NUP62_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUP62_HUMAN
• UniProt AC: P37198
• Protein Name: Nuclear pore glycoprotein p62
• Gene Name: NUP62
• Organism: Homo sapiens (Human).
• Sequence Length: 522
• Subcellular Localization: Nucleus, nuclear pore complex . Cytoplasm, cytoskeleton, spindle pole . Nucleus envelope . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Central region of the nuclear pore, within the transporter (PubMed:1915414). During mitoti
• Protein Description: Essential component of the nuclear pore complex. [PubMed: 1915414 The N-terminal is probably involved in nucleocytoplasmic transport]
• Protein Sequence: MSGFNFGGTGAPTGGFTFGTAKTATTTPATGFSFSTSGTGGFNFGAPFQPATSTPSTGLFSLATQTPATQTTGFTFGTATLASGGTGFSLGIGASKLNLSNTAATPAMANPSGFGLGSSNLTNAISSTVTSSQGTAPTGFVFGPSTTSVAPATTSGGFSFTGGSTAQPSGFNIGSAGNSAQPTAPATLPFTPATPAATTAGATQPAAPTPTATITSTGPSLFASIATAPTSSATTGLSLCTPVTTAGAPTAGTQGFSLKAPGAASGTSTTTSTAATATATTTSSSSTTGFALNLKPLAPAGIPSNTAAAVTAPPGPGAAAGAAASSAMTYAQLESLINKWSLELEDQERHFLQQATQVNAWDRTLIENGEKITSLHREVEKVKLDQKRLDQELDFILSQQKELEDLLSPLEELVKEQSGTIYLQHADEEREKTYKLAENIDAQLKRMAQDLKDIIEHLNTSGAPADTSDPLQQICKILNAHMDSLQWIDQNSALLQRKVEEVTKVCEGRRKEQERSFRITFD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGFNFGGT ------CCCCCCCCC	52.68	22223895
2	Phosphorylation	------MSGFNFGGT ------CCCCCCCCC	52.68	26074081
9	Phosphorylation	SGFNFGGTGAPTGGF CCCCCCCCCCCCCCE	30.46	26074081
13	O-linked_Glycosylation	FGGTGAPTGGFTFGT CCCCCCCCCCEEEEC	49.78	31492838
17	O-linked_Glycosylation	GAPTGGFTFGTAKTA CCCCCCEEEECCEEC	25.16	31492838
20	O-linked_Glycosylation	TGGFTFGTAKTATTT CCCEEEECCEECCCC	22.31	31492838
20	Phosphorylation	TGGFTFGTAKTATTT CCCEEEECCEECCCC	22.31	-
23	O-linked_Glycosylation	FTFGTAKTATTTPAT EEEECCEECCCCCCC	27.11	31492838
25	O-linked_Glycosylation	FGTAKTATTTPATGF EECCEECCCCCCCCE	36.11	31492838
26	O-linked_Glycosylation	GTAKTATTTPATGFS ECCEECCCCCCCCEE	28.46	31492838
27	O-linked_Glycosylation	TAKTATTTPATGFSF CCEECCCCCCCCEEE	13.43	31492838
30	O-linked_Glycosylation	TATTTPATGFSFSTS ECCCCCCCCEEEECC	39.71	31492838
33	O-linked_Glycosylation	TTPATGFSFSTSGTG CCCCCCEEEECCCCC	21.45	31492838
35	O-linked_Glycosylation	PATGFSFSTSGTGGF CCCCEEEECCCCCCC	22.06	31492838
36	O-linked_Glycosylation	ATGFSFSTSGTGGFN CCCEEEECCCCCCCC	29.21	31492838
37	O-linked_Glycosylation	TGFSFSTSGTGGFNF CCEEEECCCCCCCCC	32.91	31492838
39	O-linked_Glycosylation	FSFSTSGTGGFNFGA EEEECCCCCCCCCCC	33.62	31492838
52	O-linked_Glycosylation	GAPFQPATSTPSTGL CCCCCCCCCCCCCCC	39.55	31492838
