dbPTM

APOB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	APOB_HUMAN
UniProt AC	P04114
Protein Name	Apolipoprotein B-100
Gene Name	APOB
Organism	Homo sapiens (Human).
Sequence Length	4563
Subcellular Localization	Cytoplasm . Secreted .
Protein Description	Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor..
Protein Sequence	MDPPRPALLALLALPALLLLLLAGARAEEEMLENVSLVCPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKRGIISALLVPPETEEAKQVLFLDTVYGNCSTHFTVKTRKGNVATEISTERDLGQCDRFKPIRTGISPLALIKGMTRPLSTLISSSQSCQYTLDAKRKHVAEAICKEQHLFLPFSYKNKYGMVAQVTQTLKLEDTPKINSRFFGEGTKKMGLAFESTKSTSPPKQAEAVLKTLQELKKLTISEQNIQRANLFNKLVTELRGLSDEAVTSLLPQLIEVSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNMARDQRSRATLYALSHAVNNYHKTNPTGTQELLDIANYLMEQIQDDCTGDEDYTYLILRVIGNMGQTMEQLTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEPKDKDQEVLLQTFLDDASPGDKRLAAYLMLMRSPSQADINKIVQILPWEQNEQVKNFVASHIANILNSEELDIQDLKKLVKEALKESQLPTVMDFRKFSRNYQLYKSVSLPSLDPASAKIEGNLIFDPNNYLPKESMLKTTLTAFGFASADLIEIGLEGKGFEPTLEALFGKQGFFPDSVNKALYWVNGQVPDGVSKVLVDHFGYTKDDKHEQDMVNGIMLSVEKLIKDLKSKEVPEARAYLRILGEELGFASLHDLQLLGKLLLMGARTLQGIPQMIGEVIRKGSKNDFFLHYIFMENAFELPTGAGLQLQISSSGVIAPGAKAGVKLEVANMQAELVAKPSVSVEFVTNMGIIIPDFARSGVQMNTNFFHESGLEAHVALKAGKLKFIIPSPKRPVKLLSGGNTLHLVSTTKTEVIPPLIENRQSWSVCKQVFPGLNYCTSGAYSNASSTDSASYYPLTGDTRLELELRPTGEIEQYSVSATYELQREDRALVDTLKFVTQAEGAKQTEATMTFKYNRQSMTLSSEVQIPDFDVDLGTILRVNDESTEGKTSYRLTLDIQNKKITEVALMGHLSCDTKEERKIKGVISIPRLQAEARSEILAHWSPAKLLLQMDSSATAYGSTVSKRVAWHYDEEKIEFEWNTGTNVDTKKMTSNFPVDLSDYPKSLHMYANRLLDHRVPQTDMTFRHVGSKLIVAMSSWLQKASGSLPYTQTLQDHLNSLKEFNLQNMGLPDFHIPENLFLKSDGRVKYTLNKNSLKIEIPLPFGGKSSRDLKMLETVRTPALHFKSVGFHLPSREFQVPTFTIPKLYQLQVPLLGVLDLSTNVYSNLYNWSASYSGGNTSTDHFSLRARYHMKADSVVDLLSYNVQGSGETTYDHKNTFTLSYDGSLRHKFLDSNIKFSHVEKLGNNPVSKGLLIFDASSSWGPQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLNGESNLRFNSSYLQGTNQITGRYEDGTLSLTSTSDLQSGIIKNTASLKYENYELTLKSDTNGKYKNFATSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDKINSGAHKATLRIGQDGISTSATTNLKCSLLVLENELNAELGLSGASMKLTTNGRFREHNAKFSLDGKAALTELSLGSAYQAMILGVDSKNIFNFKVSQEGLKLSNDMMGSYAEMKFDHTNSLNIAGLSLDFSSKLDNIYSSDKFYKQTVNLQLQPYSLVTTLNSDLKYNALDLTNNGKLRLEPLKLHVAGNLKGAYQNNEIKHIYAISSAALSASYKADTVAKVQGVEFSHRLNTDIAGLASAIDMSTNYNSDSLHFSNVFRSVMAPFTMTIDAHTNGNGKLALWGEHTGQLYSKFLLKAEPLAFTFSHDYKGSTSHHLVSRKSISAALEHKVSALLTPAEQTGTWKLKTQFNNNEYSQDLDAYNTKDKIGVELTGRTLADLTLLDSPIKVPLLLSEPINIIDALEMRDAVEKPQEFTIVAFVKYDKNQDVHSINLPFFETLQEYFERNRQTIIVVLENVQRNLKHINIDQFVRKYRAALGKLPQQANDYLNSFNWERQVSHAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQLQTYMIQFDQYIKDSYDLHDLKIAIANIIDEIIEKLKSLDEHYHIRVNLVKTIHDLHLFIENIDFNKSGSSTASWIQNVDTKYQIRIQIQEKLQQLKRHIQNIDIQHLAGKLKQHIEAIDVRVLLDQLGTTISFERINDILEHVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQIQVLMDKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKKLNELSFKTFIEDVNKFLDMLIKKLKSFDYHQFVDETNDKIREVTQRLNGEIQALELPQKAEALKLFLEETKATVAVYLESLQDTKITLIINWLQEALSSASLAHMKAKFRETLEDTRDRMYQMDIQQELQRYLSLVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRMKALVEQGFTVPEIKTILGTMPAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKDLKNIKIPSRFSTPEFTILNTFHIPSFTIDFVEMKVKIIRTIDQMLNSELQWPVPDIYLRDLKVEDIPLARITLPDFRLPEIAIPEFIIPTLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDANADIGNGTTSANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKINPLALKESVKFSSKYLRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKINNQLTLDSNTKYFHKLNIPKLDFSSQADLRNEIKTLLKAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPLTSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHSVLTAKGMALFGEGKAEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVRFPLRLTGKIDFLNNYALFLSPSAQQASWQVSARFNQYKYNQNFSAGNNENIMEAHVGINGEANLDFLNIPLTIPEMRLPYTIITTPPLKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKHRHSITNPLAVLCEFISQSIKSFDRHFEKNRNNALDFVTKSYNETKIKFDKYKAEKSHDELPRTFQIPGYTVPVVNVEVSPFTIEMSAFGYVFPKAVSMPSFSILGSDVRVPSYTLILPSLELPVLHVPRNLKLSLPDFKELCTISHIFIPAMGNITYDFSFKSSVITLNTNAELFNQSDIVAHLLSSSSSVIDALQYKLEGTTRLTRKRGLKLATALSLSNKFVEGSHNSTVSLTTKNMEVSVATTTKAQIPILRMNFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLSLESLTSYFSIESSTKGDVKGSVLSREYSGTIASEANTYLNSKSTRSSVKLQGTSKIDDIWNLEVKENFAGEATLQRIYSLWEHSTKNHLQLEGLFFTNGEHTSKATLELSPWQMSALVQVHASQPSSFHDFPDLGQEVALNANTKNQKIRWKNEVRIHSGSFQSQVELSNDQEKAHLDIAGSLEGHLRFLKNIILPVYDKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSFSIPVKVLADKFIIPGLKLNDLNSVLVMPTFHVPFTDLQVPSCKLDFREIQIYKKLRTSSFALNLPTLPEVKFPEVDVLTKYSQPEDSLIPFFEITVPESQLTVSQFTLPKSVSDGIAALDLNAVANKIADFELPTIIVPEQTIEIPSIKFSVPAGIVIPSFQALTARFEVDSPVYNATWSASLKNKADYVETVLDSTCSSTVQFLEYELNVLGTHKIEDGTLASKTKGTFAHRDFSAEYEEDGKYEGLQEWEGKAHLNIKSPAFTDLHLRYQKDKKGISTSAASPAVGTVGMDMDEDDDFSKWNFYYSPQSSPDKKLTIFKTELRVRESDEETQIKVNWEEEAASGLLTSLKDNVPKATGVLYDYVNKYHWEHTGLTLREVSSKLRRNLQNNAEWVYQGAIRQIDDIDVRFQKAASGTTGTYQEWKDKAQNLYQELLTQEGQASFQGLKDNVFDGLVRVTQEFHMKVKHLIDSLIDFLNFPRFQFPGKPGIYTREELCTMFIREVGTVLSQVYSKVHNGSEILFSYFQDLVITLPFELRKHKLIDVISMYRELLKDLSKEAQEVFKAIQSLKTTEVLRNLQDLLQFIFQLIEDNIKQLKEMKFTYLINYIQDEINTIFSDYIPYVFKLLKENLCLNLHKFNEFIQNELQEASQELQQIHQYIMALREEYFDPSIVGWTVKYYELEEKIVSLIKNLLVALKDFHSEYIVSASNFTSQLSSQVEQFLHRNIQEYLSILTDPDGKGKEKIAELSATAQEIIKSQAIATKKIISDYHQQFRYKLQDFSDQLSDYYEKFIAESKRLIDLSIQNYHTFLIYITELLKKLQSTTVMNPYMKLAPGELTIIL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	N-linked_Glycosylation	AEEEMLENVSLVCPK HHHHHHHCCEEECCC	25.39	UniProtKB CARBOHYD
34	N-linked_Glycosylation	AEEEMLENVSLVCPK HHHHHHHCCEEECCC	25.39	17623646
52	Phosphorylation	RFKHLRKYTYNYEAE HHHHHHHEEEEEECC	14.18	-
103	Nitration	QCTLKEVYGFNPEGK CCCEEHHHCCCHHHH	19.66	-
129	Phosphorylation	FAAAMSRYELKLAIP HHHHHHHHHEEEECC	20.50	-
144	Nitration	EGKQVFLYPEKDEPT CCCEEEEEECCCCCE	9.62	-
185	N-linked_Glycosylation	FLDTVYGNCSTHFTV EEEECCCCCEEEEEE	10.01	12235182
185	N-linked_Glycosylation	FLDTVYGNCSTHFTV EEEECCCCCEEEEEE	10.01	12235182
220	Phosphorylation	DRFKPIRTGISPLAL CCCCCCCCCCCHHHH	39.32	23186163
223	Phosphorylation	KPIRTGISPLALIKG CCCCCCCCHHHHHCC	18.40	23917254
240	Phosphorylation	RPLSTLISSSQSCQY CCHHHHHCCCCCCCE	27.35	20860994
242	Phosphorylation	LSTLISSSQSCQYTL HHHHHCCCCCCCEEH	21.23	20860994
244	Phosphorylation	TLISSSQSCQYTLDA HHHCCCCCCCEEHHH	12.72	20860994
252	Acetylation	CQYTLDAKRKHVAEA CCEEHHHCHHHHHHH	62.74	24885847
276	Nitration	PFSYKNKYGMVAQVT CCCCCCCCCCEEEEE	21.61	-
276	Phosphorylation	PFSYKNKYGMVAQVT CCCCCCCCCCEEEEE	21.61	28270605
283	Phosphorylation	YGMVAQVTQTLKLED CCCEEEEEEEEECCC	12.08	28270605
285	Phosphorylation	MVAQVTQTLKLEDTP CEEEEEEEEECCCCC	19.25	-
