| UniProt ID | SPZ1_HUMAN | |
|---|---|---|
| UniProt AC | Q9BXG8 | |
| Protein Name | Spermatogenic leucine zipper protein 1 | |
| Gene Name | SPZ1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 430 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis (By similarity).. | |
| Protein Sequence | MASSAKSAEMPTISKTVNPTPDPHQEYLDPRITIALFEIGSHSPSSWGSLPFLKNSSHQVTEQQTAQKFNNLLKEIKDILKNMAGFEEKITEAKELFEETNITEDVSAHKENIRGLDKINEMLSTNLPVSLAPEKEDNEKKQEMILETNITEDVSAHKENIRGLDKINEMLSTNLPVSLAPEKEDNEKKQQMIMENQNSENTAQVFARDLVNRLEEKKVLNETQQSQEKAKNRLNVQEETMKIRNNMEQLLQEAEHWSKQHTELSKLIKSYQKSQKDISETLGNNGVGFQTQPNNEVSAKHELEEQVKKLSHDTYSLQLMAALLENECQILQQRVEILKELHHQKQGTLQEKPIQINYKQDKKNQKPSEAKKVEMYKQNKQAMKGTFWKKDRSCRSLDVCLNKKACNTQFNIHVARKALRGKMRSASSLR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MASSAKSAEM -----CCCCCCCCCC | 29.54 | 28509920 | |
| 4 | Phosphorylation | ----MASSAKSAEMP ----CCCCCCCCCCC | 30.12 | 28509920 | |
| 107 | Phosphorylation | TNITEDVSAHKENIR CCCCCCHHHHHHHCC | 36.66 | - | |
| 124 | Phosphorylation | DKINEMLSTNLPVSL HHHHHHHHCCCCCCC | 17.59 | 22210691 | |
| 125 | Phosphorylation | KINEMLSTNLPVSLA HHHHHHHCCCCCCCC | 36.49 | 22210691 | |
| 172 | Phosphorylation | DKINEMLSTNLPVSL HHHHHHHHCCCCCCC | 17.59 | 22210691 | |
| 173 | Phosphorylation | KINEMLSTNLPVSLA HHHHHHHCCCCCCCC | 36.49 | 22210691 | |
| 223 | Phosphorylation | EKKVLNETQQSQEKA HHHHHHHHHHHHHHH | 30.73 | 23403867 | |
| 226 | Phosphorylation | VLNETQQSQEKAKNR HHHHHHHHHHHHHHH | 30.41 | 23403867 | |
| 258 | Phosphorylation | LQEAEHWSKQHTELS HHHHHHHHHHHHHHH | 25.09 | - | |
| 265 | Phosphorylation | SKQHTELSKLIKSYQ HHHHHHHHHHHHHHH | 21.13 | - | |
| 362 | "N6,N6-dimethyllysine" | QINYKQDKKNQKPSE CCCCCCCCCCCCCCH | 51.64 | - | |
| 362 | Methylation | QINYKQDKKNQKPSE CCCCCCCCCCCCCCH | 51.64 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPZ1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPZ1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPZ1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| KDM1A_HUMAN | KDM1A | physical | 23455924 | |
| HERC2_HUMAN | HERC2 | physical | 26186194 | |
| NEUL4_HUMAN | NEURL4 | physical | 26186194 | |
| DTNA_HUMAN | DTNA | physical | 26186194 | |
| G3PT_HUMAN | GAPDHS | physical | 26186194 | |
| SNTB2_HUMAN | SNTB2 | physical | 26186194 | |
| SNTA1_HUMAN | SNTA1 | physical | 26186194 | |
| NEUL4_HUMAN | NEURL4 | physical | 28514442 | |
| HERC2_HUMAN | HERC2 | physical | 28514442 | |
| DTNA_HUMAN | DTNA | physical | 28514442 | |
| G3PT_HUMAN | GAPDHS | physical | 28514442 | |
| SNTA1_HUMAN | SNTA1 | physical | 28514442 | |
| SNTB2_HUMAN | SNTB2 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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