53	O-linked_Glycosylation	APFQPATSTPSTGLF CCCCCCCCCCCCCCE	40.19	31492838
54	O-linked_Glycosylation	PFQPATSTPSTGLFS CCCCCCCCCCCCCEE	19.53	31492838
56	O-linked_Glycosylation	QPATSTPSTGLFSLA CCCCCCCCCCCEEEC	34.88	31492838
57	O-linked_Glycosylation	PATSTPSTGLFSLAT CCCCCCCCCCEEECC	38.82	31492838
61	O-linked_Glycosylation	TPSTGLFSLATQTPA CCCCCCEEECCCCCC	23.33	31492838
64	O-linked_Glycosylation	TGLFSLATQTPATQT CCCEEECCCCCCCCC	37.96	31492838
66	O-linked_Glycosylation	LFSLATQTPATQTTG CEEECCCCCCCCCCC	15.55	31492838
69	O-linked_Glycosylation	LATQTPATQTTGFTF ECCCCCCCCCCCEEE	27.87	31492838
71	O-linked_Glycosylation	TQTPATQTTGFTFGT CCCCCCCCCCEEEEE	25.24	31492838
72	O-linked_Glycosylation	QTPATQTTGFTFGTA CCCCCCCCCEEEEEE	22.08	31492838
75	O-linked_Glycosylation	ATQTTGFTFGTATLA CCCCCCEEEEEEEEC	23.62	31492838
78	O-linked_Glycosylation	TTGFTFGTATLASGG CCCEEEEEEEECCCC	16.57	31492838
89	O-linked_Glycosylation	ASGGTGFSLGIGASK CCCCCCCEEEECCCC	27.34	31492838
95	O-linked_Glycosylation	FSLGIGASKLNLSNT CEEEECCCCCCCCCC	32.25	31492838
100	O-linked_Glycosylation	GASKLNLSNTAATPA CCCCCCCCCCCCCCC	30.94	31492838
102	O-linked_Glycosylation	SKLNLSNTAATPAMA CCCCCCCCCCCCCCC	17.81	31492838
105	O-linked_Glycosylation	NLSNTAATPAMANPS CCCCCCCCCCCCCCC	14.76	31492838
112	O-linked_Glycosylation	TPAMANPSGFGLGSS CCCCCCCCCCCCCCC	46.70	31492838
118	O-linked_Glycosylation	PSGFGLGSSNLTNAI CCCCCCCCCCHHHHH	22.54	31492838
119	O-linked_Glycosylation	SGFGLGSSNLTNAIS CCCCCCCCCHHHHHH	33.78	31492838
122	O-linked_Glycosylation	GLGSSNLTNAISSTV CCCCCCHHHHHHCEE	27.18	31492838
126	O-linked_Glycosylation	SNLTNAISSTVTSSQ CCHHHHHHCEECCCC	19.97	31492838
127	O-linked_Glycosylation	NLTNAISSTVTSSQG CHHHHHHCEECCCCC	22.30	31492838
128	O-linked_Glycosylation	LTNAISSTVTSSQGT HHHHHHCEECCCCCC	22.47	31492838
130	O-linked_Glycosylation	NAISSTVTSSQGTAP HHHHCEECCCCCCCC	23.81	31492838
131	O-linked_Glycosylation	AISSTVTSSQGTAPT HHHCEECCCCCCCCC	19.14	31492838
132	O-linked_Glycosylation	ISSTVTSSQGTAPTG HHCEECCCCCCCCCE	24.22	31492838
135	O-linked_Glycosylation	TVTSSQGTAPTGFVF EECCCCCCCCCEEEE	23.10	31492838
138	O-linked_Glycosylation	SSQGTAPTGFVFGPS CCCCCCCCEEEECCC	40.56	31492838
145	O-linked_Glycosylation	TGFVFGPSTTSVAPA CEEEECCCCCCCCCC	44.70	31492838
146	O-linked_Glycosylation	GFVFGPSTTSVAPAT EEEECCCCCCCCCCC	26.65	31492838
147	O-linked_Glycosylation	FVFGPSTTSVAPATT EEECCCCCCCCCCCC	26.07	31492838
148	O-linked_Glycosylation	VFGPSTTSVAPATTS EECCCCCCCCCCCCC	19.17	31492838
153	O-linked_Glycosylation	TTSVAPATTSGGFSF CCCCCCCCCCCCCEE	22.04	31492838
