SPEF2_HUMAN - dbPTM
SPEF2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPEF2_HUMAN
UniProt AC Q9C093
Protein Name Sperm flagellar protein 2
Gene Name SPEF2
Organism Homo sapiens (Human).
Sequence Length 1822
Subcellular Localization
Protein Description Required for correct axoneme development..
Protein Sequence MSEILCQWLNKELKVSRTVSPKSFAKAFSSGYLLGEVLHKFELQDDFSEFLDSRVSSAKLNNFSRLEPTLNLLGVQFDQNVAHGIITEKPGVATKLLYQLYIALQKKKKSGLTGVEMQTMQRLTNLRLQNMKSDTFQERLRHMIPRQTDFNLMRITYRFQEKYKHVKEDLAHLHFEKLERFQKLKEEQRCFDIEKQYLNRRRQNEIMAKIQAAIIQIPKPASNRTLKALEAQKMMKKKKEAEDVADEIKKFEALIKKDLQAKESASKTSLDTAGQTTTDLLNTYSDDEYIKKIQKRLEEDAFAREQREKRRRKLLMDQLIAHEAQEEAYREEQLINRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQHEERRLKDFQDALDREAALAKQAKIDFEEQFLKEKRFHDQIAVERAQARYEKHYSVCAEILDQIVDLSTKVADYRMLTNNLIPYKLMHDWKELFFNAKPIYEQASVKTLPANPSREQLTELEKRDLLDTNDYEEYKNMVGEWALPEEMVDNLPPSNNCILGHILHRLAEKSLPPRAESTTPELPSFAVKGCLLGKTLSGKTTILRSLQKDFPIQILSIDTLVQEAIQAFHDNEKVSEVLPIQKNDEEDALPVLQEEIKESQDPQHVFSAGPVSDEVLPETEGETMLSANADKTPKAEEVKSSDSFLKLTTRAQLGAKSEQLLKKGKSIPDVLLVDIIVNAINEIPVNQDCILDGFPMTLNQAQLLEEALTGCNRNLTEVERKKAQKSTLAIDPATSKEIPLPSPAFDFVILLDVSDTSSMSRMNDIIAEELSYKTAHEDISQRVAAENQDKDGDQNLRDQIQHRIIGFLDNWPLLEQWFSEPENILIKINAEIDKESLCEKVKEILTTEIAKKKNKVEKKLEEKEAEKKAAASLAELPLPTPPPAPPPEPEKEKEIHQSHVASKTPTAKGKPQSEAPHGKQESLQEGKGKKGETALKRKGSPKGKSSGGKVPVKKSPADSTDTSPVAIVPQPPKPGSEEWVYVNEPVPEEMPLFLVPYWELIENSYINTIKTVLRHLREDQHTVLAYLYEIRTSFQEFLKRPDHKQDFVAQWQADFNSLPDDLWDDEETKAELHQRVNDLRDRLWDICDARKEEAEQERLDIINESWLQDTLGMTMNHFFSLMQAELNRFQDTKRLLQDYYWGMESKIPVEDNKRFTRIPLVQLDSKDNSESQLRIPLVPRISISLETVTPKPKTKSVLKGKMDNSLENVESNFEADEKLVMDTWQQASLAVSHMVAAEIHQRLMEEEKENQPADPKEKSPQMGANKKVKKEPPKKKQEDKKPKGKSPPMAEATPVIVTTEEIAEIKRKNELRVKIKEEHLAALQFEEIATQFRLELIKTKALALLEDLVTKVVDVYKLMEKWLGERYLNEMASTEKLTDVARYHIETSTKIQNELYLSQEDFFINGNIKVFPDPPPSIRPPPVEKEEDGTLTIEQLDSLRDQFLDMAPKGIIGNKAFTDILIDLVTLNLGTNNFPSNWMHLTQPELQELTSLLTVNSEFVDWRKFLLVTSMPWPIPLEEELLETLQKFKAVDKEQLGTITFEQYMQAGLWFTGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADYEKDPPQLDYTQMLLYFACHPDTVEGVYRALSVAVGTHVFQQVKASIPSAEKTSSTDAGPAEEFPEPEENAAREERKLKDDTEKREQKDEEIPENANNEKMSMETLLKVFKGGSEAQDSNRFASHLKIENIYAEGFIKTFQDLGAKNLEPIEVAVLLKHPFIQDLISNYSDYKFPDIKIILQRSEHVQGSDGERSPSRHTEEKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
18PhosphorylationKELKVSRTVSPKSFA
CCCCCCCCCCHHHHH		20.1622468782
