MUC1_HUMAN - dbPTM
MUC1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MUC1_HUMAN
UniProt AC P15941
Protein Name Mucin-1
Gene Name MUC1
Organism Homo sapiens (Human).
Sequence Length 1255
Subcellular Localization Apical cell membrane
Single-pass type I membrane protein . Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvill
Protein Description The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.; The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity..
Protein Sequence MTPGTQSPFFLLLLLTVLTVVTGSGHASSTPGGEKETSATQRSSVPSSTEKNAVSMTSSVLSSHSPGSGSSTTQGQDVTLAPATEPASGSAATWGQDVTSVPVTRPALGSTTPPAHDVTSAPDNKPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDNRPALGSTAPPVHNVTSASGSASGSASTLVHNGTSARATTTPASKSTPFSIPSHHSDTPTTLASHSTKTDASSTHHSSVPPLTSSNHSTSPQLSTGVSFFFLSFHISNLQFNSSLEDPSTDYYQELQRDISEMFLQIYKQGGFLGLSNIKFRPGSVVVQLTLAFREGTINVHDVETQFNQYKTEAASRYNLTISDVSVSDVPFPFSAQSGAGVPGWGIALLVLVCVLVALAIVYLIALAVCQCRRKNYGQLDIFPARDTYHPMSEYPTYHTHGRYVPPSSTDRSPYEKVSAGNGGSSLSYTNPAVAATSANL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19O-linked_GlycosylationLLLLTVLTVVTGSGH
HHHHHHHHHHHCCCC		14.489312074
38PhosphorylationPGGEKETSATQRSSV
CCCCCCCCCCHHHCC		30.34-
47 (in isoform 10)Phosphorylation-47.97-
47 (in isoform 14)Phosphorylation-47.97-
47 (in isoform 6)Phosphorylation-47.97-
58 (in isoform 10)Phosphorylation-15.1427251275
58 (in isoform 14)Phosphorylation-15.1427251275
58 (in isoform 6)Phosphorylation-15.1427251275
59 (in isoform 10)Phosphorylation-20.2227251275
59 (in isoform 14)Phosphorylation-20.2227251275
59 (in isoform 6)Phosphorylation-20.2227251275
60 (in isoform 10)Phosphorylation-6.3527251275
60 (in isoform 14)Phosphorylation-6.3527251275
60 (in isoform 6)Phosphorylation-6.3527251275
62 (in isoform 10)Phosphorylation-24.6927251275
62 (in isoform 14)Phosphorylation-24.6927251275
62 (in isoform 6)Phosphorylation-24.6927251275
68PhosphorylationLSSHSPGSGSSTTQG
HHCCCCCCCCCCCCC		38.6027251275
69PhosphorylationSSHSPGSGSSTTQGQ
HCCCCCCCCCCCCCC		31.3727251275
71PhosphorylationHSPGSGSSTTQGQDV
CCCCCCCCCCCCCCE		38.7127251275
130O-linked_GlycosylationDNKPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.9730059200
131O-linked_GlycosylationNKPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.4530059200
139O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.6230059200
140O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.089312074
142N-linked_GlycosylationAHGVTSAPDTRPAPG
CCCCCCCCCCCCCCC		43.18-
144O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.189312074
144PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
144 (in isoform 13)Phosphorylation-37.1828111955
148 (in isoform 13)Phosphorylation-39.6928111955
150O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
150 (in isoform 13)Phosphorylation-21.9728111955
151O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
153 (in isoform 13)Phosphorylation-27.0528111955
155 (in isoform 13)Phosphorylation-15.8228111955
158 (in isoform 13)Phosphorylation-2.4728111955
159O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
160O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
162 (in isoform 13)Phosphorylation-43.1828111955
164O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
164PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
170O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
171O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
179O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
180O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
184O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
184PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
190O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
191O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
199O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
200O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
200PhosphorylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
204O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
204PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
210O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
211O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
212PhosphorylationRPAPGSTAPPAHGVT
CCCCCCCCCCCCCCC		15.13-
218O-linked_GlycosylationTAPPAHGVTSAPDTR
CCCCCCCCCCCCCCC		2.47-
218PhosphorylationTAPPAHGVTSAPDTR
CCCCCCCCCCCCCCC		2.47-
219O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
220O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
221PhosphorylationPAHGVTSAPDTRPAP
CCCCCCCCCCCCCCC		9.16-
222O-linked_GlycosylationAHGVTSAPDTRPAPG
CCCCCCCCCCCCCCC		43.18-
224O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
224PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
228O-linked_GlycosylationAPDTRPAPGSTAPPA
CCCCCCCCCCCCCCC		39.69-
230O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
231O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
231 (in isoform 17)Phosphorylation-49.4522210691
232O-linked_GlycosylationRPAPGSTAPPAHGVT
CCCCCCCCCCCCCCC		15.13-
232 (in isoform 17)Phosphorylation-15.1322210691
233O-linked_GlycosylationPAPGSTAPPAHGVTS
CCCCCCCCCCCCCCC		27.05-
233PhosphorylationPAPGSTAPPAHGVTS
CCCCCCCCCCCCCCC		27.05-
