dbPTM

GRB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GRB2_HUMAN
UniProt AC	P62993
Protein Name	Growth factor receptor-bound protein 2
Gene Name	GRB2
Organism	Homo sapiens (Human).
Sequence Length	217
Subcellular Localization	Nucleus . Cytoplasm . Endosome . Golgi apparatus.
Protein Description	Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.; Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death..
Protein Sequence	MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEAIAKYD -------CCCCCCCC	7.67	22814378
6	Acetylation	--MEAIAKYDFKATA --CCCCCCCCCCCCC	38.96	19608861
7	Phosphorylation	-MEAIAKYDFKATAD -CCCCCCCCCCCCCC	20.00	28152594
10	Ubiquitination	AIAKYDFKATADDEL CCCCCCCCCCCCCCC	41.76	-
18	Phosphorylation	ATADDELSFKRGDIL CCCCCCCCCCCCCHH	27.03	25159151
20	2-Hydroxyisobutyrylation	ADDELSFKRGDILKV CCCCCCCCCCCHHHH	52.69	-
20	Ubiquitination	ADDELSFKRGDILKV CCCCCCCCCCCHHHH	52.69	21890473
20 (in isoform 1)	Ubiquitination	-	52.69	21890473
20	Acetylation	ADDELSFKRGDILKV CCCCCCCCCCCHHHH	52.69	25953088
20 (in isoform 2)	Ubiquitination	-	52.69	21890473
26	Ubiquitination	FKRGDILKVLNEECD CCCCCHHHHHCHHHC	45.04	-
32	Glutathionylation	LKVLNEECDQNWYKA HHHHCHHHCCCEEEH	5.49	22555962
32	S-nitrosylation	LKVLNEECDQNWYKA HHHHCHHHCCCEEEH	5.49	19483679
32	S-nitrosocysteine	LKVLNEECDQNWYKA HHHHCHHHCCCEEEH	5.49	-
37	Phosphorylation	EECDQNWYKAELNGK HHHCCCEEEHHHCCC	14.10	22817900
38	Ubiquitination	ECDQNWYKAELNGKD HHCCCEEEHHHCCCC	27.31	19608861
38	Acetylation	ECDQNWYKAELNGKD HHCCCEEEHHHCCCC	27.31	23749302
44 (in isoform 1)	Ubiquitination	-	54.31	21890473
44	Ubiquitination	YKAELNGKDGFIPKN EEHHHCCCCCCCCHH	54.31	21890473
44 (in isoform 2)	Ubiquitination	-	54.31	21890473
50	Acetylation	GKDGFIPKNYIEMKP CCCCCCCHHHEECCC	58.53	19608861
52 (in isoform 2)	Phosphorylation	-	12.37	-
52	Phosphorylation	DGFIPKNYIEMKPHP CCCCCHHHEECCCCC	12.37	22817900
56	Ubiquitination	PKNYIEMKPHPWFFG CHHHEECCCCCCCCC	27.64	21890473
56	Acetylation	PKNYIEMKPHPWFFG CHHHEECCCCCCCCC	27.64	25953088
56 (in isoform 1)	Ubiquitination	-	27.64	21890473
64	Acetylation	PHPWFFGKIPRAKAE CCCCCCCCCCHHHHH	44.36	23749302
68 (in isoform 2)	Ubiquitination	-	15.28	21890473
68	Acetylation	FFGKIPRAKAEEMLS CCCCCCHHHHHHHHH	15.28	19608861
68	Ubiquitination	FFGKIPRAKAEEMLS CCCCCCHHHHHHHHH	15.28	19608861
69 (in isoform 1)	Ubiquitination	-	58.57	21890473
69	Ubiquitination	FGKIPRAKAEEMLSK CCCCCHHHHHHHHHH	58.57	6983
76 (in isoform 1)	Ubiquitination	-	47.60	21890473
76	2-Hydroxyisobutyrylation	KAEEMLSKQRHDGAF HHHHHHHHCCCCCEE	47.60	-
76	Ubiquitination	KAEEMLSKQRHDGAF HHHHHHHHCCCCCEE	47.60	21906983
78	Methylation	EEMLSKQRHDGAFLI HHHHHHCCCCCEEEE	33.33	-
88	Phosphorylation	GAFLIRESESAPGDF CEEEEEECCCCCCCE	27.31	21815630
90	Phosphorylation	FLIRESESAPGDFSL EEEEECCCCCCCEEE	49.39	25159151
96	Phosphorylation	ESAPGDFSLSVKFGN CCCCCCEEEEEEECC	25.19	24719451
109 (in isoform 1)	Ubiquitination	-	37.93	21890473
109	Acetylation	GNDVQHFKVLRDGAG CCCCEEEEEEECCCC	37.93	19608861
109	Ubiquitination	GNDVQHFKVLRDGAG CCCCEEEEEEECCCC	37.93	21890473
109	Malonylation	GNDVQHFKVLRDGAG CCCCEEEEEEECCCC	37.93	26320211
117	Acetylation	VLRDGAGKYFLWVVK EEECCCCCEEEEEEE	32.09	129889
118	Phosphorylation	LRDGAGKYFLWVVKF EECCCCCEEEEEEEC	11.73	23882029
127	Phosphorylation	LWVVKFNSLNELVDY EEEEECCCHHHHHHH	35.39	29449344
134	Phosphorylation	SLNELVDYHRSTSVS CHHHHHHHHHCCCCC	7.52	28152594
159	Phosphorylation	EQVPQQPTYVQALFD HHCCCCCCEEEEEEC	31.80	26552605
160	Phosphorylation	QVPQQPTYVQALFDF HCCCCCCEEEEEECC	9.39	21082442
195	Ubiquitination	NSDPNWWKGACHGQT CCCCCCCCCCCCCCC	28.39	-
204	Sulfoxidation	ACHGQTGMFPRNYVT CCCCCCCCCCCHHCC	4.79	30846556
209	Nitration	TGMFPRNYVTPVNRN CCCCCCHHCCCCCCC	13.64	-
209	Phosphorylation	TGMFPRNYVTPVNRN CCCCCCHHCCCCCCC	13.64	21945579
211	Phosphorylation	MFPRNYVTPVNRNV- CCCCHHCCCCCCCC-	15.91	21945579
215	Methylation	NYVTPVNRNV----- HHCCCCCCCC-----	45.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
7	Y	Phosphorylation	Kinase	JAK2	O60674	PSP
