DTNB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DTNB_HUMAN
• UniProt AC: O60941
• Protein Name: Dystrobrevin beta
• Gene Name: DTNB
• Organism: Homo sapiens (Human).
• Sequence Length: 627
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MIEESGNKRKTMAEKRQLFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNLHLVDIWNMIEAFRDNGLNTLDHTTEISVSRLETVISSIYYQLNKRLPSTHQISVEQSISLLLNFMIAAYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRYVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVFHPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNTMSSLVKELHSAEEGAEEEEEKMQNGKDRG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MIEESGNK -------CCCCCCCC	8.64	25732826
10	Acetylation	EESGNKRKTMAEKRQ CCCCCCCCCHHHHHH	44.24	18528985
11	Phosphorylation	ESGNKRKTMAEKRQL CCCCCCCCHHHHHHH	26.16	26657352
69	Phosphorylation	FRDNGLNTLDHTTEI HHHCCCCCCCCCCEE	38.31	-
77	Phosphorylation	LDHTTEISVSRLETV CCCCCEEEHHHHHHH	14.06	24719451
79	Phosphorylation	HTTEISVSRLETVIS CCCEEEHHHHHHHHH	25.10	29116813
98	Phosphorylation	QLNKRLPSTHQISVE HHHCCCCCCCCCCHH	43.01	24043423
99	Phosphorylation	LNKRLPSTHQISVEQ HHCCCCCCCCCCHHH	18.83	24043423
103	Phosphorylation	LPSTHQISVEQSISL CCCCCCCCHHHHHHH	17.03	24043423
107	Phosphorylation	HQISVEQSISLLLNF CCCCHHHHHHHHHHH	10.71	24043423
109	Phosphorylation	ISVEQSISLLLNFMI CCHHHHHHHHHHHHH	20.43	24043423
119	Phosphorylation	LNFMIAAYDSEGRGK HHHHHHHHCCCCCCC	15.81	24043423
121	Phosphorylation	FMIAAYDSEGRGKLT HHHHHHCCCCCCCEE	29.31	24043423
128	Phosphorylation	SEGRGKLTVFSVKAM CCCCCCEEEEEHHHH	24.00	-
143	Acetylation	LATMCGGKMLDKLRY HHHHHCCHHHHHHHH	22.90	19824875
165	Phosphorylation	SNGLMIFSKFDQFLK CCCEEHHHHHHHHHH	22.84	24719451
179	Phosphorylation	KEVLKLPTAVFEGPS HHHHCCCCHHHCCCC	45.98	-
193	Phosphorylation	SFGYTEHSVRTCFPQ CCCCCCHHHHHCCHH	13.68	28857561
212	Phosphorylation	MLNMFLDTMMADPPP HHHHHHHHHHCCCCH	15.82	-
245	Phosphorylation	FHPVECSYCRCESMM CCCEECCCCCCHHHC	8.79	30576142
250	Phosphorylation	CSYCRCESMMGFRYR CCCCCCHHHCCCCCC	20.07	28857561
290	Phosphorylation	QHQMKEHSSWKSPAK HHHHHHCCCCCCHHH	38.70	25627689
291	Phosphorylation	HQMKEHSSWKSPAKK HHHHHCCCCCCHHHH	40.19	29449344
294	Phosphorylation	KEHSSWKSPAKKLSH HHCCCCCCHHHHHHH	24.67	28985074
300	Phosphorylation	KSPAKKLSHAISKSL CCHHHHHHHHHHHHH	21.54	28555341
304	Phosphorylation	KKLSHAISKSLGCVP HHHHHHHHHHHCCCC	19.58	28348404
306	Phosphorylation	LSHAISKSLGCVPTR HHHHHHHHHCCCCCC	24.17	27499020
356 (in isoform 5)	Phosphorylation	-	40.98	25627689
356 (in isoform 2)	Phosphorylation	-	40.98	25627689
358 (in isoform 5)	Phosphorylation	-	31.13	-
358 (in isoform 2)	Phosphorylation	-	31.13	-
364 (in isoform 5)	Phosphorylation	-	14.39	21815630
364	Phosphorylation	PTKRLQYSQDIPSHL CCCCCCCCCCCCHHH	14.39	27251275
364 (in isoform 2)	Phosphorylation	-	14.39	21815630
366 (in isoform 5)	Phosphorylation	-	49.15	-
366 (in isoform 2)	Phosphorylation	-	49.15	-
394	Phosphorylation	HCARVLDSPSRLDEE HHHHHCCCCCCCCHH	22.18	30266825
396	Phosphorylation	ARVLDSPSRLDEEHR HHHCCCCCCCCHHHH	49.80	30266825
420	Phosphorylation	AAEAGNVTRPPTDLS HHHHCCCCCCCCCCE	41.27	-
424	Phosphorylation	GNVTRPPTDLSFNFD CCCCCCCCCCEECCC	52.86	28555341
427	Phosphorylation	TRPPTDLSFNFDANK CCCCCCCEECCCCCH	22.43	27251275
465 (in isoform 6)	Phosphorylation	-	36.07	21118733
465	Phosphorylation	RLEHEQASQPTPEKA HHHHHHHCCCCCHHH	36.07	30266825
467 (in isoform 6)	Phosphorylation	-	47.64	25849741
468	Phosphorylation	HEQASQPTPEKAQQN HHHHCCCCCHHHHHC	36.12	30266825
470 (in isoform 6)	Phosphorylation	-	64.60	25849741
471 (in isoform 6)	Phosphorylation	-	53.34	25849741
473 (in isoform 6)	Phosphorylation	-	55.43	21712546