104 (in isoform 4)Phosphorylation-5.7929116813
177UbiquitinationLAHLHFEKLERFQKL
HHHHCHHHHHHHHHH		55.49-
222PhosphorylationIQIPKPASNRTLKAL
HCCCCCCCHHHHHHH		35.0630622161
227UbiquitinationPASNRTLKALEAQKM
CCCHHHHHHHHHHHH		50.76-
227AcetylationPASNRTLKALEAQKM
CCCHHHHHHHHHHHH		50.7619821649
236UbiquitinationLEAQKMMKKKKEAED
HHHHHHHHHHHHHHH		58.92-
237UbiquitinationEAQKMMKKKKEAEDV
HHHHHHHHHHHHHHH		51.70-
264PhosphorylationKDLQAKESASKTSLD
HHHHHHHHHCCCCCC		36.8225332170
266PhosphorylationLQAKESASKTSLDTA
HHHHHHHCCCCCCCC		45.8330622161
268PhosphorylationAKESASKTSLDTAGQ
HHHHHCCCCCCCCCC		31.8430622161
269PhosphorylationKESASKTSLDTAGQT
HHHHCCCCCCCCCCH		28.1630622161
272PhosphorylationASKTSLDTAGQTTTD
HCCCCCCCCCCHHHH		37.6725693802
276PhosphorylationSLDTAGQTTTDLLNT
CCCCCCCHHHHHHHH		30.6425693802
277PhosphorylationLDTAGQTTTDLLNTY
CCCCCCHHHHHHHHC		15.4925693802
278PhosphorylationDTAGQTTTDLLNTYS
CCCCCHHHHHHHHCC		28.2125693802
393UbiquitinationDREAALAKQAKIDFE
HHHHHHHHHCCCCHH		52.19-
405UbiquitinationDFEEQFLKEKRFHDQ
CHHHHHHHHCCHHHH		63.58-
480PhosphorylationYEQASVKTLPANPSR
HHHCCCCCCCCCCCH		35.50-
486PhosphorylationKTLPANPSREQLTEL
CCCCCCCCHHHHHHH		48.5425693802
543PhosphorylationLHRLAEKSLPPRAES
HHHHHHCCCCCCCCC		37.3024719451
550PhosphorylationSLPPRAESTTPELPS
CCCCCCCCCCCCCCH		36.2725693802
551PhosphorylationLPPRAESTTPELPSF
CCCCCCCCCCCCCHH		37.5625693802
552PhosphorylationPPRAESTTPELPSFA
CCCCCCCCCCCCHHH		24.8425693802
570PhosphorylationCLLGKTLSGKTTILR
CCCCCCCCCCHHHHH		43.40-
645 (in isoform 2)Phosphorylation-31.0525693802
652 (in isoform 2)Phosphorylation-47.5625693802
660 (in isoform 2)Phosphorylation-15.9825693802
673PhosphorylationPKAEEVKSSDSFLKL
CCHHHHCCCCCHHHH		44.5530622161
674PhosphorylationKAEEVKSSDSFLKLT
CHHHHCCCCCHHHHH		31.4030622161
676PhosphorylationEEVKSSDSFLKLTTR
HHHCCCCCHHHHHHH		34.1324719451
885AcetylationLTTEIAKKKNKVEKK
HHHHHHHHHHHHHHH		53.1820167786
891AcetylationKKKNKVEKKLEEKEA
HHHHHHHHHHHHHHH		66.6920167786
892AcetylationKKNKVEKKLEEKEAE
HHHHHHHHHHHHHHH		47.8520167786
905PhosphorylationAEKKAAASLAELPLP
HHHHHHHHHHCCCCC		24.3225693802
963AcetylationLQEGKGKKGETALKR
HHCCCCCCCHHHHHC		71.327668803
969AcetylationKKGETALKRKGSPKG
CCCHHHHHCCCCCCC		49.997668811
977AcetylationRKGSPKGKSSGGKVP
CCCCCCCCCCCCCCC		47.807965555
982AcetylationKGKSSGGKVPVKKSP
CCCCCCCCCCCCCCC		47.067965565
