dbPTM

MYADM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MYADM_HUMAN
UniProt AC	Q96S97
Protein Name	Myeloid-associated differentiation marker
Gene Name	MYADM
Organism	Homo sapiens (Human).
Sequence Length	322
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description
Protein Sequence	MPVTVTRTTITTTTTSSSGLGSPMIVGSPRALTQPLGLLRLLQLVSTCVAFSLVASVGAWTGSMGNWSMFTWCFCFSVTLIILIVELCGLQARFPLSWRNFPITFACYAALFCLSASIIYPTTYVQFLSHGRSRDHAIAATFFSCIACVAYATEVAWTRARPGEITGYMATVPGLLKVLETFVACIIFAFISDPNLYQHQPALEWCVAVYAICFILAAIAILLNLGECTNVLPIPFPSFLSGLALLSVLLYATALVLWPLYQFDEKYGGQPRRSRDVSCSRSHAYYVCAWDRRLAVAILTAINLLAYVADLVHSAHLVFVKV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MPVTVTRTTIT ----CCEEEEEEEEE	15.41	22210691
6	Phosphorylation	--MPVTVTRTTITTT --CCEEEEEEEEEEE	16.97	22210691
8	Phosphorylation	MPVTVTRTTITTTTT CCEEEEEEEEEEEEC	17.12	29978859
9	Phosphorylation	PVTVTRTTITTTTTS CEEEEEEEEEEEECC	17.03	29978859
11	Phosphorylation	TVTRTTITTTTTSSS EEEEEEEEEEECCCC	18.92	21712546
12	Phosphorylation	VTRTTITTTTTSSSG EEEEEEEEEECCCCC	20.49	21712546
13	Phosphorylation	TRTTITTTTTSSSGL EEEEEEEEECCCCCC	21.30	29978859
14	Phosphorylation	RTTITTTTTSSSGLG EEEEEEEECCCCCCC	23.69	21712546
15	Phosphorylation	TTITTTTTSSSGLGS EEEEEEECCCCCCCC	25.23	21712546
16	Phosphorylation	TITTTTTSSSGLGSP EEEEEECCCCCCCCC	22.03	21712546
17	Phosphorylation	ITTTTTSSSGLGSPM EEEEECCCCCCCCCE	26.74	21712546
18	Phosphorylation	TTTTTSSSGLGSPMI EEEECCCCCCCCCEE	37.49	21712546
22	Phosphorylation	TSSSGLGSPMIVGSP CCCCCCCCCEEECCC	19.15	28355574
22	O-linked_Glycosylation	TSSSGLGSPMIVGSP CCCCCCCCCEEECCC	19.15	OGP
28	Phosphorylation	GSPMIVGSPRALTQP CCCEEECCCHHHHCH	10.58	29978859
97	Phosphorylation	LQARFPLSWRNFPIT CCCCCCCCCCCCCHH	24.99	24719451
274	Phosphorylation	YGGQPRRSRDVSCSR HCCCCCCCCCCCCCC	33.83	26699800
278	Phosphorylation	PRRSRDVSCSRSHAY CCCCCCCCCCCCCCH	15.63	26699800
280	Phosphorylation	RSRDVSCSRSHAYYV CCCCCCCCCCCCHHE	29.34	26699800

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MYADM_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MYADM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MYADM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
ARF6_HUMAN	ARF6	physical	26186194
ARF6_HUMAN	ARF6	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MYADM_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND MASSSPECTROMETRY.	18669648 [Abstract]