477	Phosphorylation	EKAQQNPTLLAELRL HHHHHCHHHHHHHHH	41.79	24076635
492 (in isoform 5)	Phosphorylation	-	11.02	24719451
494 (in isoform 5)	Phosphorylation	-	60.03	25849741
497	Phosphorylation	DELEQRMSALQESRR HHHHHHHHHHHHHHH	28.19	26437602
497 (in isoform 5)	Phosphorylation	-	28.19	25849741
498 (in isoform 5)	Phosphorylation	-	12.15	25849741
500 (in isoform 5)	Phosphorylation	-	46.46	21712546
502	Phosphorylation	RMSALQESRRELMVQ HHHHHHHHHHHHHHH	24.55	26552605
524	Phosphorylation	LKEEEQKQAAQATGS HHHHHHHHHHHHHCC	41.44	27251275
527	Phosphorylation	EEQKQAAQATGSPHT HHHHHHHHHHCCCCC	42.33	27251275
529	Phosphorylation	QKQAAQATGSPHTSP HHHHHHHHCCCCCCC	26.55	30266825
531	Phosphorylation	QAAQATGSPHTSPTH HHHHHHCCCCCCCCC	14.78	30266825
534	Phosphorylation	QATGSPHTSPTHGGG HHHCCCCCCCCCCCC	39.52	30266825
535	Phosphorylation	ATGSPHTSPTHGGGR HHCCCCCCCCCCCCC	25.43	30266825
537	Phosphorylation	GSPHTSPTHGGGRPM CCCCCCCCCCCCCCC	32.68	30266825
542 (in isoform 3)	Phosphorylation	-	27.84	28450419
543 (in isoform 3)	Phosphorylation	-	34.21	28450419
550	Phosphorylation	PMPMPVRSTSAGSTP CCCCCCCCCCCCCCC	27.27	29978859
550 (in isoform 3)	Phosphorylation	-	27.27	22617229
551	Phosphorylation	MPMPVRSTSAGSTPT CCCCCCCCCCCCCCC	16.42	29978859
552	Phosphorylation	PMPVRSTSAGSTPTH CCCCCCCCCCCCCCC	31.70	18669648
555	Phosphorylation	VRSTSAGSTPTHCPQ CCCCCCCCCCCCCCC	30.81	29978859
556	Phosphorylation	RSTSAGSTPTHCPQD CCCCCCCCCCCCCCH	31.15	18669648
558	Phosphorylation	TSAGSTPTHCPQDSL CCCCCCCCCCCCHHC	35.88	29978859
564	Phosphorylation	PTHCPQDSLSGVGGD CCCCCCHHCCCCCHH	21.13	29978859
566	Phosphorylation	HCPQDSLSGVGGDVQ CCCCHHCCCCCHHHH	35.07	27732954
580	Phosphorylation	QEAFAQGTRRNLRND HHHHHHHCHHHHHHH	17.86	27732954
594	Phosphorylation	DLLVAADSITNTMSS HHHHHHHHHHHHHHH	26.96	26657352
608	Phosphorylation	SLVKELHSAEEGAEE HHHHHHHHHHCHHHH	50.42	25849741
624	Acetylation	EEKMQNGKDRG---- HHHHHCCCCCC----	52.37	7704123

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
11	T	Phosphorylation	Kinase	PRKACA	P17612	GPS
69	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
179	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
212	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
424	T	Phosphorylation	Kinase	PRKACA	P17612	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DTNB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DTNB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIF5A_HUMAN	KIF5A	physical	14600269
TSACC_HUMAN	TSACC	physical	16189514
NUP62_HUMAN	NUP62	physical	16189514
TRAF2_HUMAN	TRAF2	physical	16189514
CC85B_HUMAN	CCDC85B	physical	16189514
PRDC1_HUMAN	PRTFDC1	physical	16189514
BEGIN_HUMAN	BEGAIN	physical	16189514
HM20A_HUMAN	HMG20A	physical	16189514
LIPB2_HUMAN	PPFIBP2	physical	16189514
KINH_HUMAN	KIF5B	physical	14600269
HM20A_HUMAN	HMG20A	physical	20530487
DTNB_HUMAN	DTNB	physical	25416956
K1H1_HUMAN	KRT31	physical	25416956
TRAF2_HUMAN	TRAF2	physical	25416956
TERA_HUMAN	VCP	physical	25416956
LIPA1_HUMAN	PPFIA1	physical	25416956
ABI2_HUMAN	ABI2	physical	25416956
HM20A_HUMAN	HMG20A	physical	25416956
MTUS2_HUMAN	MTUS2	physical	25416956
NUP62_HUMAN	NUP62	physical	25416956
GGA1_HUMAN	GGA1	physical	25416956
ABI3_HUMAN	ABI3	physical	25416956
CEP55_HUMAN	CEP55	physical	25416956
CEP63_HUMAN	CEP63	physical	25416956
NDEL1_HUMAN	NDEL1	physical	25416956
USBP1_HUMAN	USHBP1	physical	25416956
DTBP1_HUMAN	DTNBP1	physical	25416956
SPZ1_HUMAN	SPZ1	physical	25416956
K1C40_HUMAN	KRT40	physical	25416956
TXLNA_HUMAN	TXLNA	physical	25416956
ZBTB9_HUMAN	ZBTB9	physical	25416956
CEP63_HUMAN	CEP63	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.