291	Phosphorylation	QTLKLEDTPKINSRF EEEECCCCCCCCCEE	19.67	28270605
296	Phosphorylation	EDTPKINSRFFGEGT CCCCCCCCEECCCCC	33.66	-
312	O-linked_Glycosylation	KMGLAFESTKSTSPP EEEEEEECCCCCCCH	34.38	OGP
312	Phosphorylation	KMGLAFESTKSTSPP EEEEEEECCCCCCCH	34.38	23532336
313	O-linked_Glycosylation	MGLAFESTKSTSPPK EEEEEECCCCCCCHH	23.09	OGP
315	Phosphorylation	LAFESTKSTSPPKQA EEEECCCCCCCHHHH	33.92	23532336
316	Phosphorylation	AFESTKSTSPPKQAE EEECCCCCCCHHHHH	46.97	23532336
328	Phosphorylation	QAEAVLKTLQELKKL HHHHHHHHHHHHHCC	29.52	23532336
413	Nitration	LLIDVVTYLVALIPE HHHHHHHHHHHHCCC	6.38	-
441	Phosphorylation	RDQRSRATLYALSHA HHHHHHHHHHHHHHH	21.13	28555341
452	Phosphorylation	LSHAVNNYHKTNPTG HHHHHHCCCCCCCCC	10.25	29052541
509	Phosphorylation	LTPELKSSILKCVQS HCHHHHHHHHHHHHC	30.28	24719451
512	2-Hydroxyisobutyrylation	ELKSSILKCVQSTKP HHHHHHHHHHHCCCC	30.59	-
520	Phosphorylation	CVQSTKPSLMIQKAA HHHCCCCCHHHHHHH	31.93	19413330
562	Phosphorylation	GDKRLAAYLMLMRSP CHHHHHHHHHHHCCC	6.24	20860994
567	Dimethylation	AAYLMLMRSPSQADI HHHHHHHCCCCHHCH	41.26	-
567	Methylation	AAYLMLMRSPSQADI HHHHHHHCCCCHHCH	41.26	-
568	Phosphorylation	AYLMLMRSPSQADIN HHHHHHCCCCHHCHH	18.22	24043423
570	Phosphorylation	LMLMRSPSQADINKI HHHHCCCCHHCHHHH	38.97	24043423
612	Acetylation	ELDIQDLKKLVKEAL CCCHHHHHHHHHHHH	52.96	24886711
637	Phosphorylation	FRKFSRNYQLYKSVS HHHHHHHHCCCEECC	9.97	20068231
640	Phosphorylation	FSRNYQLYKSVSLPS HHHHHCCCEECCCCC	5.91	20068231
642	Phosphorylation	RNYQLYKSVSLPSLD HHHCCCEECCCCCCC	11.90	20068231
644	Phosphorylation	YQLYKSVSLPSLDPA HCCCEECCCCCCCHH	41.47	24275569
647	Phosphorylation	YKSVSLPSLDPASAK CEECCCCCCCHHHCE	51.18	20068231
666	Nitration	LIFDPNNYLPKESML EECCCCCCCCHHHHH	30.90	-
671	Phosphorylation	NNYLPKESMLKTTLT CCCCCHHHHHHHHHH	35.23	28857561
676	Phosphorylation	KESMLKTTLTAFGFA HHHHHHHHHHHHCCC	22.11	28857561
678	Phosphorylation	SMLKTTLTAFGFASA HHHHHHHHHHCCCCC	20.18	28857561
684	Phosphorylation	LTAFGFASADLIEIG HHHHCCCCCEEEECC	21.76	28857561
700	Phosphorylation	EGKGFEPTLEALFGK CCCCCHHHHHHHHCC	29.99	28857561
720	Nitration	DSVNKALYWVNGQVP CCHHHHHHHHCCCCC	16.51	-
740	Phosphorylation	VLVDHFGYTKDDKHE HHHHHCCCCCCCCCH	15.07	-
741	Phosphorylation	LVDHFGYTKDDKHEQ HHHHCCCCCCCCCHH	28.51	-
757	Phosphorylation	MVNGIMLSVEKLIKD HHHHHHHCHHHHHHH	15.73	24505115
767	Phosphorylation	KLIKDLKSKEVPEAR HHHHHHHCCCCHHHH	41.15	-
928	Phosphorylation	KLKFIIPSPKRPVKL CCEEEECCCCCCEEE	32.42	17192257
947	O-linked_Glycosylation	NTLHLVSTTKTEVIP CEEEEEECCCCCCCC	25.49	OGP
983	N-linked_Glycosylation	CTSGAYSNASSTDSA CCCCCCCCCCCCCCC	31.03	12235182
983	N-linked_Glycosylation	CTSGAYSNASSTDSA CCCCCCCCCCCCCCC	31.03	12235182
1037	Phosphorylation	VDTLKFVTQAEGAKQ HHHHHHHHHCCCCCC	25.79	28509920
1045	Phosphorylation	QAEGAKQTEATMTFK HCCCCCCEEEEEEEE	27.21	29978859
1048	Phosphorylation	GAKQTEATMTFKYNR CCCCEEEEEEEEECC	15.54	29978859
1050	Phosphorylation	KQTEATMTFKYNRQS CCEEEEEEEEECCCC	16.78	29978859
1053	Phosphorylation	EATMTFKYNRQSMTL EEEEEEEECCCCCEE	16.04	24043423
1057	Phosphorylation	TFKYNRQSMTLSSEV EEEECCCCCEECEEE	15.53	24043423
1059	Phosphorylation	KYNRQSMTLSSEVQI EECCCCCEECEEEEC	28.83	24043423
1061	Phosphorylation	NRQSMTLSSEVQIPD CCCCCEECEEEECCC	18.45	24043423