37	Y	Phosphorylation	Kinase	JAK2	O60674	PSP
52	Y	Phosphorylation	Kinase	JAK2	O60674	PSP
160	Y	Phosphorylation	Kinase	ALK	Q9UM73	PSP
160	Y	Phosphorylation	Kinase	FGFR2	P21802	PSP
209	Y	Phosphorylation	Kinase	BCR-ABL1	A9UF07	PSP
209	Y	Phosphorylation	Kinase	EGFR	P00533	PhosphoELM
209	Y	Phosphorylation	Kinase	JAK2	O60674	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GRB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GRB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GAB2_HUMAN	GAB2	physical	15143164
LY66F_HUMAN	LY6G6F	physical	12852788
NEUR3_HUMAN	NEU3	physical	12730204
DOCK1_HUMAN	DOCK1	physical	12615911
MTA1_MOUSE	Mta1	physical	11483358
MTA3_MOUSE	Mta3	physical	11483358
TNFL6_HUMAN	FASLG	physical	12023017
SHC1_HUMAN	SHC1	physical	12577067
SOS1_HUMAN	SOS1	physical	12577067
VAV2_HUMAN	VAV2	physical	12577067
VAV3_HUMAN	VAV3	physical	12577067
RGAP1_HUMAN	RACGAP1	physical	12577067
IQGA1_HUMAN	IQGAP1	physical	12577067
EGFR_HUMAN	EGFR	physical	12577067
K2C7_HUMAN	KRT7	physical	12577067
K2C8_HUMAN	KRT8	physical	12577067
K1C17_HUMAN	KRT17	physical	12577067
K1C18_HUMAN	KRT18	physical	12577067
PLEC_HUMAN	PLEC	physical	12577067
EPIPL_HUMAN	EPPK1	physical	12577067
BCAR1_HUMAN	BCAR1	physical	10822386
WASP_HUMAN	WAS	physical	8805332
M4K1_HUMAN	MAP4K1	physical	9788432
SYN1_HUMAN	SYN1	physical	8022809
PGFRB_HUMAN	PDGFRB	physical	7935391
SOS1_HUMAN	SOS1	physical	9872323
KHDR1_HUMAN	KHDRBS1	physical	9872323
CBL_HUMAN	CBL	physical	9872323
PTN6_HUMAN	PTPN6	physical	10747947
PTN11_HUMAN	PTPN11	physical	10747947
KSYK_HUMAN	SYK	physical	10747947
CD22_HUMAN	CD22	physical	10748054
WASP_HUMAN	WAS	physical	9307968
KHDR1_HUMAN	KHDRBS1	physical	11960376
SOS1_HUMAN	SOS1	physical	11960376
GAB1_HUMAN	GAB1	physical	11960376
EGFR_HUMAN	EGFR	physical	11960376
IRS1_HUMAN	IRS1	physical	8491186
SHC1_HUMAN	SHC1	physical	8491186
EGFR_HUMAN	EGFR	physical	10085134
SHC1_HUMAN	SHC1	physical	8112292
BCR_HUMAN	BCR	physical	8112292
SOS1_HUMAN	SOS1	physical	8112292
TNR1A_HUMAN	TNFRSF1A	physical	10359574
FAK1_HUMAN	PTK2	physical	10806474
PTN11_HUMAN	PTPN11	physical	8041791
CD28_HUMAN	CD28	physical	9694876
SOCS1_HUMAN	SOCS1	physical	10022833
PTPRA_HUMAN	PTPRA	physical	8670803
EPHA2_HUMAN	EPHA2	physical	12400011
DAG1_HUMAN	DAG1	physical	7744812
MTAP2_HUMAN	MAP2	physical	10781592
SHC1_HUMAN	SHC1	physical	8662733
KIT_HUMAN	KIT	physical	10377264
RON_HUMAN	MST1R	physical	7488076
SPN90_HUMAN	NCKIPSD	physical	11509578
NTRK1_HUMAN	NTRK1	physical	11733534
DOCK1_HUMAN	DOCK1	physical	8657152
JAK2_HUMAN	JAK2	physical	7500025
GRB2_HUMAN	GRB2	physical	7716522
CBLB_HUMAN	CBLB	physical	9614102
CSF3R_HUMAN	CSF3R	physical	9824671
PTN11_HUMAN	PTPN11	physical	9824671
HD_HUMAN	HTT	physical	9079622
PTN11_HUMAN	PTPN11	physical	8995399
LCP2_HUMAN	LCP2	physical	11314042
GAB1_HUMAN	GAB1	physical	11314042
SNTA1_HUMAN	SNTA1	physical	11278583
ACK1_HUMAN	TNK2	physical	11394904
EGFR_HUMAN	EGFR	physical	7527043
P85A_HUMAN	PIK3R1	physical	7737969
PTN11_HUMAN	PTPN11	physical	9362449
PGFRB_HUMAN	PDGFRB	physical	9362449
GAB3_HUMAN	GAB3	physical	11739737
P85A_HUMAN	PIK3R1	physical	7759531
SOS1_HUMAN	SOS1	physical	8695800
LCP2_HUMAN	LCP2	physical	8695800
SOS1_HUMAN	SOS1	physical	8479541
SOS1_HUMAN	SOS1	physical	11997436
KAP0_HUMAN	PRKAR1A	physical	9050991
DCTN1_HUMAN	DCTN1	physical	8955163
RET_HUMAN	RET	physical	8183561
VAV2_HUMAN	VAV2	physical	11606575
ERBB2_HUMAN	ERBB2	physical	11606575
M4K1_HUMAN	MAP4K1	physical	9346925
PTPRA_HUMAN	PTPRA	physical	7518772
REPS2_HUMAN	REPS2	physical	9422736
OCRL_HUMAN	OCRL	physical	9038219
FAK1_HUMAN	PTK2	physical	10085298
PAXI_HUMAN	PXN	physical	10085298
BCAR1_HUMAN	BCAR1	physical	10085298
PHAG1_HUMAN	PAG1	physical	10790433
TRAT1_HUMAN	TRAT1	physical	10790433
FAK1_HUMAN	PTK2	physical	8649427
SOS1_HUMAN	SOS1	physical	10319320
VAV3_HUMAN	VAV3	physical	11094073
MTAP2_HUMAN	MAP2	physical	11546790
HNRPQ_HUMAN	SYNCRIP	physical	9341187
SOS1_HUMAN	SOS1	physical	7629168
PLCG1_HUMAN	PLCG1	physical	7629168
