dbPTM

SOS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SOS1_HUMAN
UniProt AC	Q07889
Protein Name	Son of sevenless homolog 1
Gene Name	SOS1
Organism	Homo sapiens (Human).
Sequence Length	1333
Subcellular Localization
Protein Description	Promotes the exchange of Ras-bound GDP by GTP. [PubMed: 8493579 Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF]
Protein Sequence	MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDVEDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGTMRHPTPLQQEPRKISYSRIPESETESTASAPNSPRTPLTPPPASGASSTTDVCSVFDSDHSSPFHSSNDTVFIQVTLPHGPRSASVSSISLTKGTDEVPVPPPVPPRRRPESAPAESSPSKIMSKHLDSPPAIPPRQPTSKAYSPRYSISDRTSISDPPESPPLLPPREPVRTPDVFSSSPLHLQPPPLGKKSDHGNAFFPNSPSPFTPPPPQTPSPHGTRRHLPSPPLTQEVDLHSIAGPPVPPRQSTSQHIPKLPPKTYKREHTHPSMHRDGPPLLENAHSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Ubiquitination	GQVHPTLESNDDALQ CCCCCCCCCCHHHHH	50.39	-
96	Ubiquitination	DAQSAIEKRKRRNPL HHHHHHHHHHHCCCC	58.04	-
155	Phosphorylation	YVRNIRHYEITKQDI HHHHCCCEECCHHHH	10.12	-
158	Phosphorylation	NIRHYEITKQDIKVA HCCCEECCHHHHHHH	15.65	-
187	Phosphorylation	VEDINILSLTDEEPS HHHCEEEECCCCCCC	25.98	27174698
189	Phosphorylation	DINILSLTDEEPSTS HCEEEECCCCCCCCC	37.68	27174698
194	Phosphorylation	SLTDEEPSTSGEQTY ECCCCCCCCCCCCHH	38.19	27174698
195	Phosphorylation	LTDEEPSTSGEQTYY CCCCCCCCCCCCHHH	52.01	27174698
196	Phosphorylation	TDEEPSTSGEQTYYD CCCCCCCCCCCHHHH	44.67	27174698
200	Phosphorylation	PSTSGEQTYYDLVKA CCCCCCCHHHHHHHH	21.53	27174698
201	Phosphorylation	STSGEQTYYDLVKAF CCCCCCHHHHHHHHH	8.48	27174698
202	Phosphorylation	TSGEQTYYDLVKAFM CCCCCHHHHHHHHHH	13.24	27174698
378	Phosphorylation	ECLKQAITALLNVQS HHHHHHHHHHHHHHH	17.80	24719451
392	Phosphorylation	SGMEKICSKSLAKRR HHHHHHCCHHHHHHH	28.84	26699800
401	Phosphorylation	SLAKRRLSESACRFY HHHHHHCCHHHHHHH	27.91	25849741
403	Phosphorylation	AKRRLSESACRFYSQ HHHHCCHHHHHHHHH	29.32	28102081
413	Methylation	RFYSQQMKGKQLAIK HHHHHHHHCHHHHHH	59.63	-
413	Ubiquitination	RFYSQQMKGKQLAIK HHHHHHHHCHHHHHH	59.63	-
415	Ubiquitination	YSQQMKGKQLAIKKM HHHHHHCHHHHHHHH	36.30	-
420	Methylation	KGKQLAIKKMNEIQK HCHHHHHHHHHHHHH	40.12	-
421	Ubiquitination	GKQLAIKKMNEIQKN CHHHHHHHHHHHHHC	40.62	-
582	Phosphorylation	YRFAEPDSEENIIFE ECCCCCCCCCCCEEE	58.48	28348404
615	Phosphorylation	KLIERLTYHMYADPN HHHHHHHHHHHCCCH	6.81	23186163
618	Phosphorylation	ERLTYHMYADPNFVR HHHHHHHHCCCHHHH	8.44	23917254
756	Phosphorylation	GHNITFQSSPPTVEW CCCCEECCCCCEEEE	40.39	28348404
757	Phosphorylation	HNITFQSSPPTVEWH CCCEECCCCCEEEEE	24.90	25850435
760	Phosphorylation	TFQSSPPTVEWHISR EECCCCCEEEEEECC	34.15	25850435
766	Phosphorylation	PTVEWHISRPGHIET CEEEEEECCCCCEEE	21.38	25850435
802	Phosphorylation	LYRAVQPSELVGSVW HHHHHCHHHHCCCCC	26.86	-
811	Ubiquitination	LVGSVWTKEDKEINS HCCCCCCCCCCCCCC	48.48	-