1062	Phosphorylation	RQSMTLSSEVQIPDF CCCCEECEEEECCCC	44.92	24043423
1075	Phosphorylation	DFDVDLGTILRVNDE CCCCCCCCEEEECCC	24.92	24043423
1102	Phosphorylation	DIQNKKITEVALMGH EEECCEECEEEEEEE	33.03	22210691
1112	S-palmitoylation	ALMGHLSCDTKEERK EEEEEECCCCCHHHH	10.95	10679026
1114	Phosphorylation	MGHLSCDTKEERKIK EEEECCCCCHHHHCC	44.69	22210691
1121	Malonylation	TKEERKIKGVISIPR CCHHHHCCCEEECCH	50.60	26320211
1125	Phosphorylation	RKIKGVISIPRLQAE HHCCCEEECCHHHHH	24.92	24719451
1135	Phosphorylation	RLQAEARSEILAHWS HHHHHHHHHHHHHCC	35.72	-
1152	Phosphorylation	KLLLQMDSSATAYGS HHHHHCCCCCCCCCC	19.27	26552605
1153	Phosphorylation	LLLQMDSSATAYGST HHHHCCCCCCCCCCC	25.94	26552605
1155	Phosphorylation	LQMDSSATAYGSTVS HHCCCCCCCCCCCCH	23.51	26552605
1157	Phosphorylation	MDSSATAYGSTVSKR CCCCCCCCCCCCHHE	13.78	26552605
1159	Phosphorylation	SSATAYGSTVSKRVA CCCCCCCCCCHHEEE	16.98	26552605
1160	Phosphorylation	SATAYGSTVSKRVAW CCCCCCCCCHHEEEE	25.16	26552605
1162	Phosphorylation	TAYGSTVSKRVAWHY CCCCCCCHHEEEEEC	18.16	26552605
1163	Acetylation	AYGSTVSKRVAWHYD CCCCCCHHEEEEECC	46.70	26051181
1169	Phosphorylation	SKRVAWHYDEEKIEF HHEEEEECCHHCEEE	17.85	-
1190	Phosphorylation	NVDTKKMTSNFPVDL CCCCCCCCCCCCCCH	29.42	22210691
1191	Phosphorylation	VDTKKMTSNFPVDLS CCCCCCCCCCCCCHH	32.73	22210691
1198	Phosphorylation	SNFPVDLSDYPKSLH CCCCCCHHHCCHHHH	30.54	-
1200	Phosphorylation	FPVDLSDYPKSLHMY CCCCHHHCCHHHHHH	14.80	22210691
1235	Phosphorylation	SKLIVAMSSWLQKAS HHHHHHHHHHHHHHC	14.50	-
1287	Phosphorylation	KSDGRVKYTLNKNSL CCCCCEEEEECCCCE	17.38	-
1288	Phosphorylation	SDGRVKYTLNKNSLK CCCCEEEEECCCCEE	20.38	-
1318	Phosphorylation	KMLETVRTPALHFKS HHHHHCCCCCCCCEE	14.47	22210691
1368	N-linked_Glycosylation	NVYSNLYNWSASYSG CHHHHHCCEECCCCC	29.41	UniProtKB CARBOHYD
1368	N-linked_Glycosylation	NVYSNLYNWSASYSG CHHHHHCCEECCCCC	29.41	12235182
1377	N-linked_Glycosylation	SASYSGGNTSTDHFS ECCCCCCCCCCCCEE	34.09	UniProtKB CARBOHYD
1377	N-linked_Glycosylation	SASYSGGNTSTDHFS ECCCCCCCCCCCCEE	34.09	12235182
1384	Phosphorylation	NTSTDHFSLRARYHM CCCCCCEEEEEEECC	17.33	24719451
1419	Phosphorylation	YDHKNTFTLSYDGSL CCCCCEEEEEECCCH	16.86	29449344
1421	Phosphorylation	HKNTFTLSYDGSLRH CCCEEEEEECCCHHH	20.37	29449344
1422	Phosphorylation	KNTFTLSYDGSLRHK CCEEEEEECCCHHHE	27.69	29449344
1425	Phosphorylation	FTLSYDGSLRHKFLD EEEEECCCHHHEECC	21.23	29449344
1523	N-linked_Glycosylation	GESNLRFNSSYLQGT CCCCEEECCCEECCC	24.50	18638581
1523	N-linked_Glycosylation	GESNLRFNSSYLQGT CCCCEEECCCEECCC	24.50	12235182
1524	O-linked_Glycosylation	ESNLRFNSSYLQGTN CCCEEECCCEECCCC	20.04	OGP
1600	Phosphorylation	KQNALLRSEYQADYE HHHHHHHHHHHCCHH	40.39	26074081
1602	Phosphorylation	NALLRSEYQADYESL HHHHHHHHHCCHHHH	15.39	26074081
1606	Phosphorylation	RSEYQADYESLRFFS HHHHHCCHHHHHHHH	15.50	26074081
1644	Phosphorylation	NSGAHKATLRIGQDG CCCCCCEEEEECCCC	22.75	22210691
1657	Phosphorylation	DGISTSATTNLKCSL CCCCCCCCCCCCEEE	18.91	22210691
1698	Phosphorylation	REHNAKFSLDGKAAL CCCCCEECCCCHHHH	25.50	20068231
1706	Phosphorylation	LDGKAALTELSLGSA CCCHHHHHHHHCCHH	30.10	23312004
1709	Phosphorylation	KAALTELSLGSAYQA HHHHHHHHCCHHHHH	25.18	20068231
1712	Phosphorylation	LTELSLGSAYQAMIL HHHHHCCHHHHHHHH	29.15	20068231
1714	Phosphorylation	ELSLGSAYQAMILGV HHHCCHHHHHHHHCC	9.86	20068231