154	O-linked_Glycosylation	TSVAPATTSGGFSFT CCCCCCCCCCCCEEC	27.72	31492838
155	O-linked_Glycosylation	SVAPATTSGGFSFTG CCCCCCCCCCCEECC	32.34	31492838
159	O-linked_Glycosylation	ATTSGGFSFTGGSTA CCCCCCCEECCCCCC	25.77	31492838
161	O-linked_Glycosylation	TSGGFSFTGGSTAQP CCCCCEECCCCCCCC	39.16	31492838
169	O-linked_Glycosylation	GGSTAQPSGFNIGSA CCCCCCCCCCCCCCC	43.89	31492838
175	O-linked_Glycosylation	PSGFNIGSAGNSAQP CCCCCCCCCCCCCCC	29.25	31492838
179	O-linked_Glycosylation	NIGSAGNSAQPTAPA CCCCCCCCCCCCCCC	27.62	31492838
183	O-linked_Glycosylation	AGNSAQPTAPATLPF CCCCCCCCCCCCCCC	32.94	31492838
187	O-linked_Glycosylation	AQPTAPATLPFTPAT CCCCCCCCCCCCCCC	33.63	31492838
191	O-linked_Glycosylation	APATLPFTPATPAAT CCCCCCCCCCCCCCC	15.29	31492838
194	O-linked_Glycosylation	TLPFTPATPAATTAG CCCCCCCCCCCCCCC	18.05	31492838
198	O-linked_Glycosylation	TPATPAATTAGATQP CCCCCCCCCCCCCCC	21.20	31492838
199	O-linked_Glycosylation	PATPAATTAGATQPA CCCCCCCCCCCCCCC	20.54	31492838
203	O-linked_Glycosylation	AATTAGATQPAAPTP CCCCCCCCCCCCCCC	33.88	31492838
209	O-linked_Glycosylation	ATQPAAPTPTATITS CCCCCCCCCCEEEEC	28.66	31492838
211	O-linked_Glycosylation	QPAAPTPTATITSTG CCCCCCCCEEEECCC	38.62	31492838
215	O-linked_Glycosylation	PTPTATITSTGPSLF CCCCEEEECCCHHHH	18.84	31492838
216	O-linked_Glycosylation	TPTATITSTGPSLFA CCCEEEECCCHHHHH	27.76	31492838
224	O-linked_Glycosylation	TGPSLFASIATAPTS CCHHHHHEEEECCCC	12.86	31492838
227	O-linked_Glycosylation	SLFASIATAPTSSAT HHHHEEEECCCCCCC	31.34	31492838
230	O-linked_Glycosylation	ASIATAPTSSATTGL HEEEECCCCCCCCCC	32.61	31492838
231	O-linked_Glycosylation	SIATAPTSSATTGLS EEEECCCCCCCCCCC	19.54	31492838
232	O-linked_Glycosylation	IATAPTSSATTGLSL EEECCCCCCCCCCCC	31.92	31492838
234	O-linked_Glycosylation	TAPTSSATTGLSLCT ECCCCCCCCCCCCCC	24.28	31492838
235	O-linked_Glycosylation	APTSSATTGLSLCTP CCCCCCCCCCCCCCC	35.52	31492838
238	O-linked_Glycosylation	SSATTGLSLCTPVTT CCCCCCCCCCCCEEE	23.81	31492838
241	O-linked_Glycosylation	TTGLSLCTPVTTAGA CCCCCCCCCEEECCC	26.53	31492838
244	O-linked_Glycosylation	LSLCTPVTTAGAPTA CCCCCCEEECCCCCC	16.48	31492838
245	O-linked_Glycosylation	SLCTPVTTAGAPTAG CCCCCEEECCCCCCC	24.27	31492838
250	O-linked_Glycosylation	VTTAGAPTAGTQGFS EEECCCCCCCCCCEE	36.87	31492838
253	O-linked_Glycosylation	AGAPTAGTQGFSLKA CCCCCCCCCCEEEEC	24.05	31492838
265	O-linked_Glycosylation	LKAPGAASGTSTTTS EECCCCCCCCCCCCC	41.91	31492838
269	O-linked_Glycosylation	GAASGTSTTTSTAAT CCCCCCCCCCCCEEE	33.65	31492838
