LIPA3_HUMAN - dbPTM
LIPA3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LIPA3_HUMAN
UniProt AC O75145
Protein Name Liprin-alpha-3
Gene Name PPFIA3
Organism Homo sapiens (Human).
Sequence Length 1194
Subcellular Localization Cytoplasm . Cytoplasmic vesicle, secretory vesicle, acrosome . Also detected in epididymosome.
Protein Description May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates..
Protein Sequence MMCEVMPTISEDGRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDGLATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRERLRMALERVAVLEEELELSNQETLNLREQLSRRRSGLEEPGKDGDGQTLANGLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLEAQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLSEEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPSSYSRSLPGSALELRYSQAPTLPSGAHLDPYVAGSGRAGKRGRWSGVKEEPSKDWERSAPAGSIPPPFPGELDGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQRAEELESRVSSSGLDSLGRYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAPPSPAREGTDKANHVPKEEAGAPRGEGPAIPGDTPPPTPRSARLERMTQALALQAGSLEDGGPPRGSEGTPDSLHKAPKKKSIKSSIGRLFGKKEKGRMGPPGRDSSSLAGTPSDETLATDPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASSRTSTGNVWMTHEEMESLTATTKPETKEISWEQILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRKDLERRREESQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQIPTQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRKMFREKDLRGVTPDSAEMLPPNFRSAAAGALGSPGLPLRKLQPEGQTSGSSRADGVSVRTYSC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationSEDGRRGSALGPDEA
CCCCCCCCCCCCCCC		20.6430266825
55PhosphorylationEAQDGLATAQLRLRE
HHHHHHHHHHHHHHH		21.70-
75PhosphorylationDSLQRQLSIALPQEF
HHHHHHHHHHCHHHH		9.4722817900
130PhosphorylationLVSRHERSLRMTVVK
HHHHCHHHHHEEEEE		19.83-
142PhosphorylationVVKRQAQSPGGVSSE
EEEHHCCCCCCCCHH		28.6430576142
147PhosphorylationAQSPGGVSSEVEVLK
CCCCCCCCHHHHHHH		24.8527732954
148PhosphorylationQSPGGVSSEVEVLKA
CCCCCCCHHHHHHHH		43.1627732954
164UbiquitinationKSLFEHHKALDEKVR
HHHHHHHHHHHHHHH		53.1822505724
195PhosphorylationLELSNQETLNLREQL
HHHCCHHHHHHHHHH		15.9320886841
207PhosphorylationEQLSRRRSGLEEPGK
HHHHHHHCCCCCCCC		46.0130266825
220PhosphorylationGKDGDGQTLANGLGP
CCCCCCCCCCCCCCC		33.1130266825
231PhosphorylationGLGPGGDSNRRTAEL
CCCCCCCCCHHHHHH		35.2024719451
264PhosphorylationAVLCRQMSQLEEELG
HHHHHHHHHHHHHHH		24.23-
272PhosphorylationQLEEELGTAHRELGK
HHHHHHHHHHHHHHH		31.73-
286UbiquitinationKAEEANSKLQRDLKE
HHHHHHHHHHHHHHH		48.7424816145
292UbiquitinationSKLQRDLKEALAQRE
HHHHHHHHHHHHCCH		45.2724816145
340PhosphorylationLASKESLYRQSEEKS
HHCHHHHHHHCHHHH		18.8423403867
343PhosphorylationKESLYRQSEEKSRQL
HHHHHHHCHHHHHHH		38.4323403867
387UbiquitinationQRVAALNKAEERHGN
HHHHHHHHHHHHCCC		59.0124816145
409AcetylationLEAQLEEKNQELQRA
HHHHHHHHHHHHHHH		55.3326051181
431PhosphorylationDDHNKRLSETVDKLL
HHHHHHHHHHHHHHH		34.94-
439PhosphorylationETVDKLLSESNERLQ
HHHHHHHHHCHHHHH		49.7928348404
441PhosphorylationVDKLLSESNERLQLH
HHHHHHHCHHHHHHH		40.3828348404
450UbiquitinationERLQLHLKERMGALE
HHHHHHHHHHHHHHH		32.31-
505PhosphorylationRGRPPSSYSRSLPGS
CCCCCCCCCCCCCCC		16.67-
508PhosphorylationPPSSYSRSLPGSALE
CCCCCCCCCCCCCEE		32.7330266825
512PhosphorylationYSRSLPGSALELRYS
CCCCCCCCCEEEECC		27.9530266825
518PhosphorylationGSALELRYSQAPTLP
CCCEEEECCCCCCCC		20.1228796482
519PhosphorylationSALELRYSQAPTLPS
CCEEEECCCCCCCCC		17.2728796482
526PhosphorylationSQAPTLPSGAHLDPY
CCCCCCCCCCCCCCC		52.2928796482
533PhosphorylationSGAHLDPYVAGSGRA
CCCCCCCCCCCCCCC		11.5528796482
537PhosphorylationLDPYVAGSGRAGKRG
CCCCCCCCCCCCCCC		18.5028796482
639PhosphorylationEELESRVSSSGLDSL
HHHHHHHHHCCCHHH		20.0628555341
640PhosphorylationELESRVSSSGLDSLG
HHHHHHHHCCCHHHH		26.1029449344
641PhosphorylationLESRVSSSGLDSLGR
HHHHHHHCCCHHHHC		35.5529449344
645PhosphorylationVSSSGLDSLGRYRSS
HHHCCCHHHHCCCCC		37.4525849741
651PhosphorylationDSLGRYRSSCSLPPS
