| UniProt ID | SNTG2_HUMAN | |
|---|---|---|
| UniProt AC | Q9NY99 | |
| Protein Name | Gamma-2-syntrophin | |
| Gene Name | SNTG2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 539 | |
| Subcellular Localization |
Cell membrane, sarcolemma Peripheral membrane protein Cytoplasmic side. Cytoplasm, cytoskeleton. In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane. |
|
| Protein Description | Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity).. | |
| Protein Sequence | MGTEGPPPPAASRGRQGCLLVPARTKTTIALLYDEESENAYDIRLKLTKEVLTIQKQDVVCVGGSHQGRNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLGSPGPSSDHSSGASSPLFDSGLHLNGNSSTTAPSSPSSPIAKDPRYEKRWLDTLSVPLSMARISRYKAGTEKLRWNAFEVLALDGVSSGILRFYTAQDGTDWLRAVSANIRELTLQNMKMANKCCSPSDQVVHMGWVNEKLQGADSSQTFRPKFLALKGPSFYVFSTPPVSTFDWVRAERTYHLCEVLFKVHKFWLTEDCWLQANLYLGLQDFDFEDQRPYCFSIVAGHGKSHVFNVELGSELAMWEKSFQRATFMEVQRTGSRTYMCSWQGEMLCFTVDFALGFTCFESKTKNVLWRFKFSQLKGSSDDGKTRVKLLFQNLDTKQIETKELEFQDLRAVLHCIHSFIAAKVASVDPGFMDSQSLARKYMYSS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 87 | Phosphorylation | PVGGLGLSIKGGSEH CCCCCEEEECCCCCC | 22.06 | - | |
| 87 | O-linked_Glycosylation | PVGGLGLSIKGGSEH CCCCCEEEECCCCCC | 22.06 | 29351928 | |
| 92 | Phosphorylation | GLSIKGGSEHNVPVV EEEECCCCCCCCCEE | 44.33 | - | |
| 102 | Acetylation | NVPVVISKIFEDQAA CCCEEEEEHHCCCCC | 40.05 | 24469705 | |
| 168 | Phosphorylation | FLKLPLGSPGPSSDH EEECCCCCCCCCCCC | 34.07 | 22210691 | |
| 292 | Phosphorylation | KMANKCCSPSDQVVH HHHCCCCCCHHHEEE | 36.59 | - | |
| 294 | Phosphorylation | ANKCCSPSDQVVHMG HCCCCCCHHHEEEEH | 25.12 | - | |
| 319 | Ubiquitination | SSQTFRPKFLALKGP CCCCCCCCEEEEECC | 49.07 | - | |
| 348 | Phosphorylation | WVRAERTYHLCEVLF HHHHHHHHHHHHHHH | 10.06 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SNTG2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SNTG2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SNTG2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SELS_HUMAN | VIMP | physical | 25008318 | |
| DMD_HUMAN | DMD | physical | 28514442 | |
| DTNB_HUMAN | DTNB | physical | 28514442 | |
| SNTA1_HUMAN | SNTA1 | physical | 28514442 | |
| CTNL1_HUMAN | CTNNAL1 | physical | 28514442 | |
| SNTB1_HUMAN | SNTB1 | physical | 28514442 | |
| DTNA_HUMAN | DTNA | physical | 28514442 | |
| SNTB2_HUMAN | SNTB2 | physical | 28514442 | |
| UTRO_HUMAN | UTRN | physical | 28514442 | |
| RNF31_HUMAN | RNF31 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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