LIPB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIPB2_HUMAN
• UniProt AC: Q8ND30
• Protein Name: Liprin-beta-2
• Gene Name: PPFIBP2
• Organism: Homo sapiens (Human).
• Sequence Length: 876
• Protein Description: May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A..
• Protein Sequence: MASDASHALEAALEQMDGIIAGTKTGADLSDGTCEPGLASPASYMNPFPVLHLIEDLRLALEMLELPQERAALLSQIPGPTAAYIKEWFEESLSQVNHHSAASNETYQERLARLEGDKESLILQVSVLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEMLQQELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQYEWKLKATKAEVAQLQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRIEELTGLLNQYRKVKEIVMVTQGPSERTLSINEEEPEGGFSKWNATNKDPEELFKQEMPPRCSSPTVGPPPLPQKSLETRAQKKLSCSLEDLRSESVDKCMDGNQPFPVLEPKDSPFLAEHKYPTLPGKLSGATPNGEAAKSPPTICQPDATGSSLLRLRDTESGWDDTAVVNDLSSTSSGTESGPQSPLTPDGKRNPKGIKKFWGKIRRTQSGNFYTDTLGMAEFRRGGLRATAGPRLSRTRDSKGQKSDANAPFAQWSTERVCAWLEDFGLAQYVIFARQWVSSGHTLLTATPQDMEKELGIKHPLHRKKLVLAVKAINTKQEEKSALLDHIWVTRWLDDIGLPQYKDQFHESRVDRRMLQYLTVNDLLFLKVTSQLHHLSIKCAIHVLHVNKFNPHCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLRRHLTTKFNALIGPEAEQEKREKMASPAYTPLTTTAKVRPRKLGFSHFGNIRKKKFDESTDYICPMEPSDGVSDSHRVYSGYRGLSPLDAPELDGLDQVGQIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASDASHALE -----CCCHHHHHHH	32.20	19664995
6	Phosphorylation	--MASDASHALEAAL --CCCHHHHHHHHHH	17.81	22210691
19	Ubiquitination	ALEQMDGIIAGTKTG HHHHCCCEECCCCCC	1.37	33845483
23	Phosphorylation	MDGIIAGTKTGADLS CCCEECCCCCCCCCC	19.19	22210691
40	Phosphorylation	TCEPGLASPASYMNP CCCCCCCCCHHHCCC	26.49	28450419
43	Phosphorylation	PGLASPASYMNPFPV CCCCCCHHHCCCHHH	28.44	28450419
44	Phosphorylation	GLASPASYMNPFPVL CCCCCHHHCCCHHHH	11.74	28450419
166	Phosphorylation	MLQQELLSRTSLETQ HHHHHHHHCCCHHHH	46.25	24719451
168	Phosphorylation	QQELLSRTSLETQKL HHHHHHCCCHHHHHH	34.00	28857561
169	Phosphorylation	QELLSRTSLETQKLD HHHHHCCCHHHHHHH	24.09	28857561
172	Phosphorylation	LSRTSLETQKLDLMT HHCCCHHHHHHHHHH	35.98	28857561
179	Phosphorylation	TQKLDLMTEVSELKL HHHHHHHHHHHHHHH	40.30	-
182	Phosphorylation	LDLMTEVSELKLKLV HHHHHHHHHHHHHHH	30.86	-
220	Phosphorylation	RHLKIKVEELENERN HHHHHCHHHHHHHCC	52.44	33259812
251	Phosphorylation	QEQVALKDAEIERLH HHHHHHCHHHHHHHH	50.73	33259812
310	Phosphorylation	LTGLLNQYRKVKEIV HHHHHHHHHCCCEEE	16.01	22817900
320	Phosphorylation	VKEIVMVTQGPSERT CCEEEEEECCCCCCE	15.09	20860994
327	Phosphorylation	TQGPSERTLSINEEE ECCCCCCEECCCCCC	22.32	30266825
329	Phosphorylation	GPSERTLSINEEEPE CCCCCEECCCCCCCC	23.82	30266825
340	Phosphorylation	EEPEGGFSKWNATNK CCCCCCCCCCCCCCC	39.78	30266825
362	Phosphorylation	QEMPPRCSSPTVGPP CCCCCCCCCCCCCCC	40.40	23401153
363	Phosphorylation	EMPPRCSSPTVGPPP CCCCCCCCCCCCCCC	28.37	23401153
365	Phosphorylation	PPRCSSPTVGPPPLP CCCCCCCCCCCCCCC	39.79	23927012
378	Phosphorylation	LPQKSLETRAQKKLS CCCCHHHHHHHHHHC	36.28	25599653