SH2B1_HUMAN	SH2B1	physical	9742218
FRS2_HUMAN	FRS2	physical	10092678
SOS1_HUMAN	SOS1	physical	7664271
ANXA2_HUMAN	ANXA2	physical	7510700
RHG35_HUMAN	ARHGAP35	physical	12441060
RASA1_HUMAN	RASA1	physical	12441060
SHC1_HUMAN	SHC1	physical	12441060
CRKL_HUMAN	CRKL	physical	10477741
SHC1_HUMAN	SHC1	physical	10477741
SOS1_HUMAN	SOS1	physical	10477741
CBL_HUMAN	CBL	physical	8083187
FAK1_HUMAN	PTK2	physical	12005431
RET_HUMAN	RET	physical	7665556
SOS1_HUMAN	SOS1	physical	8810325
CRK_HUMAN	CRK	physical	8810325
PTN6_HUMAN	PTPN6	physical	8632004
SHC1_HUMAN	SHC1	physical	10570290
SPN90_HUMAN	NCKIPSD	physical	11157975
KIT_HUMAN	KIT	physical	8647802
EPOR_HUMAN	EPOR	physical	8647802
CBL_HUMAN	CBL	physical	9461587
SH3K1_HUMAN	SH3KBP1	physical	10921882
CBL_HUMAN	CBL	physical	9178909
PTN11_HUMAN	PTPN11	physical	9632781
SOS1_HUMAN	SOS1	physical	9344843
PTN1_HUMAN	PTPN1	physical	8940134
CBL_HUMAN	CBL	physical	11964172
SOS1_HUMAN	SOS1	physical	11964172
SHC1_HUMAN	SHC1	physical	11964172
SRC_HUMAN	SRC	physical	11964172
KSYK_HUMAN	SYK	physical	11964172
PTN6_HUMAN	PTPN6	physical	11964172
LCP2_HUMAN	LCP2	physical	8995445
M3K1_HUMAN	MAP3K1	physical	9733714
BLNK_HUMAN	BLNK	physical	9705962
FLT3_HUMAN	FLT3	physical	10080542
PTN11_HUMAN	PTPN11	physical	10080542
SHC1_HUMAN	SHC1	physical	10080542
US6NL_HUMAN	USP6NL	physical	12399475
NTRK1_HUMAN	NTRK1	physical	10748052
PTPRA_HUMAN	PTPRA	physical	11923305
CBL_HUMAN	CBL	physical	9108392
PTPRE_HUMAN	PTPRE	physical	10490839
DYN1_HUMAN	DNM1	physical	8119878
HNRPC_HUMAN	HNRNPC	physical	9516488
SOS1_HUMAN	SOS1	physical	9009162
DYN1_HUMAN	DNM1	physical	9009162
MK09_HUMAN	MAPK9	physical	9019171
SHC1_HUMAN	SHC1	physical	7524086
DRD3_HUMAN	DRD3	physical	11384839
LOX5_HUMAN	ALOX5	physical	8585605
LOX5_HUMAN	ALOX5	physical	7929073
GHR_HUMAN	GHR	physical	9632636
MK09_HUMAN	MAPK9	physical	7642542
HCLS1_HUMAN	HCLS1	physical	9670936
LAX1_HUMAN	LAX1	physical	12359715
SOS2_HUMAN	SOS2	physical	10940929
PLCG1_HUMAN	PLCG1	physical	10940929
SOS2_HUMAN	SOS2	physical	7629138
TM1L1_HUMAN	TOM1L1	physical	11711534
FRS2_HUMAN	FRS2	physical	9182757
EGFR_HUMAN	EGFR	physical	1322798
SHKB1_HUMAN	SHKBP1	physical	11152963
SH3K1_HUMAN	SH3KBP1	physical	11152963
M4K1_HUMAN	MAP4K1	physical	9891069
JAK1_HUMAN	JAK1	physical	8536716
JAK2_HUMAN	JAK2	physical	8536716
IRS1_HUMAN	IRS1	physical	8536716
SHIP1_HUMAN	INPP5D	physical	8723348
SYNJ1_RAT	Synj1	physical	9428629
EGFR_HUMAN	EGFR	physical	10026169
PGFRB_HUMAN	PDGFRB	physical	10026169
GAB2_HUMAN	GAB2	physical	10391903
SHC1_HUMAN	SHC1	physical	7514169
SOS1_HUMAN	SOS1	physical	7514169
MICA1_HUMAN	MICAL1	physical	11827972
BCR_HUMAN	BCR	physical	7529874
SHC1_HUMAN	SHC1	physical	9126968
CBL_HUMAN	CBL	physical	18273061
SPY2_HUMAN	SPRY2	physical	17974561
CBL_HUMAN	CBL	physical	17971399
ALK_HUMAN	ALK	physical	14968112
BTK_HUMAN	BTK	physical	20936779
CBL_HUMAN	CBL	physical	20936779
CBLB_HUMAN	CBLB	physical	20936779
CASB_HUMAN	CSN2	physical	20936779
DAB2_HUMAN	DAB2	physical	20936779
DOCK1_HUMAN	DOCK1	physical	20936779
EP300_HUMAN	EP300	physical	20936779
GAB1_HUMAN	GAB1	physical	20936779
RPGF1_HUMAN	RAPGEF1	physical	20936779
HNRPK_HUMAN	HNRNPK	physical	20936779
GRP78_HUMAN	HSPA5	physical	20936779
K2C8_HUMAN	KRT8	physical	20936779
LCP2_HUMAN	LCP2	physical	20936779
MAP1A_HUMAN	MAP1A	physical	20936779
ATP8_HUMAN	ATP8	physical	20936779
NU4M_HUMAN	ND4	physical	20936779
MUC1_HUMAN	MUC1	physical	20936779
MYH9_HUMAN	MYH9	physical	20936779
MYH11_HUMAN	MYH11	physical	20936779
NUCL_HUMAN	NCL	physical	20936779
NFYB_HUMAN	NFYB	physical	20936779
P85A_HUMAN	PIK3R1	physical	20936779
P85B_HUMAN	PIK3R2	physical	20936779
RBBP6_HUMAN	RBBP6	physical	20936779
EAA2_HUMAN	SLC1A2	physical	20936779
SOS2_HUMAN	SOS2	physical	20936779
SPTB2_HUMAN	SPTBN1	physical	20936779
SSXT_HUMAN	SS18	physical	20936779
RL40_HUMAN	UBA52	physical	20936779
UBC_HUMAN	UBC	physical	20936779
WIPF1_HUMAN	WIPF1	physical	20936779
M4K3_HUMAN	MAP4K3	physical	20936779
ASAP2_HUMAN	ASAP2	physical	20936779