269	Phosphorylation	GAASGTSTTTSTAAT CCCCCCCCCCCCEEE	33.65	-
270	O-linked_Glycosylation	AASGTSTTTSTAATA CCCCCCCCCCCEEEE	20.65	31492838
272	O-linked_Glycosylation	SGTSTTTSTAATATA CCCCCCCCCEEEEEE	17.60	31492838
272	Phosphorylation	SGTSTTTSTAATATA CCCCCCCCCEEEEEE	17.60	-
273	Phosphorylation	GTSTTTSTAATATAT CCCCCCCCEEEEEEE	20.44	28985074
281	Phosphorylation	AATATATTTSSSSTT EEEEEEEECCCCCCC	23.40	-
304	O-linked_Glycosylation	LAPAGIPSNTAAAVT CCCCCCCCCCEEEEE	44.91	31492838
306	O-linked_Glycosylation	PAGIPSNTAAAVTAP CCCCCCCCEEEEECC	23.24	31492838
306	Phosphorylation	PAGIPSNTAAAVTAP CCCCCCCCEEEEECC	23.24	22210691
311	O-linked_Glycosylation	SNTAAAVTAPPGPGA CCCEEEEECCCCCCH	28.81	31492838
325	O-linked_Glycosylation	AAAGAAASSAMTYAQ HHHHHHHHHHCHHHH	17.57	31492838
329	Phosphorylation	AAASSAMTYAQLESL HHHHHHCHHHHHHHH	18.54	22210691
335	Phosphorylation	MTYAQLESLINKWSL CHHHHHHHHHHHHCC	43.04	24719451
371	Acetylation	TLIENGEKITSLHRE HHHHCCHHHHHHHHH	53.32	23236377
371	Ubiquitination	TLIENGEKITSLHRE HHHHCCHHHHHHHHH	53.32	21890473
373	O-linked_Glycosylation	IENGEKITSLHREVE HHCCHHHHHHHHHHH	35.98	UniProtKB CARBOHYD
408	Phosphorylation	KELEDLLSPLEELVK HHHHHHHHHHHHHHH	34.43	28355574
415	Ubiquitination	SPLEELVKEQSGTIY HHHHHHHHHCCCCEE	63.76	-
418	Phosphorylation	EELVKEQSGTIYLQH HHHHHHCCCCEEEEE	38.71	30266825
420	Phosphorylation	LVKEQSGTIYLQHAD HHHHCCCCEEEEECH	16.22	30266825
422	Phosphorylation	KEQSGTIYLQHADEE HHCCCCEEEEECHHH	10.51	30266825
434	Phosphorylation	DEEREKTYKLAENID HHHHHHHHHHHHHHH	18.31	-
435	Acetylation	EEREKTYKLAENIDA HHHHHHHHHHHHHHH	46.59	25953088
435	Ubiquitination	EEREKTYKLAENIDA HHHHHHHHHHHHHHH	46.59	21890473
445	2-Hydroxyisobutyrylation	ENIDAQLKRMAQDLK HHHHHHHHHHHHHHH	28.22	-
445	Ubiquitination	ENIDAQLKRMAQDLK HHHHHHHHHHHHHHH	28.22	21890473
452	Ubiquitination	KRMAQDLKDIIEHLN HHHHHHHHHHHHHHH	55.99	-
467	Phosphorylation	TSGAPADTSDPLQQI CCCCCCCCCCHHHHH	36.82	23663014
468	O-linked_Glycosylation	SGAPADTSDPLQQIC CCCCCCCCCHHHHHH	37.47	UniProtKB CARBOHYD
468	Phosphorylation	SGAPADTSDPLQQIC CCCCCCCCCHHHHHH	37.47	23663014
476	Ubiquitination	DPLQQICKILNAHMD CHHHHHHHHHHHHHH	52.43	-
484	Phosphorylation	ILNAHMDSLQWIDQN HHHHHHHHHHHHHHC	18.19	29978859
492	Phosphorylation	LQWIDQNSALLQRKV HHHHHHCHHHHHHHH	18.05	29978859
498	Ubiquitination	NSALLQRKVEEVTKV CHHHHHHHHHHHHHH	40.83	-
504	Acetylation	RKVEEVTKVCEGRRK HHHHHHHHHHCCCCC	50.49	25953088
504	Ubiquitination	RKVEEVTKVCEGRRK HHHHHHHHHHCCCCC	50.49	-
516	Phosphorylation	RRKEQERSFRITFD- CCCCCCCCEEEECC-	20.37	25159151
