APOA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APOA2_HUMAN
• UniProt AC: P02652
• Protein Name: Apolipoprotein A-II
• Gene Name: APOA2
• Organism: Homo sapiens (Human).
• Sequence Length: 100
• Subcellular Localization: Secreted .
• Protein Description: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism..
• Protein Sequence: MKLLAATVLLLTICSLEGALVRRQAKEPCVESLVSQYFQTVTDYGKDLMEKVKSPELQAEAKSYFEKSKEQLTPLIKKAGTELVNFLSYFVELGTQPATQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Pyrrolidone_carboxylic_acid	EGALVRRQAKEPCVE HHHHHHHHCCCHHHH	46.34	-
24	Pyrrolidone_carboxylic_acid	EGALVRRQAKEPCVE HHHHHHHHCCCHHHH	46.34	24116940
24	Pyrrolidone_carboxylic_acid	EGALVRRQAKEPCVE HHHHHHHHCCCHHHH	46.34	24116940
32	Phosphorylation	AKEPCVESLVSQYFQ CCCHHHHHHHHHHHH	17.42	19824718
32	O-linked_Glycosylation	AKEPCVESLVSQYFQ CCCHHHHHHHHHHHH	17.42	OGP
35	Phosphorylation	PCVESLVSQYFQTVT HHHHHHHHHHHHHHH	25.18	27130503
35	O-linked_Glycosylation	PCVESLVSQYFQTVT HHHHHHHHHHHHHHH	25.18	OGP
37	Phosphorylation	VESLVSQYFQTVTDY HHHHHHHHHHHHHHH	7.08	26657352
37	Nitration	VESLVSQYFQTVTDY HHHHHHHHHHHHHHH	7.08	-
42	O-linked_Glycosylation	SQYFQTVTDYGKDLM HHHHHHHHHHHHHHH	27.22	55832773
42	Phosphorylation	SQYFQTVTDYGKDLM HHHHHHHHHHHHHHH	27.22	-
44	Nitration	YFQTVTDYGKDLMEK HHHHHHHHHHHHHHH	19.40	-
49	Oxidation	TDYGKDLMEKVKSPE HHHHHHHHHHHCCHH	7.21	12576517
49	Methionine sulfoxide	TDYGKDLMEKVKSPE HHHHHHHHHHHCCHH	7.21	-
53	Glycation	KDLMEKVKSPELQAE HHHHHHHCCHHHHHH	71.94	-
54	Phosphorylation	DLMEKVKSPELQAEA HHHHHHCCHHHHHHH	26.96	23911959
54	O-linked_Glycosylation	DLMEKVKSPELQAEA HHHHHHCCHHHHHHH	26.96	OGP
62	Acetylation	PELQAEAKSYFEKSK HHHHHHHHHHHHHHH	36.87	27178108
62	Glycation	PELQAEAKSYFEKSK HHHHHHHHHHHHHHH	36.87	-
67	Glycation	EAKSYFEKSKEQLTP HHHHHHHHHHHHHHH	57.86	-
67	Acetylation	EAKSYFEKSKEQLTP HHHHHHHHHHHHHHH	57.86	27178108
68	O-linked_Glycosylation	AKSYFEKSKEQLTPL HHHHHHHHHHHHHHH	33.94	OGP
68	Phosphorylation	AKSYFEKSKEQLTPL HHHHHHHHHHHHHHH	33.94	23911959
69	Glycation	KSYFEKSKEQLTPLI HHHHHHHHHHHHHHH	61.62	-
73	O-linked_Glycosylation	EKSKEQLTPLIKKAG HHHHHHHHHHHHHHC	18.75	OGP
73	Phosphorylation	EKSKEQLTPLIKKAG HHHHHHHHHHHHHHC	18.75	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
54	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
68	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APOA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APOA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLTP_HUMAN	PLTP	physical	9469594
APOA1_HUMAN	APOA1	physical	10722751
LCAT_HUMAN	LCAT	physical	3104518
DGAT1_HUMAN	DGAT1	physical	3104518
APOD_HUMAN	APOD	physical	3104518
CTSR1_HUMAN	CATSPER1	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"An initial characterization of the serum phosphoproteome.";
Zhou W., Ross M.M., Tessitore A., Ornstein D., Vanmeter A.,Liotta L.A., Petricoin E.F. III;
J. Proteome Res. 8:5523-5531(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32; SER-35 AND SER-68,AND MASS SPECTROMETRY.
PubMed: 19824718

Pyrrolidone carboxylic acid

"Isolation and characterization of the tryptic and cyanogen bromidepeptides of apoLp-Gln-II (apoA-II), plasma high densityapolipoprotein.";
Lux S.E., John K.M., Ronan R., Brewer H.B. Jr.;
J. Biol. Chem. 247:7519-7527(1972).
Cited for: PROTEIN SEQUENCE OF 24-100.
PubMed: 4344225