233 (in isoform 17)Phosphorylation-27.0522210691
236PhosphorylationGSTAPPAHGVTSAPD
CCCCCCCCCCCCCCC		36.71-
238O-linked_GlycosylationTAPPAHGVTSAPDTR
CCCCCCCCCCCCCCC		2.47-
238PhosphorylationTAPPAHGVTSAPDTR
CCCCCCCCCCCCCCC		2.47-
239O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
240O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
244O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
244PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
250O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
251O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
252PhosphorylationRPAPGSTAPPAHGVT
CCCCCCCCCCCCCCC		15.13-
259O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
260O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
264O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
264PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
270O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
271O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
279O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
280O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
284O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
284PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
290O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
291O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
299O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
300O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
304O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
304PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
310O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
311O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
319O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
319PhosphorylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.62-
320O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
324O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
324PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
330O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
331O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
339O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
340O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
344O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
344PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
350O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
351O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
359O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
360O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
364O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
364PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
370O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
371O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
379O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
380O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
384O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
384PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
390O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
391O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
399O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
400O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
404O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
404PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
410O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
411O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
419O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
420O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
420PhosphorylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.0818083107
424O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
424PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
430O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
431O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
431PhosphorylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.45-
432PhosphorylationRPAPGSTAPPAHGVT
CCCCCCCCCCCCCCC		15.1317545600
436PhosphorylationGSTAPPAHGVTSAPD
CCCCCCCCCCCCCCC		36.7124719451
438PhosphorylationTAPPAHGVTSAPDTR
CCCCCCCCCCCCCCC		2.4718083107
439O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
440O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
440PhosphorylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.0827251275
441PhosphorylationPAHGVTSAPDTRPAP
CCCCCCCCCCCCCCC		9.1624719451
443PhosphorylationHGVTSAPDTRPAPGS
CCCCCCCCCCCCCCC		55.8824719451
444O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
444PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
447PhosphorylationSAPDTRPAPGSTAPP
CCCCCCCCCCCCCCC		20.1417545600
450O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
451O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
451PhosphorylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.45-
453PhosphorylationPAPGSTAPPAHGVTS
CCCCCCCCCCCCCCC		27.0511877440
456PhosphorylationGSTAPPAHGVTSAPD
CCCCCCCCCCCCCCC		36.7124719451
458PhosphorylationTAPPAHGVTSAPDTR
CCCCCCCCCCCCCCC		2.4717545600
459O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
