KLH24_HUMAN - dbPTM
KLH24_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KLH24_HUMAN
UniProt AC Q6TFL4
Protein Name Kelch-like protein 24
Gene Name KLHL24
Organism Homo sapiens (Human).
Sequence Length 600
Subcellular Localization Perikaryon. Cell projection, axon . Cytoplasm . Cell junction, desmosome . Cell junction, adherens junction .
Protein Description Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. [PubMed: 27889062 As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation]
Protein Sequence MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationEDLGVRDSPATKRKV
HHCCCCCCHHHCCEE		13.0825849741
25UbiquitinationDSPATKRKVFEMDPK
CCHHHCCEEEECCCH		53.4829967540
160UbiquitinationDACAKFLEEQLDPCN
HHHHHHHHHHCCCCC		46.9921963094
181 (in isoform 2)Ubiquitination-46.3121890473
181 (in isoform 1)Ubiquitination-46.3121890473
181UbiquitinationFADTHSLKTLFTKCK
HHCCCCHHHHHHHHH		46.3123000965
185UbiquitinationHSLKTLFTKCKNFAL
CCHHHHHHHHHHHHC		38.3521963094
186UbiquitinationSLKTLFTKCKNFALQ
CHHHHHHHHHHHHCC		35.5623000965
190UbiquitinationLFTKCKNFALQTFED
HHHHHHHHHCCCCCC		4.3721963094
215UbiquitinationDKDELIDYICSDELV
CHHHHHHHHCCCCCE		9.2421963094
291PhosphorylationLLHEARRYHILGNEM
HHHHHHHHHHHCCCC		6.4026074081
300PhosphorylationILGNEMMSPRTRPRR
HHCCCCCCCCCCCCC		15.2126074081
303PhosphorylationNEMMSPRTRPRRSTG
CCCCCCCCCCCCCCC		48.70-
347UbiquitinationGEWKSLAKLPEFTKS
CCHHHHHCCCCCCCC		70.6229967540
353UbiquitinationAKLPEFTKSEYAVCA
HCCCCCCCCCHHHHH		46.76-
354PhosphorylationKLPEFTKSEYAVCAL
CCCCCCCCCHHHHHH		32.5524043423
356PhosphorylationPEFTKSEYAVCALRN
CCCCCCCHHHHHHCC		16.0724043423
368PhosphorylationLRNDILVSGGRINSR
HCCCEEEECCCCCCC		31.8924043423
374PhosphorylationVSGGRINSRDVWIYN
EECCCCCCCEEEEEE		27.7324043423
441UbiquitinationWTEVAPLKEAVSSPA
EEEEEEHHHHCCCHH		42.4421963094
455UbiquitinationAVTSCVGKLFVIGGG
HHHHCCCEEEEECCC		20.5329967540
466UbiquitinationIGGGPDDNTCSDKVQ
ECCCCCCCCCCHHHH		50.8221963094
471UbiquitinationDDNTCSDKVQSYDPE
CCCCCCHHHHHCCCC		26.3621963094
492UbiquitinationRAAIPIAKRCITAVS
HHHHHHHHHHCCCHH		48.8229967540
496PhosphorylationPIAKRCITAVSLNNL
HHHHHHCCCHHHHCE		25.32-
496UbiquitinationPIAKRCITAVSLNNL
HHHHHHCCCHHHHCE		25.3221963094
499PhosphorylationKRCITAVSLNNLIYV
HHHCCCHHHHCEEEE		23.94-
545UbiquitinationGMSVCNGKIYILGGR
EEEEECCEEEEECCC		20.53-
559PhosphorylationRRENGEATDTILCYD
CCCCCCCCCEEEEEC		29.4022210691
561PhosphorylationENGEATDTILCYDPA
CCCCCCCEEEEECCC		16.1122210691
570PhosphorylationLCYDPATSIITGVAA
EEECCCCCCHHCCCC		17.6925332170
573PhosphorylationDPATSIITGVAAMPR
CCCCCCHHCCCCCCC		24.7522210691
584PhosphorylationAMPRPVSYHGCVTIH
CCCCCCCCCCEEEEE		11.4925332170
596UbiquitinationTIHRYNEKCFKL---
EEEEECCCCCCC---		41.14-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KLH24_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KLH24_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KLH24_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PICK1_HUMANPICK1physical
18692513
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KLH24_HUMAN

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Related Literatures of Post-Translational Modification

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