LIPA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIPA2_HUMAN
• UniProt AC: O75334
• Protein Name: Liprin-alpha-2
• Gene Name: PPFIA2
• Organism: Homo sapiens (Human).
• Sequence Length: 1257
• Subcellular Localization: Cytoplasm . Cell surface . Colocalizes with PTPRF at the cell surface.
• Protein Description: Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates..
• Protein Sequence: MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLASSSPPSGHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIKCETSPPPTPRALRMTHTLPSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHKAPKKKGIKSSIGRLFGKKEKARLGQLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHELLEEARRKGLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKTKESEEGSWAQCPVFLQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRWIQAIGLREYANNILESGVHGSLIALDENFDYSSLALLLQIPTQNTQARQILEREYNNLLALGTERRLDESDDKNFRRGSTWRRQFPPREVHGISMMPGSSETLPAGFRLTTTSGQSRKMTTDVASSRLQRLDNSTVRTYSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79 (in isoform 2)	Phosphorylation	-	39.51	30631047
79	Phosphorylation	SLQRQLNSALPQDIE HHHHHHHHCCCHHHH	39.51	28122231
87	Phosphorylation	ALPQDIESLTGGLAG CCCHHHHHHHCCCCC	31.40	28122231
89	Phosphorylation	PQDIESLTGGLAGSK CHHHHHHHCCCCCCC	38.18	28122231
95	Phosphorylation	LTGGLAGSKGADPPE HHCCCCCCCCCCCHH	23.47	28122231
151	Phosphorylation	LVSRHERSLRMTVVK HHHHCHHHHHEEEEE	19.83	-
163	Phosphorylation	VVKRQAQSPSGVSSE EEEHHCCCCCCCCHH	24.85	24076635
165	Phosphorylation	KRQAQSPSGVSSEVE EHHCCCCCCCCHHHH	58.01	24076635
168	Phosphorylation	AQSPSGVSSEVEVLK CCCCCCCCHHHHHHH	25.06	-
198	Phosphorylation	VRERLRVSLERVSAL HHHHHHHHHHHHHHH	20.34	24719451
229	Ubiquitination	QNVHIQRKMASSEGS CCHHHHHHHHCCCCC	23.57	21906983
233	Phosphorylation	IQRKMASSEGSTESE HHHHHHCCCCCCCHH	36.12	26434552
236	Phosphorylation	KMASSEGSTESEHLE HHHCCCCCCCHHHHC	25.58	-
237	Phosphorylation	MASSEGSTESEHLEG HHCCCCCCCHHHHCC	55.15	-
239	Phosphorylation	SSEGSTESEHLEGME CCCCCCCHHHHCCCC	30.33	26434552
257	Phosphorylation	KVHEKRLSNGSIDST CCCHHHCCCCCCCCC	43.08	29514088
260	Phosphorylation	EKRLSNGSIDSTDET HHHCCCCCCCCCCHH	27.72	23403867
263	Phosphorylation	LSNGSIDSTDETSQI CCCCCCCCCCHHHHH	35.77	29514088
264	Phosphorylation	SNGSIDSTDETSQIV CCCCCCCCCHHHHHH	33.82	29514088
267	Phosphorylation	SIDSTDETSQIVELQ CCCCCCHHHHHHHHH	28.83	29514088
268	Phosphorylation	IDSTDETSQIVELQE CCCCCHHHHHHHHHH	18.83	29514088
315	O-linked_Glycosylation	ARKDLIKTEEMNTKY HHHHHHHHHHHHHHH	30.13	30379171
347	Phosphorylation	ITTLEKRYLSAQRES HHHHHHHHHHHHHHC	18.97	23663014
349	Phosphorylation	TLEKRYLSAQRESTS HHHHHHHHHHHHCCC	17.27	23663014
354	Phosphorylation	YLSAQRESTSIHDMN HHHHHHHCCCHHHCC	29.64	23663014
355	Phosphorylation	LSAQRESTSIHDMND HHHHHHCCCHHHCCH	27.26	23663014
356	Phosphorylation	SAQRESTSIHDMNDK HHHHHCCCHHHCCHH	27.49	23663014
405	Phosphorylation	QTMRKAETLPEVEAE HHHHHHCCHHHHHHH	53.09	30624053