1723	Phosphorylation	AMILGVDSKNIFNFK HHHHCCCCCCCCCEE	25.79	20068231
1732	Phosphorylation	NIFNFKVSQEGLKLS CCCCEEECHHHHCCC	24.09	23312004
1745	Phosphorylation	LSNDMMGSYAEMKFD CCCCCCCCCEEEECC	11.85	20860994
1774	Phosphorylation	SSKLDNIYSSDKFYK HHHCCHHHCCCCCCC	14.36	-
1775	Phosphorylation	SKLDNIYSSDKFYKQ HHCCHHHCCCCCCCE	28.41	25159151
1778	2-Hydroxyisobutyrylation	DNIYSSDKFYKQTVN CHHHCCCCCCCEECC	53.17	-
1778	Acetylation	DNIYSSDKFYKQTVN CHHHCCCCCCCEECC	53.17	23954790
1783	Phosphorylation	SDKFYKQTVNLQLQP CCCCCCEECCCEECC	13.75	25072903
1791	Phosphorylation	VNLQLQPYSLVTTLN CCCEECCCEEEEECC	11.15	25072903
1792	Phosphorylation	NLQLQPYSLVTTLNS CCEECCCEEEEECCC	24.05	25072903
1795	Phosphorylation	LQPYSLVTTLNSDLK ECCCEEEEECCCCCC	30.75	25072903
1796	Phosphorylation	QPYSLVTTLNSDLKY CCCEEEEECCCCCCC	19.23	25072903
1799	Phosphorylation	SLVTTLNSDLKYNAL EEEEECCCCCCCCEE	47.64	25072903
1840	Phosphorylation	NNEIKHIYAISSAAL CCCCCEEEEEEHHHH	9.52	24719451
1946	Phosphorylation	AFTFSHDYKGSTSHH EEEECCCCCCCCCEE	16.30	-
1959	Phosphorylation	HHLVSRKSISAALEH EEEECHHHHHHHHHH	22.21	23312004
1961	Phosphorylation	LVSRKSISAALEHKV EECHHHHHHHHHHHH	17.99	23312004
2004	Acetylation	DAYNTKDKIGVELTG HHCCCCCCCCCCCCC	42.80	19608861
2013	Phosphorylation	GVELTGRTLADLTLL CCCCCCCCHHHHCCC	27.87	20068231
2018	Phosphorylation	GRTLADLTLLDSPIK CCCHHHHCCCCCCCC	26.31	20068231
2022	Phosphorylation	ADLTLLDSPIKVPLL HHHCCCCCCCCCCEE	28.61	20068231
2146	Phosphorylation	KEKLTALTKKYRITE HHHHHHHHHHHCCCC	24.03	24505115
2211	Phosphorylation	EIIEKLKSLDEHYHI HHHHHHHCCCCCCCH	52.03	24719451
2239	N-linked_Glycosylation	FIENIDFNKSGSSTA EEEECCCCCCCCCCC	33.56	19159218
2245	O-linked_Glycosylation	FNKSGSSTASWIQNV CCCCCCCCCHHHHCC	26.80	OGP
2265	Acetylation	IRIQIQEKLQQLKRH EHHHHHHHHHHHHHH	34.91	23954790
2265	Malonylation	IRIQIQEKLQQLKRH EHHHHHHHHHHHHHH	34.91	26320211
2284	Acetylation	DIQHLAGKLKQHIEA CHHHHHHHHHHHHHH	47.07	27178108
2389	Phosphorylation	QQVKIKDYFEKLVGF HHHCCHHHHHHHHHH	14.50	20049867
2408	Phosphorylation	VKKLNELSFKTFIED HHHHHHCCHHHHHHH	20.65	24719451
2480	Phosphorylation	TKATVAVYLESLQDT HHHHHHHHHHHCCCC	8.60	-
2515	Phosphorylation	MKAKFRETLEDTRDR HHHHHHHHHHHHHHH	31.06	19664994
2524	Nitration	EDTRDRMYQMDIQQE HHHHHHHHHHHHHHH	11.11	-
2560	N-linked_Glycosylation	WWTLAAKNLTDFAEQ HHHHHHCCCHHHHHH	43.37	UniProtKB CARBOHYD
2603	Phosphorylation	TMPAFEVSLQALQKA CCCHHHHHHHHHHHC	13.94	-
2707	Phosphorylation	DIPLARITLPDFRLP CCCCEEEECCCCCCC	27.04	20068231
2760	Phosphorylation	PTFGKLYSILKIQSP CCCHHHHHHHEECCC	31.70	24719451
2779	N-linked_Glycosylation	DANADIGNGTTSANE ECCCCCCCCCCCHHH	45.00	19159218
2834	Phosphorylation	SVKFSSKYLRTEHGS HHHHCCCCCCCCCCC	11.90	-
2859	Phosphorylation	GKSNTVASLHTEKNT CCCCCEEEEEECCCE	19.15	23312004
2862	Phosphorylation	NTVASLHTEKNTLEL CCEEEEEECCCEEEE	54.68	23312004
2902	Phosphorylation	IPKLDFSSQADLRNE CCCCCCCCHHHHHHH	29.40	24505115
2911	Ubiquitination	ADLRNEIKTLLKAGH HHHHHHHHHHHHHCC	27.26	21906983
2915	Ubiquitination	NEIKTLLKAGHIAWT HHHHHHHHHCCEEEE	56.27	2190698
2926	Ubiquitination	IAWTSSGKGSWKWAC EEEECCCCCCCEEEC	52.28	-
2982	N-linked_Glycosylation	VYESGSLNFSKLEIQ EEECCCCCCEEEEEE	40.62	18638581
3101	N-linked_Glycosylation	NQYKYNQNFSAGNNE HCCCCCCCCCCCCCC	29.24	19159218