385	Phosphorylation	TRAQKKLSCSLEDLR HHHHHHHCCCHHHHH	15.56	30266825
387	Phosphorylation	AQKKLSCSLEDLRSE HHHHHCCCHHHHHHH	31.27	19664994
393	Phosphorylation	CSLEDLRSESVDKCM CCHHHHHHHCHHHHC	41.33	23403867
395	Phosphorylation	LEDLRSESVDKCMDG HHHHHHHCHHHHCCC	36.54	23403867
414	Phosphorylation	PVLEPKDSPFLAEHK CCCCCCCCCCCCCCC	24.55	25849741
422	Phosphorylation	PFLAEHKYPTLPGKL CCCCCCCCCCCCCCC	11.89	23312004
424	Phosphorylation	LAEHKYPTLPGKLSG CCCCCCCCCCCCCCC	42.36	30576142
441	Phosphorylation	PNGEAAKSPPTICQP CCCCHHCCCCCCCCC	31.24	27732954
444	Phosphorylation	EAAKSPPTICQPDAT CHHCCCCCCCCCCCC	37.46	27732954
453	Phosphorylation	CQPDATGSSLLRLRD CCCCCCCCCCEEEEC	17.29	28348404
454	Phosphorylation	QPDATGSSLLRLRDT CCCCCCCCCEEEECC	32.54	24719451
461	Ubiquitination	SLLRLRDTESGWDDT CCEEEECCCCCCCCC	26.14	33845483
487	Phosphorylation	GTESGPQSPLTPDGK CCCCCCCCCCCCCCC	25.63	29116813
490	Phosphorylation	SGPQSPLTPDGKRNP CCCCCCCCCCCCCCC	23.79	29507054
492	Ubiquitination	PQSPLTPDGKRNPKG CCCCCCCCCCCCCHH	70.75	33845483
510	Phosphorylation	FWGKIRRTQSGNFYT HHHHCEECCCCCCCC	19.76	20044836
512	Phosphorylation	GKIRRTQSGNFYTDT HHCEECCCCCCCCCC	34.78	9624153
516	Phosphorylation	RTQSGNFYTDTLGMA ECCCCCCCCCCCCCH	14.01	28102081
517	Phosphorylation	TQSGNFYTDTLGMAE CCCCCCCCCCCCCHH	20.54	28450419
519	Phosphorylation	SGNFYTDTLGMAEFR CCCCCCCCCCCHHHH	19.88	28450419
533	Phosphorylation	RRGGLRATAGPRLSR HHCCCCCCCCCCCCC	26.22	27422710
539	Phosphorylation	ATAGPRLSRTRDSKG CCCCCCCCCCCCCCC	32.65	24719451
585	Phosphorylation	FARQWVSSGHTLLTA HHHHHHHCCCEEEEE	25.60	-
604	Ubiquitination	MEKELGIKHPLHRKK HHHHHCCCCCHHHHH	37.05	33845483
663	Phosphorylation	VDRRMLQYLTVNDLL HCHHHHHHHHHHHHH	10.61	-
729	Phosphorylation	RVMEWLRSVDLAEYA HHHHHHHCCCHHHHC	20.15	28857561
756	Phosphorylation	IILEPRFTGDTLAML EEECCCCCCCHHHHH	35.11	-
759	Phosphorylation	EPRFTGDTLAMLLNI CCCCCCCHHHHHHCC	20.12	-
771	Phosphorylation	LNIPPQKTLLRRHLT HCCCHHHHHHHHHHH	26.27	-
799	Phosphorylation	EKREKMASPAYTPLT HHHHHHCCCCCCCCC	13.43	28857561
802	Phosphorylation	EKMASPAYTPLTTTA HHHCCCCCCCCCCCC	16.57	29759185
807	Phosphorylation	PAYTPLTTTAKVRPR CCCCCCCCCCCCCCC	32.22	29759185
808	Phosphorylation	AYTPLTTTAKVRPRK CCCCCCCCCCCCCCC	21.17	29759185
819	Phosphorylation	RPRKLGFSHFGNIRK CCCCCCCCCCCCCCC	18.99	24719451
832	Phosphorylation	RKKKFDESTDYICPM CCCCCCCCCCCCCCC	28.55	26356563
833	Phosphorylation	KKKFDESTDYICPME CCCCCCCCCCCCCCC	30.67	26356563
835	Phosphorylation	KFDESTDYICPMEPS CCCCCCCCCCCCCCC	12.43	26356563
859	Phosphorylation	YSGYRGLSPLDAPEL CCCCCCCCCCCCCCC	26.66	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIPB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIPB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIPB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
LIPA1_HUMAN	PPFIA1	physical	9624153
LIPA2_HUMAN	PPFIA2	physical	9624153

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.