468	Phosphorylation	HNKRLSDTVDRLLTE HHHHHHHHHHHHHHH	22.41	-
474	Phosphorylation	DTVDRLLTESNERLQ HHHHHHHHHCHHHHH	41.79	-
476	Phosphorylation	VDRLLTESNERLQLH HHHHHHHCHHHHHHH	38.46	-
485	Ubiquitination	ERLQLHLKERMAALE HHHHHHHHHHHHHHH	32.31	-
536	Phosphorylation	LDQLKMRTGSLIEPT HHHHHHHHCCCCCCC	27.85	28857561
538	Phosphorylation	QLKMRTGSLIEPTIP HHHHHHCCCCCCCCC	26.09	28857561
558	Phosphorylation	TSAELRYSVGSLVDS CCCHHHHHHHHHCCC	17.36	27499020
594	Phosphorylation	RDEPKVKSLGDHEWN CCCCCCCCCCCCCCC	40.34	27251275
687	Phosphorylation	EIENRVASVSLEGLN HHHHHHHHEEECCCC	14.91	27499020
689	Phosphorylation	ENRVASVSLEGLNLA HHHHHHEEECCCCCC	20.43	28348404
712	Phosphorylation	TASVTASSLASSSPP EEEEEHHHHHCCCCC	26.03	-
715	Phosphorylation	VTASSLASSSPPSGH EEHHHHHCCCCCCCC	36.32	-
728	Phosphorylation	GHSTPKLTPRSPARE CCCCCCCCCCCCCCC	23.84	-
743	Phosphorylation	MDRMGVMTLPSDLRK CHHCCCCCCCHHHHH	32.86	27732954
746	Phosphorylation	MGVMTLPSDLRKHRR CCCCCCCHHHHHHCC	53.00	27732954
773	Phosphorylation	KATIKCETSPPPTPR CCEEEECCCCCCCCC	56.88	23403867
774	Phosphorylation	ATIKCETSPPPTPRA CEEEECCCCCCCCCH	17.08	23403867
817	Phosphorylation	GLGSANSSQDSLHKA CCCCCCCCHHHHHCC	37.50	-
820	Phosphorylation	SANSSQDSLHKAPKK CCCCCHHHHHCCCHH	25.41	24076635
828	Acetylation	LHKAPKKKGIKSSIG HHCCCHHHCCCHHHH	72.50	130207
831	Acetylation	APKKKGIKSSIGRLF CCHHHCCCHHHHHHH	46.98	130203
832	Phosphorylation	PKKKGIKSSIGRLFG CHHHCCCHHHHHHHC	25.85	21712546
833	Phosphorylation	KKKGIKSSIGRLFGK HHHCCCHHHHHHHCH	24.86	21712546
855	Phosphorylation	QLRGFMETEAAAQES HHHHHHHHHHHHHHH	21.09	-
891 (in isoform 5)	Phosphorylation	-	60.28	27762562
901 (in isoform 5)	Phosphorylation	-	21.39	27762562
935	Phosphorylation	GAIMSALSDTEIQRE CCHHHHCCCHHHHHH	42.05	-
965 (in isoform 4)	Phosphorylation	-	30.96	27762562
966	Phosphorylation	QEMVSLTSPSAPPTS HHHHHCCCCCCCCCC	23.35	25307156
972	Phosphorylation	TSPSAPPTSRTPSGN CCCCCCCCCCCCCCC	29.76	-
975	Phosphorylation	SAPPTSRTPSGNVWV CCCCCCCCCCCCEEE	22.90	-
1068	Phosphorylation	VHLKMVDSFHRTSLQ HHHHHHHCCHHHHHH	16.13	28857561
1098	Phosphorylation	LERRREASQHEIKDV HHHHHHHHHHHHHHH	27.58	-
1179	Phosphorylation	NNLLALGTERRLDES HHHHHHCCCCCCCCC	27.46	24719451
1215	Phosphorylation	GISMMPGSSETLPAG EEEECCCCCCCCCCC	21.09	-
1218	Phosphorylation	MMPGSSETLPAGFRL ECCCCCCCCCCCEEE	39.73	-
1227	Phosphorylation	PAGFRLTTTSGQSRK CCCEEEECCCCCCCC	24.45	-
1237	Phosphorylation	GQSRKMTTDVASSRL CCCCCCCCHHHHHHH	25.61	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIPA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIPA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIPA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GIT1_HUMAN	GIT1	physical	12923177
ERC2_HUMAN	ERC2	physical	12923177
LIPA1_HUMAN	PPFIA1	physical	9624153
LIPA2_HUMAN	PPFIA2	physical	9624153
LIPA3_HUMAN	PPFIA3	physical	9624153
LIPB1_HUMAN	PPFIBP1	physical	9624153

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.