818	Phosphorylation	KEDKEINSPNLLKMI CCCCCCCCHHHHHHH	22.33	24719451
853	Phosphorylation	EERVAVVSRIIEILQ HHHHHHHHHHHHHHH	15.91	-
1000	Phosphorylation	NLNPMGNSMEKEFTD HCCCCCCHHHHHHHH	23.69	-
1006	Phosphorylation	NSMEKEFTDYLFNKS CHHHHHHHHHHHHCC	25.48	-
1012	Ubiquitination	FTDYLFNKSLEIEPR HHHHHHHCCCCCCCC	49.43	-
1032	Phosphorylation	PRFPKKYSYPLKSPG CCCCCCCCCCCCCCC	29.20	28555341
1033	Phosphorylation	RFPKKYSYPLKSPGV CCCCCCCCCCCCCCC	14.97	-
1043	Phosphorylation	KSPGVRPSNPRPGTM CCCCCCCCCCCCCCC	49.23	22817900
1054	Phosphorylation	PGTMRHPTPLQQEPR CCCCCCCCCCCCCCC	30.42	28674419
1064	Phosphorylation	QQEPRKISYSRIPES CCCCCCCCCCCCCCC	21.79	29496963
1065	Phosphorylation	QEPRKISYSRIPESE CCCCCCCCCCCCCCC	12.87	22817900
1066	Phosphorylation	EPRKISYSRIPESET CCCCCCCCCCCCCCC	19.55	24702127
1071	Phosphorylation	SYSRIPESETESTAS CCCCCCCCCCCCCCC	44.45	23403867
1073	Phosphorylation	SRIPESETESTASAP CCCCCCCCCCCCCCC	44.51	30206219
1075	Phosphorylation	IPESETESTASAPNS CCCCCCCCCCCCCCC	36.37	29255136
1076	Phosphorylation	PESETESTASAPNSP CCCCCCCCCCCCCCC	20.57	29255136
1078	Phosphorylation	SETESTASAPNSPRT CCCCCCCCCCCCCCC	44.33	23401153
1082	Phosphorylation	STASAPNSPRTPLTP CCCCCCCCCCCCCCC	18.07	29255136
1088	Phosphorylation	NSPRTPLTPPPASGA CCCCCCCCCCCCCCC	34.65	28348404
1132	Phosphorylation	TLPHGPRSASVSSIS ECCCCCCCEEEEEEE	28.20	21955146
1132	O-linked_Glycosylation	TLPHGPRSASVSSIS ECCCCCCCEEEEEEE	28.20	31373491
1134	Phosphorylation	PHGPRSASVSSISLT CCCCCCEEEEEEEEC	24.63	25159151
1136	Phosphorylation	GPRSASVSSISLTKG CCCCEEEEEEEECCC	21.32	25159151
1137	Phosphorylation	PRSASVSSISLTKGT CCCEEEEEEEECCCC	17.65	25159151
1139	Phosphorylation	SASVSSISLTKGTDE CEEEEEEEECCCCCC	31.75	22617229
1141	Phosphorylation	SVSSISLTKGTDEVP EEEEEEECCCCCCCC	22.19	28102081
1161	Phosphorylation	PPRRRPESAPAESSP CCCCCCCCCCCCCCH	42.08	29255136
1166	Phosphorylation	PESAPAESSPSKIMS CCCCCCCCCHHHHHH	50.05	25159151
1167	Phosphorylation	ESAPAESSPSKIMSK CCCCCCCCHHHHHHH	25.38	23927012
1169	Phosphorylation	APAESSPSKIMSKHL CCCCCCHHHHHHHCC	36.44	23927012
1178	Phosphorylation	IMSKHLDSPPAIPPR HHHHCCCCCCCCCCC	38.86	25159151
1188	Phosphorylation	AIPPRQPTSKAYSPR CCCCCCCCCCCCCCC	34.22	21406692
1189	Phosphorylation	IPPRQPTSKAYSPRY CCCCCCCCCCCCCCC	23.21	21406692
1190	Acetylation	PPRQPTSKAYSPRYS CCCCCCCCCCCCCCC	54.55	19815489
1192	Phosphorylation	RQPTSKAYSPRYSIS CCCCCCCCCCCCCCC	23.97	21406692
1193	Phosphorylation	QPTSKAYSPRYSISD CCCCCCCCCCCCCCC	14.04	21406692
1195	Methylation	TSKAYSPRYSISDRT CCCCCCCCCCCCCCC	31.71	115917545
1196	Phosphorylation	SKAYSPRYSISDRTS CCCCCCCCCCCCCCC	17.46	26699800
1197	Phosphorylation	KAYSPRYSISDRTSI CCCCCCCCCCCCCCC	19.52	26699800
1199	Phosphorylation	YSPRYSISDRTSISD CCCCCCCCCCCCCCC	18.33	21406692
1202	Phosphorylation	RYSISDRTSISDPPE CCCCCCCCCCCCCCC	35.09	29978859