3139	Nitration	IPEMRLPYTIITTPP CCCCCCCEEEEECCC	18.37	-
3185	Phosphorylation	KKNKHRHSITNPLAV HCCCCCCCCCCHHHH	30.94	22817900
3198	Phosphorylation	AVLCEFISQSIKSFD HHHHHHHHHHHHHHH	24.16	22817900
3220	O-linked_Glycosylation	NNALDFVTKSYNETK CCHHHHHHHHCCHHH	17.80	55832687
3224	N-linked_Glycosylation	DFVTKSYNETKIKFD HHHHHHCCHHHEECC	58.51	19159218
3238	Phosphorylation	DKYKAEKSHDELPRT CHHHHHCCCCCCCCC	27.89	23403867
3264	O-linked_Glycosylation	NVEVSPFTIEMSAFG EEEECCCEEEEEECC	21.29	OGP
3279	Phosphorylation	YVFPKAVSMPSFSIL CCCCCCCCCCCEEEC	29.81	28258704
3282	Phosphorylation	PKAVSMPSFSILGSD CCCCCCCCEEECCCC	24.00	24275569
3284	Phosphorylation	AVSMPSFSILGSDVR CCCCCCEEECCCCCC	22.65	20068231
3288	Phosphorylation	PSFSILGSDVRVPSY CCEEECCCCCCCCCE	29.50	20068231
3295	Nitration	SDVRVPSYTLILPSL CCCCCCCEEEEECCC	10.25	-
3336	N-linked_Glycosylation	IFIPAMGNITYDFSF EEEECCCCEEEEEEC	15.45	UniProtKB CARBOHYD
3342	Phosphorylation	GNITYDFSFKSSVIT CCEEEEEECCCEEEE	28.94	24719451
3358	N-linked_Glycosylation	NTNAELFNQSDIVAH CCCHHHCCHHHHHHH	53.74	14760718
3358	N-linked_Glycosylation	NTNAELFNQSDIVAH CCCHHHCCHHHHHHH	53.74	14760718
3397	Phosphorylation	KRGLKLATALSLSNK HHCHHHHHHHHHCCC	38.27	-
3400	Phosphorylation	LKLATALSLSNKFVE HHHHHHHHHCCCCCC	27.56	-
3402	Phosphorylation	LATALSLSNKFVEGS HHHHHHHCCCCCCCC	34.30	-
3411	N-linked_Glycosylation	KFVEGSHNSTVSLTT CCCCCCCCCEEEEEE	40.86	18638581
3411	N-linked_Glycosylation	KFVEGSHNSTVSLTT CCCCCCCCCEEEEEE	40.86	17623646
3424	Phosphorylation	TTKNMEVSVATTTKA EECCEEEEEEECCCC	7.85	29888752
3427	Phosphorylation	NMEVSVATTTKAQIP CEEEEEEECCCCCCC	32.61	29888752
3428	Phosphorylation	MEVSVATTTKAQIPI EEEEEEECCCCCCCE	19.30	29888752
3429	Phosphorylation	EVSVATTTKAQIPIL EEEEEECCCCCCCEE	21.74	29888752
3453	O-linked_Glycosylation	GNTKSKPTVSSSMEF CCCCCCCCCCCCEEE	36.43	OGP
3465	N-linked_Glycosylation	MEFKYDFNSSMLYST EEEEECCCCCHHHHC	30.22	18638581
3465	N-linked_Glycosylation	MEFKYDFNSSMLYST EEEEECCCCCHHHHC	30.22	16335952
3467	Phosphorylation	FKYDFNSSMLYSTAK EEECCCCCHHHHCCC	17.57	25954137
3470	Phosphorylation	DFNSSMLYSTAKGAV CCCCCHHHHCCCCCC	8.71	25954137
3471	Phosphorylation	FNSSMLYSTAKGAVD CCCCHHHHCCCCCCC	20.23	25954137
3472	Phosphorylation	NSSMLYSTAKGAVDH CCCHHHHCCCCCCCC	20.87	-
3489	Nitration	SLESLTSYFSIESST CHHHHHHCEECCCCC	8.98	-
3509	Phosphorylation	GSVLSREYSGTIASE CCEEEEEECCCEEHH	15.99	30576142
3512	O-linked_Glycosylation	LSREYSGTIASEANT EEEEECCCEEHHHCH	13.87	OGP
3512	Phosphorylation	LSREYSGTIASEANT EEEEECCCEEHHHCH	13.87	30576142
3526	Phosphorylation	TYLNSKSTRSSVKLQ HHCCCCCCCCCEEEC	38.00	30576142
3566	O-linked_Glycosylation	IYSLWEHSTKNHLQL HHHHHHHCCCCCEEE	29.57	OGP
3567	O-linked_Glycosylation	YSLWEHSTKNHLQLE HHHHHHCCCCCEEEE	37.46	OGP
3605	O-linked_Glycosylation	ALVQVHASQPSSFHD EEEEEECCCCCCCCC	27.96	OGP
3626	Phosphorylation	EVALNANTKNQKIRW HHHHCCCCCCCEEEE	29.03	-
3643	Phosphorylation	EVRIHSGSFQSQVEL EEEEECCCEECEEEC	24.11	-
3646	Phosphorylation	IHSGSFQSQVELSND EECCCEECEEECCCC	33.90	-
3680	Phosphorylation	KNIILPVYDKSLWDF HHCHHEECCHHHHHH	18.73	19835603
3748	O-linked_Glycosylation	NSVLVMPTFHVPFTD CCEEEEEEECCCCCC	14.31	OGP
3771	Nitration	DFREIQIYKKLRTSS CHHHHHHHHHHCCCC	5.91	-
