIWVAVDQPVKDNSFLSSKVLELCGDLPIFWLKPTYPKEIQRERREVVRKIVPTTTKRPHSGPRSNPGAGRLNNETRPSVQEDSQAFNPDNPYHQQEGESMTFDPRLDHEGICCIECRRSYTHCQKICEPLGGYYPWPYNYQGCRSACRVIMPCSWWVARILGMV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	Phosphorylation	DAGNNLETFKMGSGA CCCCCCCEEECCCCH		24275569
105	Phosphorylation	LETFKMGSGAEEAIA CCEEECCCCHHCEEE		24275569
121	Phosphorylation	NDFQNGITGIRFAGG CCCCCCCCEEEECCC		24719451
180	Sumoylation	VAVDQPVKDNSFLSS EEECCCCCCCCCHHH		-
226	Acetylation	KIVPTTTKRPHSGPR HHCCCCCCCCCCCCC		19811469
243	N-linked_Glycosylation	PGAGRLNNETRPSVQ CCCCCCCCCCCCCHH		UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNMD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNMD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNMD_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CNMD_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.