HBD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HBD_HUMAN
• UniProt AC: P02042
• Protein Name: Hemoglobin subunit delta
• Gene Name: HBD
• Organism: Homo sapiens (Human).
• Sequence Length: 147
• Protein Description: Involved in oxygen transport from the lung to the various peripheral tissues..
• Protein Sequence: MVHLTPEEKTAVNALWGKVNVDAVGGEALGRLLVVYPWTQRFFESFGDLSSPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFSQLSELHCDKLHVDPENFRLLGNVLVCVLARNFGKEFTPQMQAAYQKVVAGVANALAHKYH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MVHLTPEEK ------CCCCCHHHH	5.21	1787103
3	Methylation	-----MVHLTPEEKT -----CCCCCHHHHH	23.76	-
5	Phosphorylation	---MVHLTPEEKTAV ---CCCCCHHHHHHH	17.49	23025827
9	Acetylation	VHLTPEEKTAVNALW CCCCHHHHHHHHHHH	39.87	7666917
10	Phosphorylation	HLTPEEKTAVNALWG CCCHHHHHHHHHHHC	38.83	-
36	Phosphorylation	LGRLLVVYPWTQRFF HHHHEEHHHHHHHHH	5.88	21082442
39	Phosphorylation	LLVVYPWTQRFFESF HEEHHHHHHHHHHHH	12.83	28857561
45	Phosphorylation	WTQRFFESFGDLSSP HHHHHHHHHCCCCCC	29.40	26657352
50	Phosphorylation	FESFGDLSSPDAVMG HHHHCCCCCCCHHCC	44.56	26657352
51	Phosphorylation	ESFGDLSSPDAVMGN HHHCCCCCCCHHCCC	33.81	5678016
60	Acetylation	DAVMGNPKVKAHGKK CHHCCCCCCCCCCHH	61.44	7640561
62	Acetylation	VMGNPKVKAHGKKVL HCCCCCCCCCCHHEE	40.57	7612869
66	Acetylation	PKVKAHGKKVLGAFS CCCCCCCHHEEHHHH	29.82	30584519
73	Phosphorylation	KKVLGAFSDGLAHLD HHEEHHHHHHHHHHH	30.18	26657352
78	Methylation	AFSDGLAHLDNLKGT HHHHHHHHHHHCCCH	38.46	-
83	Acetylation	LAHLDNLKGTFSQLS HHHHHHCCCHHHHHH	63.26	160707
85	Phosphorylation	HLDNLKGTFSQLSEL HHHHCCCHHHHHHHH	20.65	26657352
87	Phosphorylation	DNLKGTFSQLSELHC HHCCCHHHHHHHHCC	30.01	26657352
90	Phosphorylation	KGTFSQLSELHCDKL CCHHHHHHHHCCCCC	30.40	23312004
94	S-nitrosylation	SQLSELHCDKLHVDP HHHHHHCCCCCCCCH	8.46	24105792
96	Acetylation	LSELHCDKLHVDPEN HHHHCCCCCCCCHHH	45.98	25038526
98	Methylation	ELHCDKLHVDPENFR HHCCCCCCCCHHHHH	27.89	-
131	Phosphorylation	TPQMQAAYQKVVAGV CHHHHHHHHHHHHHH	16.34	21253578
144	Methylation	GVANALAHKYH---- HHHHHHHHCCC----	31.86	-
145	Acetylation	VANALAHKYH----- HHHHHHHCCC-----	39.14	16916647
146	Phosphorylation	ANALAHKYH------ HHHHHHCCC------	11.68	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HBD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HBD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
36	Phosphorylation	28 (8)	A ⇒ T;S	rs35152987	Hemoglobin levels	26366553

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
HBAT_HUMAN	HBQ1	physical	25416956
HBAZ_HUMAN	HBZ	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-146, AND MASSSPECTROMETRY.
PubMed: 18083107