3776	Phosphorylation	QIYKKLRTSSFALNL HHHHHHCCCCCCCCC	38.88	25850435
3777	Phosphorylation	IYKKLRTSSFALNLP HHHHHCCCCCCCCCC	19.61	25850435
3778	Phosphorylation	YKKLRTSSFALNLPT HHHHCCCCCCCCCCC	17.58	25850435
3785	Phosphorylation	SFALNLPTLPEVKFP CCCCCCCCCCCCCCC	59.10	25850435
3854	O-linked_Glycosylation	IADFELPTIIVPEQT HCCCCCCEEECCCCE	35.64	OGP
3866	Phosphorylation	EQTIEIPSIKFSVPA CCEEECCCEEEEECC	44.03	24719451
3895	N-linked_Glycosylation	EVDSPVYNATWSASL ECCCCCCEECCCHHH	31.00	18638581
3895	N-linked_Glycosylation	EVDSPVYNATWSASL ECCCCCCEECCCHHH	31.00	16335952
3940	O-linked_Glycosylation	THKIEDGTLASKTKG ECEECCCCEEECCCC	31.32	OGP
3948	Phosphorylation	LASKTKGTFAHRDFS EEECCCCCCCCCCCC	21.14	28270605
3955	Phosphorylation	TFAHRDFSAEYEEDG CCCCCCCCEEECCCC	25.20	28270605
3958	Phosphorylation	HRDFSAEYEEDGKYE CCCCCEEECCCCCCC	25.08	28270605
3998	Phosphorylation	QKDKKGISTSAASPA CCCCCCCCCCCCCCC	25.61	24505115
4000	Phosphorylation	DKKGISTSAASPAVG CCCCCCCCCCCCCCC	18.30	-
4025	Phosphorylation	DFSKWNFYYSPQSSP CHHHCCEEECCCCCC	10.38	-
4026	Phosphorylation	FSKWNFYYSPQSSPD HHHCCEEECCCCCCC	15.11	-
4027	Phosphorylation	SKWNFYYSPQSSPDK HHCCEEECCCCCCCC	12.70	-
4030	Phosphorylation	NFYYSPQSSPDKKLT CEEECCCCCCCCEEE	47.42	-
4037	Phosphorylation	SSPDKKLTIFKTELR CCCCCEEEEEEEEEE	32.99	21406692
4040	Acetylation	DKKLTIFKTELRVRE CCEEEEEEEEEEECC	36.92	7972605
4041	Phosphorylation	KKLTIFKTELRVRES CEEEEEEEEEEECCC	29.51	21406692
4048	Phosphorylation	TELRVRESDEETQIK EEEEECCCCCCCCEE	39.49	23911959
4052	Phosphorylation	VRESDEETQIKVNWE ECCCCCCCCEEECHH	33.28	2994225
4078	O-linked_Glycosylation	KDNVPKATGVLYDYV HHCCCHHHCHHHHHH	33.67	OGP
4088	Nitration	LYDYVNKYHWEHTGL HHHHHHHHHHHHHCC	13.63	-
4116	Nitration	QNNAEWVYQGAIRQI HHCCHHHHHHHHEEE	11.42	-
4116	Phosphorylation	QNNAEWVYQGAIRQI HHCCHHHHHHHHEEE	11.42	24043423
4137	O-linked_Glycosylation	FQKAASGTTGTYQEW HHHHCCCCCCCHHHH	21.40	OGP
4137	Phosphorylation	FQKAASGTTGTYQEW HHHHCCCCCCCHHHH	21.40	20860994
4138	O-linked_Glycosylation	QKAASGTTGTYQEWK HHHCCCCCCCHHHHH	30.93	OGP
4138	Phosphorylation	QKAASGTTGTYQEWK HHHCCCCCCCHHHHH	30.93	20860994
4140	Phosphorylation	AASGTTGTYQEWKDK HCCCCCCCHHHHHHH	21.68	20860994
4141	Nitration	ASGTTGTYQEWKDKA CCCCCCCHHHHHHHH	13.04	-
4211	Nitration	FPGKPGIYTREELCT CCCCCCCCCHHHHHH	12.98	-
4229	Phosphorylation	REVGTVLSQVYSKVH HHHHHHHHHHHHHHC	17.17	-
4237	N-linked_Glycosylation	QVYSKVHNGSEILFS HHHHHHCCCCHHHHH	59.69	UniProtKB CARBOHYD
4244	Phosphorylation	NGSEILFSYFQDLVI CCCHHHHHHHHHHEE	22.92	26074081
4245	Phosphorylation	GSEILFSYFQDLVIT CCHHHHHHHHHHEEE	9.64	26074081
4252	Phosphorylation	YFQDLVITLPFELRK HHHHHEEECCHHHCC	22.39	26074081
4388	Phosphorylation	IMALREEYFDPSIVG HHHHHHHHCCCCHHC	14.45	20068231
4409	Phosphorylation	ELEEKIVSLIKNLLV CHHHHHHHHHHHHHH	28.05	24719451
4431	N-linked_Glycosylation	EYIVSASNFTSQLSS HHEEECCHHHHHHHH	43.88	UniProtKB CARBOHYD
4507	Phosphorylation	QDFSDQLSDYYEKFI HCHHHHHHHHHHHHH	20.24	17924679
4510	Phosphorylation	SDQLSDYYEKFIAES HHHHHHHHHHHHHHH	20.03	22817900
4544	Phosphorylation	ELLKKLQSTTVMNPY HHHHHHCCCCCCCCC	36.16	30206219
4545	Phosphorylation	LLKKLQSTTVMNPYM HHHHHCCCCCCCCCC	15.50	30206219
4546	Phosphorylation	LKKLQSTTVMNPYMK HHHHCCCCCCCCCCC	24.01	30206219
4551	Phosphorylation	STTVMNPYMKLAPGE CCCCCCCCCCCCCCE	11.24	30206219