1203	Phosphorylation	YSISDRTSISDPPES CCCCCCCCCCCCCCC	22.46	29978859
1205	Phosphorylation	ISDRTSISDPPESPP CCCCCCCCCCCCCCC	43.78	30266825
1210	Phosphorylation	SISDPPESPPLLPPR CCCCCCCCCCCCCCC	37.28	23401153
1222	Phosphorylation	PPREPVRTPDVFSSS CCCCCCCCCCCCCCC	24.87	25159151
1227	Phosphorylation	VRTPDVFSSSPLHLQ CCCCCCCCCCCCCCC	29.74	25159151
1228	Phosphorylation	RTPDVFSSSPLHLQP CCCCCCCCCCCCCCC	25.22	25159151
1229	Phosphorylation	TPDVFSSSPLHLQPP CCCCCCCCCCCCCCC	30.22	25159151
1242	Phosphorylation	PPPLGKKSDHGNAFF CCCCCCCCCCCCCCC	38.02	27080861
1252	Phosphorylation	GNAFFPNSPSPFTPP CCCCCCCCCCCCCCC	27.30	20873877
1254	Phosphorylation	AFFPNSPSPFTPPPP CCCCCCCCCCCCCCC	32.25	20873877
1257	Phosphorylation	PNSPSPFTPPPPQTP CCCCCCCCCCCCCCC	37.97	27273156
1263	Phosphorylation	FTPPPPQTPSPHGTR CCCCCCCCCCCCCCC	31.35	23401153
1265	Phosphorylation	PPPPQTPSPHGTRRH CCCCCCCCCCCCCCC	32.68	23401153
1269	Phosphorylation	QTPSPHGTRRHLPSP CCCCCCCCCCCCCCC	22.84	28152594
1275	Phosphorylation	GTRRHLPSPPLTQEV CCCCCCCCCCCCCEE	45.57	29255136
1279	Phosphorylation	HLPSPPLTQEVDLHS CCCCCCCCCEECHHH	28.58	22617229
1286	Phosphorylation	TQEVDLHSIAGPPVP CCEECHHHCCCCCCC	22.79	20068231
1297	Phosphorylation	PPVPPRQSTSQHIPK CCCCCCCCCCCCCCC	31.16	21406692
1298	Phosphorylation	PVPPRQSTSQHIPKL CCCCCCCCCCCCCCC	24.86	21406692
1299	Phosphorylation	VPPRQSTSQHIPKLP CCCCCCCCCCCCCCC	25.63	21406692
1309	Phosphorylation	IPKLPPKTYKREHTH CCCCCCCCCCCCCCC	39.80	21406692
1310	Phosphorylation	PKLPPKTYKREHTHP CCCCCCCCCCCCCCC	17.74	21406692
1332	Phosphorylation	PLLENAHSS------ CCCCCCCCC------	35.02	25159151
1333	Phosphorylation	LLENAHSS------- CCCCCCCC-------	34.08	25159151

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1132	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
1134	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
1134	S	Phosphorylation	Kinase	RPS6KA3	P51812	Uniprot
1137	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
1161	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
1161	S	Phosphorylation	Kinase	RPS6KA3	P51812	Uniprot
1167	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
1167	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
1178	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
1178	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
1193	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
1193	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
1197	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
1197	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
1134	S	Phosphorylation	18669648
Phosphorylation at Ser-1134 and Ser-1161 by RPS6KA3 create YWHAB and YWHAE binding sites and which contribute to the negative regulation of EGF-induced MAPK1/3 phosphorylation.