520	Phosphorylation	QERSFRITFD----- CCCCEEEECC-----	19.93	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
269	T	Phosphorylation	Kinase	P38G	P53778	PSP
272	S	Phosphorylation	Kinase	P38G	P53778	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUP62_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUP62_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUP54_HUMAN	NUP54	physical	16189514
WASC3_HUMAN	CCDC53	physical	16189514
THAP1_HUMAN	THAP1	physical	16189514
GORS2_HUMAN	GORASP2	physical	16189514
RED_HUMAN	IK	physical	16169070
NTF2_HUMAN	NUTF2	physical	8707840
IMA5_HUMAN	KPNA1	physical	8707840
TRAF3_HUMAN	TRAF3	physical	10781837
HSF2_HUMAN	HSF2	physical	9367915
NTF2_HUMAN	NUTF2	physical	7744965
IMB1_HUMAN	KPNB1	physical	12894213
CTNB1_HUMAN	CTNNB1	physical	22110128
NUCL_HUMAN	NCL	physical	18292223
BIG1_HUMAN	ARFGEF1	physical	18292223
NXF1_HUMAN	NXF1	physical	16314397
MUC1_HUMAN	MUC1	physical	17500061
SP1_HUMAN	SP1	physical	9407313
NUP93_HUMAN	NUP93	physical	9348540
BIG1_HUMAN	ARFGEF1	physical	14973189
NUCL_HUMAN	NCL	physical	14973189
BL1S6_HUMAN	BLOC1S6	physical	25416956
WASC3_HUMAN	CCDC53	physical	25416956
PF21A_HUMAN	PHF21A	physical	25416956
NUP54_HUMAN	NUP54	physical	25416956
K1C20_HUMAN	KRT20	physical	25416956
CCHCR_HUMAN	CCHCR1	physical	25416956
CRCT1_HUMAN	CRCT1	physical	25416956
THAP1_HUMAN	THAP1	physical	25416956
CC146_HUMAN	CCDC146	physical	25416956
CC121_HUMAN	CCDC121	physical	25416956
CENPU_HUMAN	CENPU	physical	25416956
IFT20_HUMAN	IFT20	physical	25416956
KLH32_HUMAN	KLHL32	physical	25416956
HAUS1_HUMAN	HAUS1	physical	25416956
IKIP_HUMAN	IKBIP	physical	25416956
CA216_HUMAN	C1orf216	physical	25416956
AGR3_HUMAN	AGR3	physical	25416956
TXLNA_HUMAN	TXLNA	physical	25416956
CC153_HUMAN	CCDC153	physical	25416956
KANL1_HUMAN	KANSL1	physical	25416956
SRCRL_HUMAN	SSC5D	physical	25416956
CC150_HUMAN	CCDC150	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956
NUP54_HUMAN	NUP54	physical	8045926
RBP2_HUMAN	RANBP2	physical	16730000
NU214_HUMAN	NUP214	physical	16730000
NU153_HUMAN	NUP153	physical	16730000
NUP62_HUMAN	NUP62	physical	16730000
KANL1_HUMAN	KANSL1	physical	21516116
WASC3_HUMAN	CCDC53	physical	21516116
IFT25_HUMAN	HSPB11	physical	21516116
NUP54_HUMAN	NUP54	physical	21516116
THAP1_HUMAN	THAP1	physical	21516116
CC121_HUMAN	CCDC121	physical	21516116
OGT1_HUMAN	OGT	physical	21516116
NUP58_HUMAN	NUPL1	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 271930: Infantile striatonigral degeneration (SNDI)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.