dbPTM

SELS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SELS_HUMAN
UniProt AC	Q9BQE4
Protein Name	Selenoprotein S {ECO:0000303\|PubMed:27645994}
Gene Name	SELENOS {ECO:0000303\|PubMed:27645994, ECO:0000312\|HGNC:HGNC:30396}
Organism	Homo sapiens (Human).
Sequence Length	189
Subcellular Localization	Endoplasmic reticulum membrane Single-pass membrane protein. Cytoplasm.
Protein Description	Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination..
Protein Sequence	MERQEESLSARPALETEGLRFLHTTVGSLLATYGWYIVFSCILLYVVFQKLSARLRALRQRQLDRAAAAVEPDVVVKRQEALAAARLKMQEELNAQVEKHKEKLKQLEEEKRRQKIEMWDSMQEGKSYKGNAKKPQEEDSPGPSTSSVLKRKSDRKPLRGGGYNPLSGEGGGACSWRPGRRGPSSGGUG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
77	Ubiquitination	VEPDVVVKRQEALAA CCCCHHHHHHHHHHH	36.43	21890473
88	Ubiquitination	ALAAARLKMQEELNA HHHHHHHHHHHHHHH	32.74	-
115	Ubiquitination	EEEKRRQKIEMWDSM HHHHHHHHHHHHHHH	38.53	-
121	Phosphorylation	QKIEMWDSMQEGKSY HHHHHHHHHHCCCCC	13.57	28348404
126	Acetylation	WDSMQEGKSYKGNAK HHHHHCCCCCCCCCC	50.27	19816919
126	Ubiquitination	WDSMQEGKSYKGNAK HHHHHCCCCCCCCCC	50.27	-
133	Ubiquitination	KSYKGNAKKPQEEDS CCCCCCCCCCCCCCC	69.82	-
133	Acetylation	KSYKGNAKKPQEEDS CCCCCCCCCCCCCCC	69.82	19816925
133	Methylation	KSYKGNAKKPQEEDS CCCCCCCCCCCCCCC	69.82	19816925
134	Ubiquitination	SYKGNAKKPQEEDSP CCCCCCCCCCCCCCC	49.91	21906983
140	Phosphorylation	KKPQEEDSPGPSTSS CCCCCCCCCCCCHHH	34.73	30266825
144	Phosphorylation	EEDSPGPSTSSVLKR CCCCCCCCHHHHHHC	47.00	27050516
145	Phosphorylation	EDSPGPSTSSVLKRK CCCCCCCHHHHHHCC	28.31	29396449
146	Phosphorylation	DSPGPSTSSVLKRKS CCCCCCHHHHHHCCC	23.84	29396449
147	Phosphorylation	SPGPSTSSVLKRKSD CCCCCHHHHHHCCCC	31.40	25159151
150	Methylation	PSTSSVLKRKSDRKP CCHHHHHHCCCCCCC	56.47	115982003
150	Ubiquitination	PSTSSVLKRKSDRKP CCHHHHHHCCCCCCC	56.47	2190698
167	Phosphorylation	GGGYNPLSGEGGGAC CCCCCCCCCCCCCCC	35.73	28348404

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SELS_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SELS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SELS_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TERA_HUMAN	VCP	physical	15215856
UFD1_HUMAN	UFD1L	physical	15215856
HSP74_HUMAN	HSPA4	physical	15215856
DERL1_HUMAN	DERL1	physical	15215856
SAA1_HUMAN	SAA1	physical	12031974
SVIP_HUMAN	SVIP	physical	17872946
SYVN1_HUMAN	SYVN1	physical	17872946
AMFR_HUMAN	AMFR	physical	17872946
DERL1_HUMAN	DERL1	physical	17872946
TERA_HUMAN	VCP	physical	17872946
NPL4_HUMAN	NPLOC4	physical	17872946
HERP1_HUMAN	HERPUD1	physical	16289116
SYVN1_HUMAN	SYVN1	physical	16289116
DERL1_HUMAN	DERL1	physical	16289116
TERA_HUMAN	VCP	physical	16289116
DERL1_HUMAN	DERL1	physical	16186510
DERL1_HUMAN	DERL1	physical	16186509
DERL2_HUMAN	DERL2	physical	16186509
TERA_HUMAN	VCP	physical	21832065
IMB1_HUMAN	KPNB1	physical	21832065
AMFR_HUMAN	AMFR	physical	21832065
DERL1_HUMAN	DERL1	physical	21832065
SELK_HUMAN	SELK	physical	22119785
KLDC2_HUMAN	KLHDC2	physical	22119785
UBXN8_HUMAN	UBXN8	physical	22119785
DERL1_HUMAN	DERL1	physical	22119785
DERL2_HUMAN	DERL2	physical	22119785
TERA_HUMAN	VCP	physical	22119785
UBE4A_HUMAN	UBE4A	physical	22119785
FAF2_HUMAN	FAF2	physical	22119785
TERA_HUMAN	VCP	physical	24424410
CKAP4_HUMAN	CKAP4	physical	25008318
TERA_HUMAN	VCP	physical	25008318
SNTG2_HUMAN	SNTG2	physical	25008318
TERA_HUMAN	VCP	physical	24700463

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SELS_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140, AND MASSSPECTROMETRY.	18669648 [Abstract]