460O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
462PhosphorylationAHGVTSAPDTRPAPG
CCCCCCCCCCCCCCC		43.1824719451
464O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
464PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
469PhosphorylationPDTRPAPGSTAPPAH
CCCCCCCCCCCCCCC		39.4727251275
470O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
471O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
471PhosphorylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.4524719451
472PhosphorylationRPAPGSTAPPAHGVT
CCCCCCCCCCCCCCC		15.1316888623
473PhosphorylationPAPGSTAPPAHGVTS
CCCCCCCCCCCCCCC		27.0524719451
479O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
480O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
481PhosphorylationPAHGVTSAPDTRPAP
CCCCCCCCCCCCCCC		9.1627251275
484O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
484PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
490O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
491O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
499O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
500O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
504O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
504PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
510O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
511O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
519O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
520O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
524O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
524PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
530O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
531O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
539O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
540O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
544O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
544PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
550O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
551O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
559O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
560O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
564O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
564PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
570O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
571O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
579O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
580O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
584O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
584PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
590O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
591O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
599O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
600O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
604O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
604PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
610O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
611O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
619O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
620O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
624O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
624PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
630O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
631O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
639O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
640O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
644O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
644PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
650O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
651O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
659O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
660O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
664O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
664PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
670O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
671O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
679O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
680O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
684O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
684PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
690O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
691O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
699O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
700O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
704O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
704PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
710O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
711O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
719O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
720O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
724O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
724PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
730O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
