RET4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RET4_HUMAN
• UniProt AC: P02753
• Protein Name: Retinol-binding protein 4
• Gene Name: RBP4
• Organism: Homo sapiens (Human).
• Sequence Length: 201
• Subcellular Localization: Secreted .
• Protein Description: Retinol-binding protein that mediates retinol transport in blood plasma. [PubMed: 5541771 Delivers retinol from the liver stores to the peripheral tissues (Probable Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane]
• Protein Sequence: MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MKWVWALLL ------CHHHHHHHH	50.91	235536
30	Acetylation	RVSSFRVKENFDKAR CCCEEEECCCCCCCE	42.56	235536
35	Acetylation	RVKENFDKARFSGTW EECCCCCCCEECCEE	37.01	235536
47	Acetylation	GTWYAMAKKDPEGLF CEEEEEEEECCCCCC	44.62	235536
48	Acetylation	TWYAMAKKDPEGLFL EEEEEEEECCCCCCC	69.82	235536
76	Acetylation	GQMSATAKGRVRLLN CCCCEEECCCEEECC	42.78	235536
103	Acetylation	TDTEDPAKFKMKYWG CCCCCHHHHHCEEHH	51.40	235536
105	Acetylation	TEDPAKFKMKYWGVA CCCHHHHHCEEHHHH	33.50	235536
107	Acetylation	DPAKFKMKYWGVASF CHHHHHCEEHHHHHH	38.14	235536
108	Phosphorylation	PAKFKMKYWGVASFL HHHHHCEEHHHHHHH	12.14	-
117	Acetylation	GVASFLQKGNDDHWI HHHHHHHCCCCCCEE	62.93	235536
139	Methylation	YAVQYSCRLLNLDGT HHHEEEEEEECCCCC	35.95	-
168	Acetylation	GLPPEAQKIVRQRQE CCCHHHHHHHHHHHH	50.66	235536
191	Phosphorylation	RLIVHNGYCDGRSER EEEEECCCCCCCCCC	7.84	-
196	Phosphorylation	NGYCDGRSERNLL-- CCCCCCCCCCCCC--	46.57	24505115
196	O-linked_Glycosylation	NGYCDGRSERNLL-- CCCCCCCCCCCCC--	46.57	OGP

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RET4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RET4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RET4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTO1_HUMAN	MTO1	physical	28514442
RPC4_HUMAN	POLR3D	physical	28514442
KLH24_HUMAN	KLHL24	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.