SYNJ2_HUMAN	SYNJ2	physical	20936779
WASL_HUMAN	WASL	physical	20936779
DLGP1_HUMAN	DLGAP1	physical	20936779
RHG32_HUMAN	ARHGAP32	physical	20936779
GAB2_HUMAN	GAB2	physical	20936779
PDC6I_HUMAN	PDCD6IP	physical	20936779
HIPK3_HUMAN	HIPK3	physical	20936779
ACK1_HUMAN	TNK2	physical	20936779
VAV3_HUMAN	VAV3	physical	20936779
DCTN2_HUMAN	DCTN2	physical	20936779
STABP_HUMAN	STAMBP	physical	20936779
KHDR1_HUMAN	KHDRBS1	physical	20936779
TCRG1_HUMAN	TCERG1	physical	20936779
KIF3A_HUMAN	KIF3A	physical	20936779
M4K5_HUMAN	MAP4K5	physical	20936779
K154L_HUMAN	KIAA1549L	physical	20936779
TARSH_HUMAN	ABI3BP	physical	20936779
PTN23_HUMAN	PTPN23	physical	20936779
ASAP1_HUMAN	ASAP1	physical	20936779
ERRFI_HUMAN	ERRFI1	physical	20936779
WDR44_HUMAN	WDR44	physical	20936779
UBP53_HUMAN	USP53	physical	20936779
RIF1_HUMAN	RIF1	physical	20936779
SH24A_HUMAN	SH2D4A	physical	20936779
GARE1_HUMAN	GAREM	physical	20936779
RBM33_HUMAN	RBM33	physical	20936779
MSI2H_HUMAN	MSI2	physical	20936779
WIPF2_HUMAN	WIPF2	physical	20936779
SH319_HUMAN	SH3D19	physical	20936779
NP1L5_HUMAN	NAP1L5	physical	20936779
ST32C_HUMAN	STK32C	physical	20936779
MY18A_HUMAN	MYO18A	physical	20936779
SHC1_HUMAN	SHC1	physical	15812354
CBL_HUMAN	CBL	physical	12839496
EGFR_HUMAN	EGFR	physical	20124286
CBL_HUMAN	CBL	physical	20124286
EPS15_HUMAN	EPS15	physical	19109251
A2MG_HUMAN	A2M	physical	18624398
AEBP1_HUMAN	AEBP1	physical	18624398
ANGT_HUMAN	AGT	physical	18624398
FETUA_HUMAN	AHSG	physical	18624398
HEM0_HUMAN	ALAS2	physical	18624398
STRAB_HUMAN	STRADB	physical	18624398
AMBP_HUMAN	AMBP	physical	18624398
SAMP_HUMAN	APCS	physical	18624398
APOH_HUMAN	APOH	physical	18624398
U520_HUMAN	SNRNP200	physical	18624398
B2MG_HUMAN	B2M	physical	18624398
GPAN1_HUMAN	GPANK1	physical	18624398
PMGE_HUMAN	BPGM	physical	18624398
CLUS_HUMAN	CLU	physical	18624398
DNJA3_HUMAN	DNAJA3	physical	18624398
DJB11_HUMAN	DNAJB11	physical	18624398
ESTD_HUMAN	ESD	physical	18624398
FABPL_HUMAN	FABP1	physical	18624398
FHOD1_HUMAN	FHOD1	physical	18624398
FINC_HUMAN	FN1	physical	18624398
VTDB_HUMAN	GC	physical	18624398
H10_HUMAN	H1F0	physical	18624398
HPT_HUMAN	HP	physical	18624398
RED_HUMAN	IK	physical	18624398
PBIP1_HUMAN	PBXIP1	physical	18624398
RPB1_HUMAN	POLR2A	physical	18624398
AAKB1_HUMAN	PRKAB1	physical	18624398
RNF10_HUMAN	RNF10	physical	18624398
TRFE_HUMAN	TF	physical	18624398
TFG_HUMAN	TFG	physical	18624398
TSC2_HUMAN	TSC2	physical	18624398
ENOA_HUMAN	ENO1	physical	18624398
ITIH4_HUMAN	ITIH4	physical	18624398
AP4S1_HUMAN	AP4S1	physical	18624398
CUTA_HUMAN	CUTA	physical	18624398
POMP_HUMAN	POMP	physical	18624398
CU058_HUMAN	C21orf58	physical	18624398
MUC24_HUMAN	CD164	physical	18624398
EURL_HUMAN	C21orf91	physical	18624398
CFAH_HUMAN	CFH	physical	18624398
CX6A1_HUMAN	COX6A1	physical	18624398
ECHM_HUMAN	ECHS1	physical	18624398
FUMH_HUMAN	FH	physical	18624398
NADK_HUMAN	NADK	physical	18624398
FRIL_HUMAN	FTL	physical	18624398
PRAP1_HUMAN	PRAP1	physical	18624398
GSTK1_HUMAN	GSTK1	physical	18624398
TCAL8_HUMAN	TCEAL8	physical	18624398
RET4_HUMAN	RBP4	physical	18624398
SHBG_HUMAN	SHBG	physical	18624398
WDR1_HUMAN	WDR1	physical	18624398
PP2BA_HUMAN	PPP3CA	physical	21900206
GIT1_HUMAN	GIT1	physical	21900206
FAK1_HUMAN	PTK2	physical	21900206
CDC42_HUMAN	CDC42	physical	21900206
CBLB_HUMAN	CBLB	physical	21900206
CASP2_HUMAN	CASP2	physical	21900206
ERBB2_HUMAN	ERBB2	physical	17875712
VAV3_HUMAN	VAV3	physical	18654987
REPS2_HUMAN	REPS2	physical	18647389
SYNEM_HUMAN	SYNM	physical	8552632
SYN1_HUMAN	SYN1	physical	8552632
AP2A2_HUMAN	AP2A2	physical	8552632
SOS1_HUMAN	SOS1	physical	8943292
RPGF1_HUMAN	RAPGEF1	physical	8943292
SHC1_HUMAN	SHC1	physical	9434624
P85A_HUMAN	PIK3R1	physical	9886492
EGFR_HUMAN	EGFR	physical	9886492
SHC1_HUMAN	SHC1	physical	9886492
CBL_HUMAN	CBL	physical	12941616
P85A_HUMAN	PIK3R1	physical	11418612
SHIP1_HUMAN	INPP5D	physical	22267732
NCK1_HUMAN	NCK1	physical	22267732
CBL_HUMAN	CBL	physical	9234717
CBL_HUMAN	CBL	physical	7791764