4560	Phosphorylation	KLAPGELTIIL---- CCCCCEEEEEC----	11.15	30206219

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
4048	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	AMFR	Q9UKV5	PMID:12670940

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of APOB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of APOB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTP_HUMAN	MTTP	physical	9915855
PGS1_HUMAN	BGN	physical	12070165
ENPL_HUMAN	HSP90B1	physical	12397072
PDIA4_HUMAN	PDIA4	physical	12397072
CALCR_HUMAN	CALCR	physical	12397072
PPIB_HUMAN	PPIB	physical	12397072
ENPL_HUMAN	HSP90B1	physical	9694898
PDIA4_HUMAN	PDIA4	physical	9694898
LIPC_HUMAN	LIPC	physical	9685400
LRP6_HUMAN	LRP6	physical	18948618
CALX_HUMAN	CANX	physical	9765244
TERA_HUMAN	VCP	physical	18550891
APOB_HUMAN	APOB	physical	19164805
TERA_HUMAN	VCP	physical	19164805
GRP78_HUMAN	HSPA5	physical	19164805
SYVN1_HUMAN	SYVN1	physical	19164805
DERL1_HUMAN	DERL1	physical	19164805
SELS_HUMAN	VIMP	physical	19164805
APOA1_HUMAN	APOA1	physical	19164805
FAF2_HUMAN	FAF2	physical	22238364
ARFG1_HUMAN	ARFGAP1	physical	21988832
SMAD3_HUMAN	SMAD3	physical	21988832
PRDX4_HUMAN	PRDX4	physical	21988832
PSDE_HUMAN	PSMD14	physical	26344197
CALR_HUMAN	CALR	physical	9694898
MTP_HUMAN	MTTP	physical	26224785
AUP1_HUMAN	AUP1	physical	28183703
TERA_HUMAN	VCP	physical	28183703
APOA1_HUMAN	APOA1	physical	28183703

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615558	Hypobetalipoproteinemia, familial, 1 (FHBL1)
144010	Familial ligand-defective apolipoprotein B-100 (FDB)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of APOB_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2004, AND MASS SPECTROMETRY.	19608861 [Abstract]
N-linked Glycosylation
Reference	PubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry."; Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.; J. Proteome Res. 8:651-661(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-185; ASN-1523; ASN-2239;ASN-2779; ASN-2982; ASN-3101; ASN-3224; ASN-3411; ASN-3465 ANDASN-3895, AND MASS SPECTROMETRY.	19159218 [Abstract]
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry."; Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.; J. Proteome Res. 4:2070-2080(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1523; ASN-2982; ASN-3465AND ASN-3895, AND MASS SPECTROMETRY.	16335952 [Abstract]
"Screening for N-glycosylated proteins by liquid chromatography massspectrometry."; Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.; Proteomics 4:454-465(2004). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-3358, AND MASSSPECTROMETRY.	14760718 [Abstract]
Palmitoylation
Reference	PubMed
"Palmitoylation of apolipoprotein B is required for properintracellular sorting and transport of cholesteroyl esters andtriglycerides."; Zhao Y., McCabe J.B., Vance J., Berthiaume L.G.; Mol. Biol. Cell 11:721-734(2000). Cited for: PALMITOYLATION AT CYS-1112.	10679026 [Abstract]
Phosphorylation
Reference	PubMed
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-928, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4507, AND MASSSPECTROMETRY.	17924679 [Abstract]