731O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
739O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
740O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
744O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
744PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
750O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
751O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
759O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
760O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
764O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
764PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
770O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
771O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
779O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
780O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
784O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
784PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
790O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
791O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
799O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
800O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
804O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
804PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
810O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
811O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
819O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
820O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
824O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
824PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
830O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
831O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
839O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
840O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
844O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
844PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
850O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
851O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
859O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
860O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
864O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
864PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
870O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
871O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
879O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
880O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
884O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
884PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
890O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
891O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
899O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
900O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
904O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
904PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
910O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
911O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
919O-linked_GlycosylationAPPAHGVTSAPDTRP
CCCCCCCCCCCCCCC		24.628206912
920O-linked_GlycosylationPPAHGVTSAPDTRPA
CCCCCCCCCCCCCCC		35.08-
924O-linked_GlycosylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.18-
924PhosphorylationGVTSAPDTRPAPGST
CCCCCCCCCCCCCCC		37.1811877440
930O-linked_GlycosylationDTRPAPGSTAPPAHG
CCCCCCCCCCCCCCC		21.97-
931O-linked_GlycosylationTRPAPGSTAPPAHGV
CCCCCCCCCCCCCCC		49.458206912
939O-linked_GlycosylationAPPAHGVTSAPDNRP
CCCCCCCCCCCCCCC		24.628206912
940O-linked_GlycosylationPPAHGVTSAPDNRPA
CCCCCCCCCCCCCCC		35.08-
957N-linked_GlycosylationSTAPPVHNVTSASGS
CCCCCCCCCCCCCCC		38.71UniProtKB CARBOHYD
975N-linked_GlycosylationSASTLVHNGTSARAT
CCCEEEECCCCCEEE		48.21UniProtKB CARBOHYD
989O-linked_GlycosylationTTTPASKSTPFSIPS
ECCCCCCCCCCCCCC		38.53OGP
990O-linked_GlycosylationTTPASKSTPFSIPSH
CCCCCCCCCCCCCCC		31.89OGP
993O-linked_GlycosylationASKSTPFSIPSHHSD
CCCCCCCCCCCCCCC		34.49OGP
999O-linked_GlycosylationFSIPSHHSDTPTTLA
CCCCCCCCCCCCCCC		37.44OGP
1001O-linked_GlycosylationIPSHHSDTPTTLASH
CCCCCCCCCCCCCCC		26.08OGP
1003O-linked_GlycosylationSHHSDTPTTLASHST
CCCCCCCCCCCCCCC		36.21OGP
1004O-linked_GlycosylationHHSDTPTTLASHSTK
CCCCCCCCCCCCCCC		22.87OGP
1009O-linked_GlycosylationPTTLASHSTKTDASS
CCCCCCCCCCCCCCC		29.15OGP
1010O-linked_GlycosylationTTLASHSTKTDASST
CCCCCCCCCCCCCCC		32.32OGP
1029N-linked_GlycosylationVPPLTSSNHSTSPQL
CCCCCCCCCCCCCCH		32.66UniProtKB CARBOHYD
1055N-linked_GlycosylationHISNLQFNSSLEDPS
EHHHCCCCCCCCCCC		20.09UniProtKB CARBOHYD
1074PhosphorylationQELQRDISEMFLQIY
HHHHHHHHHHHHHHH		27.5728674151
1081PhosphorylationSEMFLQIYKQGGFLG
HHHHHHHHHHCCEEC		5.5828674151
1090PhosphorylationQGGFLGLSNIKFRPG
HCCEECCCCCEECCC		34.41-
1133N-linked_GlycosylationTEAASRYNLTISDVS
HHHHHHCCCEEECCC		29.60UniProtKB CARBOHYD
1184S-palmitoylationYLIALAVCQCRRKNY
HHHHHHHHHHHHCCC		2.3516507569
1186S-palmitoylationIALAVCQCRRKNYGQ
HHHHHHHHHHCCCCC		3.7216507569
1191PhosphorylationCQCRRKNYGQLDIFP
