MTMR1_HUMAN - dbPTM
MTMR1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MTMR1_HUMAN
UniProt AC Q13613
Protein Name Myotubularin-related protein 1
Gene Name MTMR1
Organism Homo sapiens (Human).
Sequence Length 665
Subcellular Localization Cell membrane
Peripheral membrane protein
Cytoplasmic side . Cytoplasm .
Protein Description Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. [PubMed: 11733541]
Protein Sequence MDRPAAAAAAGCEGGGGPNPGPAGGRRPPRAAGGATAGSRQPSVETLDSPTGSHVEWCKQLIAATISSQISGSVTSENVSRDYKALRDGNKLAQMEEAPLFPGESIKAIVKDVMYICPFMGAVSGTLTVTDFKLYFKNVERDPHFILDVPLGVISRVEKIGAQSHGDNSCGIEIVCKDMRNLRLAYKQEEQSKLGIFENLNKHAFPLSNGQALFAFSYKEKFPINGWKVYDPVSEYKRQGLPNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVAAFRAKGRVPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLIIFDARQNSVADTNKTKGGGYESESAYPNAELVFLEIHNIHVMRESLRKLKEIVYPSIDEARWLSNVDGTHWLEYIRMLLAGAVRIADKIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIKGFETLVEKEWISFGHRFALRVGHGNDNHADADRSPIFLQFVDCVWQMTRQFPSAFEFNELFLITILDHLYSCLFGTFLCNCEQQRFKEDVYTKTISLWSYINSQLDEFSNPFFVNYENHVLYPVASLSHLELWVNYYVRWNPRMRPQMPIHQNLKELLAVRAELQKRVEGLQREVATRAVSSSSERGSSPSHSATSVHTSV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MDRPAAAA
-------CCCHHHHH		9.9522223895
36PhosphorylationPRAAGGATAGSRQPS
CCCCCCCCCCCCCCC		34.5223927012
39PhosphorylationAGGATAGSRQPSVET
CCCCCCCCCCCCCCC		25.8623927012
43PhosphorylationTAGSRQPSVETLDSP
CCCCCCCCCCCCCCC		25.0123401153
46PhosphorylationSRQPSVETLDSPTGS
CCCCCCCCCCCCCCH		33.4423927012
49PhosphorylationPSVETLDSPTGSHVE
CCCCCCCCCCCHHHH		27.7225159151
51PhosphorylationVETLDSPTGSHVEWC
CCCCCCCCCHHHHHH		56.0923927012
53PhosphorylationTLDSPTGSHVEWCKQ
CCCCCCCHHHHHHHH		27.1723403867
65PhosphorylationCKQLIAATISSQISG
HHHHHHHHHHHHCCC		16.6321406692
67PhosphorylationQLIAATISSQISGSV
HHHHHHHHHHCCCCC		16.3121406692
68PhosphorylationLIAATISSQISGSVT
HHHHHHHHHCCCCCC		27.9021406692
71PhosphorylationATISSQISGSVTSEN
HHHHHHCCCCCCCCC		19.8521406692
73PhosphorylationISSQISGSVTSENVS
HHHHCCCCCCCCCCC		18.5521406692
75PhosphorylationSQISGSVTSENVSRD
HHCCCCCCCCCCCHH		31.8321406692
76PhosphorylationQISGSVTSENVSRDY
HCCCCCCCCCCCHHH		25.6421406692
80PhosphorylationSVTSENVSRDYKALR
CCCCCCCCHHHHHHH		30.8921406692
91 (in isoform 2)Ubiquitination-51.2121890473
91UbiquitinationKALRDGNKLAQMEEA
HHHHCCCCCCCHHCC		51.2121906983
91 (in isoform 1)Ubiquitination-51.2121890473
107UbiquitinationLFPGESIKAIVKDVM
CCCHHHHHHHHHHHH		41.14-
115PhosphorylationAIVKDVMYICPFMGA
HHHHHHHHHHHCCCC		10.1421406692
124PhosphorylationCPFMGAVSGTLTVTD
HHCCCCCCCEEEEEE		26.0621406692
126PhosphorylationFMGAVSGTLTVTDFK
CCCCCCCEEEEEEEE		16.2621406692
128PhosphorylationGAVSGTLTVTDFKLY
CCCCCEEEEEEEEEE		22.6121406692
130PhosphorylationVSGTLTVTDFKLYFK
CCCEEEEEEEEEEEE		30.4021406692