SHC1_HUMAN	SHC1	physical	9129019
EPOR_HUMAN	EPOR	physical	9129019
CBL_HUMAN	CBL	physical	10829062
CBL_HUMAN	CBL	physical	10521482
CBL_HUMAN	CBL	physical	8626404
KIT_HUMAN	KIT	physical	12444928
EGFR_HUMAN	EGFR	physical	19836242
CBL_HUMAN	CBL	physical	19836242
CBL_HUMAN	CBL	physical	8950973
CBL_HUMAN	CBL	physical	11263968
EGFR_HUMAN	EGFR	physical	9416834
SHC1_HUMAN	SHC1	physical	12898421
CBL_HUMAN	CBL	physical	8824292
CBL_HUMAN	CBL	physical	8900205
CBL_HUMAN	CBL	physical	9174058
P85A_HUMAN	PIK3R1	physical	9174058
ACK1_HUMAN	TNK2	physical	16137687
SHC1_HUMAN	SHC1	physical	7537740
CBL_HUMAN	CBL	physical	7537740
CBL_HUMAN	CBL	physical	11399323
CBL_HUMAN	CBL	physical	8621719
SHC1_HUMAN	SHC1	physical	8621719
LAT_HUMAN	LAT	physical	8063801
CBL_HUMAN	CBL	physical	9233773
CBL_HUMAN	CBL	physical	7642581
ACK1_HUMAN	TNK2	physical	14506255
SPY2_HUMAN	SPRY2	physical	15004239
DYN2_HUMAN	DNM2	physical	19380743
SOS1_HUMAN	SOS1	physical	19380743
ARAP1_HUMAN	ARAP1	physical	19380743
PTPRA_HUMAN	PTPRA	physical	19380743
LRRK1_HUMAN	LRRK1	physical	19380743
KRT85_HUMAN	KRT85	physical	19380743
HSP7C_HUMAN	HSPA8	physical	19380743
PGBM_HUMAN	HSPG2	physical	19380743
KRT86_HUMAN	KRT86	physical	19380743
K2C1_HUMAN	KRT1	physical	19380743
KRT81_HUMAN	KRT81	physical	19380743
KRT35_HUMAN	KRT35	physical	19380743
PYR1_HUMAN	CAD	physical	19380743
K1C10_HUMAN	KRT10	physical	19380743
GRB2_HUMAN	GRB2	physical	19380743
K22E_HUMAN	KRT2	physical	19380743
GRP75_HUMAN	HSPA9	physical	19380743
KRT83_HUMAN	KRT83	physical	19380743
TCPQ_HUMAN	CCT8	physical	19380743
P85B_HUMAN	PIK3R2	physical	19380743
BTK_HUMAN	BTK	physical	19380743
PTN11_HUMAN	PTPN11	physical	19380743
K1C9_HUMAN	KRT9	physical	19380743
ASAP1_HUMAN	ASAP1	physical	19380743
DYN1_HUMAN	DNM1	physical	19380743
KT33B_HUMAN	KRT33B	physical	19380743
HS90A_HUMAN	HSP90AA1	physical	19380743
DYN3_HUMAN	DNM3	physical	19380743
DYHC1_HUMAN	DYNC1H1	physical	19380743
IQGA1_HUMAN	IQGAP1	physical	19380743
TBB5_HUMAN	TUBB	physical	19380743
KRT34_HUMAN	KRT34	physical	19380743
RS19_HUMAN	RPS19	physical	19380743
HS90B_HUMAN	HSP90AB1	physical	19380743
K1C17_HUMAN	KRT17	physical	19380743
SKAP2_HUMAN	SKAP2	physical	19380743
TCPD_HUMAN	CCT4	physical	19380743
K2C6A_HUMAN	KRT6A	physical	19380743
K1C14_HUMAN	KRT14	physical	19380743
LCP2_HUMAN	LCP2	physical	19380743
TBB4B_HUMAN	TUBB4B	physical	19380743
TBA1C_HUMAN	TUBA1C	physical	19380743
K1C16_HUMAN	KRT16	physical	19380743
GAB1_HUMAN	GAB1	physical	19380743
TCPA_HUMAN	TCP1	physical	19380743
ANXA2_HUMAN	ANXA2	physical	19380743
TCPB_HUMAN	CCT2	physical	19380743
GRP78_HUMAN	HSPA5	physical	19380743
ACTB_HUMAN	ACTB	physical	19380743
SOS2_HUMAN	SOS2	physical	19380743
ABRX2_HUMAN	FAM175B	physical	19380743
CBL_HUMAN	CBL	physical	19380743
TCPG_HUMAN	CCT3	physical	19380743
K2C5_HUMAN	KRT5	physical	19380743
K1C15_HUMAN	KRT15	physical	19380743
SHC1_HUMAN	SHC1	physical	19380743
CLPX_HUMAN	CLPX	physical	19380743
EF1G_HUMAN	EEF1G	physical	19380743
PSD11_HUMAN	PSMD11	physical	19380743
P85A_HUMAN	PIK3R1	physical	19380743
HS71L_HUMAN	HSPA1L	physical	19380743
K1H2_HUMAN	KRT32	physical	19380743
SYDC_HUMAN	DARS	physical	19380743
CH60_HUMAN	HSPD1	physical	19380743
EF1D_HUMAN	EEF1D	physical	19380743
SHIP2_HUMAN	INPPL1	physical	19380743
CNOT1_HUMAN	CNOT1	physical	19380743
UBR4_HUMAN	UBR4	physical	19380743
AHNK_HUMAN	AHNAK	physical	19380743
CLH1_HUMAN	CLTC	physical	19380743
KRT36_HUMAN	KRT36	physical	19380743
BCR_HUMAN	BCR	physical	19380743
TFG_HUMAN	TFG	physical	19380743
KRT82_HUMAN	KRT82	physical	19380743
MFAP4_HUMAN	MFAP4	physical	19380743
GAB2_HUMAN	GAB2	physical	19380743
PPIP2_HUMAN	PSTPIP2	physical	19380743
SPN90_HUMAN	NCKIPSD	physical	19380743
PRS7_HUMAN	PSMC2	physical	19380743
PSME1_HUMAN	PSME1	physical	19380743
PSDE_HUMAN	PSMD14	physical	19380743
P3C2B_HUMAN	PIK3C2B	physical	19380743
CD2AP_HUMAN	CD2AP	physical	19380743
FUS_HUMAN	FUS	physical	19380743
BABA2_HUMAN	BRE	physical	19380743
K1C19_HUMAN	KRT19	physical	19380743
SRC8_HUMAN	CTTN	physical	19380743