HHHHHCCCCCCCEEE		14.8628152594
1202PhosphorylationDIFPARDTYHPMSEY
CEEECCCCCCCHHHC		20.4121945579
1203PhosphorylationIFPARDTYHPMSEYP
EEECCCCCCCHHHCC		14.2821945579
1207PhosphorylationRDTYHPMSEYPTYHT
CCCCCCHHHCCCCCC		38.1321945579
1209PhosphorylationTYHPMSEYPTYHTHG
CCCCHHHCCCCCCCC		8.1221945579
1211PhosphorylationHPMSEYPTYHTHGRY
CCHHHCCCCCCCCCC		27.3421945579
1212PhosphorylationPMSEYPTYHTHGRYV
CHHHCCCCCCCCCCC		10.5421945579
1214PhosphorylationSEYPTYHTHGRYVPP
HHCCCCCCCCCCCCC		18.6621945579
1218PhosphorylationTYHTHGRYVPPSSTD
CCCCCCCCCCCCCCC		23.1521082442
1222PhosphorylationHGRYVPPSSTDRSPY
CCCCCCCCCCCCCCC		39.5421712546
1223PhosphorylationGRYVPPSSTDRSPYE
CCCCCCCCCCCCCCC		39.8528355574
1224PhosphorylationRYVPPSSTDRSPYEK
CCCCCCCCCCCCCCC		39.5128355574
1227PhosphorylationPPSSTDRSPYEKVSA
CCCCCCCCCCCCCCC		34.3425159151
1229PhosphorylationSSTDRSPYEKVSAGN
CCCCCCCCCCCCCCC		29.6321082442
1233PhosphorylationRSPYEKVSAGNGGSS
CCCCCCCCCCCCCCC		41.3421945579
1239PhosphorylationVSAGNGGSSLSYTNP
CCCCCCCCCCCCCCH		29.5121945579
1240PhosphorylationSAGNGGSSLSYTNPA
CCCCCCCCCCCCCHH		25.3021945579
1242PhosphorylationGNGGSSLSYTNPAVA
CCCCCCCCCCCHHHH		31.6821945579
1243PhosphorylationNGGSSLSYTNPAVAA
CCCCCCCCCCHHHHH		18.8121945579
1244PhosphorylationGGSSLSYTNPAVAAT
CCCCCCCCCHHHHHH		31.2021945579
1251PhosphorylationTNPAVAATSANL---
CCHHHHHHCCCC---		20.7321945579
1252PhosphorylationNPAVAATSANL----
CHHHHHHCCCC----		15.5021945579
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1203YPhosphorylationKinasePDGFRBP09619
PSP
1203YPhosphorylationKinasePDGFR-Uniprot
1218YPhosphorylationKinasePDGFRBP09619
PSP
1218YPhosphorylationKinasePDGFR-Uniprot
1224TPhosphorylationKinaseKPCDQ05655
PhosphoELM
1227SPhosphorylationKinaseGSK3BP49841
PSP
1229YPhosphorylationKinaseCSKP41240
Uniprot
1229YPhosphorylationKinaseEGFRP00533
Uniprot
1229YPhosphorylationKinaseFYNP06241
GPS
1229YPhosphorylationKinaseSRCP12931
Uniprot
1229YPhosphorylationKinaseSRC64-PhosphoELM
1243YPhosphorylationKinaseABL1P00519
PhosphoELM
1243YPhosphorylationKinaseABL-FAMILY-GPS
-KUbiquitinationE3 ubiquitin ligasePPARGP37231
PMID:24292674
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
1227SPhosphorylation

9819408
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MUC1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CTNB1_HUMANCTNNB1physical
9139698
GSK3B_HUMANGSK3Bphysical
9819408
CTNB1_HUMANCTNNB1physical
12750561
ERBB2_HUMANERBB2physical
12939402
CTNB1_HUMANCTNNB1physical
9819408
PLAK_HUMANJUPphysical
12939402
CTNB1_MOUSECtnnb1physical
15221004
GRB2_HUMANGRB2physical
7664271
SOS1_HUMANSOS1physical
7664271
SRC_HUMANSRCphysical
11152665
GSK3B_HUMANGSK3Bphysical
11152665
CTND1_HUMANCTNND1physical
11181067
ERBB2_HUMANERBB2physical
11278868
ERBB3_HUMANERBB3physical
11278868
ERBB4_HUMANERBB4physical
11278868
SOS1_HUMANSOS1physical
11278868
EGFR_HUMANEGFRphysical
11278868
KPCD_HUMANPRKCDphysical
11877440
CTNB1_HUMANCTNNB1physical
11877440
EGFR_HUMANEGFRphysical
11483589
SRC_HUMANSRCphysical
11483589
CTNB1_HUMANCTNNB1physical
11483589
ESR1_HUMANESR1physical
16427018
P53_HUMANTP53physical
15710329
TBP_HUMANTBPphysical
15710329
JUN_HUMANJUNphysical
20697347
SRC_HUMANSRCphysical
21798038
ABL1_HUMANABL1physical
16888623
EGFR_HUMANEGFRphysical
21258405
NUP62_HUMANNUP62physical
17500061
PPARG_HUMANPPARGphysical
24292674
VPP2_HUMANATP6V0A2physical
26186194
VPP1_HUMANATP6V0A1physical
26186194
HBD_HUMANHBDphysical
26186194
VPP2_HUMANATP6V0A2physical
28514442
TM199_HUMANTMEM199physical
28514442
VPP1_HUMANATP6V0A1physical
28514442
AT11C_HUMANATP11Cphysical
28514442
TM59L_HUMANTMEM59Lphysical
28514442
CSCL2_HUMANTMEM63Bphysical
28514442
MYADM_HUMANMYADMphysical
28514442
MKS3_HUMANTMEM67physical
28514442
CC115_HUMANCCDC115physical
28514442
TNFL9_HUMANTNFSF9physical
28514442
ACTBL_HUMANACTBL2physical
28514442
VAMP2_HUMANVAMP2physical
28514442
ACTA_HUMANACTA2physical
28514442
Drug and Disease Associations
Kegg Disease
H00031 Breast cancer
OMIM Disease
20816948). Decreased levels over time may be indicative of a positive response to treatment. Conversely, increased levels may indicate disease progression. At an early stage disease, only 21% of patients exhibit high MUC1/CA 15-3 levels, that is why CA 15-3 is not a useful screening test. Most antibodies target the highly immunodominant core peptide domain of 20 amino acid (APDTRPAPGSTAPPAHGVTS) tandem repeats. Some antibodies recognize glycosylated epitopes. {ECONote=MUC1/CA 15-3 is used as a serological clinical marker of breast cancer to monitor response to breast cancer treatment and disease recurrence (PubMed
174000
Kegg Drug
D02977 Arcitumomab (USAN/INN); Cea-Scan (TN)
D06028 Technetium Tc 99m arcitumomab (USP)
D09700 Yttrium Y 90 clivatuzumab tetraxetan (USAN)
D09895 Emepepimut-S (USAN); Stimuvax (TN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MUC1_HUMAN

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Related Literatures of Post-Translational Modification
Palmitoylation
ReferencePubMed
"Recycling of MUC1 is dependent on its palmitoylation.";
Kinlough C.L., McMahan R.J., Poland P.A., Bruns J.B., Harkleroad K.L.,Stremple R.J., Kashlan O.B., Weixel K.M., Weisz O.A., Hughey R.P.;
