LIPC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIPC_HUMAN
• UniProt AC: P11150
• Protein Name: Hepatic triacylglycerol lipase
• Gene Name: LIPC
• Organism: Homo sapiens (Human).
• Sequence Length: 499
• Subcellular Localization: Secreted.
• Protein Description: Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin..
• Protein Sequence: MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVETNKTLHEMKTRFLLFGETNQGCQIRINHPDTLQECGFNSSLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVGLVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQLSRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAAGPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIKQPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQTIKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLCLSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVYHYQFKIQFINQTETPIQTTFTMSLLGTKEKMQKIPITLGKGIASNKTYSFLITLDVDIGELIMIKFKWENSAVWANVWDTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSENTDDLLLRPTQEKIFVKCEIKSKTSKRKIR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	N-linked_Glycosylation	RAQAVETNKTLHEMK HHHHHHHCCHHHHHH	23.08	UniProtKB CARBOHYD
78	N-linked_Glycosylation	TLQECGFNSSLPLVM HHHHCCCCCCCCEEE	18.90	UniProtKB CARBOHYD
282	Phosphorylation	IKCSHERSVHLFIDS CCCCCCCHHHHHHHH	15.76	28787133
307	Phosphorylation	YPCGDMNSFSQGLCL EECCCCCCCCCCCHH	21.45	28787133
347	Phosphorylation	FLVTRAQSPFKVYHY EEEEECCCCCEEEEE	31.17	18510355
362	N-linked_Glycosylation	QFKIQFINQTETPIQ EEEEEEECCCCCCCE	43.97	UniProtKB CARBOHYD
397	N-linked_Glycosylation	LGKGIASNKTYSFLI ECCCHHCCCEEEEEE	31.50	UniProtKB CARBOHYD
486	Acetylation	TQEKIFVKCEIKSKT CCCEEEEEEEECCCC	18.53	7307287

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIPC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIPC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIPC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LMF1_HUMAN	LMF1	physical	19783858
ATP4A_HUMAN	ATP4A	physical	28514442
MTMR1_HUMAN	MTMR1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614025: Hepatic lipase deficiency (HL deficiency)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.