VASP_HUMAN	VASP	physical	19380743
TCPH_HUMAN	CCT7	physical	19380743
K2C73_HUMAN	KRT73	physical	19380743
HNRPU_HUMAN	HNRNPU	physical	19380743
BABA1_HUMAN	BABAM1	physical	19380743
HNRPD_HUMAN	HNRNPD	physical	19380743
DRG1_HUMAN	DRG1	physical	19380743
IMDH2_HUMAN	IMPDH2	physical	19380743
PAIRB_HUMAN	SERBP1	physical	19380743
PK3CA_HUMAN	PIK3CA	physical	19380743
BRCC3_HUMAN	BRCC3	physical	19380743
DOK3_HUMAN	DOK3	physical	19380743
G3P_HUMAN	GAPDH	physical	19380743
RUVB1_HUMAN	RUVBL1	physical	19380743
PSD13_HUMAN	PSMD13	physical	19380743
RS20_HUMAN	RPS20	physical	19380743
ACL6A_HUMAN	ACTL6A	physical	19380743
SYRC_HUMAN	RARS	physical	19380743
HNRPK_HUMAN	HNRNPK	physical	19380743
TCPE_HUMAN	CCT5	physical	19380743
DHB4_HUMAN	HSD17B4	physical	19380743
TS101_HUMAN	TSG101	physical	19380743
PTN11_HUMAN	PTPN11	physical	9361008
P85A_HUMAN	PIK3R1	physical	9541596
CBL_HUMAN	CBL	physical	9541596
GAB1_HUMAN	GAB1	physical	9242692
CBL_HUMAN	CBL	physical	9242692
SOS1_HUMAN	SOS1	physical	16906159
CBL_HUMAN	CBL	physical	16906159
LAT_HUMAN	LAT	physical	16906159
DAB2_HUMAN	DAB2	physical	10542228
KIT_HUMAN	KIT	physical	8950973
JAK2_HUMAN	JAK2	physical	8950973
SHC1_HUMAN	SHC1	physical	8950973
MET_HUMAN	MET	physical	21222362
PDE4D_HUMAN	PDE4D	physical	10571082
SPY2_HUMAN	SPRY2	physical	16893902
SOS1_HUMAN	SOS1	physical	16893902
CBL_HUMAN	CBL	physical	15677445
RET_HUMAN	RET	physical	15677445
IRS4_HUMAN	IRS4	physical	21706016
DYN2_HUMAN	DNM2	physical	21706016
WIPF2_HUMAN	WIPF2	physical	21706016
PTN11_HUMAN	PTPN11	physical	21706016
DOCK1_HUMAN	DOCK1	physical	21706016
SOS1_HUMAN	SOS1	physical	21706016
BCR_HUMAN	BCR	physical	21706016
ELMO2_HUMAN	ELMO2	physical	21706016
DYN1_HUMAN	DNM1	physical	21706016
WDR6_HUMAN	WDR6	physical	21706016
MEP50_HUMAN	WDR77	physical	21706016
P85B_HUMAN	PIK3R2	physical	21706016
WASL_HUMAN	WASL	physical	21706016
SNX18_HUMAN	SNX18	physical	21706016
WIPF1_HUMAN	WIPF1	physical	21706016
CBL_HUMAN	CBL	physical	21706016
P85A_HUMAN	PIK3R1	physical	21706016
DYN3_HUMAN	DNM3	physical	21706016
NISCH_HUMAN	NISCH	physical	21706016
1433Z_HUMAN	YWHAZ	physical	21706016
SHC1_HUMAN	SHC1	physical	21706016
ASAP1_HUMAN	ASAP1	physical	21706016
GAB1_HUMAN	GAB1	physical	21706016
STA10_HUMAN	STARD10	physical	21706016
1433E_HUMAN	YWHAE	physical	21706016
SPD2B_HUMAN	SH3PXD2B	physical	21706016
DOCK4_HUMAN	DOCK4	physical	21706016
CBLB_HUMAN	CBLB	physical	21706016
PEAK1_HUMAN	PEAK1	physical	21706016
KHDR1_HUMAN	KHDRBS1	physical	21706016
IRS2_HUMAN	IRS2	physical	21706016
PK3CB_HUMAN	PIK3CB	physical	21706016
ADT2_HUMAN	SLC25A5	physical	21706016
1433B_HUMAN	YWHAB	physical	21706016
PPIP2_HUMAN	PSTPIP2	physical	21706016
1433T_HUMAN	YWHAQ	physical	21706016
PK3CA_HUMAN	PIK3CA	physical	21706016
SHIP2_HUMAN	INPPL1	physical	21706016
2ABA_HUMAN	PPP2R2A	physical	21706016
SHPS1_HUMAN	SIRPA	physical	21706016
GIT1_HUMAN	GIT1	physical	21706016
SYNJ1_HUMAN	SYNJ1	physical	21706016
FGD6_HUMAN	FGD6	physical	21706016
SOS2_HUMAN	SOS2	physical	21706016
BCAP_HUMAN	PIK3AP1	physical	21706016
KIRR1_HUMAN	KIRREL	physical	21706016
GAB2_HUMAN	GAB2	physical	21706016
EGFR_HUMAN	EGFR	physical	21706016
1433G_HUMAN	YWHAG	physical	21706016
P3C2B_HUMAN	PIK3C2B	physical	21706016
FRS2_HUMAN	FRS2	physical	21706016
GARE2_HUMAN	GAREML	physical	21706016
RAGE_HUMAN	AGER	physical	21706016
TS101_HUMAN	TSG101	physical	21706016
WIPF3_HUMAN	WIPF3	physical	21706016
PTN18_HUMAN	PTPN18	physical	21706016
CMC2_HUMAN	SLC25A13	physical	21706016
CYFP2_HUMAN	CYFIP2	physical	21706016
ARHG7_HUMAN	ARHGEF7	physical	21706016
PP1A_HUMAN	PPP1CA	physical	21706016
CSK_HUMAN	CSK	physical	21706016
PTPRJ_HUMAN	PTPRJ	physical	21706016
1433F_HUMAN	YWHAH	physical	21706016
WDR44_HUMAN	WDR44	physical	21706016
CSRP1_HUMAN	CSRP1	physical	21706016
STABP_HUMAN	STAMBP	physical	21706016
SPD2A_HUMAN	SH3PXD2A	physical	21706016
TTYH2_HUMAN	TTYH2	physical	21706016
P55G_HUMAN	PIK3R3	physical	21706016
FLNA_HUMAN	FLNA	physical	21706016
RHG12_HUMAN	ARHGAP12	physical	21706016
