KRT86_HUMAN - dbPTM
KRT86_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KRT86_HUMAN
UniProt AC O43790
Protein Name Keratin, type II cuticular Hb6
Gene Name KRT86
Organism Homo sapiens (Human).
Sequence Length 486
Subcellular Localization
Protein Description
Protein Sequence MTCGSYCGGRAFSCISACGPRPGRCCITAAPYRGISCYRGLTGGFGSHSVCGGFRAGSCGRSFGYRSGGVCGPSPPCITTVSVNESLLTPLNLEIDPNAQCVKQEEKEQIKSLNSRFAAFIDKVRFLEQQNKLLETKLQFYQNRECCQSNLEPLFEGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKKYEEEVSLRATAENEFVALKKDVDCAYLRKSDLEANVEALIQEIDFLRRLYEEEIRVLQSHISDTSVVVKLDNSRDLNMDCIIAEIKAQYDDIVTRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMIQRLTAEVENAKCQNSKLEAAVAQSEQQGEAALSDARCKLAELEGALQKAKQDMACLIREYQEVMNSKLGLDIEIATYRRLLEGEEQRLCEGVGSVNVCVSSSRGGVVCGDLCASTTAPVVSTRVSSVPSNSNVVVGTTNACAPSARVGVCGGSCKRC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTCGSYCGG
------CCCCCCCCC		26.1024043423
5Phosphorylation---MTCGSYCGGRAF
---CCCCCCCCCCCC		21.2824043423
6Phosphorylation--MTCGSYCGGRAFS
--CCCCCCCCCCCCC		4.7624043423
42PhosphorylationISCYRGLTGGFGSHS
CCCCCCCCCCCCCCC		37.7820068231
47PhosphorylationGLTGGFGSHSVCGGF
CCCCCCCCCCCCCCC		15.4420068231
49PhosphorylationTGGFGSHSVCGGFRA
CCCCCCCCCCCCCCC		22.3226657352
62PhosphorylationRAGSCGRSFGYRSGG
CCCCCCCCCCCCCCC		14.3324719451
132UbiquitinationRFLEQQNKLLETKLQ
HHHHHHHHHHHHHHH		50.54-
193"N6,N6-dimethyllysine"VLEGYKKKYEEEVSL
HHHHHHHHHHHHHCH		54.46-
193MethylationVLEGYKKKYEEEVSL
HHHHHHHHHHHHHCH		54.46-
203PhosphorylationEEVSLRATAENEFVA
HHHCHHEEECCCEEE		28.2420068231
222"N6,N6-dimethyllysine"VDCAYLRKSDLEANV
CCCEECCHHHHHHHH		45.81-
222MethylationVDCAYLRKSDLEANV
CCCEECCHHHHHHHH		45.81-
243PhosphorylationIDFLRRLYEEEIRVL
HHHHHHHHHHHHHHH		21.3420071362
252PhosphorylationEEIRVLQSHISDTSV
HHHHHHHHHCCCCEE		20.73-
257PhosphorylationLQSHISDTSVVVKLD
HHHHCCCCEEEEEEC		19.3420068231
258PhosphorylationQSHISDTSVVVKLDN
HHHCCCCEEEEEECC		20.2220068231
282PhosphorylationIAEIKAQYDDIVTRS
EEEHHHHHCHHHHHH		22.0522461510
289PhosphorylationYDDIVTRSRAEAESW
HCHHHHHHHHHHHHH		26.8628348404
295PhosphorylationRSRAEAESWYRSKCE
HHHHHHHHHHHHHHH		36.1328348404
297PhosphorylationRAEAESWYRSKCEEM
HHHHHHHHHHHHHHH		17.81-
300UbiquitinationAESWYRSKCEEMKAT
HHHHHHHHHHHHHHH		36.35-
305UbiquitinationRSKCEEMKATVIRHG
HHHHHHHHHHHHHCC		44.15-
307PhosphorylationKCEEMKATVIRHGET
HHHHHHHHHHHCCHH		15.7924719451
314PhosphorylationTVIRHGETLRRTKEE
HHHHCCHHHHHHHHH		30.1124719451
318PhosphorylationHGETLRRTKEEINEL
CCHHHHHHHHHHHHH		36.0524719451
319UbiquitinationGETLRRTKEEINELN
CHHHHHHHHHHHHHH		52.09-
340UbiquitinationTAEVENAKCQNSKLE
HHHHHHHHHHCHHHH		48.19-
345UbiquitinationNAKCQNSKLEAAVAQ
HHHHHCHHHHHHHHC		58.87-
362PhosphorylationQQGEAALSDARCKLA
HHHHHHHHHHHHHHH		25.2128348404
367UbiquitinationALSDARCKLAELEGA
HHHHHHHHHHHHHHH		45.22-
377MethylationELEGALQKAKQDMAC
HHHHHHHHHHHHHHH		59.40-
377UbiquitinationELEGALQKAKQDMAC
HHHHHHHHHHHHHHH		59.40-
377"N6,N6-dimethyllysine"ELEGALQKAKQDMAC
HHHHHHHHHHHHHHH		59.40-
379UbiquitinationEGALQKAKQDMACLI
HHHHHHHHHHHHHHH		54.59-
395PhosphorylationEYQEVMNSKLGLDIE
HHHHHHHHCCCCCEE		15.9127251275
454PhosphorylationPVVSTRVSSVPSNSN
CEEEEEEECCCCCCC		23.4827273156
455PhosphorylationVVSTRVSSVPSNSNV
EEEEEEECCCCCCCE		34.88-
458PhosphorylationTRVSSVPSNSNVVVG
EEEECCCCCCCEEEE		51.2227273156
460PhosphorylationVSSVPSNSNVVVGTT
EECCCCCCCEEEEEC		35.03-
466PhosphorylationNSNVVVGTTNACAPS
CCCEEEEECCCCCCC		12.7927273156
482PhosphorylationRVGVCGGSCKRC---
CEEECCCCCCCC---		11.1828348404
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KRT86_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KRT86_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KRT86_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MEOX2_HUMANMEOX2physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
158000Monilethrix (MNLIX)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KRT86_HUMAN

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Related Literatures of Post-Translational Modification

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