ABCA6_HUMAN - dbPTM
ABCA6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ABCA6_HUMAN
UniProt AC Q8N139
Protein Name ATP-binding cassette sub-family A member 6
Gene Name ABCA6
Organism Homo sapiens (Human).
Sequence Length 1617
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Probable transporter which may play a role in macrophage lipid homeostasis..
Protein Sequence MNMKQKSVYQQTKALLCKNFLKKWRMKRESLLEWGLSILLGLCIALFSSSMRNVQFPGMAPQNLGRVDKFNSSSLMVVYTPISNLTQQIMNKTALAPLLKGTSVIGAPNKTHMDEILLENLPYAMGIIFNETFSYKLIFFQGYNSPLWKEDFSAHCWDGYGEFSCTLTKYWNRGFVALQTAINTAIIEITTNHPVMEELMSVTAITMKTLPFITKNLLHNEMFILFFLLHFSPLVYFISLNVTKERKKSKNLMKMMGLQDSAFWLSWGLIYAGFIFIISIFVTIIITFTQIIVMTGFMVIFILFFLYGLSLVALVFLMSVLLKKAVLTNLVVFLLTLFWGCLGFTVFYEQLPSSLEWILNICSPFAFTTGMIQIIKLDYNLNGVIFPDPSGDSYTMIATFSMLLLDGLIYLLLALYFDKILPYGDERHYSPLFFLNSSSCFQHQRTNAKVIEKEIDAEHPSDDYFEPVAPEFQGKEAIRIRNVKKEYKGKSGKVEALKGLLFDIYEGQITAILGHSGAGKSSLLNILNGLSVPTEGSVTIYNKNLSEMQDLEEIRKITGVCPQFNVQFDILTVKENLSLFAKIKGIHLKEVEQEVQRILLELDMQNIQDNLAKHLSEGQKRKLTFGITILGDPQILLLDEPTTGLDPFSRDQVWSLLRERRADHVILFSTQSMDEADILADRKVIMSNGRLKCAGSSMFLKRRWGLGYHLSLHRNEICNPEQITSFITHHIPDAKLKTENKEKLVYTLPLERTNTFPDLFSDLDKCSDQGVTGYDISMSTLNEVFMKLEGQSTIEQDFEQVEMIRDSESLNEMELAHSSFSEMQTAVSDMGLWRMQVFAMARLRFLKLKRQTKVLLTLLLVFGIAIFPLIVENIMYAMLNEKIDWEFKNELYFLSPGQLPQEPRTSLLIINNTESNIEDFIKSLKHQNILLEVDDFENRNGTDGLSYNGAIIVSGKQKDYRFSVVCNTKRLHCFPILMNIISNGLLQMFNHTQHIRIESSPFPLSHIGLWTGLPDGSFFLFLVLCSISPYITMGSISDYKKNAKSQLWISGLYTSAYWCGQALVDVSFFILILLLMYLIFYIENMQYLLITSQIVFALVIVTPGYAASLVFFIYMISFIFRKRRKNSGLWSFYFFFASTIMFSITLINHFDLSILITTMVLVPSYTLLGFKTFLEVRDQEHYREFPEANFELSATDFLVCFIPYFQTLLFVFVLRCMELKCGKKRMRKDPVFRISPQSRDAKPNPEEPIDEDEDIQTERIRTATALTTSILDEKPVIIASCLHKEYAGQKKSCFSKRKKKIAARNISFCVQEGEILGLLGPNGAGKSSSIRMISGITKPTAGEVELKGCSSVLGHLGYCPQENVLWPMLTLREHLEVYAAVKGLRKADARLAIARLVSAFKLHEQLNVPVQKLTAGITRKLCFVLSLLGNSPVLLLDEPSTGIDPTGQQQMWQAIQAVVKNTERGVLLTTHNLAEAEALCDRVAIMVSGRLRCIGSIQHLKNKLGKDYILELKVKETSQVTLVHTEILKLFPQAAGQERYSSLLTYKLPVADVYPLSQTFHKLEAVKHNFNLEEYSLSQCTLEKVFLELSKEQEVGNFDEEIDTTMRWKLLPHSDEP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MNMKQKSVYQQTKA
-CCCCHHHHHHHHHH		24.4629759185
84N-linked_GlycosylationVVYTPISNLTQQIMN
EEEEEHHHHHHHHHC		48.07UniProtKB CARBOHYD
109N-linked_GlycosylationTSVIGAPNKTHMDEI