RADIL_HUMAN	RADIL	physical	21706016
SH2D5_HUMAN	SH2D5	physical	21706016
ERRFI_HUMAN	ERRFI1	physical	21706016
UBIM_HUMAN	FAU	physical	21706016
RBBP6_HUMAN	RBBP6	physical	21706016
NCKP1_HUMAN	NCKAP1	physical	21706016
DIAP1_HUMAN	DIAPH1	physical	21706016
VAV3_HUMAN	VAV3	physical	21706016
IRS1_HUMAN	IRS1	physical	21706016
HGS_HUMAN	HGS	physical	21706016
CLAP2_HUMAN	CLASP2	physical	21706016
TEC_HUMAN	TEC	physical	21706016
ADT3_HUMAN	SLC25A6	physical	21706016
HUNK_HUMAN	HUNK	physical	21706016
AFAD_HUMAN	MLLT4	physical	21706016
ODR4_HUMAN	C1orf27	physical	21706016
PP1G_HUMAN	PPP1CC	physical	21706016
HDGR3_HUMAN	HDGFRP3	physical	21706016
M4K3_HUMAN	MAP4K3	physical	21706016
PTN12_HUMAN	PTPN12	physical	21706016
CD2AP_HUMAN	CD2AP	physical	21706016
SLAI2_HUMAN	SLAIN2	physical	21706016
EP15R_HUMAN	EPS15L1	physical	21706016
IF2B1_HUMAN	IGF2BP1	physical	21706016
PPP5_HUMAN	PPP5C	physical	21706016
CXA9_HUMAN	GJA9	physical	21706016
TAB1_HUMAN	TAB1	physical	21706016
SHC1_HUMAN	SHC1	physical	8662998
CBL_HUMAN	CBL	physical	8662998
EGFR_HUMAN	EGFR	physical	8662998
EGFR_HUMAN	EGFR	physical	23799367
SHC1_MOUSE	Shc1	physical	10202139
ABL1_HUMAN	ABL1	physical	23950177
HNRPK_HUMAN	HNRNPK	physical	21988832
PHAR4_HUMAN	PHACTR4	physical	21988832
SF3B4_HUMAN	SF3B4	physical	21988832
VIME_HUMAN	VIM	physical	21988832
WIPF2_HUMAN	WIPF2	physical	21988832
UBA1_HUMAN	UBA1	physical	21988832
PHC2_HUMAN	PHC2	physical	21988832
IMA1_HUMAN	KPNA2	physical	21988832
PON2_HUMAN	PON2	physical	21988832
SOS1_HUMAN	SOS1	physical	21988832
SOS2_HUMAN	SOS2	physical	21988832
WIPF1_HUMAN	WIPF1	physical	21988832
PDC6I_HUMAN	PDCD6IP	physical	21988832
KHDR1_HUMAN	KHDRBS1	physical	21988832
MLXPL_HUMAN	MLXIPL	physical	21988832
WBP11_HUMAN	WBP11	physical	21988832
YLPM1_HUMAN	YLPM1	physical	21988832
SHAN3_HUMAN	SHANK3	physical	21988832
NKD2_HUMAN	NKD2	physical	21988832
BCAP_HUMAN	PIK3AP1	physical	21988832
ACTG_HUMAN	ACTG1	physical	12577067
CBR1_HUMAN	CBR1	physical	12577067
AP2A1_HUMAN	AP2A1	physical	12577067
AP2B1_HUMAN	AP2B1	physical	12577067
AP2M1_HUMAN	AP2M1	physical	12577067
AP2S1_HUMAN	AP2S1	physical	12577067
CBLB_HUMAN	CBLB	physical	12577067
PTN11_HUMAN	PTPN11	physical	12577067
H31_HUMAN	HIST1H3A	physical	12577067
SMU1_HUMAN	SMU1	physical	12577067
SMD2_HUMAN	SNRPD2	physical	12577067
CD59_HUMAN	CD59	physical	12577067
EGFR_HUMAN	EGFR	physical	7506413
CBL_HUMAN	CBL	physical	11792427
SHC1_HUMAN	SHC1	physical	11792427
SHC1_HUMAN	SHC1	physical	11370743
EGFR_HUMAN	EGFR	physical	11370743
HNRPK_HUMAN	HNRNPK	physical	25416956
LCP2_HUMAN	LCP2	physical	25416956
RBTN2_HUMAN	LMO2	physical	25416956
REL_HUMAN	REL	physical	25416956
TRI27_HUMAN	TRIM27	physical	25416956
ASPP2_HUMAN	TP53BP2	physical	25416956
WASL_HUMAN	WASL	physical	25416956
GAB2_HUMAN	GAB2	physical	25416956
DDX17_HUMAN	DDX17	physical	25416956
STABP_HUMAN	STAMBP	physical	25416956
IKZF3_HUMAN	IKZF3	physical	25416956
ZBT7B_HUMAN	ZBTB7B	physical	25416956
ABI3_HUMAN	ABI3	physical	25416956
WBP11_HUMAN	WBP11	physical	25416956
NTM2F_HUMAN	NUTM2F	physical	25416956
DPPA4_HUMAN	DPPA4	physical	25416956
HOMEZ_HUMAN	HOMEZ	physical	25416956
NIF3L_HUMAN	NIF3L1	physical	25416956
RHG09_HUMAN	ARHGAP9	physical	25416956
GARE1_HUMAN	GAREM	physical	25416956
LZTS2_HUMAN	LZTS2	physical	25416956
LNX1_HUMAN	LNX1	physical	25416956
CA094_HUMAN	C1orf94	physical	25416956
PNMA5_HUMAN	PNMA5	physical	25416956
PRR22_HUMAN	PRR22	physical	25416956
INCA1_HUMAN	INCA1	physical	25416956
BCAR1_HUMAN	BCAR1	physical	16105984
ALK_HUMAN	ALK	physical	16105984
DOK1_HUMAN	DOK1	physical	15151996
FKBP2_HUMAN	FKBP2	physical	26344197
HEXB_HUMAN	HEXB	physical	26344197
PTN23_HUMAN	PTPN23	physical	26344197
DYN1_RAT	Dnm1	physical	9736607
ACAP1_HUMAN	ACAP1	physical	25814554
PKHS1_HUMAN	PLEKHS1	physical	25814554
AUNIP_HUMAN	AUNIP	physical	25814554
UQCC2_HUMAN	UQCC2	physical	25814554
CRBN_HUMAN	CRBN	physical	25814554
LMX1A_HUMAN	LMX1A	physical	25814554
MYOZ1_HUMAN	MYOZ1	physical	25814554
PACRL_HUMAN	PACRGL	physical	25814554