155PhosphorylationDVPLGVISRVEKIGA
ECCHHHHHHHHHHCC		28.0624719451
159UbiquitinationGVISRVEKIGAQSHG
HHHHHHHHHCCCCCC		43.51-
159AcetylationGVISRVEKIGAQSHG
HHHHHHHHHCCCCCC		43.5125953088
177UbiquitinationCGIEIVCKDMRNLRL
CCEEEEEHHHHHCHH		43.60-
186PhosphorylationMRNLRLAYKQEEQSK
HHHCHHHHHHHHHHH		20.1430622161
187UbiquitinationRNLRLAYKQEEQSKL
HHCHHHHHHHHHHHH		45.70-
192PhosphorylationAYKQEEQSKLGIFEN
HHHHHHHHHHCHHCC		32.8830622161
193UbiquitinationYKQEEQSKLGIFENL
HHHHHHHHHCHHCCC		50.88-
237 (in isoform 2)Ubiquitination-33.9121890473
237AcetylationYDPVSEYKRQGLPNE
ECCHHHHHHCCCCCC		33.9130590509
237 (in isoform 1)Ubiquitination-33.9121890473
237UbiquitinationYDPVSEYKRQGLPNE
ECCHHHHHHCCCCCC		33.9121890473
247UbiquitinationGLPNESWKISKINSN
CCCCCCCEEEECCCC		46.51-
250UbiquitinationNESWKISKINSNYEF
CCCCEEEECCCCCCC		49.75-
253PhosphorylationWKISKINSNYEFCDT
CEEEECCCCCCCCCC		44.24-
278UbiquitinationVKDDDLSKVAAFRAK
CCCCCHHHHHHHHHC		43.10-
292O-linked_GlycosylationKGRVPVLSWIHPESQ
CCCCCEEEEECHHHC		24.9930379171
315UbiquitinationPLVGPNDKRCKEDEK
CCCCCCCCCCCCCHH		67.35-
458PhosphorylationLAMLMLDSYYRTIKG
HHHHHHHHHHHHHCC		21.8025072903
459PhosphorylationAMLMLDSYYRTIKGF
HHHHHHHHHHHHCCH		9.1625072903
460PhosphorylationMLMLDSYYRTIKGFE
HHHHHHHHHHHCCHH		12.7725072903
468PhosphorylationRTIKGFETLVEKEWI
HHHCCHHHHHHHHEC		33.57-
555PhosphorylationQRFKEDVYTKTISLW
HHCHHCCCHHHHHHH		18.1625839225
645PhosphorylationEVATRAVSSSSERGS
HHHHHHHCCCCCCCC		24.4224732914
646PhosphorylationVATRAVSSSSERGSS
HHHHHHCCCCCCCCC		31.1424732914
647PhosphorylationATRAVSSSSERGSSP
HHHHHCCCCCCCCCC		28.8124732914
648PhosphorylationTRAVSSSSERGSSPS
HHHHCCCCCCCCCCC		33.0124732914
650MethylationAVSSSSERGSSPSHS
HHCCCCCCCCCCCCC		52.84115484057
652PhosphorylationSSSSERGSSPSHSAT
CCCCCCCCCCCCCCC		45.3422167270
653PhosphorylationSSSERGSSPSHSATS
CCCCCCCCCCCCCCC		32.9922167270
655PhosphorylationSERGSSPSHSATSVH
CCCCCCCCCCCCCCC		31.8322167270
657PhosphorylationRGSSPSHSATSVHTS
CCCCCCCCCCCCCCC		37.2622167270
659PhosphorylationSSPSHSATSVHTSV-
CCCCCCCCCCCCCC-		34.0122167270
660PhosphorylationSPSHSATSVHTSV--
CCCCCCCCCCCCC--		16.1822167270
663PhosphorylationHSATSVHTSV-----
CCCCCCCCCC-----		29.0925159151
664O-linked_GlycosylationSATSVHTSV------
CCCCCCCCC------		15.7930379171
664PhosphorylationSATSVHTSV------
CCCCCCCCC------		15.7925159151
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MTMR1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MTMR1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MTMR1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NADAP_HUMANSLC4A1APphysical
27880917
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MTMR1_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.

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