MTP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTP_HUMAN
• UniProt AC: P55157
• Protein Name: Microsomal triglyceride transfer protein large subunit
• Gene Name: MTTP
• Organism: Homo sapiens (Human).
• Sequence Length: 894
• Subcellular Localization: Endoplasmic reticulum . Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785).
• Protein Description: Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. [PubMed: 23475612]
• Protein Sequence: MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	O-linked_Glycosylation	NDRLYKLTYSTEVLL CCCEEEEEEEEEEEE	15.98	OGP
99	Acetylation	VNQQRGEKSIFKGKS CHHHCCCCCHHCCCC	52.23	7959797
100	Phosphorylation	NQQRGEKSIFKGKSP HHHCCCCCHHCCCCH	29.02	24719451
105	Acetylation	EKSIFKGKSPSKIMG CCCHHCCCCHHHHCC	60.84	7959807
123	O-linked_Glycosylation	LEALQRPTLLHLIHG HHHHHCHHHHHHHCC	44.11	OGP
199	Phosphorylation	DSCKIARSGFTTPNQ CCCCCCCCCCCCHHH	29.27	28111955
202	Phosphorylation	KIARSGFTTPNQVLG CCCCCCCCCHHHEEE	44.89	28111955
203	Phosphorylation	IARSGFTTPNQVLGV CCCCCCCCHHHEEEE	20.27	28111955
211	Phosphorylation	PNQVLGVSSKATSVT HHHEEEECCCCCCCE	25.07	28111955
212	Phosphorylation	NQVLGVSSKATSVTT HHEEEECCCCCCCEE	24.73	28111955
261	Phosphorylation	QKLELKTTEAGPRLM CCEEEEECCCCCCCC	23.42	-
269	Phosphorylation	EAGPRLMSGKQAAAI CCCCCCCCHHHHHHH	47.64	24719451
427	Phosphorylation	GSSDIRETVMIITGT CCCCHHHHHHHHHHH	12.91	-
432	Phosphorylation	RETVMIITGTLVRKL HHHHHHHHHHHHHHH	17.12	19413330
434	Phosphorylation	TVMIITGTLVRKLCQ HHHHHHHHHHHHHHH	17.27	19413330
470	Phosphorylation	KAEKKEDTRMYLLAL HHCCHHHHHHHHHHH	20.58	29083192
473	Phosphorylation	KKEDTRMYLLALKNA CHHHHHHHHHHHHHC	8.69	29083192
488	Phosphorylation	LLPEGIPSLLKYAEA CCCCCHHHHHHHHHC	44.40	24719451
511	Phosphorylation	ATTALQRYDLPFITD HHHHHHHCCCCCCCH	14.63	23186163
563	Phosphorylation	DVKNILLSIGELPQE CHHHHHHHHCCCCHH	25.71	25850435
624	Phosphorylation	YTGYIERSPRSASTY CCEECCCCCCCCCEE	16.33	17081983
849	Phosphorylation	KKYERLSTGRGYVSQ HHHHHHCCCCCCCCH	35.17	23403867
855	Phosphorylation	STGRGYVSQKRKESV CCCCCCCCHHHHHHH	22.85	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTP_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MTP_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 200100: Abetalipoproteinemia (ABL)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB01094: Hesperetin
• DB08827: Lomitapide