HHHHCCCCCCCCCCC		27.1127732954
652PhosphorylationSLGRYRSSCSLPPSL
HHHCCCCCCCCCCCC		9.9527732954
654PhosphorylationGRYRSSCSLPPSLTT
HCCCCCCCCCCCCCC		45.9527732954
658PhosphorylationSSCSLPPSLTTSTLA
CCCCCCCCCCCCCCC		36.0927732954
660PhosphorylationCSLPPSLTTSTLASP
CCCCCCCCCCCCCCC		24.0427732954
661PhosphorylationSLPPSLTTSTLASPS
CCCCCCCCCCCCCCC		25.6327732954
662PhosphorylationLPPSLTTSTLASPSP
CCCCCCCCCCCCCCC		19.0527732954
663PhosphorylationPPSLTTSTLASPSPP
CCCCCCCCCCCCCCC		25.0127732954
666PhosphorylationLTTSTLASPSPPSSG
CCCCCCCCCCCCCCC		29.0827732954
668PhosphorylationTSTLASPSPPSSGHS
CCCCCCCCCCCCCCC		47.1227732954
671PhosphorylationLASPSPPSSGHSTPR
CCCCCCCCCCCCCCC		52.9527732954
672PhosphorylationASPSPPSSGHSTPRL
CCCCCCCCCCCCCCC		46.4227732954
675PhosphorylationSPPSSGHSTPRLAPP
CCCCCCCCCCCCCCC		43.5627732954
676PhosphorylationPPSSGHSTPRLAPPS
CCCCCCCCCCCCCCC		13.5227732954
683PhosphorylationTPRLAPPSPAREGTD
CCCCCCCCCCCCCCC		30.0830266825
689PhosphorylationPSPAREGTDKANHVP
CCCCCCCCCCCCCCC		29.5823898821
697UbiquitinationDKANHVPKEEAGAPR
CCCCCCCHHHCCCCC		68.0724816145
714PhosphorylationGPAIPGDTPPPTPRS
CCCCCCCCCCCCCCH		43.5430266825
718PhosphorylationPGDTPPPTPRSARLE
CCCCCCCCCCHHHHH		36.7930266825
721PhosphorylationTPPPTPRSARLERMT
CCCCCCCHHHHHHHH		20.9526074081
728PhosphorylationSARLERMTQALALQA
HHHHHHHHHHHHHHH		19.5328258704
737PhosphorylationALALQAGSLEDGGPP
HHHHHHCCCCCCCCC		31.4428258704
762PhosphorylationHKAPKKKSIKSSIGR
CCCCCCCCHHHHHHH		44.0923909892
765PhosphorylationPKKKSIKSSIGRLFG
CCCCCHHHHHHHHHC		26.0521712546
766PhosphorylationKKKSIKSSIGRLFGK
CCCCHHHHHHHHHCC		24.8621712546
792PhosphorylationDSSSLAGTPSDETLA
CCCCCCCCCCCCCCC		17.6325332170
794PhosphorylationSSLAGTPSDETLATD
CCCCCCCCCCCCCCC		48.17-
807UbiquitinationTDPLGLAKLTGPGDK
CCCCCCHHHHCCCCH		52.1829967540
821UbiquitinationKDRRNKRKHELLEEA
HHHHHHHHHHHHHHH		42.94-
866UbiquitinationAACRANVKSGAIMAN
HHHHCCCCCCCEEEC		42.8730230243
989UbiquitinationRMLDHLNKKELRGQL
HHHHHCCHHHHHHHH		54.72-
1001PhosphorylationGQLKMVDSFHRVSLH
HHHCCHHCCHHHHHH		16.1328857561
1033O-linked_GlycosylationRRREESQTQIRDVMV
HHHHHHHHHHHHHHH		34.9330379171
1102UbiquitinationQARQLLEKEFSNLIS
HHHHHHHHHHHHHHH		65.1230230243
1105PhosphorylationQLLEKEFSNLISLGT
HHHHHHHHHHHHHCC		31.64-
1112PhosphorylationSNLISLGTDRRLDED
HHHHHHCCCCCCCHH		31.46-
1113UbiquitinationNLISLGTDRRLDEDS
HHHHHCCCCCCCHHH		31.7224816145
1122UbiquitinationRLDEDSAKSFSRSPS
CCCHHHHHHHCCCHH		56.8624816145
1123PhosphorylationLDEDSAKSFSRSPSW
CCHHHHHHHCCCHHH		28.3323312004
1125PhosphorylationEDSAKSFSRSPSWRK
HHHHHHHCCCHHHHH		38.6523312004
1127PhosphorylationSAKSFSRSPSWRKMF
HHHHHCCCHHHHHHH		23.3028555341
1129PhosphorylationKSFSRSPSWRKMFRE
HHHCCCHHHHHHHHH		40.5426074081
1143PhosphorylationEKDLRGVTPDSAEML
HHHHCCCCCCCHHHC		24.9727251275
1146PhosphorylationLRGVTPDSAEMLPPN
HCCCCCCCHHHCCCC		27.6027251275
1156PhosphorylationMLPPNFRSAAAGALG
HCCCCHHHHHCHHHC		20.3726074081
1162UbiquitinationRSAAAGALGSPGLPL
HHHHCHHHCCCCCCC		7.3524816145
1164PhosphorylationAAAGALGSPGLPLRK
HHCHHHCCCCCCCCC		19.3530266825
1171UbiquitinationSPGLPLRKLQPEGQT
CCCCCCCCCCCCCCC		60.1924816145
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LIPA3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LIPA3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LIPA3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GIT1_HUMANGIT1physical
12923177
ERC2_HUMANERC2physical
12923177
LIPA3_HUMANPPFIA3physical
9624153
LIPB1_HUMANPPFIBP1physical
9624153
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LIPA3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; SER-207; THR-714 ANDTHR-718, AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-683; THR-714 ANDSER-1164, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; THR-714 AND THR-718,AND MASS SPECTROMETRY.

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