982UbiquitinationKGKSSGGKVPVKKSP
CCCCCCCCCCCCCCC		47.0617370265
1044PhosphorylationSYINTIKTVLRHLRE
HHHHHHHHHHHHHCC		22.4124719451
1198PhosphorylationIPLVQLDSKDNSESQ
EEEEEECCCCCCCCC		50.9625693802
1202PhosphorylationQLDSKDNSESQLRIP
EECCCCCCCCCCCCC		49.0825693802
1204PhosphorylationDSKDNSESQLRIPLV
CCCCCCCCCCCCCEE		34.0425693802
1215PhosphorylationIPLVPRISISLETVT
CCEECEEEEEEEECC		13.8530622161
1217PhosphorylationLVPRISISLETVTPK
EECEEEEEEEECCCC		17.2330622161
1220PhosphorylationRISISLETVTPKPKT
EEEEEEEECCCCCCC		34.6730622161
1222PhosphorylationSISLETVTPKPKTKS
EEEEEECCCCCCCHH		32.7724719451
1319PhosphorylationDKKPKGKSPPMAEAT
CCCCCCCCCCHHHCC		42.7930622161
1326PhosphorylationSPPMAEATPVIVTTE
CCCHHHCCCEEEEHH		15.0325693802
1471PhosphorylationLTIEQLDSLRDQFLD
EEHHHHHHHHHHHHH		33.6224719451
1664PhosphorylationVFQQVKASIPSAEKT
HHHHHHHHCCCCCCC		29.3425693802
1667PhosphorylationQVKASIPSAEKTSST
HHHHHCCCCCCCCCC		47.6025693802
1671PhosphorylationSIPSAEKTSSTDAGP
HCCCCCCCCCCCCCC		21.2925693802
1672PhosphorylationIPSAEKTSSTDAGPA
CCCCCCCCCCCCCCH		42.1625693802
1673PhosphorylationPSAEKTSSTDAGPAE
CCCCCCCCCCCCCHH		35.2225693802
1674PhosphorylationSAEKTSSTDAGPAEE
CCCCCCCCCCCCHHH		29.6325693802
1697AcetylationAREERKLKDDTEKRE
HHHHHHCCCHHHHHH		57.5018526205
1706AcetylationDTEKREQKDEEIPEN
HHHHHHHHHHCCCCC		63.4518526213
1726AcetylationMSMETLLKVFKGGSE
CCHHHHHHHHCCCCC		49.0611688545
1750PhosphorylationHLKIENIYAEGFIKT
HCCEEEEHHHCHHHH		15.35-
1813PhosphorylationQGSDGERSPSRHTEE
CCCCCCCCCCCCCCC		23.9517081983
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPEF2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPEF2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPEF2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SPEF2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPEF2_HUMAN

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Related Literatures of Post-Translational Modification
Ubiquitylation
ReferencePubMed
"Tryptic digestion of ubiquitin standards reveals an improved strategyfor identifying ubiquitinated proteins by mass spectrometry.";
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.;
Proteomics 7:868-874(2007).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-982, AND MASSSPECTROMETRY.

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