1161	S	Phosphorylation	22827337
Phosphorylation at Ser-1134 and Ser-1161 by RPS6KA3 create YWHAB and YWHAE binding sites and which contribute to the negative regulation of EGF-induced MAPK1/3 phosphorylation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SOS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RASH_HUMAN	HRAS	physical	12628188
SH3K1_HUMAN	SH3KBP1	physical	11071869
BCR_HUMAN	BCR	physical	8112292
ABL1_HUMAN	ABL1	physical	8112292
SHC1_HUMAN	SHC1	physical	10675333
EGFR_HUMAN	EGFR	physical	10675333
SHC1_HUMAN	SHC1	physical	10783152
FRS2_HUMAN	FRS2	physical	10783152
GRB2_HUMAN	GRB2	physical	11997436
GRB2_HUMAN	GRB2	physical	8188688
EGFR_HUMAN	EGFR	physical	9447973
ABI1_HUMAN	ABI1	physical	10499589
EPS8_HUMAN	EPS8	physical	10499589
GRB2_HUMAN	GRB2	physical	7510700
ANXA2_HUMAN	ANXA2	physical	7510700
ITSN1_HUMAN	ITSN1	physical	10716926
GRB2_HUMAN	GRB2	physical	10716926
GRB2_HUMAN	GRB2	physical	8810325
NCK1_HUMAN	NCK1	physical	8810325
CRK_HUMAN	CRK	physical	8810325
PTN6_HUMAN	PTPN6	physical	8632004
GRB2_HUMAN	GRB2	physical	10207103
GRB2_HUMAN	GRB2	physical	10570290
SHC1_HUMAN	SHC1	physical	10570290
PLCG1_HUMAN	PLCG1	physical	10913276
PTN11_HUMAN	PTPN11	physical	9632781
PLCG1_HUMAN	PLCG1	physical	10940929
FRS2_HUMAN	FRS2	physical	9182757
RIT2_HUMAN	RIT2	physical	12099688
FAK2_RAT	Ptk2b	physical	7544443
FYN_HUMAN	FYN	physical	9856337
BCR_HUMAN	BCR	physical	7529874
VIGLN_HUMAN	HDLBP	physical	20936779
ITSN1_HUMAN	ITSN1	physical	20936779
SPTN1_HUMAN	SPTAN1	physical	20936779
ITSN2_HUMAN	ITSN2	physical	20936779
SHC1_HUMAN	SHC1	physical	10025673
GRB2_HUMAN	GRB2	physical	10025673
GRB2_HUMAN	GRB2	physical	9716598
SRBS1_HUMAN	SORBS1	physical	17548467
LAT_HUMAN	LAT	physical	16906159
SHC1_HUMAN	SHC1	physical	8950973
BIN1_MOUSE	Bin1	physical	9182529
CSF1R_HUMAN	CSF1R	physical	10025673
GRB2_HUMAN	GRB2	physical	28166272
RAC1_HUMAN	RAC1	physical	27629044
EPS8_HUMAN	EPS8	physical	27629044
PTN11_HUMAN	PTPN11	physical	20473329

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
135300	Gingival fibromatosis 1 (GGF1)
610733	Noonan syndrome 4 (NS4)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SOS1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1134 AND SER-1137, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1082 AND SER-1210, ANDMASS SPECTROMETRY.	15302935 [Abstract]

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