CCCCCCCCCCCHHHH		62.41UniProtKB CARBOHYD
153PhosphorylationPLWKEDFSAHCWDGY
CCCCCCHHCCCCCCC		29.4450558477
160PhosphorylationSAHCWDGYGEFSCTL
HCCCCCCCCEEEEEE		15.8250558485
464PhosphorylationAEHPSDDYFEPVAPE
CCCCCCCCCCCCCHH		18.1621253578
485AcetylationIRIRNVKKEYKGKSG
EEEEECCHHHCCCCC		63.097696667
488AcetylationRNVKKEYKGKSGKVE
EECCHHHCCCCCCHH		62.047696679
498AcetylationSGKVEALKGLLFDIY
CCCHHHHHHHHHEEC		55.347696691
613UbiquitinationNIQDNLAKHLSEGQK
HHHHHHHHHCCHHHH		48.5230230243
683AcetylationADILADRKVIMSNGR
HHHHHCCEEEEECCC		36.347964299
701AcetylationAGSSMFLKRRWGLGY
CCCCCHHHHHHCCCC		28.757964311
746PhosphorylationENKEKLVYTLPLERT
CCCCCEEEEEECCCC		17.0020563963
753PhosphorylationYTLPLERTNTFPDLF
EEEECCCCCCCHHHH		29.2730108239
755PhosphorylationLPLERTNTFPDLFSD
EECCCCCCCHHHHHC		35.6127499020
809PhosphorylationEMIRDSESLNEMELA
HHHHCCCCCCHHHHH		40.2126420203
849UbiquitinationRLRFLKLKRQTKVLL
HHHHHHHHHHHHHHH		40.65-
892PhosphorylationWEFKNELYFLSPGQL
CHHCCEEEEECCCCC		9.0428450419
895PhosphorylationKNELYFLSPGQLPQE
CCEEEEECCCCCCCC		19.6528450419
940N-linked_GlycosylationVDDFENRNGTDGLSY
EECCCCCCCCCCCCC		70.1119159218
942PhosphorylationDFENRNGTDGLSYNG
CCCCCCCCCCCCCCC		30.3723403867
947PhosphorylationNGTDGLSYNGAIIVS
CCCCCCCCCCEEEEE		23.7423403867
1327PhosphorylationGPNGAGKSSSIRMIS
CCCCCCCCHHCEECC		28.5322210691
1337PhosphorylationIRMISGITKPTAGEV
CEECCCCCCCCCCEE		34.20113326619
1340PhosphorylationISGITKPTAGEVELK
CCCCCCCCCCEEEEE		49.18113326627
1488PhosphorylationDRVAIMVSGRLRCIG
HHHHHHHCCCHHHHH		10.7923612710
1517PhosphorylationLELKVKETSQVTLVH
EEEEECCCCEEEEEE		20.8128348404
1518PhosphorylationELKVKETSQVTLVHT
EEEECCCCEEEEEEH		24.6024719451
1521PhosphorylationVKETSQVTLVHTEIL
ECCCCEEEEEEHHHH		18.5428348404
1525PhosphorylationSQVTLVHTEILKLFP
CEEEEEEHHHHHHCC		19.7628348404
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ABCA6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ABCA6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ABCA6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of ABCA6_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ABCA6_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-940, AND MASSSPECTROMETRY.

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