PAR6A_HUMAN	PARD6A	physical	25814554
PCDB5_HUMAN	PCDHB5	physical	25814554
PPARA_HUMAN	PPARA	physical	25814554
RB_HUMAN	RB1	physical	25814554
SOCS4_HUMAN	SOCS4	physical	25814554
TM128_HUMAN	TMEM128	physical	25814554
TSN2_HUMAN	TSPAN2	physical	25814554
TERA_HUMAN	VCP	physical	25814554
WDFY3_HUMAN	WDFY3	physical	25814554
DREB_HUMAN	DBN1	physical	25814554
E2F2_HUMAN	E2F2	physical	25814554
AR6P4_HUMAN	ARL6IP4	physical	25814554
OLIG1_HUMAN	OLIG1	physical	25814554
MET27_HUMAN	WBSCR27	physical	25814554
ZMAT1_HUMAN	ZMAT1	physical	25814554
CBL_HUMAN	CBL	physical	25814554
CBL_HUMAN	CBL	physical	25872741
ARHG5_HUMAN	ARHGEF5	physical	24189400
EGFR_HUMAN	EGFR	physical	24189400
ERRFI_HUMAN	ERRFI1	physical	24189400
GFAP_HUMAN	GFAP	physical	24189400
NFH_HUMAN	NEFH	physical	24189400
ROA2_HUMAN	HNRNPA2B1	physical	24189400
RS27A_HUMAN	RPS27A	physical	24189400
SHC1_HUMAN	SHC1	physical	24189400
UBS3B_HUMAN	UBASH3B	physical	24189400
ACTB_HUMAN	ACTB	physical	24189400
ACTG_HUMAN	ACTG1	physical	24189400
GRB2_HUMAN	GRB2	physical	24189400
LG3BP_HUMAN	LGALS3BP	physical	24189400
ML12A_HUMAN	MYL12A	physical	24189400
ML12B_HUMAN	MYL12B	physical	24189400
MYH9_HUMAN	MYH9	physical	24189400
PTPRA_HUMAN	PTPRA	physical	24189400
S10A8_HUMAN	S100A8	physical	24189400
S10A9_HUMAN	S100A9	physical	24189400
EGFR_HUMAN	EGFR	physical	27059931
NTAL_HUMAN	LAT2	physical	19879355
LIME1_HUMAN	LIME1	physical	19879355
CSF3R_HUMAN	CSF3R	physical	14557262
EGFR_HUMAN	EGFR	physical	7650032
LTK_HUMAN	LTK	physical	7650032
SHC1_HUMAN	SHC1	physical	7650032
P85A_HUMAN	PIK3R1	physical	18346204
SOS1_HUMAN	SOS1	physical	28514442
SOS2_HUMAN	SOS2	physical	28514442
ARAP1_HUMAN	ARAP1	physical	28514442
CBL_HUMAN	CBL	physical	28514442
WIPF1_HUMAN	WIPF1	physical	28514442
WIPF2_HUMAN	WIPF2	physical	28514442
WASL_HUMAN	WASL	physical	28514442
CBLB_HUMAN	CBLB	physical	28514442
ASAP1_HUMAN	ASAP1	physical	28514442
BCAP_HUMAN	PIK3AP1	physical	28514442
GARE1_HUMAN	GAREM	physical	28514442
CYLD_HUMAN	CYLD	physical	28514442
DOCK1_HUMAN	DOCK1	physical	28514442
GAB1_HUMAN	GAB1	physical	28514442
ELMO2_HUMAN	ELMO2	physical	28514442
VP37B_HUMAN	VPS37B	physical	28514442
DYN3_HUMAN	DNM3	physical	28514442
GARE2_HUMAN	GAREML	physical	28514442
ASAP2_HUMAN	ASAP2	physical	28514442
P3C2B_HUMAN	PIK3C2B	physical	28514442
NKX25_HUMAN	NKX2-5	physical	28514442
GAB2_HUMAN	GAB2	physical	28514442
DYN1_HUMAN	DNM1	physical	28514442
SPA2L_HUMAN	SPATA2L	physical	28514442
PEAK1_HUMAN	PEAK1	physical	28514442
DOCK4_HUMAN	DOCK4	physical	28514442
PTN11_HUMAN	PTPN11	physical	28514442
ERRFI_HUMAN	ERRFI1	physical	28514442
MB12A_HUMAN	MVB12A	physical	28514442
SNX18_HUMAN	SNX18	physical	28514442
M4K5_HUMAN	MAP4K5	physical	28514442
DYN2_HUMAN	DNM2	physical	28514442
PTN23_HUMAN	PTPN23	physical	28514442
PK3CA_HUMAN	PIK3CA	physical	28514442
STABP_HUMAN	STAMBP	physical	28514442
ZMYM6_HUMAN	ZMYM6	physical	28514442
WIPF3_HUMAN	WIPF3	physical	28514442
VPS28_HUMAN	VPS28	physical	28514442
BCR_HUMAN	BCR	physical	28514442
ACK1_HUMAN	TNK2	physical	28514442
DOCK5_HUMAN	DOCK5	physical	28514442
SYNJ1_HUMAN	SYNJ1	physical	28514442
PK3CB_HUMAN	PIK3CB	physical	28514442
EGFR_HUMAN	EGFR	physical	20473329
GAB1_HUMAN	GAB1	physical	20473329
PTN11_HUMAN	PTPN11	physical	20473329
SOS1_HUMAN	SOS1	physical	20473329
PTN11_HUMAN	PTPN11	physical	8959326
SHIP1_HUMAN	INPP5D	physical	12149229
SHC1_HUMAN	SHC1	physical	12149229
SOS1_HUMAN	SOS1	physical	15192046
PTPRA_HUMAN	PTPRA	physical	23532252
SHC1_MOUSE	Shc1	physical	10995764
RET_HUMAN	RET	physical	10995764
GAB2_HUMAN	GAB2	physical	16371368
PLCG1_HUMAN	PLCG1	physical	16038803
PLCG1_RAT	Plcg1	physical	16038803

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00061	Pegademase bovine

Regulatory Network of GRB2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-6; LYS-50 AND LYS-109, ANDMASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-211, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-160 AND TYR-209, ANDMASS SPECTROMETRY.	17081983 [Abstract]