J. Biol. Chem. 281:12112-12122(2006).
Cited for: PALMITOYLATION AT CYS-1184 AND CYS-1186, SUBCELLULAR LOCATION,INTERACTION WITH AP1S1 AND AP1S2, AND MUTAGENESIS OF CYS-1184;CYS-1186; TYR-1203 AND 1187-ARG--LYS-1189.
Phosphorylation
ReferencePubMed
"Interaction of glycogen synthase kinase 3beta with the DF3/MUC1carcinoma-associated antigen and beta-catenin.";
Li Y., Bharti A., Chen D., Gong J., Kufe D.;
Mol. Cell. Biol. 18:7216-7224(1998).
Cited for: INTERACTION WITH GSK3B AND CTNNB1, PHOSPHORYLATION AT SER-1227, ANDMUTAGENESIS OF SER-1223 AND SER-1227.
"Protein kinase C delta regulates function of the DF3/MUC1 carcinomaantigen in beta-catenin signaling.";
Ren J., Li Y., Kufe D.;
J. Biol. Chem. 277:17616-17622(2002).
Cited for: PHOSPHORYLATION AT THR-1224, INTERACTION WITH PRKCD, FUNCTION, ANDMUTAGENESIS OF SER-1223; THR-1224 AND SER-1227.
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1191; TYR-1203;TYR-1209; TYR-1212; TYR-1218; TYR-1229 AND TYR-1243, AND MASSSPECTROMETRY.
"Platelet-derived growth factor receptor beta-mediated phosphorylationof MUC1 enhances invasiveness in pancreatic adenocarcinoma cells.";
Singh P.K., Wen Y., Swanson B.J., Shanmugam K., Kazlauskas A.,Cerny R.L., Gendler S.J., Hollingsworth M.A.;
Cancer Res. 67:5201-5210(2007).
Cited for: PHOSPHORYLATION AT TYR-1203; TYR-1218 AND TYR-1229, MUTAGENESIS OFTYR-1203 AND TYR-1218, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
"Identification of four sites of stimulated tyrosine phosphorylationin the MUC1 cytoplasmic tail.";
Wang H., Lillehoj E.P., Kim K.C.;
Biochem. Biophys. Res. Commun. 310:341-346(2003).
Cited for: PHOSPHORYLATION AT TYR-1203; TYR-1212; TYR-1229 AND TYR-1243.
"The epidermal growth factor receptor regulates interaction of thehuman DF3/MUC1 carcinoma antigen with c-Src and beta-catenin.";
Li Y., Ren J., Yu W., Li Q., Kuwahara H., Yin L., Carraway K.L. III,Kufe D.;
J. Biol. Chem. 276:35239-35242(2001).
Cited for: INTERACTION WITH EGFR, PHOSPHORYLATION AT TYR-1229 BY EGFR, ANDMUTAGENESIS OF TYR-1191; TYR-1203; TYR-1209; TYR-1218 AND TYR-1229.
"The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1carcinoma-associated antigen with GSK3 beta and beta-catenin.";
Li Y., Kuwahara H., Ren J., Wen G., Kufe D.;
J. Biol. Chem. 276:6061-6064(2001).
Cited for: INTERACTION WITH SRC; GSK3B AND CTNNB1, PHOSPHORYLATION AT TYR-1229,AND MUTAGENESIS OF TYR-1229.

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